NO20083395L - Fremgangsmåte for fremstilling av en A2A-adenosinreseptoragonist og dens polymorfer - Google Patents

Fremgangsmåte for fremstilling av en A2A-adenosinreseptoragonist og dens polymorfer

Info

Publication number
NO20083395L
NO20083395L NO20083395A NO20083395A NO20083395L NO 20083395 L NO20083395 L NO 20083395L NO 20083395 A NO20083395 A NO 20083395A NO 20083395 A NO20083395 A NO 20083395A NO 20083395 L NO20083395 L NO 20083395L
Authority
NO
Norway
Prior art keywords
polymorphs
receptor agonist
adenosine receptor
preparation
isolating
Prior art date
Application number
NO20083395A
Other languages
English (en)
Other versions
NO341322B1 (no
Inventor
Jeff Zablocki
Elfatih Elzein
Robert Seemayer
Travis Lemons
Original Assignee
Cv Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38120353&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083395(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cv Therapeutics Inc filed Critical Cv Therapeutics Inc
Publication of NO20083395L publication Critical patent/NO20083395L/no
Publication of NO341322B1 publication Critical patent/NO341322B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Abstract

Det beskrives en syntese egnet for fremstilling i stor målestokk av en A2A-adenosinreseptor-agonist, samt polymorfer av denne forbindelse og fremgangsmåter for isolering av en spesifikk polymorf.
NO20083395A 2006-02-03 2008-08-01 Fremgangsmåte for storskala fremstilling av en A2A-adenosinreseptoragonist og dens polymorfer NO341322B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76511406P 2006-02-03 2006-02-03
US80185706P 2006-05-18 2006-05-18
PCT/US2007/003022 WO2007092372A1 (en) 2006-02-03 2007-02-02 Process for preparing an a2a-adenosine receptor agonist and its polymorphs

Publications (2)

Publication Number Publication Date
NO20083395L true NO20083395L (no) 2008-08-01
NO341322B1 NO341322B1 (no) 2017-10-09

Family

ID=38120353

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083395A NO341322B1 (no) 2006-02-03 2008-08-01 Fremgangsmåte for storskala fremstilling av en A2A-adenosinreseptoragonist og dens polymorfer

Country Status (18)

Country Link
US (8) US7732595B2 (no)
EP (2) EP2581381A3 (no)
JP (3) JP5326156B2 (no)
KR (2) KR20080090491A (no)
CN (1) CN102260311A (no)
AU (1) AU2007212542B2 (no)
CA (1) CA2640089C (no)
ES (1) ES2593028T3 (no)
HK (1) HK1127358A1 (no)
IL (2) IL193153A (no)
MX (1) MX2010014060A (no)
NO (1) NO341322B1 (no)
NZ (1) NZ570239A (no)
PL (1) PL1989214T3 (no)
PT (1) PT1989214T (no)
RU (1) RU2447081C2 (no)
SI (1) SI1989214T1 (no)
WO (1) WO2007092372A1 (no)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403567B1 (en) * 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
CA2671940A1 (en) 2000-02-23 2001-08-30 Cv Therapeutics, Inc. Identification of partial agonists of the a2a adenosine receptor
US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
CA2492855C (en) * 2002-07-29 2012-09-18 Cv Therapeutics, Inc. Myocardial perfusion imaging using a2a receptor agonists
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
KR20070083714A (ko) * 2004-10-20 2007-08-24 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ2ａ 아데노신 수용체 작용제의 용도
NZ570239A (en) * 2006-02-03 2011-09-30 Gilead Palo Alto Inc Preparation of (1-{ 9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl} pyrazol-4-yl)-N-methylcarboxamide monohydrate
EP2068850A1 (en) * 2006-06-22 2009-06-17 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists in the treatment of ischemia
JP2010502649A (ja) * 2006-09-01 2010-01-28 シーブイ・セラピューティクス・インコーポレイテッド 心筋層画像化法中の患者の耐性を増加させるための方法および組成物
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
CA2663361A1 (en) * 2006-09-29 2008-04-10 Cv Therapeutics, Inc. Methods for myocardial imaging in patients having a history of pulmonary disease
CA2673653A1 (en) * 2007-01-03 2008-07-17 Cv Therapeutics, Inc. Myocardial perfusion imaging
NZ580940A (en) * 2007-05-17 2012-02-24 Gilead Palo Alto Inc Process for preparing an a2a-adenosine receptor agonist and its polymorphs
US20100324279A1 (en) * 2007-12-20 2010-12-23 Andres Patricia M J Crystal forms of 2-[2-(4-chlorophenyl)ethoxy]adenosine
CA2716501A1 (en) * 2008-02-29 2009-09-03 King Pharmaceuticals Research And Development, Inc. Crystal forms of 2-{2-[(cyclohexyl)methylene]hydrazino}adenosine
WO2009149392A1 (en) * 2008-06-06 2009-12-10 Hollis-Eden Pharmaceuticals, Inc. Methods for preparing 17-alkynyl-7-hydroxy steroids and related compounds
AU2009296235A1 (en) * 2008-09-29 2010-04-01 Gilead Sciences, Inc. Combinations of a rate control agent and an A-2-alpha receptor antagonist for use in multidetector computed tomography methods
US8859522B2 (en) 2011-04-27 2014-10-14 Reliable Biopharmaceutical Corporation Processes for the preparation of regadenoson and a new crystalline form thereof
CZ308577B6 (cs) * 2011-08-18 2020-12-16 Farmak, A. S. Způsob přípravy 2-(4-methoxykarbonylpyrazol-1-yl)adenosinu a 2-(4-ethoxykarbonylpyrazol-1-yl)adenosinu
CZ304053B6 (cs) 2011-08-22 2013-09-04 Farmak, A. S. Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
US9381245B2 (en) 2012-10-19 2016-07-05 New York University Methods for inhibiting osteolysis
EP3760637A3 (en) 2013-04-11 2021-04-07 AMRI Italy S.r.l. Stable solid forms of regadenoson
CZ305213B6 (cs) 2013-04-29 2015-06-10 Farmak, A. S. Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
WO2014207758A2 (en) 2013-05-30 2014-12-31 Biophore India Pharmaceuticals Pvt. Ltd. Novel polymorph of regadenoson
EP3080139A4 (en) * 2013-12-10 2017-09-06 Scinopharm Taiwan Ltd. A process for the preparation of regadenoson
CN105085593A (zh) * 2014-04-21 2015-11-25 上海紫源制药有限公司 瑞加德松的晶型及其制备方法
CN105175468B (zh) * 2014-06-17 2018-06-19 上海紫源制药有限公司 一种瑞加德松晶型b的制备方法
CN105198950B (zh) * 2014-06-17 2018-10-02 上海紫源制药有限公司 一种瑞加德松晶型e的制备方法
WO2016126734A1 (en) 2015-02-06 2016-08-11 Apicore Us Llc Process of making regadenoson and novel polymorph thereof
US9809617B2 (en) 2015-07-03 2017-11-07 Shanghai Ziyuan Pharmaceutical Co., Ltd. Crystal form of regadenoson and preparation method thereof
CN106397442B (zh) * 2015-07-28 2020-03-27 国药集团国瑞药业有限公司 一种瑞加德松的纯化方法
US10392417B2 (en) 2016-11-04 2019-08-27 Apicore Us Llc Polymorph of regadenoson and process for preparation thereof
CN106749254B (zh) * 2017-01-10 2018-05-25 青岛科技大学 一种6-氨基嘌呤乙基萘乙酸酯类化合物及其作为植物生长调节剂的用途
WO2019191389A1 (en) 2018-03-29 2019-10-03 Johnson Matthey Public Limited Company Solid-state forms of regadenoson, their use and preparation
US10815265B2 (en) 2018-06-29 2020-10-27 Usv Private Limited Process for preparation of regadenoson and polymorphs thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078779A2 (en) * 1999-06-22 2000-12-28 Cv Therapeutics, Inc. N-pyrazole a2a receptor agonists

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4826038Y1 (no) 1970-12-25 1973-07-30
DK135130B (da) 1970-12-28 1977-03-07 Takeda Chemical Industries Ltd Analogifremgangsmåde til fremstilling af 2-substituerede adenosinderivater eller syreadditionssalte deraf.
BE787064A (fr) 1971-08-03 1973-02-01 Philips Nv Dispositif magnetique comportant des domaines
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4120947A (en) 1976-03-31 1978-10-17 Cooper Laboratories, Inc. Xanthine compounds and method of treating bronchospastic and allergic diseases
US4089959A (en) 1976-03-31 1978-05-16 Cooper Laboratories, Inc. Long-acting xanthine bronchodilators and antiallergy agents
SE7810946L (sv) 1978-10-20 1980-04-21 Draco Ab Metod att behandla kronisk obstruktiv luftvegssjukdom
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US4593095A (en) 1983-02-18 1986-06-03 The Johns Hopkins University Xanthine derivatives
US5364620A (en) 1983-12-22 1994-11-15 Elan Corporation, Plc Controlled absorption diltiazem formulation for once daily administration
US4696932A (en) 1984-10-26 1987-09-29 The United States Of America As Represented By The Department Of Health And Human Services Biologically-active xanthine derivatives
JPS6299395A (ja) 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
US4968697A (en) 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US4990498A (en) 1988-04-26 1991-02-05 Temple University-Of The Commonwealth System Of Higher Education 2- and 8-azido(2'-5')oligoadenylates and antiviral uses thereof
US4902514A (en) 1988-07-21 1990-02-20 Alza Corporation Dosage form for administering nilvadipine for treating cardiovascular symptoms
US5070877A (en) 1988-08-11 1991-12-10 Medco Research, Inc. Novel method of myocardial imaging
DE3831430A1 (de) 1988-09-15 1990-03-22 Bayer Ag Substituierte 4-heterocyclyloximino-pyrazolin-5-one, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
KR0137786B1 (ko) 1988-11-15 1998-05-15 하마구찌 미찌오 심장 또는 뇌의 허혈성 질환의 치료, 예방제
IT1229195B (it) 1989-03-10 1991-07-25 Poli Ind Chimica Spa Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche.
CA2035038C (en) 1989-06-20 1998-12-29 Toyofumi Yamaguchi Synthetic intermediates of 2-alkynyladenosines, processes for preparing the synthetic intermediates, processes for preparing 2-alkynyladenosines utilizing the synthetic intermediates, and stable 2-alkynyladenosine derivatives
US5032252A (en) 1990-04-27 1991-07-16 Mobil Oil Corporation Process and apparatus for hot catalyst stripping in a bubbling bed catalyst regenerator
DE4019892A1 (de) 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
US5189027A (en) 1990-11-30 1993-02-23 Yamasa Shoyu Kabushiki Kaisha 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases
FR2671356B1 (fr) 1991-01-09 1993-04-30 Inst Nat Sante Rech Med Procede de description des repertoires d'anticorps (ab) et des recepteurs des cellules t (tcr) du systeme immunitaire d'un individu.
JP2740362B2 (ja) 1991-02-12 1998-04-15 ヤマサ醤油株式会社 安定な固体状２‐オクチニルアデノシンおよびその製造法
JP3053908B2 (ja) 1991-06-28 2000-06-19 ヤマサ醤油株式会社 ２‐アルキニルアデノシン誘導体
US5516894A (en) 1992-03-11 1996-05-14 The General Hospital Corporation A2b -adenosine receptors
IT1254915B (it) 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
GB9210839D0 (en) 1992-05-21 1992-07-08 Smithkline Beecham Plc Novel compounds
WO1993025677A1 (en) 1992-06-12 1993-12-23 Garvan Institute Of Medical Research DNA SEQUENCES ENCODING THE HUMAN A1, A2a and A2b ADENOSINE RECEPTORS
US5705491A (en) 1992-10-27 1998-01-06 Nippon Zoki Pharmaceutical Co., Ltd. Adenosine deaminase inhibitor
CA2112031A1 (en) 1992-12-24 1994-06-25 Fumio Suzuki Xanthine derivatives
US5477857A (en) 1993-09-10 1995-12-26 Discovery Therapeutics, Inc. Diagnostic uses of hydrazinoadenosines
WO1995011681A1 (en) 1993-10-29 1995-05-04 Merck & Co., Inc. Human adenosine receptor antagonists
DE69526822T2 (de) 1994-02-23 2003-01-23 Kyowa Hakko Kogyo Kk Xanthin-derivate
US5704491A (en) 1995-07-21 1998-01-06 Cummins-Allison Corp. Method and apparatus for discriminating and counting documents
US5646156A (en) 1994-04-25 1997-07-08 Merck & Co., Inc. Inhibition of eosinophil activation through A3 adenosine receptor antagonism
US6514949B1 (en) 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US5877180A (en) 1994-07-11 1999-03-02 University Of Virginia Patent Foundation Method for treating inflammatory diseases with A2a adenosine receptor agonists
US6448235B1 (en) 1994-07-11 2002-09-10 University Of Virginia Patent Foundation Method for treating restenosis with A2A adenosine receptor agonists
US5854081A (en) 1996-06-20 1998-12-29 The University Of Patent Foundation Stable expression of human A2B adenosine receptors, and assays employing the same
US5780481A (en) 1996-08-08 1998-07-14 Merck & Co., Inc. Method for inhibiting activation of the human A3 adenosine receptor to treat asthma
US5776960A (en) 1996-10-16 1998-07-07 Buckman Laboratories International, Inc. Synergistic antimicrobial compositions containing an ionene polymer and a pyrithione salt and methods of using the same
US5770716A (en) 1997-04-10 1998-06-23 The Perkin-Elmer Corporation Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same
AU7449598A (en) 1997-05-23 1998-12-11 Nippon Shinyaku Co. Ltd. Medicinal composition for prevention or treatment of hepatopathy
AU740770B2 (en) 1997-06-18 2001-11-15 Aderis Pharmaceuticals, Inc. Compositions and methods for preventing restenosis following revascularization procedures
US6026317A (en) 1998-02-06 2000-02-15 Baylor College Of Medicine Myocardial perfusion imaging during coronary vasodilation with selective adenosine A2 receptor agonists
US6117878A (en) 1998-02-24 2000-09-12 University Of Virginia 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors
AU4675699A (en) 1998-06-08 1999-12-30 Epigenesis Pharmaceuticals, Inc. Composition and method for prevention and treatment of cardiopulmonary and renal failure or damage associated with ischemia, endotoxin release, ards or brought about by administration of certain drugs
GB9913932D0 (en) * 1999-06-15 1999-08-18 Pfizer Ltd Purine derivatives
US6322771B1 (en) 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
US6214807B1 (en) 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
KR100502757B1 (ko) 1999-08-31 2005-07-22 반더빌트유니버시티 Ａ２ｂ 아데노신 수용체의 선택적인 길항제
US6368573B1 (en) 1999-11-15 2002-04-09 King Pharmaceuticals Research And Development, Inc. Diagnostic uses of 2-substituted adenosine carboxamides
US6294522B1 (en) 1999-12-03 2001-09-25 Cv Therapeutics, Inc. N6 heterocyclic 8-modified adenosine derivatives
US6605597B1 (en) 1999-12-03 2003-08-12 Cv Therapeutics, Inc. Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives
US6552023B2 (en) 2000-02-22 2003-04-22 Cv Therapeutics, Inc. Aralkyl substituted piperazine compounds
US6677336B2 (en) 2000-02-22 2004-01-13 Cv Therapeutics, Inc. Substituted piperazine compounds
CA2671940A1 (en) 2000-02-23 2001-08-30 Cv Therapeutics, Inc. Identification of partial agonists of the a2a adenosine receptor
US6387913B1 (en) 2000-12-07 2002-05-14 S. Jamal Mustafa Method of treating airway diseases with combined administration of A2B and A3 adenosine receptor antagonists
US6670334B2 (en) 2001-01-05 2003-12-30 University Of Virginia Patent Foundation Method and compositions for treating the inflammatory response
US6758388B1 (en) 2001-02-27 2004-07-06 Rohr, Inc. Titanium aluminide honeycomb panel structures and fabrication method for the same
