NO305656B1 - Nye dihydropyridinforbindelser, farmas°ytiske preparater inneholdende slike forbindelser samt anvendelse av forbindelsene - Google Patents

Nye dihydropyridinforbindelser, farmas°ytiske preparater inneholdende slike forbindelser samt anvendelse av forbindelsene

Info

Publication number
NO305656B1
NO305656B1 NO961776A NO961776A NO305656B1 NO 305656 B1 NO305656 B1 NO 305656B1 NO 961776 A NO961776 A NO 961776A NO 961776 A NO961776 A NO 961776A NO 305656 B1 NO305656 B1 NO 305656B1
Authority
NO
Norway
Prior art keywords
compounds
hydrogen
pct
chloro
pharmaceutical preparations
Prior art date
Application number
NO961776A
Other languages
English (en)
Norwegian (no)
Other versions
NO961776L (no
NO961776D0 (no
Inventor
Kjell Hjalmar Andersson
Margareta Nordlander
Rolf Christer Westerlund
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO961776L publication Critical patent/NO961776L/no
Publication of NO961776D0 publication Critical patent/NO961776D0/no
Publication of NO305656B1 publication Critical patent/NO305656B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
NO961776A 1993-11-05 1996-05-02 Nye dihydropyridinforbindelser, farmas°ytiske preparater inneholdende slike forbindelser samt anvendelse av forbindelsene NO305656B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9303657A SE9303657D0 (sv) 1993-11-05 1993-11-05 Short-acting dihydropyridines
PCT/SE1994/001031 WO1995012578A1 (fr) 1993-11-05 1994-11-03 Dihydropyridines a activite courte

Publications (3)

Publication Number Publication Date
NO961776L NO961776L (no) 1996-05-02
NO961776D0 NO961776D0 (no) 1996-05-02
NO305656B1 true NO305656B1 (no) 1999-07-05

Family

ID=20391655

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961776A NO305656B1 (no) 1993-11-05 1996-05-02 Nye dihydropyridinforbindelser, farmas°ytiske preparater inneholdende slike forbindelser samt anvendelse av forbindelsene

Country Status (36)

Country Link
US (1) US5856346A (fr)
EP (1) EP0726894B1 (fr)
JP (1) JP3712209B2 (fr)
KR (1) KR100331663B1 (fr)
CN (1) CN1049428C (fr)
AT (1) ATE194330T1 (fr)
AU (1) AU685532B2 (fr)
BR (1) BR9407946A (fr)
CA (1) CA2174969C (fr)
CZ (1) CZ285691B6 (fr)
DE (1) DE69425152T2 (fr)
DK (1) DK0726894T3 (fr)
EE (1) EE03230B1 (fr)
EG (1) EG20539A (fr)
ES (1) ES2150544T3 (fr)
FI (1) FI110429B (fr)
FR (1) FR12C0053I2 (fr)
GR (1) GR3034469T3 (fr)
HK (1) HK1013292A1 (fr)
HU (1) HU215591B (fr)
IL (1) IL111127A (fr)
IS (1) IS1674B (fr)
LU (1) LU92209I2 (fr)
MY (1) MY111770A (fr)
NO (1) NO305656B1 (fr)
NZ (1) NZ275915A (fr)
PL (1) PL185099B1 (fr)
PT (1) PT726894E (fr)
RU (1) RU2139278C1 (fr)
SA (1) SA94150250B1 (fr)
SE (1) SE9303657D0 (fr)
SK (1) SK281467B6 (fr)
TW (1) TW279859B (fr)
UA (1) UA45959C2 (fr)
WO (1) WO1995012578A1 (fr)
ZA (1) ZA947570B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9804002D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New manufacturing process
JP4580649B2 (ja) * 2001-12-21 2010-11-17 アルコン、インコーポレイテッド ナノ粒子を殺生物剤の担体として眼科用組成物に使用する方法
FR2922439B1 (fr) * 2007-10-18 2010-12-10 Hill Rom Ind Sa Procede de gonflage alterne d'un dispositif de support a cellules gonflables et dispositif pour sa mise en oeuvre
JP5674660B2 (ja) * 2008-08-01 2015-02-25 ザ メディシンズ カンパニー 医薬組成物および不純物の濃度が低い医薬組成物の製造方法
KR20120100945A (ko) * 2009-09-30 2012-09-12 마이크로도스 테라퓨특스, 인코포레이티드 레이노 증후군의 치료를 위한 방법들 및 조성물들
CN101780036B (zh) * 2010-03-30 2011-11-16 武汉武药科技有限公司 丁酸氯维地平脂微球注射液及其制备方法
CA2701087A1 (fr) * 2010-04-12 2011-10-12 Alphora Research Inc. Preparation de butyrate de clevidipine
US8455655B2 (en) 2010-05-07 2013-06-04 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
EP2386544B1 (fr) 2010-05-07 2016-02-10 Laboratorios Lesvi, S.L. Préparation of dihydropyridines
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
EA022849B1 (ru) 2010-10-12 2016-03-31 Дзе Медсинз Компани Эмульсионные композиции клевидипина, содержащие противомикробные агенты
RU2623039C2 (ru) * 2011-04-01 2017-06-21 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Дигидропиридины (клевидипин) кратковременного действия для применения в восстановлении после инсульта
EP2747757A1 (fr) 2011-08-26 2014-07-02 Wockhardt Limited Procédés de traitement de troubles cardiovasculaires
CN103420899B (zh) * 2012-05-25 2016-01-27 四川科伦药物研究有限公司 一种丁酸氯维地平的纯化方法
PL2925128T3 (pl) 2012-10-26 2018-10-31 Chiesi Farmaceutici S.P.A. Sposoby kontrolowania ciśnienia krwi i zmniejszania duszności w niewydolności serca
CN103073485B (zh) * 2013-01-17 2015-09-02 北京嘉林药业股份有限公司 一种丁酸氯维地平的制备方法
CN103086956B (zh) * 2013-01-17 2015-11-04 北京嘉林药业股份有限公司 一种丁酸氯维地平中间体的纯化方法
CA2947486C (fr) 2014-05-19 2023-09-26 The Medicines Company Nanoparticules de clevidipine et compositions pharmaceutiques les contenant
CN105367487A (zh) * 2014-08-23 2016-03-02 南京海纳医药科技有限公司 一种丁酸氯维地平重要中间体新的合成方法
CN104370802A (zh) * 2014-09-24 2015-02-25 北京蓝丹医药科技有限公司 氯维地平衍生物及其制备方法
RU2707298C2 (ru) 2015-05-20 2019-11-26 Мериал, Инк. Противогельминтные депсипептидные соединения
RU2715556C2 (ru) 2015-12-28 2020-03-02 Мериал, Инк. Противогельминтные депсипептидные соединения
JP2020504710A (ja) 2016-11-16 2020-02-13 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 駆虫性デプシペプチド化合物
RU2755349C1 (ru) * 2021-02-16 2021-09-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4154839A (en) * 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
KR940003492B1 (ko) * 1988-10-27 1994-04-23 주식회사 유한양행 1,4-디하이드로피리딘유도체 및 그의 제조방법
US5134139A (en) * 1989-08-31 1992-07-28 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and preparation thereof
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法

