NO306979B1 - Fremgangsmåte for fremstilling av et farmasoeytisk preparat for behandling av kardial så vel som vaskulaer hypertrofi og hyperplasi - Google Patents
Fremgangsmåte for fremstilling av et farmasoeytisk preparat for behandling av kardial så vel som vaskulaer hypertrofi og hyperplasi Download PDFInfo
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- NO306979B1 NO306979B1 NO903532A NO903532A NO306979B1 NO 306979 B1 NO306979 B1 NO 306979B1 NO 903532 A NO903532 A NO 903532A NO 903532 A NO903532 A NO 903532A NO 306979 B1 NO306979 B1 NO 306979B1
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- alkyl
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- carboxylic acid
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- 239000002674 ointment Substances 0.000 description 1
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- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 description 1
- 229960002582 perindopril Drugs 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 125000004344 phenylpropyl group Chemical group 0.000 description 1
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 description 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- IAIDUHCBNLFXEF-MNEFBYGVSA-N zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 description 1
- 229960002769 zofenopril Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3926606A DE3926606A1 (de) | 1989-08-11 | 1989-08-11 | Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO903532D0 NO903532D0 (no) | 1990-08-10 |
| NO903532L NO903532L (no) | 1991-02-12 |
| NO306979B1 true NO306979B1 (no) | 2000-01-24 |
Family
ID=6386970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO903532A NO306979B1 (no) | 1989-08-11 | 1990-08-10 | Fremgangsmåte for fremstilling av et farmasoeytisk preparat for behandling av kardial så vel som vaskulaer hypertrofi og hyperplasi |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5231083A (da) |
| EP (1) | EP0417473B1 (da) |
| JP (1) | JP3452199B2 (da) |
| KR (1) | KR0185969B1 (da) |
| AT (1) | ATE94409T1 (da) |
| AU (1) | AU631914B2 (da) |
| CA (1) | CA2023089C (da) |
| CS (1) | CS277644B6 (da) |
| DD (1) | DD297063A5 (da) |
| DE (2) | DE3926606A1 (da) |
| DK (1) | DK0417473T3 (da) |
| ES (1) | ES2059931T3 (da) |
| FI (1) | FI903936A0 (da) |
| HU (1) | HU205008B (da) |
| IE (1) | IE64604B1 (da) |
| IL (1) | IL95327A (da) |
| NO (1) | NO306979B1 (da) |
| NZ (1) | NZ234836A (da) |
| PH (1) | PH30831A (da) |
| PL (1) | PL286442A1 (da) |
| PT (1) | PT94957B (da) |
| ZA (1) | ZA906327B (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE157871T1 (de) | 1994-05-19 | 1997-09-15 | Mitsubishi Chem Corp | Arzneimittel zur therapeutischen und prophylaktischen behandlung von krankheiten, die durch hyperplasie der glatten muskelzellen bedingt sind |
| SG68529A1 (en) * | 1995-05-25 | 1999-11-16 | Univ Singapore | The use of des-aspartate-angiotensin i (agr-val-tyr-ile-his-pro-phe-his-leu) as an anti-cardiac hypertrophic agent |
| SE9903028D0 (sv) * | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| WO2001015674A2 (en) * | 1999-08-30 | 2001-03-08 | Aventis Pharma Deutschland Gmbh | Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events |
| US6395767B2 (en) * | 2000-03-10 | 2002-05-28 | Bristol-Myers Squibb Company | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method |
| EP1817007A2 (en) * | 2004-11-05 | 2007-08-15 | King Pharmaceuticals Research and Development Inc. | Stabilized individually coated ramipril particles, compositions and methods |
| US8980924B2 (en) | 2010-11-24 | 2015-03-17 | The Trustees Of Columbia University In The City Of New York | Non-retinoid RBP4 antagonist for treatment of age-related macular degeneration and stargardt disease |
| US9333202B2 (en) | 2012-05-01 | 2016-05-10 | The Trustees Of Columbia University In The City Of New York | Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease |
| US10273243B2 (en) | 2013-03-14 | 2019-04-30 | The Trustees Of Columbia University In The City Of New York | 4-phenylpiperidines, their preparation and use |
| US9944644B2 (en) | 2013-03-14 | 2018-04-17 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles their preparation and use |
| ES2700541T3 (es) | 2013-03-14 | 2019-02-18 | Univ Columbia | Octahidrociclopentapirroles, su preparación y uso |
| US9938291B2 (en) | 2013-03-14 | 2018-04-10 | The Trustess Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
| WO2015168286A1 (en) | 2014-04-30 | 2015-11-05 | The Trustees Of Columbia University In The City Of New York | Substituted 4-phenylpiperidines, their preparaiton and use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| US4311705A (en) * | 1980-10-06 | 1982-01-19 | E. R. Squibb & Sons, Inc. | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines |
| US4337201A (en) * | 1980-12-04 | 1982-06-29 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted prolines |
| US4381297A (en) * | 1981-05-04 | 1983-04-26 | E. R. Squibb & Sons, Inc. | Substituted carbonyl phosphinyl-alkanoyl compounds |
| US4602002A (en) * | 1983-02-07 | 1986-07-22 | Merck & Co., Inc. | N-carboxymethyl substituted lysyl and α-(ε-aminoalkyl) glycyl amino acid antihypertensive agents |
| US4548941A (en) * | 1984-07-30 | 1985-10-22 | Merck & Co., Inc. | 1,5-Methano-1H-4-benzazonine dicarboxylates, process for preparing and use as calcium blockers |
| US4587253A (en) * | 1984-07-30 | 1986-05-06 | Merck & Co., Inc. | Bridged pyridine compounds useful as calcium channel blockers and analgesics |
| US4599341A (en) * | 1984-10-01 | 1986-07-08 | Merck & Co., Inc. | Substituted and bridged pyridines useful as calcium channel blockers |
| US4656188A (en) * | 1985-10-09 | 1987-04-07 | Merck & Co., Inc. | Ace inhibitors in macular degeneration |
| DE3705220A1 (de) * | 1987-02-19 | 1988-09-01 | Boehringer Ingelheim Kg | Mittel zur behandlung von coronarerkrankungen oder organischem hirnsyndrom |
| ZA896851B (en) * | 1988-09-14 | 1990-06-27 | Hoffmann La Roche | Use of ace-inhibitors |
-
1989
- 1989-08-11 DE DE3926606A patent/DE3926606A1/de not_active Withdrawn
-
1990
- 1990-08-08 DK DK90115230.6T patent/DK0417473T3/da active
- 1990-08-08 EP EP90115230A patent/EP0417473B1/de not_active Expired - Lifetime
- 1990-08-08 ES ES90115230T patent/ES2059931T3/es not_active Expired - Lifetime
- 1990-08-08 AT AT90115230T patent/ATE94409T1/de not_active IP Right Cessation
- 1990-08-08 DE DE90115230T patent/DE59002721D1/de not_active Expired - Lifetime
- 1990-08-09 DD DD90343366A patent/DD297063A5/de unknown
- 1990-08-09 PH PH41000A patent/PH30831A/en unknown
- 1990-08-09 PT PT94957A patent/PT94957B/pt not_active IP Right Cessation
- 1990-08-09 US US07/564,618 patent/US5231083A/en not_active Expired - Lifetime
- 1990-08-09 FI FI903936A patent/FI903936A0/fi not_active Application Discontinuation
- 1990-08-09 IL IL9532790A patent/IL95327A/en unknown
- 1990-08-09 NZ NZ234836A patent/NZ234836A/en unknown
- 1990-08-10 CS CS903958A patent/CS277644B6/cs not_active IP Right Cessation
- 1990-08-10 IE IE291090A patent/IE64604B1/en not_active IP Right Cessation
- 1990-08-10 ZA ZA906327A patent/ZA906327B/xx unknown
- 1990-08-10 CA CA002023089A patent/CA2023089C/en not_active Expired - Lifetime
- 1990-08-10 KR KR1019900012267A patent/KR0185969B1/ko not_active IP Right Cessation
- 1990-08-10 PL PL28644290A patent/PL286442A1/xx unknown
- 1990-08-10 NO NO903532A patent/NO306979B1/no not_active IP Right Cessation
- 1990-08-10 AU AU60920/90A patent/AU631914B2/en not_active Expired
- 1990-08-10 HU HU904966A patent/HU205008B/hu unknown
- 1990-08-10 JP JP21056490A patent/JP3452199B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PT94957A (pt) | 1991-05-22 |
| HUT54504A (en) | 1991-03-28 |
| IL95327A0 (en) | 1991-06-30 |
| NZ234836A (en) | 1997-05-26 |
| HU205008B (en) | 1992-03-30 |
| PL286442A1 (en) | 1992-03-09 |
| DD297063A5 (de) | 1992-01-02 |
| ES2059931T3 (es) | 1994-11-16 |
| HU904966D0 (en) | 1991-01-28 |
| NO903532L (no) | 1991-02-12 |
| PH30831A (en) | 1997-10-17 |
| CA2023089C (en) | 2003-01-14 |
| KR0185969B1 (ko) | 1999-05-01 |
| ATE94409T1 (de) | 1993-10-15 |
| AU6092090A (en) | 1991-02-14 |
| CS277644B6 (en) | 1993-03-17 |
| DE3926606A1 (de) | 1991-02-14 |
| CS395890A3 (en) | 1992-08-12 |
| DE59002721D1 (de) | 1993-10-21 |
| US5231083A (en) | 1993-07-27 |
| PT94957B (pt) | 1997-05-28 |
| EP0417473B1 (de) | 1993-09-15 |
| NO903532D0 (no) | 1990-08-10 |
| DK0417473T3 (da) | 1993-12-13 |
| IL95327A (en) | 1995-10-31 |
| KR910004189A (ko) | 1991-03-28 |
| ZA906327B (en) | 1991-05-29 |
| EP0417473A1 (de) | 1991-03-20 |
| IE64604B1 (en) | 1995-08-23 |
| CA2023089A1 (en) | 1991-02-12 |
| AU631914B2 (en) | 1992-12-10 |
| IE902910A1 (en) | 1991-02-27 |
| FI903936A0 (fi) | 1990-08-09 |
| JPH0383957A (ja) | 1991-04-09 |
| JP3452199B2 (ja) | 2003-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |