NO314715B1 - Apparat og fremgangsmate for separering av en vaeskeprove - Google Patents
Apparat og fremgangsmate for separering av en vaeskeprove Download PDFInfo
- Publication number
- NO314715B1 NO314715B1 NO19944422A NO944422A NO314715B1 NO 314715 B1 NO314715 B1 NO 314715B1 NO 19944422 A NO19944422 A NO 19944422A NO 944422 A NO944422 A NO 944422A NO 314715 B1 NO314715 B1 NO 314715B1
- Authority
- NO
- Norway
- Prior art keywords
- chamber
- annular chamber
- phase
- wall
- separation
- Prior art date
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- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/0485—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with a displaceable piston in the centrifuge chamber
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Clinical Laboratory Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Ecology (AREA)
- Centrifugal Separators (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- External Artificial Organs (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15598493A | 1993-11-19 | 1993-11-19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO944422D0 NO944422D0 (no) | 1994-11-18 |
| NO944422L NO944422L (no) | 1995-05-22 |
| NO314715B1 true NO314715B1 (no) | 2003-05-12 |
Family
ID=22557593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19944422A NO314715B1 (no) | 1993-11-19 | 1994-11-18 | Apparat og fremgangsmate for separering av en vaeskeprove |
Country Status (26)
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| EP (2) | EP1152241A3 (xx) |
| JP (1) | JP3745397B2 (xx) |
| KR (1) | KR950013582A (xx) |
| CN (1) | CN1044977C (xx) |
| AT (1) | ATE213329T1 (xx) |
| AU (1) | AU688390B2 (xx) |
| BR (1) | BR9404484A (xx) |
| CA (1) | CA2136148C (xx) |
| CZ (1) | CZ280694A3 (xx) |
| DE (1) | DE69429852T2 (xx) |
| DK (1) | DK0654669T3 (xx) |
| ES (1) | ES2170763T3 (xx) |
| FI (2) | FI114340B (xx) |
| HU (1) | HU215246B (xx) |
| IL (1) | IL111524A (xx) |
| MX (1) | MXPA99004700A (xx) |
| NO (1) | NO314715B1 (xx) |
| NZ (1) | NZ264859A (xx) |
| PL (1) | PL176963B1 (xx) |
| PT (1) | PT654669E (xx) |
| RU (1) | RU2133468C1 (xx) |
| SG (1) | SG49212A1 (xx) |
| SK (1) | SK138394A3 (xx) |
| UA (1) | UA27898C2 (xx) |
| ZA (1) | ZA948564B (xx) |
Families Citing this family (148)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0778841A1 (en) * | 1994-08-29 | 1997-06-18 | Akzo Nobel N.V. | Device for use in the isolation of a biological material such as nucleic acid |
| PL320512A1 (en) * | 1994-12-02 | 1997-10-13 | Bristol Myers Squibb Co | System for feeding a reagent into a centrifuge |
| DE69535816D1 (de) * | 1994-12-02 | 2008-10-02 | Vivolution As | Methode und vorrichtung zum abtrennen von fibrinmonomer aus blutplasma |
| US5926387A (en) * | 1995-06-30 | 1999-07-20 | Beckman Instruments, Inc. | Ultracentrifuge operation by computer system |
| USD420444S (en) | 1995-12-07 | 2000-02-08 | Bristol-Myers Squibb Company | Blood processor |
| ATE186235T1 (de) * | 1996-04-24 | 1999-11-15 | Claude Fell | Zelltrennungsvorrichtung für biologische flüssigkeiten wie blut |
| DK0951642T3 (da) | 1997-01-08 | 2007-03-12 | Bristol Myers Squibb Co | Udstyr og fremgangsmåde til fremstilling af oplösninger bestående af blod- eller plasmabestanddele i en kendt koncentration |