Also Published As

Publication number Publication date
JP3712209B2 (ja) 2005-11-02
WO1995012578A1 (fr) 1995-05-11
SA94150250B1 (ar) 2006-03-01
MY111770A (en) 2000-12-30
PL185099B1 (pl) 2003-02-28
RU2139278C1 (ru) 1999-10-10
SK55996A3 (en) 1996-12-04
SE9303657D0 (sv) 1993-11-05
PT726894E (pt) 2000-10-31
NZ275915A (en) 1997-04-24
ATE194330T1 (de) 2000-07-15
DE69425152T2 (de) 2001-03-22
IL111127A0 (en) 1994-12-29
CZ127396A3 (en) 1996-09-11
IS4218A (is) 1995-05-06
CN1049428C (zh) 2000-02-16
CA2174969A1 (fr) 1995-05-11
FI110429B (fi) 2003-01-31
CN1137269A (zh) 1996-12-04
GR3034469T3 (en) 2000-12-29
FR12C0053I1 (fr) 2012-02-11
HUT75316A (en) 1997-05-28
CA2174969C (fr) 2005-05-17
EP0726894B1 (fr) 2000-07-05
NO961776L (no) 1996-05-02
JPH09504542A (ja) 1997-05-06
SK281467B6 (sk) 2001-04-09
HK1013292A1 (en) 1999-08-20
ES2150544T3 (es) 2000-12-01
BR9407946A (pt) 1996-11-26
EP0726894A1 (fr) 1996-08-21
KR100331663B1 (ko) 2002-09-26
CZ285691B6 (cs) 1999-10-13
UA45959C2 (uk) 2002-05-15
FR12C0053I2 (fr) 2013-08-16
HU215591B (hu) 1999-01-28
LU92209I2 (fr) 2013-08-23
TW279859B (fr) 1996-07-01
IL111127A (en) 2000-11-21
NO961776D0 (no) 1996-05-02
EG20539A (en) 1999-07-31
ZA947570B (en) 1995-05-29
FI961914A0 (fi) 1996-05-06
HU9601187D0 (en) 1996-07-29
DE69425152D1 (de) 2000-08-10
US5856346A (en) 1999-01-05
DK0726894T3 (da) 2000-10-23
EE03230B1 (et) 1999-10-15
PL314128A1 (en) 1996-08-19
AU685532B2 (en) 1998-01-22
IS1674B (is) 1997-12-31
FI961914A (fi) 1996-05-06
AU8119694A (en) 1995-05-23

Similar Documents

Publication Publication Date Title
NO305656B1 (no) Nye dihydropyridinforbindelser, farmas°ytiske preparater inneholdende slike forbindelser samt anvendelse av forbindelsene
KR960700707A (ko) 맥관형성 억제제로서 유용한, 생물학적 활성의 3-치환된 옥신돌 유도체(Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents)
DK0533280T4 (da) Ny medicinsk anvendelse af tachykininantagonister
ATE88468T1 (de) Arylalkoxycumarine, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel.
ES8401460A1 (es) Un procedimiento para preparar derivados de benzamida.
NO923413D0 (no) Terapeutiske benzazepin-forbindelser
IL108970A0 (en) Substituted (arylalkylaminobenzyl) aminopropionamide derivatives, their preparation and pharmaceutical compositions containing them
ATE31410T1 (de) Aryloxypropanolaminderivate, verfahren zu deren herstellung, pharmazeutische praeparate und therapeutische anwendung.
ES8207519A1 (es) Procedimiento para la obtencion de derivados del imidazol.

Legal Events

Date Code Title Description
MK1K Patent expired