DE69722360D1 - Piperazin-derivate und verfahren zu ihrer herstellung - Google Patents
Piperazin-derivate und verfahren zu ihrer herstellungInfo
- Publication number
- DE69722360D1 DE69722360D1 DE69722360T DE69722360T DE69722360D1 DE 69722360 D1 DE69722360 D1 DE 69722360D1 DE 69722360 T DE69722360 T DE 69722360T DE 69722360 T DE69722360 T DE 69722360T DE 69722360 D1 DE69722360 D1 DE 69722360D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- unsubstituted
- pct
- alkyl
- thioalkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000005309 thioalkoxy group Chemical group 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 1
- 125000004418 C2-C8 unsaturated alkyl group Chemical group 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 150000007970 thio esters Chemical class 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR19960025827 | 1996-06-29 | ||
| KR19960025826 | 1996-06-29 | ||
| KR19960025825 | 1996-06-29 | ||
| KR19960040596 | 1996-09-18 | ||
| KR1019970022984A KR100204320B1 (ko) | 1996-06-29 | 1997-06-03 | 신규 피페라진 유도체 및 그 제조방법 |
| KR1019970022985A KR100204319B1 (ko) | 1996-06-29 | 1997-06-03 | 신규 피페라진 유도체 및 그 제조방법 |
| KR1019970023193A KR100197111B1 (ko) | 1996-09-18 | 1997-06-04 | 신규 피페라진 유도체 및 그 제조방법 |
| KR1019970023192A KR100204318B1 (ko) | 1996-06-29 | 1997-06-04 | 신규 피페라진 유도체 및 그 제조방법 |
| PCT/KR1997/000128 WO1998000402A1 (en) | 1996-06-29 | 1997-06-28 | Piperazine derivatives and process for the preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69722360D1 true DE69722360D1 (de) | 2003-07-03 |
| DE69722360T2 DE69722360T2 (de) | 2003-11-27 |
Family
ID=27573799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69722360T Expired - Lifetime DE69722360T2 (de) | 1996-06-29 | 1997-06-28 | Piperazin-derivate und verfahren zu ihrer herstellung |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6028195A (de) |
| EP (1) | EP0850222B1 (de) |
| JP (1) | JP3032303B2 (de) |
| CN (1) | CN1152015C (de) |
| AT (1) | ATE241600T1 (de) |
| AU (1) | AU713171B2 (de) |
| BG (1) | BG102286A (de) |
| CA (1) | CA2230960C (de) |
| CZ (1) | CZ59398A3 (de) |
| DE (1) | DE69722360T2 (de) |
| NO (1) | NO311616B1 (de) |
| NZ (1) | NZ329847A (de) |
| PL (1) | PL325341A1 (de) |
| RU (1) | RU2146254C1 (de) |
| SK (1) | SK27598A3 (de) |
| TR (1) | TR199800371T1 (de) |
| WO (1) | WO1998000402A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2300151T3 (es) | 1998-09-22 | 2008-06-01 | Astellas Pharma Inc. | Derivados de cianofenilo. |
| EP1690853B1 (de) | 1999-01-13 | 2010-03-10 | Bayer HealthCare LLC | Verwendung von Omega-Carboxyaryl-substituierten Diphenylharnstoffen als raf-Kinase-Inhibitoren |
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| US20020065296A1 (en) | 1999-01-13 | 2002-05-30 | Bayer Corporation | Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors |
| WO2000052001A1 (en) * | 1999-03-03 | 2000-09-08 | Samjin Pharmaceutical Co., Ltd. | Piperazine derivatives and process for the preparation thereof |
| JP2004525071A (ja) | 2000-07-20 | 2004-08-19 | ニューロジェン コーポレイション | カプサイシン受容体リガンド |
| DE10035928A1 (de) * | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
| DE10035927A1 (de) * | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
| DE10035908A1 (de) * | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
