PL1819698T3 - Pochodne 1-[(6-podstawione alkoksychinoksalinylo)aminokarbonylo]-4-(hetero)arylopiperazyny - Google Patents

Pochodne 1-[(6-podstawione alkoksychinoksalinylo)aminokarbonylo]-4-(hetero)arylopiperazyny

Info

Publication number
PL1819698T3
PL1819698T3 PL05809031T PL05809031T PL1819698T3 PL 1819698 T3 PL1819698 T3 PL 1819698T3 PL 05809031 T PL05809031 T PL 05809031T PL 05809031 T PL05809031 T PL 05809031T PL 1819698 T3 PL1819698 T3 PL 1819698T3
Authority
PL
Poland
Prior art keywords
aminocarbonyl
hetero
arylpiperazine derivatives
alkoxyquinoxalinyl
substituted
Prior art date
Application number
PL05809031T
Other languages
English (en)
Inventor
Young-Dae Gong
Moon-Kook Jeon
Dong-Su Kim
Jae Yang Kong
Gun-Do Kim
Chang-Ho Ahn
Young Bok Lee
Original Assignee
Rexahn Pharmaceuticals Inc
Korea Res Inst Chemical Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36407350&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1819698(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from KR1020040094232A external-priority patent/KR20060053788A/ko
Priority claimed from KR1020040094233A external-priority patent/KR100739233B1/ko
Application filed by Rexahn Pharmaceuticals Inc, Korea Res Inst Chemical Tech filed Critical Rexahn Pharmaceuticals Inc
Publication of PL1819698T3 publication Critical patent/PL1819698T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL05809031T 2004-11-17 2005-10-18 Pochodne 1-[(6-podstawione alkoksychinoksalinylo)aminokarbonylo]-4-(hetero)arylopiperazyny PL1819698T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1020040094232A KR20060053788A (ko) 2004-11-17 2004-11-17 1-[(2-알콕시-6-치환-퀴녹살린-3-일)아미노카르보닐]-4-(헤테로)아릴피페라진 유도체
KR1020040094233A KR100739233B1 (ko) 2004-11-17 2004-11-17 1-[(3-알콕시-6-치환-퀴녹살린-2-일)아미노카르보닐]-4-(헤테로)아릴피페라진 유도체
PCT/KR2005/003463 WO2006054830A1 (en) 2004-11-17 2005-10-18 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives
EP05809031A EP1819698B1 (en) 2004-11-17 2005-10-18 1-[(6-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives

Publications (1)

Publication Number Publication Date
PL1819698T3 true PL1819698T3 (pl) 2011-08-31

Family

ID=36407350

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05809031T PL1819698T3 (pl) 2004-11-17 2005-10-18 Pochodne 1-[(6-podstawione alkoksychinoksalinylo)aminokarbonylo]-4-(hetero)arylopiperazyny

Country Status (12)

Country Link
US (2) US8314100B2 (pl)
EP (1) EP1819698B1 (pl)
JP (1) JP6097946B2 (pl)
CN (1) CN103524436B (pl)
AT (1) ATE499366T1 (pl)
AU (1) AU2005307209B2 (pl)
BR (1) BRPI0517734A (pl)
CA (1) CA2587891C (pl)
DE (1) DE602005026557D1 (pl)
MX (1) MX2007005863A (pl)
PL (1) PL1819698T3 (pl)
WO (1) WO2006054830A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8314100B2 (en) 2004-11-17 2012-11-20 Rexahn Pharmaceuticals, Inc. 1-[6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives
KR101140133B1 (ko) 2010-02-17 2012-05-02 한국화학연구원 1-(6,7-다이플루오르-3-메톡시퀴녹살린-2-일)-3-［1-(헤테로아릴메틸)피페리딘-4-일］ 우레아 유도체, 그 제조방법 및 그의 용도
MX363378B (es) * 2013-06-28 2019-03-21 Rexahn Pharmaceuticals Inc Composiciones nanoparticuladas y formulaciones de compuestos de piperazina.
US10059721B2 (en) 2014-12-08 2018-08-28 Dongguk University Industry-Academic Cooperation Foundation Substituted thieno[3,2-b]pyrazines for inhibiting cancer cell proliferation and inducing cancer cell apoptosis
US9969698B2 (en) 2015-09-04 2018-05-15 Rexahn Pharmaceuticals, Inc. Quinoxalinyl-piperazinamide methods of use
KR101872645B1 (ko) * 2016-06-09 2018-08-03 동국대학교 산학협력단 신규한 4-(아릴)-N-(3-알콕시퓨로[2,3-b]피라진-2-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과
WO2017213452A1 (ko) * 2016-06-09 2017-12-14 동국대학교 산학협력단 신규한 4-(아릴)-n-(3-알콕시퓨로[2,3-b]피라진-2-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59104A (en) * 1979-02-09 1984-02-29 Roussel Uclaf Heterotricyclic derivatives,process for their preparation and pharmaceutical compositions incorporating them
FR2448541A1 (fr) * 1979-02-09 1980-09-05 Roussel Uclaf Nouveaux derives de l'oxoimidazoquinoxaline et leurs sels, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US6028184A (en) * 1996-12-31 2000-02-22 Max-Plank-Gesellschaft Zur Forderung Der Wissenschaften E.V. Pax6 and Pax4 nucleic acid mixtures
US6028195A (en) * 1996-06-29 2000-02-22 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
DE60010988T2 (de) 1999-03-03 2005-06-09 Samjin Pharmaceutical Co., Ltd. Piperazinderivate und verfahren zu ihrer herstellung
AU2001264376A1 (en) * 2000-06-15 2001-12-24 Chaconne Nsi Co., Ltd. Urea derivative useful as an anti-cancer agent and process for preparing same
AR043059A1 (es) * 2002-11-12 2005-07-13 Bayer Pharmaceuticals Corp Derivados de indolil pirazinona utiles para el tratamiento de trastornos hiper-proliferativos
CA2522079A1 (en) * 2003-04-16 2004-11-04 Astrazeneca Ab Quinazoline derivatives for treatment of cancer
US8314100B2 (en) 2004-11-17 2012-11-20 Rexahn Pharmaceuticals, Inc. 1-[6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives

Also Published As

Publication number Publication date
JP2008520653A (ja) 2008-06-19
US8314100B2 (en) 2012-11-20
EP1819698A1 (en) 2007-08-22
BRPI0517734A (pt) 2008-10-21
US20080318963A1 (en) 2008-12-25
DE602005026557D1 (de) 2011-04-07
US20130053390A1 (en) 2013-02-28
ATE499366T1 (de) 2011-03-15
MX2007005863A (es) 2007-10-19
US8598173B2 (en) 2013-12-03
CN103524436B (zh) 2015-09-23
WO2006054830A1 (en) 2006-05-26
CA2587891A1 (en) 2006-05-26
CA2587891C (en) 2010-08-31
AU2005307209A1 (en) 2006-05-26
AU2005307209B2 (en) 2009-11-19
CN103524436A (zh) 2014-01-22
EP1819698B1 (en) 2011-02-23
JP6097946B2 (ja) 2017-03-22

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