KR960010023A - 면역접합체 ii - Google Patents

면역접합체 ii Download PDF

Info

Publication number
KR960010023A
KR960010023A KR1019950030385A KR19950030385A KR960010023A KR 960010023 A KR960010023 A KR 960010023A KR 1019950030385 A KR1019950030385 A KR 1019950030385A KR 19950030385 A KR19950030385 A KR 19950030385A KR 960010023 A KR960010023 A KR 960010023A
Authority
KR
South Korea
Prior art keywords
antibody
immunoconjugate
mab
fragment
conjugate
Prior art date
Application number
KR1019950030385A
Other languages
English (en)
Other versions
KR100386171B1 (ko
Inventor
홀쩌 볼프강
폰 회겐 일카
스트리트마터 볼프강
마츠쿠 지그프리트
Original Assignee
위르겐 호이만·라인하르트 쉬틀러
메르크 파텐트 게젤샤프트 미트 베슈랭크터 하프퉁
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 위르겐 호이만·라인하르트 쉬틀러, 메르크 파텐트 게젤샤프트 미트 베슈랭크터 하프퉁 filed Critical 위르겐 호이만·라인하르트 쉬틀러
Publication of KR960010023A publication Critical patent/KR960010023A/ko
Application granted granted Critical
Publication of KR100386171B1 publication Critical patent/KR100386171B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

본 발명은 인간 EGF-수용체 분자에 특이적인 단클로항체 또는 이의 단면과 케모킨족 부류, 바람직하게는 C-X-C족, 예컨데 인터루이킨-8(IL-8)중에서 선택되는 케모킨류로 이루어지는 신규한 면역접합체를 제공한다. 본 면역접합체는 세포독성 및 주화성 활성을 유도하며 표적종양 치료에 적합하다.

Description

면역접합체 Ⅱ
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 표피 성장 인자 수용체(EGFR)의 항원 결정기를 함유하고 있는 종양세포에 대해 지향성을 갖는 단클론성 항체 또는 이의 단편 : 및 상기 항체 또는 항체 단편에 융합된 케모킨 단백질을 포함하여 이루어지는 것을 특징으로 하는 면역접합체
  2. 제1항에 있어서, 상기한 케모킨이 C-X-C족인 것을 특징으로 하는 면역접합체
  3. 제2항에 있어서, 상기한 케모킨이 IL-8인 것을 특징으로 하는 면역접합체
  4. 제1항 내지 제3항 중의 어느 한 항에 있어서, 상기한 항체가 항체중쇄의 가변부, 불변부의 CH1 구역 및 적절한 경쇄(항체-CH1 접합체)로 구성되는 Fab 단편 및 F(ab')2 단편인 것을 특징으로 하는 면역접합체
  5. 제1항 내지 제3항 중의 어느 한 항에 있어서, 상기한 항체가 항체중쇄의 가변부, 불변부의 CH1 및 CH2 구역 및 적절한 경쇄(항체-CH2 접합체)로 구성되는 항체단편인 것을 특징으로 하는 면역접합체
  6. 제1항 내지 제3항 중의 어느 한 항에 있어서, 상기한 항체가 항체중쇄의 가변부, 불변부의 CH1, CH2 및 CH3 구역, 및 적절한 경쇄(항체-CH3 접합체)로 구성되는 항체단편인 것을 특징으로 하는 면역접합체
  7. 제1항 내지 제3항 중의 어느 한 항에 있어서, 상기한 항체가 항체중쇄의 가변부, 적절한 경쇄 및 중쇄를 연결하는 폴리펩티드 서열(항체-Fv 접합체)로 구성되는 것임을 특징으로 하는 면역접합체
  8. 제1항 내지 제6항 중 어느 한 항에 있어서, 상기한 면역접합체가 항체/항체 단편과 생물학적 활성 리간드 사이에서 완전 융합 형성물내에서 유일하게 존재하는, DNA 제한부위에 대해 연역 가능한 아미노산(서열)을 포함하여 이루어지고, 상기 제한 부위가 완전 융합 형성물내에서 유일하게 존재하는 것을 특징으로 하는 면역접합체
  9. 제1항 내지 제7항 중 어느 한 항에 있어서, 상기한 면역접합체가 항체/항체 단편과 생물학적 활성 리간드 사이의 링커 펩티드를 포함하여 이루어지는 것을 특징으로 하는 면역접합체
  10. 제1항 내지 제3항 중의 어느 한 항에 있어서, 상기한 항체 또는 항체단편이 쥐, 인간 또는 키메라성 MAb 425로부터 유도되는 것임을 특징으로 하는 면역접합체
  11. MAb 425-CH1-IL8, MAb 425-CH2-(Ncol)-IL-8, MAb 425-CH2-(Bcll)-IL-8, MAb 25-Fv-IL-8, MAb 425-CH3-IL-8 중에서 선택되는 것임을 특징으로 하는 면역접합체
  12. 제1항 내지 제10항 중의 한 항에 기재된 면역접합체를 제조하는 방법에 있어서, 목적하는 융합 DNA-서열에 상보적인 올리고 뉴클레오티드를 사용하여 항체 또는 항체단편 및 생물학적 활성 리간드 각각을 암호화하는 DNA서열을 단일가닥 DNA상에 상호 융합시키고; 생성된 형성물을 발현 벡터에 위치시킨 후, 상기 숙주세포로 도입하여 형질전환시키고; 상기 숙주세포를 배양액중에서 배양하여 융합 단백질을 발현시키는 것으로 이루어지는 면역접합체의 제조방법
  13. 제1항 내지 제10항 중의 어느 한 항에 따른 면역접합체 1종 이상과, 생리학적으로 허용되는 담체를 포함하여 이루어지는 것을 특징으로 하는 약제학적 조성물
  14. 종양 지향성 약물을 제조하기 위하여 제1항 내지 제10항 중의 어느 한 항에 기재된 면역접합체를 사용하는 방법
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950030385A 1994-09-16 1995-09-15 면역접합체ii KR100386171B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94114572.4 1994-09-16
DE94114572.4 1994-09-16
EP94114572 1994-09-16

Publications (2)

Publication Number Publication Date
KR960010023A true KR960010023A (ko) 1996-04-20
KR100386171B1 KR100386171B1 (ko) 2003-08-21

Family

ID=8216289

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950030385A KR100386171B1 (ko) 1994-09-16 1995-09-15 면역접합체ii

Country Status (20)

Country Link
US (1) US5824782A (ko)
EP (1) EP0706799B1 (ko)
JP (2) JP3865802B2 (ko)
KR (1) KR100386171B1 (ko)
CN (1) CN1123185A (ko)
AT (1) ATE208633T1 (ko)
AU (1) AU702184B2 (ko)
CA (1) CA2158322C (ko)
CZ (1) CZ289641B6 (ko)
DE (1) DE69523857T2 (ko)
DK (1) DK0706799T3 (ko)
ES (1) ES2167391T3 (ko)
HU (1) HU221989B1 (ko)
NO (1) NO315976B1 (ko)
PL (1) PL182636B1 (ko)
PT (1) PT706799E (ko)
RU (1) RU2157701C2 (ko)
SK (1) SK282263B6 (ko)
UA (1) UA40611C2 (ko)
ZA (1) ZA957808B (ko)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055607A2 (en) * 1997-06-04 1998-12-10 Oxford Biomedica (Uk) Limited Tumor targeted vector
US7276488B2 (en) * 1997-06-04 2007-10-02 Oxford Biomedica (Uk) Limited Vector system
US7635687B2 (en) * 1997-06-04 2009-12-22 Oxford Biomedica (Uk) Limited Vector system
DE69824039T2 (de) 1997-12-08 2005-08-18 Lexigen Pharmaceuticals Corp., Lexington Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung
WO1999046392A1 (en) * 1998-03-12 1999-09-16 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions of chemokine-tumor antigen fusion proteins as cancer vaccines
CA2326427A1 (en) * 1998-03-31 1999-10-07 Koichiro Yamada Preventives/remedies for urinary disorder
WO1999052562A2 (en) * 1998-04-15 1999-10-21 Lexigen Pharmaceuticals Corp. Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor
CN1305387A (zh) * 1998-04-17 2001-07-25 利思进药品公司 通过共同给予前列腺素抑制剂增强抗体－细胞因子融合蛋白介导的免疫应答
US6869606B1 (en) 1999-02-22 2005-03-22 Millennium Pharmaceuticals, Inc. Biotinylated-chemokine antibody complexes
WO2000078334A1 (en) * 1999-06-17 2000-12-28 University Of Maryland Biotechnology Institute Chimeric chemokine-antigen polypeptides and uses therefor
GB9915074D0 (en) * 1999-06-28 1999-08-25 Cortecs Plc Ligand-binding composition
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
US6617135B1 (en) 1999-08-09 2003-09-09 Emd Lexigen Research Center Corp. Multiple cytokine protein complexes
JP2003515323A (ja) * 1999-11-18 2003-05-07 オックスフォード バイオメディカ（ユーケイ）リミテッド 抗 体
US7208152B2 (en) * 1999-11-24 2007-04-24 Millennium Pharmaceuticals, Inc. Antibodies for “Bonzo” chemokine receptor and therapeutic uses thereof
US6319675B1 (en) 1999-11-24 2001-11-20 Millennium Pharmaceuticals, Inc. Methods for detecting and/or identifying agents which bind and/or modulate function of “bonzo” chemokine receptor
WO2001058957A2 (en) 2000-02-11 2001-08-16 Lexigen Pharmaceuticals Corp. Enhancing the circulating half-life of antibody-based fusion proteins
DE10019157A1 (de) * 2000-04-18 2001-11-15 Stefan Duebel Verfahren zum Einbringen von Liganden in lebende Zellen
US20040091485A1 (en) * 2000-05-19 2004-05-13 Ellis John Robert Maxwell Humanised antibodies to the epidermal growth factor receptor
US7754676B2 (en) 2000-09-15 2010-07-13 The United States Of America As Represented By The Department Of Health And Human Services Defensin-antigen fusion proteins
AU2001291050A1 (en) 2000-09-15 2002-03-26 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Viral chemokine-tumur antigen fusion proteins
GB0029407D0 (en) * 2000-12-01 2001-01-17 Affitech As Product
MXPA03008031A (es) 2001-03-07 2003-12-04 Merck Patent Gmbh Tecnologia de expresion para proteinas que contienen porcion de anticuerpo isotipo hibrida.
US6992174B2 (en) 2001-03-30 2006-01-31 Emd Lexigen Research Center Corp. Reducing the immunogenicity of fusion proteins
CN100503639C (zh) 2001-05-03 2009-06-24 默克专利有限公司 重组肿瘤特异性抗体及其应用
EP1256354A1 (en) * 2001-05-11 2002-11-13 Schering Corporation Methods for treating cancer
US20020193569A1 (en) * 2001-06-04 2002-12-19 Idec Pharmaceuticals Corporation Bispecific fusion protein and method of use for enhancing effector cell killing of target cells
BRPI0210405B8 (pt) 2001-06-13 2021-05-25 Genmab As anticorpo monoclonal humano, molécula biespecífica, método in vitro para inibir o crescimento de uma célula expressando egfr, para induzir a citólise de uma célula expressando egfr, e para detectar a presença de antígeno egfr ou uma célula expressando egfr em uma amostra, e, vetor de expressão
US7595378B2 (en) 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
DK1399484T3 (da) * 2001-06-28 2010-11-08 Domantis Ltd Dobbelt-specifik ligand og anvendelse af denne
GB0126378D0 (en) * 2001-11-02 2002-01-02 Oxford Biomedica Ltd Antigen
WO2003048334A2 (en) 2001-12-04 2003-06-12 Merck Patent Gmbh Immunocytokines with modulated selectivity
JP4212921B2 (ja) 2002-03-29 2009-01-21 独立行政法人科学技術振興機構 抗体を提示するタンパク質中空ナノ粒子を用いる治療薬剤およびタンパク質中空ナノ粒子
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
EP2135879A3 (en) * 2002-06-28 2010-06-23 Domantis Limited Ligand
US9321832B2 (en) * 2002-06-28 2016-04-26 Domantis Limited Ligand
US20040110929A1 (en) * 2002-07-12 2004-06-10 Bjorn Soren E. TF binding compound
DE60336406D1 (de) 2002-10-16 2011-04-28 Purdue Pharma Lp Antikörper, die an zellassoziiertes ca 125/0722p binden, und verfahren zu deren anwendung
US7388079B2 (en) * 2002-11-27 2008-06-17 The Regents Of The University Of California Delivery of pharmaceutical agents via the human insulin receptor
ATE471946T1 (de) 2002-12-17 2010-07-15 Merck Patent Gmbh Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2
CA2511910A1 (en) * 2002-12-27 2004-07-15 Domantis Limited Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
EP1599572A4 (en) * 2003-02-14 2007-06-13 Univ Southern California COMPOSITIONS AND METHODS FOR CANCER IMMUNOTHERAPY
JP2008502317A (ja) 2003-12-30 2008-01-31 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング Ｉｌ−７融合タンパク質
AU2005203962C1 (en) 2004-01-05 2012-11-08 Antisoma Research Limited Interleukin-12 targeted to oncofoetal fibronectin
US7670595B2 (en) 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
GB2424886A (en) * 2005-04-04 2006-10-11 Dxs Ltd Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
US8124095B2 (en) * 2005-10-07 2012-02-28 Armagen Technologies, Inc. Fusion proteins for delivery of erythropoietin to the CNS
US8053569B2 (en) * 2005-10-07 2011-11-08 Armagen Technologies, Inc. Nucleic acids encoding and methods of producing fusion proteins
US8741260B2 (en) * 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
EP1957536A2 (en) * 2005-12-01 2008-08-20 Domantis Limited Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1
WO2008022349A2 (en) * 2006-08-18 2008-02-21 Armagen Technologies, Inc. Agents for blood-brain barrier delivery
CN101173008B (zh) * 2006-11-01 2011-06-22 复旦大学 一种双功能融合蛋白及其制备方法和应用
US20090011040A1 (en) * 2007-05-02 2009-01-08 Naash Muna I Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases
WO2008149147A2 (en) 2007-06-06 2008-12-11 Domantis Limited Polypeptides, antibody variable domains and antagonists
CA3184105A1 (en) * 2007-07-27 2009-02-05 Armagen Inc. Methods and compositions for increasing alpha-l-iduronidase activity in the cns
WO2009039409A1 (en) * 2007-09-21 2009-03-26 The Regents Of The University Of Californina Targeted interferon demonstrates potent apoptotic and anti-tumor activities
EP2262531A1 (en) * 2008-03-08 2010-12-22 Immungene, Inc. Engineered fusion molecules immunotherapy in cancer and inflammatory diseases
US20100098693A1 (en) * 2008-10-07 2010-04-22 Pardridge William M Compositions and methods for blood-brain barrier delivery of organophosphatases