| IT1318651B1 (it) * | 2000-07-28 | 2003-08-27 | Dompe Spa | Sintesi di (+-)1,3-diossolani e loro risoluzione ottica. |
| CA2444467A1 (en) | 2001-04-18 | 2002-10-24 | Ulrich J. Krull | Gradient resolved hybridisation platform |
| GB0126902D0 (en) * | 2001-11-08 | 2002-01-02 | Novartis Ag | Organic compounds |
| WO2003066595A2 (en) | 2002-02-01 | 2003-08-14 | Euro-Celtique S.A. | 2 - piperazine - pyridines useful for treating pain |
| PT1556354E (pt) * | 2002-06-28 | 2008-04-17 | Euro Celtique Sa | Derivados de piperazina úteis como agentes terapêuticos para o tratamento da dor |
| CN100509790C (zh) * | 2002-06-29 | 2009-07-08 | 赞塔里斯有限公司 | 芳基羰基哌嗪和杂芳基羰基哌嗪及其治疗良性和恶性肿瘤疾病的用途 |
| US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| US7157462B2 (en) * | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| US20050130989A1 (en) * | 2003-01-28 | 2005-06-16 | Aventis Pharma S. A. | N-arylheteroaromatic products compositions containing them and use thereof |
| BRPI0407088A (pt) * | 2003-01-28 | 2006-01-24 | Aventis Pharma Sa | Produtos n-aril-heteroaromáticos, composições contendo os mesmos e seu uso |
| WO2004113274A2 (en) | 2003-05-20 | 2004-12-29 | Bayer Pharmaceuticals Corporation | Diaryl ureas with kinase inhibiting activity |
| CA2587891C (en) | 2004-11-17 | 2010-08-31 | Rexhan Pharmaceuticals, Inc. | 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)alylpiperazine derivatives |
| ES2528674T3 (es) * | 2005-02-17 | 2015-02-11 | Astellas Pharma Inc. | Piperidina y carboxilatos de piperacina como inhibidores de FAAH |
| WO2007020888A1 (ja) | 2005-08-12 | 2007-02-22 | Takeda Pharmaceutical Company Limited | 脳・神経細胞保護剤および睡眠障害治療薬 |
| CA2627875A1 (en) | 2005-10-31 | 2007-05-10 | Bayer Pharmaceuticals Corporation | Combinations comprising sorafenib and interferon for the treatment of cancer |
| TW200924778A (en) * | 2007-10-10 | 2009-06-16 | Takeda Pharmaceutical | Amide compound |
| US7946206B2 (en) * | 2007-11-21 | 2011-05-24 | Rocksmart, Llc | Quick-release system |
| TWI434842B (zh) * | 2008-07-14 | 2014-04-21 | Astellas Pharma Inc | Azole compounds |
| WO2014127350A1 (en) * | 2013-02-18 | 2014-08-21 | The Scripps Research Institute | Modulators of vasopressin receptors with therapeutic potential |
| MA44007A (fr) | 2016-02-05 | 2018-12-19 | Denali Therapeutics Inc | Inhibiteurs du récepteur interagissant avec protéine kinase 1 |
| HRP20220636T1 (hr) | 2016-12-09 | 2022-07-22 | Denali Therapeutics Inc. | Spojevi korisni kao inhibitori ripk1 |
| IL314082A (en) | 2022-01-12 | 2024-09-01 | Denali Therapeutics Inc | Crystal forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazapin-3-yl)- H4- 1,2,4-triazole-3-carboxamide |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA04700A (fr) * | 1973-05-15 | 1980-07-31 | Rhone Poulenc Sa | Nouveaux dérivés de la naphtyridine et leur procédé de préparation. |
| US4038391A (en) * | 1973-05-15 | 1977-07-26 | Rhone-Poulenc S.A. | 6-(1,8-Naphthyridin-2-yl)-5-piperazino carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo-[3,4-b]pyrazines and related pyridines |
| US4016274A (en) * | 1973-05-15 | 1977-04-05 | Rhone-Poulenc S.A. | Naphthyridine derivatives |
| JPS59222484A (ja) * | 1983-06-02 | 1984-12-14 | Kowa Co | テトラヒドロナフチルカルボン酸フエニルエステル誘導体 |
| JPS63115167A (ja) * | 1986-10-31 | 1988-05-19 | Konica Corp | ハロゲン化銀写真感光材料 |
| US5001160A (en) * | 1988-04-28 | 1991-03-19 | Marion Laboratories, Inc. | 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders |
| US5391571A (en) * | 1989-11-15 | 1995-02-21 | American Home Products Corporation | Cholesterol ester hydrolase inhibitors |
| DE4018070A1 (de) * | 1990-06-06 | 1991-12-12 | Bayer Ag | Morpholinoharnstoff-derivate |
| ZA929008B (en) * | 1991-12-13 | 1993-05-21 | Bristol Myers Squibb Co | Piperazinyl- and piperidinyl-cyclohexanols. |
| DE4216364A1 (de) * | 1991-12-14 | 1993-11-25 | Thomae Gmbh Dr K | Neue Pyridylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5461047A (en) * | 1993-06-16 | 1995-10-24 | G. D. Searle & Co. | 2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use |
| FR2722788B1 (fr) * | 1994-07-20 | 1996-10-04 | Pf Medicament | Nouvelles piperazides derivees d'aryl piperazine, leurs procedes de preparation, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant |
| CZ288002B6 (cs) | 1995-01-11 | 2001-03-14 | Samjin Pharmaceutical Co., Ltd. | Piperazinové deriváty a farmaceutický prostředek s protinádorovou aktivitou je obsahující |
-
1997
- 1997-06-28 NZ NZ329847A patent/NZ329847A/xx not_active IP Right Cessation
- 1997-06-28 PL PL97325341A patent/PL325341A1/xx unknown
- 1997-06-28 WO PCT/KR1997/000128 patent/WO1998000402A1/en not_active Ceased
- 1997-06-28 AT AT97930868T patent/ATE241600T1/de not_active IP Right Cessation
- 1997-06-28 RU RU98105684A patent/RU2146254C1/ru active
- 1997-06-28 SK SK275-98A patent/SK27598A3/sk unknown
- 1997-06-28 JP JP10504004A patent/JP3032303B2/ja not_active Expired - Fee Related
- 1997-06-28 US US09/029,660 patent/US6028195A/en not_active Expired - Lifetime
- 1997-06-28 AU AU34642/97A patent/AU713171B2/en not_active Expired
- 1997-06-28 EP EP97930868A patent/EP0850222B1/de not_active Expired - Lifetime
- 1997-06-28 CN CNB971908001A patent/CN1152015C/zh not_active Expired - Lifetime
- 1997-06-28 CZ CZ98593A patent/CZ59398A3/cs unknown
- 1997-06-28 DE DE69722360T patent/DE69722360T2/de not_active Expired - Lifetime
- 1997-06-28 TR TR1998/00371T patent/TR199800371T1/xx unknown
- 1997-06-28 CA CA002230960A patent/CA2230960C/en not_active Expired - Lifetime
-
1998
- 1998-02-27 NO NO19980856A patent/NO311616B1/no unknown
- 1998-02-27 BG BG102286A patent/BG102286A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69722360T2 (de) | 2003-11-27 |
| NO311616B1 (no) | 2001-12-17 |
| CN1196724A (zh) | 1998-10-21 |
| CA2230960A1 (en) | 1998-01-08 |
| JPH11501680A (ja) | 1999-02-09 |
| WO1998000402A1 (en) | 1998-01-08 |
| TR199800371T1 (xx) | 1998-06-22 |
| ATE241600T1 (de) | 2003-06-15 |
| NZ329847A (en) | 1999-01-28 |
| CZ59398A3 (cs) | 1998-07-15 |
| AU3464297A (en) | 1998-01-21 |
| US6028195A (en) | 2000-02-22 |
| PL325341A1 (en) | 1998-07-20 |
| CA2230960C (en) | 2007-08-28 |
| EP0850222A1 (de) | 1998-07-01 |
| BG102286A (en) | 1999-08-31 |
| CN1152015C (zh) | 2004-06-02 |
| AU713171B2 (en) | 1999-11-25 |
| SK27598A3 (en) | 1998-11-04 |
| NO980856L (no) | 1998-04-27 |
| JP3032303B2 (ja) | 2000-04-17 |
| RU2146254C1 (ru) | 2000-03-10 |
| EP0850222B1 (de) | 2003-05-28 |
| NO980856D0 (no) | 1998-02-27 |
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