NO309142B1 - N<alfa>-2-(4-nitrofenylsulfonyl)etoksykarbonylaminosyrer og fremgangsmåter derfor - Google Patents
N<alfa>-2-(4-nitrofenylsulfonyl)etoksykarbonylaminosyrer og fremgangsmåter derfor Download PDFInfo
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- NO309142B1 NO309142B1 NO973752A NO973752A NO309142B1 NO 309142 B1 NO309142 B1 NO 309142B1 NO 973752 A NO973752 A NO 973752A NO 973752 A NO973752 A NO 973752A NO 309142 B1 NO309142 B1 NO 309142B1
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- 150000007524 organic acids Chemical class 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 description 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000003774 sulfhydryl reagent Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU9595102102A RU2079491C1 (ru) | 1995-02-15 | 1995-02-15 | Nα -2-(4-НИТРОФЕНИЛСУЛЬФОНИЛ)ЭТОКСИКАРБОНИЛ-АМИНОКИСЛОТЫ В КАЧЕСТВЕ Nα -ЗАЩИЩЕННЫХ АМИНОКИСЛОТ ДЛЯ ТВЕРДОФАЗНОГО СИНТЕЗА ПЕПТИДОВ |
| PCT/KR1996/000012 WO1996025394A1 (en) | 1995-02-15 | 1996-01-27 | Nα-2-(4-NITROPHENULSULFONYL)ETHOXYCARBONYL-AMINO ACIDS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO973752D0 NO973752D0 (no) | 1997-08-14 |
| NO973752L NO973752L (no) | 1997-10-14 |
| NO309142B1 true NO309142B1 (no) | 2000-12-18 |
Family
ID=20164784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO973752A NO309142B1 (no) | 1995-02-15 | 1997-08-14 | N<alfa>-2-(4-nitrofenylsulfonyl)etoksykarbonylaminosyrer og fremgangsmåter derfor |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5616788A (ko) |
| EP (1) | EP0765307B1 (ko) |
| JP (1) | JP2888991B2 (ko) |
| KR (1) | KR100241948B1 (ko) |
| CN (1) | CN1058260C (ko) |
| AT (1) | ATE185796T1 (ko) |
| AU (1) | AU705716B2 (ko) |
| CA (1) | CA2212052C (ko) |
| CZ (1) | CZ289747B6 (ko) |
| DE (1) | DE69604759T2 (ko) |
| DK (1) | DK0765307T3 (ko) |
| ES (1) | ES2140061T3 (ko) |
| FI (1) | FI973338A (ko) |
| GR (1) | GR3031832T3 (ko) |
| HU (1) | HUP9801150A3 (ko) |
| NO (1) | NO309142B1 (ko) |
| PL (1) | PL184205B1 (ko) |
| RU (1) | RU2079491C1 (ko) |
| WO (1) | WO1996025394A1 (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090615C (zh) * | 1996-10-19 | 2002-09-11 | Hyundai药物工业株式会社 | Nα－2－(4－硝基苯基磺酰基)乙氧羰基氨基酸 |
| WO1998017638A1 (en) * | 1996-10-19 | 1998-04-30 | Hyundai Pharm. Ind. Co., Ltd. | Nα-2-(4-NITROPHENYLSULFONYL)ETHOXYCARBONYL-AMINO ACIDS |
| KR100378252B1 (ko) * | 1999-11-12 | 2003-03-29 | 학교법인 포항공과대학교 | 니트로술포닐에톡시카르보닐-아미노산을 이용한 합성테트라펩티드 라이브러리의 제조방법 |
| WO2001051505A1 (en) * | 1999-12-24 | 2001-07-19 | Hyundai Pharmaceutical Ind. Co., Ltd. | Nα-2-(4-NITROPHENYLSULFONYL)ETHOXYCARBONYL-AMINO ACID FLUORIDES AND PROCESS FOR THE PREPARATION THEREOF |
| KR100418962B1 (ko) * | 2001-06-07 | 2004-02-14 | 김학주 | 2-(4-나이트로페닐설포닐)에톡시카르보닐-아미노산류를사용하여 펩티드를 고수율 및 고순도로 제조하는 방법 |
| WO2009014177A1 (ja) * | 2007-07-25 | 2009-01-29 | Ajinomoto Co., Inc. | ジベンゾフルベン誘導体の淘汰方法 |
| CN103421087A (zh) * | 2013-04-12 | 2013-12-04 | 上海捌加壹医药科技有限公司 | 一种多肽的液相合成方法 |
| WO2024079043A1 (en) | 2022-10-10 | 2024-04-18 | Bachem Holding Ag | Method of manufacturing a peptide with a lysine derivative |
-
1995
- 1995-02-15 RU RU9595102102A patent/RU2079491C1/ru active
-
1996
- 1996-01-27 AT AT96901556T patent/ATE185796T1/de not_active IP Right Cessation
- 1996-01-27 CN CN96191913A patent/CN1058260C/zh not_active Expired - Fee Related
- 1996-01-27 AU AU45496/96A patent/AU705716B2/en not_active Ceased
- 1996-01-27 WO PCT/KR1996/000012 patent/WO1996025394A1/en not_active Application Discontinuation
- 1996-01-27 KR KR1019970705664A patent/KR100241948B1/ko not_active IP Right Cessation
- 1996-01-27 CZ CZ19972477A patent/CZ289747B6/cs not_active IP Right Cessation
- 1996-01-27 CA CA002212052A patent/CA2212052C/en not_active Expired - Fee Related
- 1996-01-27 PL PL96321864A patent/PL184205B1/pl not_active IP Right Cessation
- 1996-01-27 EP EP96901556A patent/EP0765307B1/en not_active Revoked
- 1996-01-27 JP JP8524843A patent/JP2888991B2/ja not_active Expired - Fee Related
- 1996-01-27 DK DK96901556T patent/DK0765307T3/da active
- 1996-01-27 ES ES96901556T patent/ES2140061T3/es not_active Expired - Lifetime
- 1996-01-27 HU HU9801150A patent/HUP9801150A3/hu unknown
- 1996-01-27 DE DE69604759T patent/DE69604759T2/de not_active Revoked
- 1996-02-01 US US08/595,381 patent/US5616788A/en not_active Expired - Lifetime
-
1997
- 1997-08-14 NO NO973752A patent/NO309142B1/no unknown
- 1997-08-14 FI FI973338A patent/FI973338A/fi unknown
-
1999
- 1999-11-12 GR GR990402922T patent/GR3031832T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0765307B1 (en) | 1999-10-20 |
| RU2079491C1 (ru) | 1997-05-20 |
| KR19980702267A (ko) | 1998-07-15 |
| PL321864A1 (en) | 1997-12-22 |
| DE69604759D1 (de) | 1999-11-25 |
| DE69604759T2 (de) | 2000-06-21 |
| FI973338A (fi) | 1997-10-14 |
| DK0765307T3 (da) | 1999-12-27 |
| CZ289747B6 (cs) | 2002-03-13 |
| JP2888991B2 (ja) | 1999-05-10 |
| FI973338A0 (fi) | 1997-08-14 |
| CA2212052C (en) | 2002-09-03 |
| CZ247797A3 (cs) | 1998-02-18 |
| HUP9801150A2 (hu) | 1998-09-28 |
| GR3031832T3 (en) | 2000-02-29 |
| HUP9801150A3 (en) | 2000-07-28 |
| CN1058260C (zh) | 2000-11-08 |
| WO1996025394A1 (en) | 1996-08-22 |
| RU95102102A (ru) | 1996-11-20 |
| CA2212052A1 (en) | 1996-08-22 |
| EP0765307A1 (en) | 1997-04-02 |
| PL184205B1 (pl) | 2002-09-30 |
| NO973752D0 (no) | 1997-08-14 |
| US5616788A (en) | 1997-04-01 |
| KR100241948B1 (ko) | 2000-02-01 |
| ATE185796T1 (de) | 1999-11-15 |
| JPH10503216A (ja) | 1998-03-24 |
| AU705716B2 (en) | 1999-05-27 |
| ES2140061T3 (es) | 2000-02-16 |
| CN1173865A (zh) | 1998-02-18 |
| AU4549696A (en) | 1996-09-04 |
| NO973752L (no) | 1997-10-14 |
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