ATE166345T1 - Benzospiroalken-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen - Google Patents
Benzospiroalken-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- ATE166345T1 ATE166345T1 AT94401549T AT94401549T ATE166345T1 AT E166345 T1 ATE166345 T1 AT E166345T1 AT 94401549 T AT94401549 T AT 94401549T AT 94401549 T AT94401549 T AT 94401549T AT E166345 T1 ATE166345 T1 AT E166345T1
- Authority
- AT
- Austria
- Prior art keywords
- branched
- linear
- group
- unsubstituted
- substituted
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9308861A FR2709306B1 (fr) | 1993-07-20 | 1993-07-20 | Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE166345T1 true ATE166345T1 (de) | 1998-06-15 |
Family
ID=9449388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94401549T ATE166345T1 (de) | 1993-07-20 | 1994-07-06 | Benzospiroalken-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5436261A (de) |
| EP (1) | EP0635497B1 (de) |
| JP (1) | JP3105138B2 (de) |
| AT (1) | ATE166345T1 (de) |
| AU (1) | AU674080B2 (de) |
| CA (1) | CA2128359C (de) |
| CY (1) | CY2158B1 (de) |
| DE (1) | DE69410359T2 (de) |
| DK (1) | DK0635497T3 (de) |
| ES (1) | ES2119106T3 (de) |
| FR (1) | FR2709306B1 (de) |
| NZ (1) | NZ264050A (de) |
| ZA (1) | ZA945337B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2707981B1 (fr) * | 1993-07-20 | 1995-09-01 | Adir | Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| US6156783A (en) * | 1996-04-30 | 2000-12-05 | Smithkline Beecham P.L.C. | Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use |
| FR2787450B1 (fr) * | 1998-12-18 | 2001-01-26 | Adir | Nouveaux derives spiroimidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US7288559B2 (en) * | 2003-03-14 | 2007-10-30 | Merck + Co, Inc. | Carboxamide spirohydantoin CGRP receptor antagonists |
| US7115767B2 (en) * | 2003-07-18 | 2006-10-03 | Abbott Laboratories | Tetraline derivatives as ghrelin receptor modulators |
| CA2629406A1 (en) | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Spirohydantoin aryl cgrp receptor antagonists |
| EP1954268B1 (de) * | 2005-11-18 | 2012-09-26 | Merck Sharp & Dohme Corp. | Spirolactam-bicyclische cgrp-rezeptor-antagonisten |
| EP1951042B1 (de) * | 2005-11-18 | 2012-10-10 | Merck Sharp & Dohme Corp. | Spirolactam tricyclische cgrp-rezeptor-antagonisten |
| US7968540B2 (en) | 2005-11-18 | 2011-06-28 | Merck Sharp & Dohme Corp. | Spirohydantoin tricyclic CGRP receptor antagonists |
| AU2006316645A1 (en) | 2005-11-18 | 2007-05-31 | Merck Sharp & Dohme Corp. | Bicyclic spirohydantoin CGRP receptor antagonists |
| EP1954135B1 (de) * | 2005-11-18 | 2012-10-10 | Merck Sharp & Dohme Corp. | Spirolactam-aryl cgrp-rezeptor-antagonisten |
| EP2356106A1 (de) | 2008-10-07 | 2011-08-17 | Schering Corporation | Biarylspiroaminooxazolinanaloga als modu modulatoren des alpha2c-adrenergen rezeptors |
| WO2011041181A1 (en) * | 2009-10-01 | 2011-04-07 | Schering Corporation | Reversed biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2716648A (en) * | 1955-08-30 | Hydantoin derivatives | ||
| US3532744A (en) * | 1967-07-28 | 1970-10-06 | American Home Prod | 1- and 2-amino substituted indane and tetralene carboxylic acids |
-
1993
- 1993-07-20 FR FR9308861A patent/FR2709306B1/fr not_active Expired - Fee Related
-
1994
- 1994-07-06 EP EP94401549A patent/EP0635497B1/de not_active Expired - Lifetime
- 1994-07-06 DK DK94401549T patent/DK0635497T3/da active
- 1994-07-06 AT AT94401549T patent/ATE166345T1/de not_active IP Right Cessation
- 1994-07-06 DE DE69410359T patent/DE69410359T2/de not_active Expired - Fee Related
- 1994-07-06 ES ES94401549T patent/ES2119106T3/es not_active Expired - Lifetime
- 1994-07-18 AU AU67550/94A patent/AU674080B2/en not_active Ceased
- 1994-07-19 US US08/276,918 patent/US5436261A/en not_active Expired - Fee Related
- 1994-07-19 CA CA002128359A patent/CA2128359C/fr not_active Expired - Fee Related
- 1994-07-20 JP JP06198901A patent/JP3105138B2/ja not_active Expired - Fee Related
- 1994-07-20 ZA ZA945337A patent/ZA945337B/xx unknown
- 1994-07-20 NZ NZ264050A patent/NZ264050A/en unknown
-
1999
- 1999-11-19 CY CY9900039A patent/CY2158B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3105138B2 (ja) | 2000-10-30 |
| HK1009648A1 (en) | 1999-06-04 |
| FR2709306B1 (fr) | 1995-10-20 |
| ZA945337B (en) | 1995-03-01 |
| CA2128359C (fr) | 2002-03-19 |
| ES2119106T3 (es) | 1998-10-01 |
| EP0635497B1 (de) | 1998-05-20 |
| EP0635497A3 (de) | 1995-02-22 |
| EP0635497A2 (de) | 1995-01-25 |
| FR2709306A1 (fr) | 1995-03-03 |
| NZ264050A (en) | 1995-07-26 |
| AU6755094A (en) | 1995-02-02 |
| JPH07304753A (ja) | 1995-11-21 |
| DK0635497T3 (da) | 1999-03-08 |
| CA2128359A1 (fr) | 1995-01-21 |
| US5436261A (en) | 1995-07-25 |
| CY2158B1 (en) | 2002-08-23 |
| AU674080B2 (en) | 1996-12-05 |
| DE69410359T2 (de) | 1999-01-07 |
| DE69410359D1 (de) | 1998-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |