NO303731B1 - Imidazodiazepiner - Google Patents

Imidazodiazepiner

Info

Publication number
NO303731B1
NO303731B1 NO950999A NO950999A NO303731B1 NO 303731 B1 NO303731 B1 NO 303731B1 NO 950999 A NO950999 A NO 950999A NO 950999 A NO950999 A NO 950999A NO 303731 B1 NO303731 B1 NO 303731B1
Authority
NO
Norway
Prior art keywords
formula
lower alkyl
atom
imidazodiazepine
imidazodiazepines
Prior art date
Application number
NO950999A
Other languages
English (en)
Norwegian (no)
Other versions
NO950999L (no
NO950999D0 (no
Inventor
Thierry Godel
Walter Hunkeler
Heinz Stadler
Ulrich Widmer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO950999D0 publication Critical patent/NO950999D0/no
Publication of NO950999L publication Critical patent/NO950999L/no
Publication of NO303731B1 publication Critical patent/NO303731B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
NO950999A 1994-03-16 1995-03-15 Imidazodiazepiner NO303731B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH78394 1994-03-16
CH1095 1995-01-03

Publications (3)

Publication Number Publication Date
NO950999D0 NO950999D0 (no) 1995-03-15
NO950999L NO950999L (no) 1995-09-18
NO303731B1 true NO303731B1 (no) 1998-08-24

Family

ID=25683249

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950999A NO303731B1 (no) 1994-03-16 1995-03-15 Imidazodiazepiner

Country Status (27)

Country Link
US (1) US5665718A (cs)
EP (1) EP0672666B1 (cs)
JP (1) JP2690282B2 (cs)
KR (1) KR100214800B1 (cs)
CN (1) CN1036995C (cs)
AT (1) ATE203536T1 (cs)
AU (1) AU679608B2 (cs)
BG (1) BG62210B1 (cs)
CA (1) CA2143246C (cs)
CZ (1) CZ288594B6 (cs)
DE (1) DE59509432D1 (cs)
DK (1) DK0672666T3 (cs)
ES (1) ES2160646T3 (cs)
FI (1) FI112487B (cs)
GR (1) GR3037019T3 (cs)
HU (1) HU219987B (cs)
IL (1) IL112955A (cs)
IS (1) IS4273A (cs)
LV (1) LV11327B (cs)
MA (1) MA23479A1 (cs)
NO (1) NO303731B1 (cs)
NZ (1) NZ270685A (cs)
PH (1) PH31443A (cs)
PT (1) PT672666E (cs)
RO (1) RO117698B1 (cs)
RU (1) RU2139873C1 (cs)
SK (1) SK33995A3 (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5905176A (en) * 1998-08-28 1999-05-18 Eastman Chemical Company Process for the production of cyclobutyl halides
MXPA01011449A (es) 1999-05-12 2002-06-04 Hoffmann La Roche Derivados de imidazodiazepina.
US7160880B1 (en) * 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
RU2199309C1 (ru) * 2001-12-29 2003-02-27 Закрытое акционерное общество "Брынцалов-А" Лекарственное средство нобрассит седативного и анксиолитического действия
US20060065608A1 (en) * 2004-09-29 2006-03-30 Choate Chris E Process and apparatus for generating useful biomass from organic waste streams
WO2006078576A2 (en) * 2005-01-19 2006-07-27 Merck & Co., Inc. Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease
JP2008526999A (ja) * 2005-01-19 2008-07-24 メルク エンド カムパニー インコーポレーテッド アルツハイマー病治療用ベータ−セクレターゼインヒビターとして活性な置換へテロ環含有三級カルビナミン
US7595395B2 (en) * 2005-05-16 2009-09-29 Wisys Technology Foundation Gabaergic agents to treat memory deficits
GB0613693D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
CN104059072B (zh) 2006-07-10 2016-06-22 Paion英国有限公司 短效苯并二氮杂*盐及其多晶型
WO2009024324A2 (en) * 2007-08-20 2009-02-26 Evotec Neurosciences Gmbh Treatment of sleep disorders
WO2009024325A2 (en) 2007-08-20 2009-02-26 Evotec Neurosciences Gmbh Treatment of sleep disorders
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
RU2503681C2 (ru) * 2008-09-30 2014-01-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Новое конденсированное производное аминодигидротиазина
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
CN108578413A (zh) 2012-05-22 2018-09-28 Paion英国有限公司 包含短效苯二氮杂*类化合物的组合物
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
RS57508B1 (sr) 2013-09-06 2018-10-31 Aurigene Discovery Tech Ltd 1,2,4-derivati oksadiazola kao imunomodulatori
HK1243348A1 (zh) * 2015-03-10 2018-07-13 Aurigene Discovery Technologies Limited 作为免疫调节剂的3-取代的-1，2，4-恶二唑和噻二唑化合物
US10781189B2 (en) * 2015-03-10 2020-09-22 Aurigene Discovery Technologies Limited 1,2,4-Oxadiazole and thiadiazole compounds as immunomodulators
CN109641000A (zh) 2016-04-14 2019-04-16 Paion英国有限公司 经口吸入和经鼻用的苯并二氮杂*类
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
EA202090536A1 (ru) 2017-10-11 2020-07-22 Ориджен Дискавери Текнолоджис Лимитед Кристаллические формы 3-замещенного 1,2,4-оксадиазола
BR112020008537A2 (pt) 2017-11-03 2020-10-06 Aurigene Discovery Technologies Limited inibidores duplos de vias da tim-3 e da pd-1
EP3706798A1 (en) 2017-11-06 2020-09-16 Aurigene Discovery Technologies Limited Conjoint therapies for immunomodulation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA755418B (en) * 1974-09-11 1977-06-29 Hoffmann La Roche Diazepine derivatives
SE422580B (sv) * 1975-08-07 1982-03-15 Hoffmann La Roche Analogiforfarande for framstellning av imidazo (1,5-a)(1,4)diazepin-foreningar
IL49161A (en) * 1975-08-07 1982-04-30 Sparamedica Ag Imidazo(1,5-a)(1,4)-diazepine derivatives,their manufacture and pharmaceutical compositions containing them
FI63033C (fi) * 1977-07-21 1983-04-11 Boehringer Sohn Ingelheim Foerfarande foer framstaellning av anxiolytiska tranquilliserande sedativa och/eller neuroleptiska substituerade 1-piperazinyl-4h-s-triazolo(3,4-c)tieno(2,3-e)-1,4-diazepiner
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
IL74070A (en) * 1984-01-19 1988-12-30 Hoffmann La Roche Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
US4904654A (en) * 1989-07-26 1990-02-27 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine
US4939139A (en) * 1989-07-26 1990-07-03 Merck & Co., Inc. 7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine

Also Published As

Publication number Publication date
BG62210B1 (bg) 1999-05-31
NO950999L (no) 1995-09-18
KR100214800B1 (ko) 1999-08-02
ES2160646T3 (es) 2001-11-16
SK33995A3 (en) 1995-10-11
PH31443A (en) 1998-11-03
GR3037019T3 (en) 2002-01-31
FI951251A0 (fi) 1995-03-16
EP0672666A3 (de) 1995-11-08
NZ270685A (en) 1996-05-28
HU9500743D0 (en) 1995-04-28
CN1111632A (zh) 1995-11-15
IL112955A0 (en) 1995-06-29
EP0672666A2 (de) 1995-09-20
AU1476095A (en) 1995-09-28
DK0672666T3 (da) 2001-11-12
MA23479A1 (fr) 1995-10-01
IS4273A (is) 1995-09-17
FI112487B (fi) 2003-12-15
RU95103921A (ru) 1996-12-10
RO117698B1 (ro) 2002-06-28
US5665718A (en) 1997-09-09
CN1036995C (zh) 1998-01-14
LV11327A (lv) 1996-06-20
KR950032199A (ko) 1995-12-20
LV11327B (en) 1996-10-20
JPH07258260A (ja) 1995-10-09
AU679608B2 (en) 1997-07-03
EP0672666B1 (de) 2001-07-25
CA2143246A1 (en) 1995-09-17
CZ288594B6 (cs) 2001-07-11
HUT71817A (en) 1996-02-28
HU219987B (hu) 2001-10-28
NO950999D0 (no) 1995-03-15
JP2690282B2 (ja) 1997-12-10
CA2143246C (en) 2000-08-22
BG99505A (en) 1996-01-31
DE59509432D1 (de) 2001-08-30
ATE203536T1 (de) 2001-08-15
CZ66395A3 (en) 1995-10-18
IL112955A (en) 1998-02-08
RU2139873C1 (ru) 1999-10-20
FI951251A7 (fi) 1995-09-17
PT672666E (pt) 2002-01-30

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Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN SEPTEMBER 2002