NO314846B1 - Benzopyraner, fremgangsmåter for deres fremstilling, samt anvendelse som farmasöytiske midler og farmasöytiske sammensetninger inneholdendedem - Google Patents
Benzopyraner, fremgangsmåter for deres fremstilling, samt anvendelse som farmasöytiske midler og farmasöytiske sammensetninger inneholdendedem Download PDFInfo
- Publication number
- NO314846B1 NO314846B1 NO19975365A NO975365A NO314846B1 NO 314846 B1 NO314846 B1 NO 314846B1 NO 19975365 A NO19975365 A NO 19975365A NO 975365 A NO975365 A NO 975365A NO 314846 B1 NO314846 B1 NO 314846B1
- Authority
- NO
- Norway
- Prior art keywords
- benzopyran
- dimethyl
- dihydro
- hydroxy
- sulfonamide
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 16
- 238000002360 preparation method Methods 0.000 title claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 7
- 239000003814 drug Substances 0.000 title claims description 5
- 150000001562 benzopyrans Chemical class 0.000 title description 8
- 150000001875 compounds Chemical class 0.000 claims description 68
- 229940124530 sulfonamide Drugs 0.000 claims description 29
- 238000011282 treatment Methods 0.000 claims description 26
- -1 trifluoromethylphenyl Chemical group 0.000 claims description 24
- 229910052739 hydrogen Inorganic materials 0.000 claims description 17
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 16
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- 208000023504 respiratory system disease Diseases 0.000 claims description 14
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- 125000004076 pyridyl group Chemical group 0.000 claims description 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
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- 230000017105 transposition Effects 0.000 claims description 4
- 230000010933 acylation Effects 0.000 claims description 3
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- 125000001424 substituent group Chemical group 0.000 claims description 3
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9510477.4A GB9510477D0 (en) | 1995-05-24 | 1995-05-24 | Organic compounds |
| PCT/EP1996/002257 WO1996037490A1 (en) | 1995-05-24 | 1996-05-24 | Benzopyrans and pharmaceutical compositions containing them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO975365D0 NO975365D0 (no) | 1997-11-21 |
| NO975365L NO975365L (no) | 1998-01-15 |
| NO314846B1 true NO314846B1 (no) | 2003-06-02 |
Family
ID=10774940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19975365A NO314846B1 (no) | 1995-05-24 | 1997-11-21 | Benzopyraner, fremgangsmåter for deres fremstilling, samt anvendelse som farmasöytiske midler og farmasöytiske sammensetninger inneholdendedem |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5905156A (sk) |
| EP (1) | EP0828733B1 (sk) |
| JP (1) | JPH11505820A (sk) |
| KR (1) | KR100437981B1 (sk) |
| CN (1) | CN1077888C (sk) |
| AR (1) | AR004489A1 (sk) |
| AT (1) | ATE205204T1 (sk) |
| AU (1) | AU703276B2 (sk) |
| BR (1) | BR9609048A (sk) |
| CA (1) | CA2217821C (sk) |
| CO (1) | CO4700520A1 (sk) |
| CZ (1) | CZ294474B6 (sk) |
| DE (1) | DE69615019T2 (sk) |
| DK (1) | DK0828733T3 (sk) |
| ES (1) | ES2163634T3 (sk) |
| FI (1) | FI973992A (sk) |
| GB (1) | GB9510477D0 (sk) |
| HK (1) | HK1014137A1 (sk) |
| HU (1) | HU222772B1 (sk) |
| IL (1) | IL118382A (sk) |
| MY (1) | MY114924A (sk) |
| NO (1) | NO314846B1 (sk) |
| NZ (1) | NZ309765A (sk) |
| PL (1) | PL184144B1 (sk) |
| PT (1) | PT828733E (sk) |
| RU (1) | RU2160735C2 (sk) |
| SK (1) | SK283215B6 (sk) |
| TR (1) | TR199701417T1 (sk) |
| TW (1) | TW421646B (sk) |
| WO (1) | WO1996037490A1 (sk) |
| ZA (1) | ZA964209B (sk) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5972894A (en) * | 1997-08-07 | 1999-10-26 | Cytran, Inc. | Peptides having potassium channel opener activity |
