ES2140061T3 - Acidos n alfa-2-(4-nitrofenilsulfonil)etoxicarbonil-amino. - Google Patents

Acidos n alfa-2-(4-nitrofenilsulfonil)etoxicarbonil-amino.

Info

Publication number
ES2140061T3
ES2140061T3 ES96901556T ES96901556T ES2140061T3 ES 2140061 T3 ES2140061 T3 ES 2140061T3 ES 96901556 T ES96901556 T ES 96901556T ES 96901556 T ES96901556 T ES 96901556T ES 2140061 T3 ES2140061 T3 ES 2140061T3
Authority
ES
Spain
Prior art keywords
sub
terc
butyl
methyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96901556T
Other languages
English (en)
Inventor
Vladimir Vasilyevich Samukov
Ayda Nadzhatovich Sabirov
Pavel Ivanovich Pozdnyarkov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hyundai Pharm Co Ltd
Original Assignee
Hyundai Pharmaceutical Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20164784&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2140061(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hyundai Pharmaceutical Ind Co Ltd filed Critical Hyundai Pharmaceutical Ind Co Ltd
Application granted granted Critical
Publication of ES2140061T3 publication Critical patent/ES2140061T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

DERIVADOS DE AMINOACIDOS PROTEGIDOS, DE FORMULA GENERAL (I), DONDE R{SUB,1} REPRESENTA UN ATOMO DE HIDROGENO, Y R{SUB,2} REPRESENTA HIDROGENO, METILO, ISOPROPILO, 1-METILPROPILO, 2METILPROPILO, TERC-BUTOXIMETILO, 1-TERC-BUTOXIETILO, , 2METILTIOETILO, BENCILO, CARBOXAMIDOMETIL, 2-CARBOXAMIDOETIL, TERC-BUTOXICARBONILMETIL, 2-(TERC-BUTOXICARBONIL)ETILO, 4-(TERCBUTOXICARBAMIDO)BUTILO, 4-TERC-BUTOXIBENCILO, INDOLIL-3-METILO, S(TRIFENILMETIL)TIOMETIL, 1-(TRIFENILMETIL)IMIDAZOLIL-4-METILO, 3-(N{SUP,G}MESITILENSULFONIL)GUANIDINOPROPIL, NXANTILCARBOXAMIDOMETIL, 2-(N-XANTILCARBOXAMIDO)ETILO O S(ACETAMIDOMETIL)TIOMETILO; O R{SUB,1} Y R{SUB,2} UNIDOS, REPRESENTAN EL RADICAL PROPILENO. SE PROPORCIONAN METODOS DE PREPARACION DE DICHOS DERIVADOS, Y SE DESCRIBE UN PROCEDIMIENTO DE SINTESIS DE PEPTIDOS EN FASE SOLIDA, UTILIZANDO DICHOS DERIVADOS.
ES96901556T 1995-02-15 1996-01-27 Acidos n alfa-2-(4-nitrofenilsulfonil)etoxicarbonil-amino. Expired - Lifetime ES2140061T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU9595102102A RU2079491C1 (ru) 1995-02-15 1995-02-15 Nα -2-(4-НИТРОФЕНИЛСУЛЬФОНИЛ)ЭТОКСИКАРБОНИЛ-АМИНОКИСЛОТЫ В КАЧЕСТВЕ Nα -ЗАЩИЩЕННЫХ АМИНОКИСЛОТ ДЛЯ ТВЕРДОФАЗНОГО СИНТЕЗА ПЕПТИДОВ

Publications (1)

Publication Number Publication Date
ES2140061T3 true ES2140061T3 (es) 2000-02-16

Family

ID=20164784

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96901556T Expired - Lifetime ES2140061T3 (es) 1995-02-15 1996-01-27 Acidos n alfa-2-(4-nitrofenilsulfonil)etoxicarbonil-amino.

Country Status (19)

Country Link
US (1) US5616788A (es)
EP (1) EP0765307B1 (es)
JP (1) JP2888991B2 (es)
KR (1) KR100241948B1 (es)
CN (1) CN1058260C (es)
AT (1) ATE185796T1 (es)
AU (1) AU705716B2 (es)
CA (1) CA2212052C (es)
CZ (1) CZ289747B6 (es)
DE (1) DE69604759T2 (es)
DK (1) DK0765307T3 (es)
ES (1) ES2140061T3 (es)
FI (1) FI973338A (es)
GR (1) GR3031832T3 (es)
HU (1) HUP9801150A3 (es)
NO (1) NO309142B1 (es)
PL (1) PL184205B1 (es)
RU (1) RU2079491C1 (es)
WO (1) WO1996025394A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU729889B2 (en) * 1996-10-19 2001-02-15 Hyundai Pharm. Ind. Co., Ltd. N alpha-2-(4-nitrophenylsulfonyl)ethoxycarbonyl-amino acids
CN1090615C (zh) * 1996-10-19 2002-09-11 Hyundai药物工业株式会社 Nα－2－(4－硝基苯基磺酰基)乙氧羰基氨基酸
KR100378252B1 (ko) * 1999-11-12 2003-03-29 학교법인 포항공과대학교 니트로술포닐에톡시카르보닐-아미노산을 이용한 합성테트라펩티드 라이브러리의 제조방법
WO2001051505A1 (en) * 1999-12-24 2001-07-19 Hyundai Pharmaceutical Ind. Co., Ltd. Nα-2-(4-NITROPHENYLSULFONYL)ETHOXYCARBONYL-AMINO ACID FLUORIDES AND PROCESS FOR THE PREPARATION THEREOF
KR100418962B1 (ko) * 2001-06-07 2004-02-14 김학주 2-(4-나이트로페닐설포닐)에톡시카르보닐-아미노산류를사용하여 펩티드를 고수율 및 고순도로 제조하는 방법
JP5515738B2 (ja) * 2007-07-25 2014-06-11 味の素株式会社 ジベンゾフルベン誘導体の淘汰方法
CN103421087A (zh) * 2013-04-12 2013-12-04 上海捌加壹医药科技有限公司 一种多肽的液相合成方法
WO2024079043A1 (en) 2022-10-10 2024-04-18 Bachem Holding Ag Method of manufacturing a peptide with a lysine derivative

Also Published As

Publication number Publication date
AU705716B2 (en) 1999-05-27
NO309142B1 (no) 2000-12-18
US5616788A (en) 1997-04-01
CA2212052A1 (en) 1996-08-22
PL184205B1 (pl) 2002-09-30
KR19980702267A (ko) 1998-07-15
EP0765307B1 (en) 1999-10-20
CZ289747B6 (cs) 2002-03-13
CA2212052C (en) 2002-09-03
GR3031832T3 (en) 2000-02-29
HUP9801150A2 (hu) 1998-09-28
DK0765307T3 (da) 1999-12-27
RU95102102A (ru) 1996-11-20
KR100241948B1 (ko) 2000-02-01
EP0765307A1 (en) 1997-04-02
RU2079491C1 (ru) 1997-05-20
ATE185796T1 (de) 1999-11-15
DE69604759T2 (de) 2000-06-21
AU4549696A (en) 1996-09-04
HUP9801150A3 (en) 2000-07-28
JPH10503216A (ja) 1998-03-24
JP2888991B2 (ja) 1999-05-10
NO973752L (no) 1997-10-14
PL321864A1 (en) 1997-12-22
CN1058260C (zh) 2000-11-08
DE69604759D1 (de) 1999-11-25
FI973338A (fi) 1997-10-14
CZ247797A3 (cs) 1998-02-18
NO973752D0 (no) 1997-08-14
WO1996025394A1 (en) 1996-08-22
FI973338A0 (fi) 1997-08-14
CN1173865A (zh) 1998-02-18

Similar Documents

Publication Publication Date Title
ATE271546T1 (de) Herstellung von 1,3-disubstituierter imidazolsalzen
KR910009684A (ko) 방향족 아민 화합물, 이의 제조방법 및 이들의 존재하는 약제학적 조성물
NO986055D0 (no) Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat
NO963053D0 (no) Kosmetiske eller farmasöytiske preparater inneholdende mangiferin eller derivater derav
ATE343383T1 (de) Hemmer der zelladhäsion
KR850002472A (ko) 5-피리딜-1,3-티아졸 유도체의 제조방법
NO865235L (no) Nye derivater av ((4-(4-(4-fenyl-1-piperazinyl)fenoksymetyl)-1,3-dioksolan-2-yl metyl)-1h-imidazoler-og-1h-1,2,4-triazoler.
KR850006008A (ko) 레닌 억제 펩타이드의 제조방법
ES2140061T3 (es) Acidos n alfa-2-(4-nitrofenilsulfonil)etoxicarbonil-amino.
NO20000722L (no) 2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater
NO177677C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive forbindelser
ATE59294T1 (de) Stabilisierte arzneimittel.
FI923189A0 (fi) 2-substituerade 4,5-difenylimidatsoler.
DK227789A (da) Svovlholdige eicosanoider og deres anvendelse i laegemidler og kosmetik
RU94046387A (ru) Производные пиримидина, способ их получения, фармацевтическая композиция, ее применение и промежуточные продукты
TW221429B (es)
KR910000652A (ko) (1,2,3,4-테트라하이드로-9-아크리딘이미노) 사이클로헥산 카복실산 및 관련 화합물, 이들의 제조방법 및 약제로서의 용도
FI951398A0 (fi) Reniiniä inhiboivat N-(2-amino-2-oksoetyyli)butaanidiamidijohdannaiset
ATE194388T1 (de) Stereoselektive herstellung von 2-substituierten succinatderivaten
KR930010037A (ko) 아미노산 유도체
AU8317882A (en) 4-aminomethyl-5-acyl-1,3 dihydro-2h-imidazol-2-ones
RU94045946A (ru) Фторированные производные 4-аминоандростадиенона, способ их получения, фармацевтическая композиция
ES8302692A1 (es) "procedimiento para la obtencion de n-(2-oxo-1-pirrolidinil)acetil piperazinas sustituidas".
FI944076A (fi) Menetelmä terapeuttisesti käytt¦kelpoisten N-(3-hydroksi-4-piperidinyyli)(dihydrobentsofuraani-, dihydro-2H-bentsopyraani- tai dihydrobentsodioksiini)karboksamidijohdannaisten valmistamiseksi ja välituote

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 765307

Country of ref document: ES