| CA2277860C (en) * | 1997-01-08 | 2005-11-29 | Bristol-Myers Squibb Company | Centrifuge apparatus for separating blood |
| US6132598A (en) * | 1997-01-08 | 2000-10-17 | Bristol-Myers Squibb Company | Centrifuge apparatus with temperature control means |
| WO1998030304A1 (en) * | 1997-01-08 | 1998-07-16 | Bristol-Myers Squibb Company | A centrifuge apparatus with temperature control means |
| US6979307B2 (en) | 1997-06-24 | 2005-12-27 | Cascade Medical Enterprises Llc | Systems and methods for preparing autologous fibrin glue |
| US6846298B1 (en) | 1997-07-25 | 2005-01-25 | Bristol-Myers Squibb Company | Blood product delivery system |
| JP2001510813A (ja) * | 1997-07-25 | 2001-08-07 | ブリストル−マイヤーズ スクイブ カンパニー | 血液生成物供給装置 |
| ES2259286T3 (es) | 1999-03-15 | 2006-10-01 | Implant Innovations, Inc. | Sistema de recogida de trombocitos. |
| US6393369B1 (en) * | 1999-04-30 | 2002-05-21 | Bristol-Myers Squibb Company | System for control of blood processor |
| ATE337806T1 (de) * | 1999-07-08 | 2006-09-15 | Implant Innovations Inc | Spritzenkit für die konzentration von thrombozyten und verfahren |
| US6716187B1 (en) | 1999-07-08 | 2004-04-06 | Implant Innovations, Inc. | Platelet concentration syringe kit |
| US6387263B1 (en) * | 1999-09-02 | 2002-05-14 | Bristol-Myers Squibb Company | Apparatus and methods for preparing plasma solutions from blood with improved separation of plasma |
| US6524231B1 (en) * | 1999-09-03 | 2003-02-25 | Baxter International Inc. | Blood separation chamber with constricted interior channel and recessed passage |
| US7033501B1 (en) * | 1999-09-24 | 2006-04-25 | Bristol-Myers Squibb Company | Centrifuge apparatus and method with improved temperature control |
| US7045283B2 (en) * | 2000-10-18 | 2006-05-16 | The Regents Of The University Of California | Methods of high-throughput screening for internalizing antibodies |
| JP2004536794A (ja) * | 2001-04-09 | 2004-12-09 | メドトロニック、インコーポレイテッド | マイクロ遠心機を用いる血液成分の分離方法及びその使用法 |
| US6589155B2 (en) | 2001-04-09 | 2003-07-08 | Medtronic, Inc. | Miniaturized blood centrifuge having side mounted motor with belt drive |
| US6610002B2 (en) | 2001-04-09 | 2003-08-26 | Medtronic, Inc. | Method for handling blood sample to ensure blood components are isolated |
| US6612975B2 (en) | 2001-04-09 | 2003-09-02 | Medtronic, Inc. | Blood centrifuge with an enhanced internal drive assembly |
| US6790371B2 (en) * | 2001-04-09 | 2004-09-14 | Medtronic, Inc. | System and method for automated separation of blood components |
| US6596181B2 (en) | 2001-04-09 | 2003-07-22 | Medtronic, Inc. | Hard shell disposable reservoir having complex internal design for use in a centrifuge |
| US20020144939A1 (en) * | 2001-04-09 | 2002-10-10 | Dolecek Victor D. | Miniaturized blood centrifuge having side mounted motor with belt drive |
| US6605028B2 (en) | 2001-04-09 | 2003-08-12 | Medtronic, Inc. | Blood centrifuge having integral heating to control cellular component temperature |
| US6582350B2 (en) | 2001-04-09 | 2003-06-24 | Medtronic, Inc. | Centrifuge container having curved linear shape |
| US6835316B2 (en) | 2001-04-09 | 2004-12-28 | Medtronic, Inc. | Clam shell blood reservoir holder with index line |
| US6579219B2 (en) * | 2001-04-09 | 2003-06-17 | Medtronic, Inc. | Centrifuge bag and methods of use |
| US8101077B2 (en) * | 2001-05-07 | 2012-01-24 | Sivaprasad Sukavaneshvar | Device for separating platelets from fluid suspensions |
| US7011852B2 (en) * | 2001-05-07 | 2006-03-14 | Hemogenesis, Llc | Separation of platelets from whole blood for use as a healant |
| US6890291B2 (en) * | 2001-06-25 | 2005-05-10 | Mission Medical, Inc. | Integrated automatic blood collection and processing unit |
| SE0102922D0 (sv) * | 2001-08-31 | 2001-08-31 | Astrazeneca Ab | Method and apparatus for sample preparation |
| US6589153B2 (en) | 2001-09-24 | 2003-07-08 | Medtronic, Inc. | Blood centrifuge with exterior mounted, self-balancing collection chambers |
| US7479123B2 (en) | 2002-03-04 | 2009-01-20 | Therakos, Inc. | Method for collecting a desired blood component and performing a photopheresis treatment |
| US7211037B2 (en) * | 2002-03-04 | 2007-05-01 | Therakos, Inc. | Apparatus for the continuous separation of biological fluids into components and method of using same |
| US6820506B2 (en) * | 2002-03-27 | 2004-11-23 | 3M Innovative Properties Company | Multi-chambered pump-valve device |
| EP1497645A2 (en) * | 2002-04-19 | 2005-01-19 | Mission Medical, Inc. | Integrated automatic blood processing unit |
| US7832566B2 (en) * | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US7374678B2 (en) * | 2002-05-24 | 2008-05-20 | Biomet Biologics, Inc. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US7553413B2 (en) * | 2005-02-07 | 2009-06-30 | Hanuman Llc | Plasma concentrator device |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| DE10392686T5 (de) * | 2002-05-24 | 2005-07-07 | Biomet Mfg. Corp., Warsaw | Vorrichtung und Verfahren zum Trennen und Konzentrieren von Flüssigkeiten, welche mehrere Komponenten enthalten |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| AU2003298519A1 (en) * | 2002-06-27 | 2004-06-23 | Roberto Beretta | Methods for preparing a solid-fibrin web |
| US7297272B2 (en) * | 2002-10-24 | 2007-11-20 | Fenwal, Inc. | Separation apparatus and method |
| IL158789A (en) * | 2002-11-13 | 2009-11-18 | Biomet 3I Llc | Dental implant system |
| CN101496917B (zh) | 2003-05-21 | 2013-07-31 | 株式会社Jms | 细胞培养的血清调制装置和血清调制方法及细胞培养方法 |
| JP4682591B2 (ja) * | 2003-05-21 | 2011-05-11 | 株式会社ジェイ・エム・エス | 血液成分分離収容装置及び血清調製方法 |
| US20050054506A1 (en) * | 2003-07-30 | 2005-03-10 | Bradley Bruce J. | Microbial concentration system |
| US20050049539A1 (en) * | 2003-09-03 | 2005-03-03 | O'hara Gerald P. | Control system for driving fluids through an extracorporeal blood circuit |
| US20070161491A1 (en) * | 2003-09-30 | 2007-07-12 | Kabushiki Kaisha Kitazato Supply | Centrifuging settling tube and organic cell collection tube |
| EP1677889A4 (en) | 2003-09-30 | 2009-01-14 | Capitalbio Corp | APPARATUS AND METHOD FOR CENTRIFUGAL SEPARATION |
| US7354515B2 (en) * | 2004-02-23 | 2008-04-08 | Millennium Medical Technologies, Inc. | Fluid concentrator |
| US7588732B2 (en) * | 2004-03-30 | 2009-09-15 | Genesis Biosystems, Inc. | Autologus tissue harvesting and irrigation device |
| JP4412029B2 (ja) * | 2004-03-30 | 2010-02-10 | パナソニック株式会社 | 密度勾配遠心分離による微生物抽出方法 |
| JP4533706B2 (ja) * | 2004-09-01 | 2010-09-01 | 旭化成株式会社 | 濾過方法及びそのシステム |
| JP2008512128A (ja) * | 2004-09-09 | 2008-04-24 | マイクロフルイディク システムズ インコーポレイテッド | 抽出装置及び試料準備方法 |
| US7476209B2 (en) * | 2004-12-21 | 2009-01-13 | Therakos, Inc. | Method and apparatus for collecting a blood component and performing a photopheresis treatment |
| US7866485B2 (en) * | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
| WO2006086201A2 (en) | 2005-02-07 | 2006-08-17 | Hanuman Llc | Platelet rich plasma concentrate apparatus and method |
| JP4961354B2 (ja) * | 2005-02-07 | 2012-06-27 | ハヌマン リミテッド ライアビリティ カンパニー | 多血小板血漿濃縮装置および方法 |
| US9581942B1 (en) | 2005-03-23 | 2017-02-28 | Shippert Enterprises, Llc | Tissue transfer method and apparatus |
| US7794449B2 (en) | 2005-03-23 | 2010-09-14 | Shippert Ronald D | Tissue transplantation method and apparatus |
| US7780649B2 (en) * | 2005-03-23 | 2010-08-24 | Shippert Ronald D | Tissue transplantation method and apparatus |
| US8062286B2 (en) * | 2005-03-23 | 2011-11-22 | Shippert Ronald D | Tissue transplantation method and apparatus |
| US8622997B2 (en) | 2005-03-23 | 2014-01-07 | Ronald D. Shippert | Tissue transfer method and apparatus |
| US7789872B2 (en) | 2005-03-23 | 2010-09-07 | Shippert Ronald D | Tissue transplantation method and apparatus |
| EP2323774B1 (en) * | 2005-04-20 | 2019-08-21 | SpineSmith Holdings, LLC | Fluid concentrator |
| US7694828B2 (en) * | 2005-04-27 | 2010-04-13 | Biomet Manufacturing Corp. | Method and apparatus for producing autologous clotting components |
| FR2888585B1 (fr) * | 2005-07-12 | 2007-09-14 | Hemosystem Sa | Dispositif de preparation d'un echantillon de fluide biologique en vue d'une analyse bacteriologique |
| US7618361B2 (en) * | 2005-09-01 | 2009-11-17 | Wagner Development, Inc. | Gas driven solids discharge and pumping piston for a centrifugal separator |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| KR100855621B1 (ko) | 2006-06-26 | 2008-09-01 | 연세대학교 산학협력단 | 자가 트롬빈 및 피브리노겐의 제조장치 및 방법 |
| NL1033365C2 (nl) * | 2007-02-09 | 2008-08-12 | Medavinci Dev B V | Inrichting en werkwijze voor scheiden en analyseren van bloed. |
| EP1967278A1 (de) * | 2007-03-06 | 2008-09-10 | Herbert Weidner | Mehrstufige Zentrifuge mit Energie-Rückgewinnung zur Entsalzung von Meerwasser |
| US7806276B2 (en) * | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| US8267911B2 (en) * | 2007-06-08 | 2012-09-18 | Smiths Medical Asd, Inc. | Flow-through fluid reservoir |
| JP2010531142A (ja) * | 2007-06-22 | 2010-09-24 | サークル バイオロジクス、 エルエルシー． | 液体濃縮装置、オートロガスな濃縮体液、およびそれらの使用方法 |
| JP5163395B2 (ja) * | 2007-09-26 | 2013-03-13 | 株式会社ジェイ・エム・エス | 血液成分調製用容器及び血液成分分離収容装置 |
| US9168028B2 (en) * | 2007-10-23 | 2015-10-27 | Lotus Bio (Nymphaea) Ltd | Cartridge for a biological sample |
| WO2009054441A1 (ja) * | 2007-10-24 | 2009-04-30 | Jms Co., Ltd. | 分離容器、アタッチメントおよび分離方法 |
| EP3338895B1 (en) * | 2007-12-07 | 2022-08-10 | Miltenyi Biotec B.V. & Co. KG | Sample processing systems and methods |
| CN101298008B (zh) * | 2008-01-14 | 2012-10-03 | 经建中 | 应用于混合液体连续离心分离系统上的盘管结构 |
| EP2259774B1 (en) | 2008-02-27 | 2012-12-12 | Biomet Biologics, LLC | Methods and compositions for delivering interleukin-1 receptor antagonist |
| US8685258B2 (en) * | 2008-02-27 | 2014-04-01 | Fenwal, Inc. | Systems and methods for conveying multiple blood components to a recipient |
| US8075468B2 (en) * | 2008-02-27 | 2011-12-13 | Fenwal, Inc. | Systems and methods for mid-processing calculation of blood composition |
| US8337711B2 (en) * | 2008-02-29 | 2012-12-25 | Biomet Biologics, Llc | System and process for separating a material |
| NL2001577C2 (nl) | 2008-05-14 | 2009-11-17 | Medavinci Dev B V | Inrichting en werkwijze voor scheiden en analyseren van bloed. |
| US8177072B2 (en) * | 2008-12-04 | 2012-05-15 | Thermogenesis Corp. | Apparatus and method for separating and isolating components of a biological fluid |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| BRPI1006683A2 (pt) * | 2009-04-15 | 2016-04-12 | Koninkl Philips Electronics Nv | "câmara de fluido, uso de uma câmara de fluido, método para preencher completamente uma câmara de fluido com um líquido e dispositivo" |
| CN201404734Y (zh) * | 2009-04-28 | 2010-02-17 | 厦门市毕恩生物技术有限公司 | 底部控制式标本过滤容器 |
| US9199250B2 (en) | 2009-05-01 | 2015-12-01 | Trustees Of Boston University | Disposable separator/concentrator device and method of use |
| US9011800B2 (en) * | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| KR101069877B1 (ko) * | 2009-10-28 | 2011-10-05 | 임기표 | 원심분리 키트 및 이를 이용한 원심분리 방법 |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US11504464B2 (en) * | 2010-08-09 | 2022-11-22 | Foce Technology International Bv | Blood centrifuge with separation, sensor and dispense control system |
| US9555171B2 (en) | 2010-09-30 | 2017-01-31 | Depuy Mitek, Llc | Methods and devices for collecting separate components of whole blood |
| US8469871B2 (en) | 2010-11-19 | 2013-06-25 | Kensey Nash Corporation | Centrifuge |
| US8556794B2 (en) | 2010-11-19 | 2013-10-15 | Kensey Nash Corporation | Centrifuge |
| US8394006B2 (en) | 2010-11-19 | 2013-03-12 | Kensey Nash Corporation | Centrifuge |
| US8317672B2 (en) | 2010-11-19 | 2012-11-27 | Kensey Nash Corporation | Centrifuge method and apparatus |
| US8870733B2 (en) | 2010-11-19 | 2014-10-28 | Kensey Nash Corporation | Centrifuge |
| EP2654957B1 (en) * | 2010-12-21 | 2019-07-17 | GE Healthcare UK Limited | Filtration apparatus |
| US9011684B2 (en) | 2011-03-07 | 2015-04-21 | Spinesmith Holdings, Llc | Fluid concentrator with removable cartridge |
| US8887770B1 (en) | 2011-03-17 | 2014-11-18 | Ronald D. Shippert | Vessel fill control method and apparatus |
| US9011846B2 (en) | 2011-05-02 | 2015-04-21 | Biomet Biologics, Llc | Thrombin isolated from blood and blood fractions |
| US10201405B2 (en) | 2011-06-28 | 2019-02-12 | Biomet 3I, Llc | System and method of dental implant and interface to abutment for restoration |
| CN103120865A (zh) * | 2011-11-18 | 2013-05-29 | 博研国际有限公司 | 旋转容器、使用该旋转容器的流体过滤装置及系统 |
| DK2597153T3 (en) | 2011-11-25 | 2016-12-05 | Miltenyi Biotec Gmbh | Method for cell separation |
| WO2013096621A2 (en) * | 2011-12-23 | 2013-06-27 | The Broad Institute, Inc. | Device and method for fragmenting polymers and particles |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US9468709B2 (en) | 2012-11-12 | 2016-10-18 | Shippert Enterprises, Llc | Syringe fill method and apparatus |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| JP5896571B2 (ja) * | 2013-10-15 | 2016-03-30 | キム ホンＫｉｍ Ｈｏｎｇ | 全血から高濃縮血漿を抽出する装置及び方法 |
| US10125345B2 (en) | 2014-01-31 | 2018-11-13 | Dsm Ip Assets, B.V. | Adipose tissue centrifuge and method of use |
| US9550028B2 (en) | 2014-05-06 | 2017-01-24 | Biomet Biologics, LLC. | Single step desiccating bead-in-syringe concentrating device |
| US10772997B2 (en) | 2014-05-15 | 2020-09-15 | Ronald D. Shippert | Tissue parcelization method and apparatus |
| GB201416944D0 (en) * | 2014-09-25 | 2014-11-12 | Benson Viscometers Ltd | An Apparatus for monitoring blood coagulation |
| US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US10413902B2 (en) * | 2015-07-17 | 2019-09-17 | Stat-Diagnostica & Innovation, S.L. | Apparatus for sample separation and collection |
| US10501715B1 (en) | 2015-09-11 | 2019-12-10 | Mark H. Widick | System for the formation of fibrin foam |
| EP3426400B1 (en) | 2016-03-10 | 2020-09-02 | Arthrex Inc | System for preparing protein enhanced serums |
| AU2017230806B2 (en) | 2016-03-10 | 2021-06-24 | Arthrex, Inc. | Systems and methods for preparing a thrombin serum |
| US10702629B2 (en) * | 2016-05-13 | 2020-07-07 | Black Tie Medical Inc. | Conditioning harvested fat for re-injection |
| KR101926710B1 (ko) * | 2016-07-19 | 2018-12-07 | 이준석 | 원심 분리용 용기, 및 원심 분리용 용기 내의 물질 이동 방법 |
| CH713443A2 (de) * | 2017-02-08 | 2018-08-15 | Roth Felix | Medizinalröhrchen. |
| EP3470142A1 (de) * | 2017-10-11 | 2019-04-17 | Orthogen AG | Vorrichtung mit einer ersten kammer zur aufnahme eines körperfluids |
| US11229722B2 (en) | 2018-01-29 | 2022-01-25 | Omer Peled | System and method for harvesting autologous adipose tissue |
| US11911778B2 (en) * | 2018-05-31 | 2024-02-27 | Eppendorf Himac Technologies Co., Ltd. | Continuous centrifuge with air trap for capturing bubbles |
| KR101979382B1 (ko) * | 2018-11-30 | 2019-05-17 | (주)레보메드 | 줄기세포를 포함하는 체액세포 분리 및 농축키트 |
| CN109593824B (zh) * | 2019-01-04 | 2022-03-18 | 宁波艾捷康宁生物科技有限公司 | 一种游离核酸保存剂及采血保存装置 |
| CN109750087A (zh) * | 2019-03-05 | 2019-05-14 | 温州广立生物医药科技有限公司 | 一种血液cfDNA提取试剂盒 |
| CN109731740B (zh) * | 2019-03-08 | 2021-02-02 | 立讯精密工业（滁州）有限公司 | 一种灌胶装置及灌胶方法 |
| CN111141569B (zh) * | 2020-01-22 | 2020-12-29 | 兰州大学 | 一种积液类病理分析沉淀层提取装置 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1346485A (en) * | 1918-05-13 | 1920-07-13 | Arrigunaga Manuel De | Device for the preparation of coffee or like beverages |
| US3064647A (en) * | 1957-06-13 | 1962-11-20 | Baxter Laboratories Inc | Blood component separation method and apparatus |
| US3078847A (en) * | 1959-05-06 | 1963-02-26 | Baxter Laboratories Inc | Blood handling method and apparatus |
| US3560163A (en) * | 1968-12-23 | 1971-02-02 | Armour Pharma | Diagnostic device |
| US3799342A (en) * | 1970-07-27 | 1974-03-26 | Medical Res & Dev Inc | Method of using a serum separator |
| US3911918A (en) * | 1972-04-13 | 1975-10-14 | Ralph D Turner | Blood collection, storage and administering bag |
| US3846077A (en) * | 1972-09-18 | 1974-11-05 | P Ohringer | Liquid sample collection tube |
| US3838809A (en) * | 1973-04-16 | 1974-10-01 | M Williams | Automatic serum preparation station |
| US3932277A (en) * | 1974-03-29 | 1976-01-13 | Bio-Logics Products, Inc. | Method and apparatus for separating blood fractions |
| FR2274918A1 (fr) * | 1974-03-30 | 1976-01-09 | Sarstedt Kunststoff | Dispositif de filtrage pour la separation de fractions de sang |
| US4784715A (en) * | 1975-07-09 | 1988-11-15 | Milton Stoll | Methods and apparatus for producing coherent or monolithic elements |
| DE2609089A1 (de) * | 1976-03-05 | 1977-09-08 | Heinz Kijewski | Kaffeekanne mit siebeinsatz |
| DE2624373C2 (de) * | 1976-05-31 | 1983-02-03 | Arnold Dr. 8782 Karlstadt Seufert | Verfahren zur Herstellung von steril filtriertem Kryopräzipilat mit einer Anreicherung des Faktors VIII |
| US4086924A (en) * | 1976-10-06 | 1978-05-02 | Haemonetics Corporation | Plasmapheresis apparatus |
| US4300717A (en) * | 1979-04-02 | 1981-11-17 | Haemonetics Corporation | Rotary centrifuge seal |
| AT366916B (de) * | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
| US4334647A (en) * | 1980-12-03 | 1982-06-15 | Bird Machine Company, Inc. | Centrifuges |
| DE3128611C2 (de) * | 1981-07-20 | 1994-07-14 | Hilti Ag | Dosiergerät für Mehrkomponenten-Massen |
| US4735726A (en) * | 1981-07-22 | 1988-04-05 | E. I. Du Pont De Nemours And Company | Plasmapheresis by reciprocatory pulsatile filtration |
| US4729829A (en) * | 1981-07-22 | 1988-03-08 | E. I. Du Pont De Nemours And Company | Hollow fiber plasmapheresis module |
| US4668399A (en) * | 1982-02-16 | 1987-05-26 | E. I. Du Pont De Nemours And Company | Hollow fiber plasmapheresis process |
| US4596657A (en) * | 1982-06-04 | 1986-06-24 | Miles Laboratories, Inc. | Blood bag system with integral filtering means |
| DE3234250A1 (de) * | 1982-09-15 | 1984-03-15 | Hilti AG, 9494 Schaan | Handgeraet zum abgeben von mehrkomponenten-massen |
| DE3305216C2 (de) * | 1983-02-16 | 1986-04-10 | Westfalia Separator Ag, 4740 Oelde | Zentrifuge mit einer selbstentleerenden Schleudertrommel |
| US4530691A (en) * | 1983-12-13 | 1985-07-23 | Baxter Travenol Laboratories, Inc. | Centrifuge with movable mandrel |
| CA1339745C (en) * | 1984-04-10 | 1998-03-17 | Martin Anderson | Pesticidal benzoylurea compounds |
| ATE66392T1 (de) * | 1985-09-16 | 1991-09-15 | Mueller Drm Ag | Klaer-filter-zentrifuge und verfahren zum trennen von suspensionen. |
| GB8602732D0 (en) * | 1986-02-04 | 1986-03-12 | Univ Brunel | Taking samples from patients |
| US4666429A (en) * | 1986-02-26 | 1987-05-19 | Intelligent Medicine, Inc. | Infusion device having improved valving apparatus |
| US4810378A (en) * | 1986-04-21 | 1989-03-07 | Miles Laboratories, Inc. | Red blood cell filtering system |
| DK475386D0 (da) * | 1986-10-03 | 1986-10-03 | Weis Fogh Ulla Sivertsen | Fremgangsmaade og apparat til fremstilling af biologiske stoffer |
| US4767396A (en) * | 1987-03-03 | 1988-08-30 | Haemonetics Corporation | Method and apparatus for processing biological fluids |
| DE3706998A1 (de) * | 1987-03-05 | 1988-09-15 | Hettich Andreas Fa | Zentrifugationskammer zur zytologischen untersuchung von zellsuspensionen |
| US4828716A (en) * | 1987-04-03 | 1989-05-09 | Andronic Devices, Ltd. | Apparatus and method for separating phases of blood |
| US4795441A (en) * | 1987-04-16 | 1989-01-03 | Bhatt Kunjlata M | Medication administration system |