| GB9822024D0 (en) * | 1998-10-09 | 1998-12-02 | Novartis Ag | Organic compounds |
| GB9909792D0 (en) * | 1998-12-04 | 1999-06-23 | Cambridge Bioclinical Limited | Potassium channel activators and their use |
| US6384244B2 (en) | 2000-05-18 | 2002-05-07 | Merck & Co., Inc. | Process for preparing cis- aminochromanols |
| US7098340B2 (en) * | 2003-05-14 | 2006-08-29 | Warner Lambert Company Llc | Benzyl sulfonamide derivatives |
| KR100704009B1 (ko) * | 2005-08-30 | 2007-04-04 | 한국화학연구원 | 염증억제 활성을 가지는6-알킬아미노-2-메틸-2'-(ｎ-메틸치환술폰아미도)메틸-2ｈ-1-벤조피란 유도체 |
| SG10202007787RA (en) | 2015-09-28 | 2020-09-29 | Genentech Inc | Therapeutic compounds and methods of use thereof |
| CN106008288A (zh) * | 2016-06-15 | 2016-10-12 | 西北农林科技大学 | 一种苯磺酰胺类化合物及其用途 |
| CN110546148A (zh) * | 2017-03-24 | 2019-12-06 | 基因泰克公司 | 作为钠通道抑制剂的4-哌啶-n-(嘧啶-4-基)色满-7-磺酰胺衍生物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2030627A6 (es) * | 1990-11-28 | 1992-11-01 | Uriach & Cia Sa J | Procedimiento para la obtencion de compuestos benzopiranicos. |
| KR950009863B1 (ko) * | 1991-05-22 | 1995-08-29 | 재단법인한국화학연구소 | 벤조피란 유도체와 그의 제조방법 |
| TW244350B (sk) * | 1991-12-14 | 1995-04-01 | Hoechst Ag | |
| US5236935A (en) * | 1992-05-21 | 1993-08-17 | Korea Research Institute Of Chemical Technology | Benzopyran derivatives and processes for the preparation thereof |
-
1995
- 1995-05-24 GB GBGB9510477.4A patent/GB9510477D0/en active Pending
-
1996
- 1996-05-22 MY MYPI96001911A patent/MY114924A/en unknown
- 1996-05-22 TW TW085106034A patent/TW421646B/zh not_active IP Right Cessation
- 1996-05-22 IL IL11838296A patent/IL118382A/xx not_active IP Right Cessation
- 1996-05-23 CO CO96026387A patent/CO4700520A1/es unknown
- 1996-05-24 PL PL96324042A patent/PL184144B1/pl not_active IP Right Cessation
- 1996-05-24 AT AT96917431T patent/ATE205204T1/de active
- 1996-05-24 EP EP96917431A patent/EP0828733B1/en not_active Expired - Lifetime
- 1996-05-24 ZA ZA9604209A patent/ZA964209B/xx unknown
- 1996-05-24 RU RU97120993/04A patent/RU2160735C2/ru not_active IP Right Cessation
- 1996-05-24 DE DE69615019T patent/DE69615019T2/de not_active Expired - Lifetime
- 1996-05-24 TR TR97/01417T patent/TR199701417T1/xx unknown
- 1996-05-24 HU HU9801751A patent/HU222772B1/hu not_active IP Right Cessation
- 1996-05-24 DK DK96917431T patent/DK0828733T3/da active
- 1996-05-24 ES ES96917431T patent/ES2163634T3/es not_active Expired - Lifetime
- 1996-05-24 JP JP8535402A patent/JPH11505820A/ja not_active Ceased
- 1996-05-24 SK SK1577-97A patent/SK283215B6/sk not_active IP Right Cessation
- 1996-05-24 AR ARP960102708A patent/AR004489A1/es active IP Right Grant
- 1996-05-24 CN CN96194146A patent/CN1077888C/zh not_active Expired - Fee Related
- 1996-05-24 PT PT96917431T patent/PT828733E/pt unknown
- 1996-05-24 KR KR1019970708400A patent/KR100437981B1/ko not_active IP Right Cessation
- 1996-05-24 CA CA002217821A patent/CA2217821C/en not_active Expired - Fee Related
- 1996-05-24 BR BR9609048A patent/BR9609048A/pt not_active IP Right Cessation
- 1996-05-24 NZ NZ309765A patent/NZ309765A/xx unknown
- 1996-05-24 US US08/952,549 patent/US5905156A/en not_active Expired - Lifetime
- 1996-05-24 WO PCT/EP1996/002257 patent/WO1996037490A1/en active IP Right Grant
- 1996-05-24 AU AU60008/96A patent/AU703276B2/en not_active Ceased
- 1996-05-24 CZ CZ19973688A patent/CZ294474B6/cs not_active IP Right Cessation
-
1997
- 1997-10-17 FI FI973992A patent/FI973992A/fi unknown
- 1997-11-21 NO NO19975365A patent/NO314846B1/no unknown
-
1998
- 1998-12-11 HK HK98113216A patent/HK1014137A1/xx not_active IP Right Cessation
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