ATE499366T1 - 1-ä(6-substituiertes alkoxychinoxalinyl) - Google Patents
1-ä(6-substituiertes alkoxychinoxalinyl)Info
- Publication number
- ATE499366T1 ATE499366T1 AT05809031T AT05809031T ATE499366T1 AT E499366 T1 ATE499366 T1 AT E499366T1 AT 05809031 T AT05809031 T AT 05809031T AT 05809031 T AT05809031 T AT 05809031T AT E499366 T1 ATE499366 T1 AT E499366T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- alkoxychinoxalinyl
- compounds
- piperazine compounds
- quioxaline
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020040094233A KR100739233B1 (ko) | 2004-11-17 | 2004-11-17 | 1-[(3-알콕시-6-치환-퀴녹살린-2-일)아미노카르보닐]-4-(헤테로)아릴피페라진 유도체 |
| KR1020040094232A KR20060053788A (ko) | 2004-11-17 | 2004-11-17 | 1-[(2-알콕시-6-치환-퀴녹살린-3-일)아미노카르보닐]-4-(헤테로)아릴피페라진 유도체 |
| PCT/KR2005/003463 WO2006054830A1 (en) | 2004-11-17 | 2005-10-18 | 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE499366T1 true ATE499366T1 (de) | 2011-03-15 |
Family
ID=36407350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05809031T ATE499366T1 (de) | 2004-11-17 | 2005-10-18 | 1-ä(6-substituiertes alkoxychinoxalinyl) |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8314100B2 (de) |
| EP (1) | EP1819698B1 (de) |
| JP (1) | JP6097946B2 (de) |
| CN (1) | CN103524436B (de) |
| AT (1) | ATE499366T1 (de) |
| AU (1) | AU2005307209B2 (de) |
| BR (1) | BRPI0517734A (de) |
| CA (1) | CA2587891C (de) |
| DE (1) | DE602005026557D1 (de) |
| MX (1) | MX2007005863A (de) |
| PL (1) | PL1819698T3 (de) |
| WO (1) | WO2006054830A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6097946B2 (ja) | 2004-11-17 | 2017-03-22 | レクサン ファーマシューティカルズ インコーポレイテッド | １−［（６，７−置換−アルコキシキノキサリニル）アミノカルボニル］−４−（ヘテロ）アリールピペラジン誘導体 |
| KR101140133B1 (ko) | 2010-02-17 | 2012-05-02 | 한국화학연구원 | 1-(6,7-다이플루오르-3-메톡시퀴녹살린-2-일)-3-［1-(헤테로아릴메틸)피페리딘-4-일］ 우레아 유도체, 그 제조방법 및 그의 용도 |
| US9744167B2 (en) | 2013-06-28 | 2017-08-29 | Rexahn Pharmaceuticals, Inc. | Nanoparticulate compositions and formulations of piperazine compounds |
| KR101727412B1 (ko) * | 2014-12-08 | 2017-04-17 | 동국대학교 산학협력단 | 신규한 4-(아릴)-N-(2-알콕시티에노[3,2-b]피라진-3-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과 |
| JP2018526392A (ja) | 2015-09-04 | 2018-09-13 | レクサン ファーマシューティカルズ インコーポレイテッド | キノキサリニル−ピペラジンアミドの使用方法 |
| WO2017213452A1 (ko) * | 2016-06-09 | 2017-12-14 | 동국대학교 산학협력단 | 신규한 4-(아릴)-n-(3-알콕시퓨로[2,3-b]피라진-2-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과 |
| KR101872645B1 (ko) | 2016-06-09 | 2018-08-03 | 동국대학교 산학협력단 | 신규한 4-(아릴)-N-(3-알콕시퓨로[2,3-b]피라진-2-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE441449B (sv) * | 1979-02-09 | 1985-10-07 | Roussel Uclaf | Heterocykliska derivat och farmaceutiska kompositioner innehallande dessa derivat |
| FR2448541A1 (fr) | 1979-02-09 | 1980-09-05 | Roussel Uclaf | Nouveaux derives de l'oxoimidazoquinoxaline et leurs sels, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| US6071697A (en) * | 1992-08-03 | 2000-06-06 | Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. | Method for testing the differentiation status in pancreatic cells of a mammal |
| EP0850222B1 (de) | 1996-06-29 | 2003-05-28 | Samjin Pharmaceutical Co., Ltd. | Piperazin-derivate und verfahren zu ihrer herstellung |
| WO2000052001A1 (en) * | 1999-03-03 | 2000-09-08 | Samjin Pharmaceutical Co., Ltd. | Piperazine derivatives and process for the preparation thereof |
| AU2001264376A1 (en) * | 2000-06-15 | 2001-12-24 | Chaconne Nsi Co., Ltd. | Urea derivative useful as an anti-cancer agent and process for preparing same |
| AR043059A1 (es) | 2002-11-12 | 2005-07-13 | Bayer Pharmaceuticals Corp | Derivados de indolil pirazinona utiles para el tratamiento de trastornos hiper-proliferativos |
| RU2005135337A (ru) | 2003-04-16 | 2006-06-10 | Астразенека Аб (Se) | Производные хиназолина для лечения злокачественного новообразования |
| JP6097946B2 (ja) | 2004-11-17 | 2017-03-22 | レクサン ファーマシューティカルズ インコーポレイテッド | １−［（６，７−置換−アルコキシキノキサリニル）アミノカルボニル］−４−（ヘテロ）アリールピペラジン誘導体 |
-
2005
- 2005-10-18 JP JP2007542886A patent/JP6097946B2/ja not_active Expired - Fee Related
- 2005-10-18 BR BRPI0517734-0A patent/BRPI0517734A/pt not_active Application Discontinuation
- 2005-10-18 US US11/667,923 patent/US8314100B2/en not_active Expired - Fee Related
- 2005-10-18 EP EP05809031A patent/EP1819698B1/de not_active Expired - Lifetime
- 2005-10-18 MX MX2007005863A patent/MX2007005863A/es active IP Right Grant
- 2005-10-18 CN CN201310540633.7A patent/CN103524436B/zh not_active Expired - Fee Related
- 2005-10-18 AU AU2005307209A patent/AU2005307209B2/en not_active Ceased
- 2005-10-18 CA CA2587891A patent/CA2587891C/en not_active Expired - Fee Related
- 2005-10-18 PL PL05809031T patent/PL1819698T3/pl unknown
- 2005-10-18 AT AT05809031T patent/ATE499366T1/de active
- 2005-10-18 DE DE602005026557T patent/DE602005026557D1/de not_active Expired - Lifetime
- 2005-10-18 WO PCT/KR2005/003463 patent/WO2006054830A1/en not_active Ceased
-
2012
- 2012-10-26 US US13/661,975 patent/US8598173B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005026557D1 (de) | 2011-04-07 |
| AU2005307209B2 (en) | 2009-11-19 |
| US8314100B2 (en) | 2012-11-20 |
| US20130053390A1 (en) | 2013-02-28 |
| JP2008520653A (ja) | 2008-06-19 |
| EP1819698B1 (de) | 2011-02-23 |
| CN103524436B (zh) | 2015-09-23 |
| US8598173B2 (en) | 2013-12-03 |
| WO2006054830A1 (en) | 2006-05-26 |
| US20080318963A1 (en) | 2008-12-25 |
| AU2005307209A1 (en) | 2006-05-26 |
| MX2007005863A (es) | 2007-10-19 |
| CA2587891A1 (en) | 2006-05-26 |
| CN103524436A (zh) | 2014-01-22 |
| CA2587891C (en) | 2010-08-31 |
| PL1819698T3 (pl) | 2011-08-31 |
| JP6097946B2 (ja) | 2017-03-22 |
| BRPI0517734A (pt) | 2008-10-21 |
| EP1819698A1 (de) | 2007-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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