| DE3723517A1 (de) * | 1987-07-16 | 1989-01-26 | Licentia Gmbh | Handgefuehrtes, motorisch angetriebenes elektrowerkzeug |
| US4818386A (en) * | 1987-10-08 | 1989-04-04 | Becton, Dickinson And Company | Device for separating the components of a liquid sample having higher and lower specific gravities |
| US4902281A (en) * | 1988-08-16 | 1990-02-20 | Corus Medical Corporation | Fibrinogen dispensing kit |
| DE3920694A1 (de) * | 1989-06-24 | 1991-01-10 | Friedhelm Schneider | Dosierpistole fuer zwei komponenten mit dynamischer mischkammer |
| CA2013021C (en) * | 1989-11-29 | 1995-05-09 | Richard Lewis Columbus | Blood collection device |
| US5030215A (en) * | 1990-01-03 | 1991-07-09 | Cryolife, Inc. | Preparation of fibrinogen/factor XIII precipitate |
| US5100372A (en) * | 1990-03-02 | 1992-03-31 | Haemonetics Corporation | Core for blood processing apparatus |
| US5102407A (en) * | 1990-03-13 | 1992-04-07 | Miles Inc. | Blood separation system |
| US5061381A (en) * | 1990-06-04 | 1991-10-29 | Abaxis, Inc. | Apparatus and method for separating cells from biological fluids |
| US5137181A (en) * | 1990-07-18 | 1992-08-11 | Wilhelm A. Keller | Manually operated appliance, in particular for a double dispensing cartridge for two-component substances |
| CN2089341U (zh) * | 1990-10-24 | 1991-11-27 | 北京医科大学第一医院 | 血液回收机 |
| IT1246530B (it) * | 1991-03-29 | 1994-11-24 | Miramed Spa | Metodo e corredo pre-assemblato per l'ottenimento di colla di fibrina in ambiente completamente sterile. |
| CN1091315A (zh) * | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
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1994
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- 1994-11-15 CZ CZ942806A patent/CZ280694A3/cs unknown
- 1994-11-16 SK SK1383-94A patent/SK138394A3/sk unknown
- 1994-11-16 FI FI945401A patent/FI114340B/fi not_active IP Right Cessation
- 1994-11-17 UA UA94119038A patent/UA27898C2/uk unknown
- 1994-11-17 BR BR9404484A patent/BR9404484A/pt not_active Application Discontinuation
- 1994-11-18 AU AU78897/94A patent/AU688390B2/en not_active Ceased
- 1994-11-18 RU RU94040895A patent/RU2133468C1/ru active
- 1994-11-18 HU HU9403324A patent/HU215246B/hu not_active IP Right Cessation
- 1994-11-18 PL PL94305907A patent/PL176963B1/pl unknown
- 1994-11-18 CA CA002136148A patent/CA2136148C/en not_active Expired - Fee Related
- 1994-11-18 KR KR1019940030362A patent/KR950013582A/ko not_active Application Discontinuation
- 1994-11-18 NO NO19944422A patent/NO314715B1/no unknown
- 1994-11-18 JP JP28495794A patent/JP3745397B2/ja not_active Expired - Fee Related
- 1994-11-19 CN CN94118719A patent/CN1044977C/zh not_active Expired - Fee Related
- 1994-11-21 EP EP01113608A patent/EP1152241A3/en not_active Withdrawn
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- 1994-11-21 EP EP94203381A patent/EP0654669B1/en not_active Expired - Lifetime
- 1994-11-21 AT AT94203381T patent/ATE213329T1/de not_active IP Right Cessation
- 1994-11-21 DK DK94203381T patent/DK0654669T3/da active
- 1994-11-21 DE DE69429852T patent/DE69429852T2/de not_active Expired - Fee Related
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- 1995-04-12 US US08/421,599 patent/US5603845A/en not_active Expired - Fee Related
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