CN106995495A (zh) 2009-01-12 2017-08-01 希托马克斯医疗有限责任公司 修饰抗体组合物及其制备和使用方法
JP5873003B2 (ja) 2009-03-18 2016-03-01 アーメイゲン・テクノロジーズ・インコーポレイテッドＡｒｍａｇｅｎ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． ＩｇＧデコイ受容体融合タンパク質の血液脳関門送達のための組成物および方法
EP2421896A1 (en) 2009-04-22 2012-02-29 Merck Patent GmbH Antibody fusion proteins with modified fcrn binding sites
DK2485761T3 (da) 2009-10-09 2019-05-06 Armagen Inc Fremgangsmåder og sammensætninger til øgning af iduronat-2-sulfatase-aktivitet i CNS
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
CN109022465B (zh) 2011-10-28 2022-04-29 特瓦制药澳大利亚私人有限公司 多肽构建体及其用途
EP2785378B1 (en) 2011-12-02 2020-05-13 Armagen, Inc. Methods and compositions for increasing arylsulfatase a activity in the cns
US9790268B2 (en) 2012-09-12 2017-10-17 Genzyme Corporation Fc containing polypeptides with altered glycosylation and reduced effector function
US9803021B2 (en) 2012-12-07 2017-10-31 The Regents Of The University Of California CD138-targeted interferon demonstrates potent apoptotic and anti-tumor activities
KR20240023184A (ko) 2013-03-11 2024-02-20 젠자임 코포레이션 과글리코실화된 결합 폴리펩티드
US11117975B2 (en) 2013-04-29 2021-09-14 Teva Pharmaceuticals Australia Pty Ltd Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
DK3677591T5 (da) 2013-04-29 2024-08-26 Teva Pharmaceuticals Australia Pty Ltd Anti-CD38 antistoffer og fusioner til svækket interferon alpha-2b
WO2014194100A1 (en) 2013-05-29 2014-12-04 The Regents Of The University Of California Anti-cspg4 fusions with interferon for the treatment of malignancy
CN106471010A (zh) 2014-03-19 2017-03-01 建新公司 靶向模块的位点特异性糖工程化
UA119352C2 (uk) 2014-05-01 2019-06-10 Тева Фармасьютикалз Острейліа Пті Лтд Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину
ES2838680T3 (es) 2014-10-09 2021-07-02 Genzyme Corp Conjugados de anticuerpo-fármaco glucomodificados
PE20170908A1 (es) 2014-10-29 2017-07-12 Teva Pharmaceuticals Australia Pty Ltd VARIANTES DE INTERFERON a2b
US10538589B2 (en) 2015-01-14 2020-01-21 Armagen Inc. Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
CN108700565B (zh) * 2015-10-07 2021-10-29 善威生物私人有限公司 血液制备和图谱分析
JP7241677B2 (ja) 2016-07-19 2023-03-17 テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド 抗ｃｄ４７併用療法
CN111164099A (zh) * 2017-09-29 2020-05-15 河谷细胞有限公司 抗原蛋白及其方法
JP2022515198A (ja) 2018-12-19 2022-02-17 アレイ バイオファーマ インコーポレイテッド ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物
CN113474337A (zh) 2018-12-19 2021-10-01 奥瑞生物药品公司 作为fgfr抑制剂用于治疗癌症的7-((3，5-二甲氧基苯基)氨基)喹喔啉衍生物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470571A (en) * 1988-01-27 1995-11-28 The Wistar Institute Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425
IE63847B1 (en) * 1989-05-05 1995-06-14 Res Dev Foundation A novel antibody delivery system for biological response modifiers
US5112946A (en) * 1989-07-06 1992-05-12 Repligen Corporation Modified pf4 compositions and methods of use
US5314995A (en) * 1990-01-22 1994-05-24 Oncogen Therapeutic interleukin-2-antibody based fusion proteins
AU654811B2 (en) * 1990-03-20 1994-11-24 Trustees Of Columbia University In The City Of New York, The Chimeric antibodies with receptor binding ligands in place of their constant region
CA2095836C (en) * 1990-11-09 1999-04-06 Stephen D. Gillies Cytokine immunoconjugates
ES2204890T3 (es) * 1991-03-06 2004-05-01 Merck Patent Gmbh Anticuerpos monoclonales humanizados.
EP0603194A4 (en) * 1991-07-05 1994-12-07 Seragen Inc TO THE RECEPTOR OF THE EPIDERMAL GROWTH FACTOR TARGETED MOLECULES FOR TREATING INFLAMMABLE ARTHRITIS.
ES2144440T3 (es) * 1992-08-18 2000-06-16 Centro Inmunologia Molecular Anticuerpos monoclonales que reconocen el receptor del factor de crecimiento epidermico, celulas y metodos para su produccion y compuestos que los contienen.

Also Published As

Publication number Publication date
CZ237595A3 (en) 1996-04-17
CZ289641B6 (cs) 2002-03-13
EP0706799A3 (en) 1996-12-04
SK114595A3 (en) 1997-03-05
ATE208633T1 (de) 2001-11-15
JP2006117684A (ja) 2006-05-11
ZA957808B (en) 1996-05-07
AU702184B2 (en) 1999-02-18
RU2157701C2 (ru) 2000-10-20
NO315976B1 (no) 2003-11-24
PL182636B1 (pl) 2002-02-28
DE69523857T2 (de) 2002-06-13
US5824782A (en) 1998-10-20
CN1123185A (zh) 1996-05-29
NO953650D0 (no) 1995-09-15
HUT75836A (en) 1997-05-28
JPH0899901A (ja) 1996-04-16
AU3053395A (en) 1996-03-28
PT706799E (pt) 2002-05-31
UA40611C2 (uk) 2001-08-15
DE69523857D1 (de) 2001-12-20
DK0706799T3 (da) 2002-02-25
CA2158322C (en) 2009-06-16
PL310493A1 (en) 1996-03-18
JP3865802B2 (ja) 2007-01-10
CA2158322A1 (en) 1996-03-17
SK282263B6 (sk) 2001-12-03
HU9502711D0 (en) 1995-11-28
ES2167391T3 (es) 2002-05-16
EP0706799A2 (en) 1996-04-17
HU221989B1 (hu) 2003-03-28
KR100386171B1 (ko) 2003-08-21
EP0706799B1 (en) 2001-11-14
NO953650L (no) 1996-03-18

Similar Documents

Publication Publication Date Title
KR960010023A (ko) 면역접합체 ii
RU95115976A (ru) Иммуноконъюгаты, способ получения, фармацевтическая композиция, применение иммуноконъюгата
KR950016781A (ko) 면역접합체
DK172630B1 (da) Modificeret antistofmolekyle eller derivat heraf og fremgangsmåde til fremstilling af det modificerede antistofmolekyle
Pavlinkova et al. Pharmacokinetics and biodistribution of engineered single-chain antibody constructs of MAb CC49 in colon carcinoma xenografts
Kriangkum et al. Bispecific and bifunctional single chain recombinant antibodies
RU2355705C2 (ru) Одноцепочечное цикличное триспецифическое антитело
AU618317B2 (en) Unique antigenic epitopes on ige-bearing b lymphocytes
US5420251A (en) Anti-idiotype antibodies specific for the parotope of antibodies which bind to IgE-bearing B cells but not basophils
ES2234241T3 (es) Derivados de anticuerpo de multiples fines.
AU2001257206B2 (en) Bispecific molecules and uses thereof
US5428133A (en) Chimeric anti-human IgE-monoclonal antibody which binds to secreted IgE and membrane-bound IgE expressed by IgE-expressing B cells but notto IgE bound to FC receptors on basophils
US5422258A (en) Methods for producing high affinity anti-human IgE-monoclonal antibodies which binds to IgE on IgEabearing B cells but not basophils
US5614611A (en) Humanized monoclonal antibodies binding to IgE-bearing B cells but not basophils
CN106687479A (zh) 抗ctla4的单克隆抗体或其抗原结合片段、药物组合物及用途
WO1994009131A1 (en) Recombinant specific binding protein
AU2001257206A1 (en) Bispecific molecules and uses thereof
EA200301098A1 (ru) Ассоциированные с ганглиозидами рекомбинантные антитела и их применение в диагностике и лечении опухолей
JPH04501061A (ja) 抗イディオタイプ抗体による抗腫瘍応答の誘導
KR960040375A (ko) 표피성장인자 수용체에 대한 면역반응을 유도하는 항-이디오타입 항체
KR890016165A (ko) 수도모나스 아에루기노사(Pseudomonas aeruginosa)에 대한 모노클로날 항체, 이의 제조방법 및 용도
Shul et al. Generation and characterization of a single-gene encoded single-chain immunoglobulin-interleukin-2 fusion protein
ES2218717T3 (es) Peptido portenciador de la vasopermeabilidad de la interleuquina-2 humana e inmunoconjugados del mismo.
JT George et al. Section Review Biologicals & Immunologicals: Advances in antibody engineering
Smith et al. Production of heterologous antibodies specific for murine B-cell leukemia (BCL1) immunoglobulin by immunization with synthetic peptides homologous to heavy chain hypervariable regions

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20090508

Year of fee payment: 7

LAPS Lapse due to unpaid annual fee