NO311616B1 - Piperazinderivater og fremgangsmåte for fremstilling derav - Google Patents

Piperazinderivater og fremgangsmåte for fremstilling derav Download PDF

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Publication number
NO311616B1
NO311616B1 NO19980856A NO980856A NO311616B1 NO 311616 B1 NO311616 B1 NO 311616B1 NO 19980856 A NO19980856 A NO 19980856A NO 980856 A NO980856 A NO 980856A NO 311616 B1 NO311616 B1 NO 311616B1
Authority
NO
Norway
Prior art keywords
piperazine
nmr
cdcl
yield
title compound
Prior art date
Application number
NO19980856A
Other languages
English (en)
Norwegian (no)
Other versions
NO980856L (no
NO980856D0 (no
Inventor
Eui-Hwan Cho
Sun-Gan Chung
Sun-Hwan Lee
Ho-Seok Kwon
Jae-Eung Lee
Dong-Wook Kang
Jeong-Ho Joo
Young-Hee Lee
Original Assignee
Samjin Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019970022985A external-priority patent/KR100204319B1/ko
Priority claimed from KR1019970022984A external-priority patent/KR100204320B1/ko
Priority claimed from KR1019970023192A external-priority patent/KR100204318B1/ko
Priority claimed from KR1019970023193A external-priority patent/KR100197111B1/ko
Application filed by Samjin Pharm Co Ltd filed Critical Samjin Pharm Co Ltd
Publication of NO980856D0 publication Critical patent/NO980856D0/no
Publication of NO980856L publication Critical patent/NO980856L/no
Publication of NO311616B1 publication Critical patent/NO311616B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
NO19980856A 1996-06-29 1998-02-27 Piperazinderivater og fremgangsmåte for fremstilling derav NO311616B1 (no)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
KR19960025827 1996-06-29
KR19960025825 1996-06-29
KR19960025826 1996-06-29
KR19960040596 1996-09-18
KR1019970022985A KR100204319B1 (ko) 1996-06-29 1997-06-03 신규 피페라진 유도체 및 그 제조방법
KR1019970022984A KR100204320B1 (ko) 1996-06-29 1997-06-03 신규 피페라진 유도체 및 그 제조방법
KR1019970023192A KR100204318B1 (ko) 1996-06-29 1997-06-04 신규 피페라진 유도체 및 그 제조방법
KR1019970023193A KR100197111B1 (ko) 1996-09-18 1997-06-04 신규 피페라진 유도체 및 그 제조방법
PCT/KR1997/000128 WO1998000402A1 (en) 1996-06-29 1997-06-28 Piperazine derivatives and process for the preparation thereof

Publications (3)

Publication Number Publication Date
NO980856D0 NO980856D0 (no) 1998-02-27
NO980856L NO980856L (no) 1998-04-27
NO311616B1 true NO311616B1 (no) 2001-12-17

Family

ID=27573799

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19980856A NO311616B1 (no) 1996-06-29 1998-02-27 Piperazinderivater og fremgangsmåte for fremstilling derav

Country Status (17)

Country Link
US (1) US6028195A (xx)
EP (1) EP0850222B1 (xx)
JP (1) JP3032303B2 (xx)
CN (1) CN1152015C (xx)
AT (1) ATE241600T1 (xx)
AU (1) AU713171B2 (xx)
BG (1) BG102286A (xx)
CA (1) CA2230960C (xx)
CZ (1) CZ59398A3 (xx)
DE (1) DE69722360T2 (xx)
NO (1) NO311616B1 (xx)
NZ (1) NZ329847A (xx)
PL (1) PL325341A1 (xx)
RU (1) RU2146254C1 (xx)
SK (1) SK27598A3 (xx)
TR (1) TR199800371T1 (xx)
WO (1) WO1998000402A1 (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1129581C (zh) 1998-09-22 2003-12-03 山之内制药株式会社 氰基苯基衍生物
SI1140840T1 (sl) 1999-01-13 2006-06-30 Bayer Pharmaceuticals Corp Omega-karboksiarilno substituirane difenil secnine kot inhibitorji raf kinaze
IL144144A0 (en) 1999-01-13 2002-05-23 Bayer Ag Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US20020065296A1 (en) 1999-01-13 2002-05-30 Bayer Corporation Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors
KR100396738B1 (ko) * 1999-03-03 2003-09-03 삼진제약주식회사 피페라진 유도체 및 그 제조방법
NZ523526A (en) 2000-07-20 2004-10-29 Neurogen Corp Diaryl piperazines as capsaicin receptor ligands
DE10035928A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10035908A1 (de) 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10035927A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
CA2444467A1 (en) 2001-04-18 2002-10-24 Ulrich J. Krull Gradient resolved hybridisation platform
ES2345044T3 (es) 2002-02-01 2010-09-14 Euro-Celtique S.A. 2-piperazin-piridinas utiles para tratar el dolor.
RS114804A (xx) * 2002-06-28 2006-12-15 Euro-Celtique S.A. Terapeutski agensi korisni za lečenje bola
PL375527A1 (en) * 2002-06-29 2005-11-28 Zentaris Gmbh Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases
US7262194B2 (en) 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US7157462B2 (en) * 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US20050130989A1 (en) * 2003-01-28 2005-06-16 Aventis Pharma S. A. N-arylheteroaromatic products compositions containing them and use thereof
EP1590329A1 (fr) * 2003-01-28 2005-11-02 Aventis Pharma S.A. Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation
ATE384264T1 (de) 2003-05-20 2008-02-15 Bayer Pharmaceuticals Corp Diaryl-harnstoffe mit kinasehemmender wirkung
AU2005307209B2 (en) * 2004-11-17 2009-11-19 Korea Research Institute Of Chemical Technology 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives
EP1923388A4 (en) 2005-08-12 2011-03-09 Takeda Pharmaceutical BRAIN / NERVE CELL PROTECTION AND THERAPEUTIC FOR SLEEP DISORDERS
US20090068146A1 (en) 2005-10-31 2009-03-12 Scott Wilhelm Diaryl ureas and combinations
MX2010003918A (es) * 2007-10-10 2010-08-04 Takeda Pharmaceutical Compuesto de amida.
US7946206B2 (en) * 2007-11-21 2011-05-24 Rocksmart, Llc Quick-release system
TWI434842B (zh) * 2008-07-14 2014-04-21 Astellas Pharma Inc Azole compounds
WO2014127350A1 (en) * 2013-02-18 2014-08-21 The Scripps Research Institute Modulators of vasopressin receptors with therapeutic potential
KR20180114910A (ko) 2016-02-05 2018-10-19 데날리 테라퓨틱스 인크. 수용체-상호작용 단백질 키나제 1의 억제제
WO2018107060A1 (en) 2016-12-09 2018-06-14 Denali Therapeutics Inc. Compounds, compositions and methods
US11999750B2 (en) 2022-01-12 2024-06-04 Denali Therapeutics Inc. Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016274A (en) * 1973-05-15 1977-04-05 Rhone-Poulenc S.A. Naphthyridine derivatives
US4038391A (en) * 1973-05-15 1977-07-26 Rhone-Poulenc S.A. 6-(1,8-Naphthyridin-2-yl)-5-piperazino carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo-[3,4-b]pyrazines and related pyridines
OA04700A (fr) * 1973-05-15 1980-07-31 Rhone Poulenc Sa Nouveaux dérivés de la naphtyridine et leur procédé de préparation.
JPS63115167A (ja) * 1986-10-31 1988-05-19 Konica Corp ハロゲン化銀写真感光材料
US5391571A (en) * 1989-11-15 1995-02-21 American Home Products Corporation Cholesterol ester hydrolase inhibitors
DE4018070A1 (de) * 1990-06-06 1991-12-12 Bayer Ag Morpholinoharnstoff-derivate
ZA929008B (en) * 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
DE4216364A1 (de) * 1991-12-14 1993-11-25 Thomae Gmbh Dr K Neue Pyridylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5461047A (en) * 1993-06-16 1995-10-24 G. D. Searle & Co. 2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
FR2722788B1 (fr) * 1994-07-20 1996-10-04 Pf Medicament Nouvelles piperazides derivees d'aryl piperazine, leurs procedes de preparation, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant
CA2184919C (en) * 1995-01-11 2000-03-14 Eui-Hwan Cho New piperazine derivatives and methods for the preparation thereof and compositions containing the same

Also Published As

Publication number Publication date
PL325341A1 (en) 1998-07-20
RU2146254C1 (ru) 2000-03-10
CN1196724A (zh) 1998-10-21
NO980856L (no) 1998-04-27
CA2230960C (en) 2007-08-28
CN1152015C (zh) 2004-06-02
CA2230960A1 (en) 1998-01-08
DE69722360D1 (de) 2003-07-03
JP3032303B2 (ja) 2000-04-17
US6028195A (en) 2000-02-22
DE69722360T2 (de) 2003-11-27
EP0850222B1 (en) 2003-05-28
NO980856D0 (no) 1998-02-27
AU3464297A (en) 1998-01-21
ATE241600T1 (de) 2003-06-15
EP0850222A1 (en) 1998-07-01
JPH11501680A (ja) 1999-02-09
TR199800371T1 (xx) 1998-06-22
SK27598A3 (en) 1998-11-04
AU713171B2 (en) 1999-11-25
NZ329847A (en) 1999-01-28
CZ59398A3 (cs) 1998-07-15
BG102286A (en) 1999-08-31
WO1998000402A1 (en) 1998-01-08

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