US6995148B2 (en) 2001-04-05 2006-02-07 University Of Pittsburgh Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy
US6599283B1 (en) 2001-05-04 2003-07-29 Cv Therapeutics, Inc. Method of preventing reperfusion injury
ES2340664T3 (es) 2001-05-14 2010-06-08 Novartis Ag Derivados de sulfonamidas.
PT1444233E (pt) 2001-11-09 2011-09-29 Gilead Palo Alto Inc Antagonistas de receptor de adenosina a2b
US6977300B2 (en) 2001-11-09 2005-12-20 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
US7125993B2 (en) 2001-11-09 2006-10-24 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
WO2003053366A2 (en) 2001-12-20 2003-07-03 Osi Pharmaceuticals, Inc. Pyrimidine a2b selective antagonist compounds, their synthesis and use
WO2003086451A1 (en) 2002-04-05 2003-10-23 Centocor, Inc. Asthma-related anti-il-13 immunoglobulin derived proteins, compositions, methods and uses
WO2003088978A1 (en) 2002-04-18 2003-10-30 Cv Therapeutics, Inc. Method of treating arrhythmias comprising administration of an a1 adenosine agonist with a beta blocker, calcium channel blocker or a cardiac glycoside
CA2492855C (en) 2002-07-29 2012-09-18 Cv Therapeutics, Inc. Myocardial perfusion imaging using a2a receptor agonists
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
US20050020915A1 (en) 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
SI2366396T1 (sl) 2004-01-27 2013-10-30 Gilead Sciences, Inc. Slikanje miokardne perfuzije ob uporabi adenozinskih receptorskih agonistov
RU2391103C2 (ru) 2004-10-15 2010-06-10 Си Ви Терапьютикс, Инк. Способ предупреждения и лечения ремоделирования дыхательных путей и воспаления легких с применением антагонистов аденозиновых рецепторов a2b
KR20070083714A (ko) 2004-10-20 2007-08-24 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ2ａ 아데노신 수용체 작용제의 용도
US20060159621A1 (en) 2005-01-12 2006-07-20 Barrett Richard J Method of detecting myocardial dysfunction in patients having a history of asthma or bronchospasm
US20070114269A1 (en) 2005-11-22 2007-05-24 Straza George C Formed metal core sandwich structure and method and system for making same
NZ570239A (en) 2006-02-03 2011-09-30 Gilead Palo Alto Inc Preparation of (1-{ 9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl} pyrazol-4-yl)-N-methylcarboxamide monohydrate
EP2068850A1 (en) 2006-06-22 2009-06-17 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists in the treatment of ischemia
JP2010502649A (ja) 2006-09-01 2010-01-28 シーブイ・セラピューティクス・インコーポレイテッド 心筋層画像化法中の患者の耐性を増加させるための方法および組成物
US20090081120A1 (en) 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
CA2663361A1 (en) 2006-09-29 2008-04-10 Cv Therapeutics, Inc. Methods for myocardial imaging in patients having a history of pulmonary disease
CA2673653A1 (en) 2007-01-03 2008-07-17 Cv Therapeutics, Inc. Myocardial perfusion imaging
NZ580940A (en) 2007-05-17 2012-02-24 Gilead Palo Alto Inc Process for preparing an a2a-adenosine receptor agonist and its polymorphs
WO2009076580A2 (en) 2007-12-12 2009-06-18 Thomas Jefferson University Compositions and methods for the treatment and prevention of cardiovascular diseases
AU2009296235A1 (en) 2008-09-29 2010-04-01 Gilead Sciences, Inc. Combinations of a rate control agent and an A-2-alpha receptor antagonist for use in multidetector computed tomography methods
WO2014068589A2 (en) * 2012-10-29 2014-05-08 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of (1-{9-[(4s, 2r, 3r, 5r)-3, 4-dihydroxy-5-(hydroxymethyl) oxolan-2-yl)-6-aminopurin-2-yl} pyrazole-4-yl)-n-methylcarboxamide
CZ305213B6 (cs) * 2013-04-29 2015-06-10 Farmak, A. S. Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
WO2014207758A2 (en) * 2013-05-30 2014-12-31 Biophore India Pharmaceuticals Pvt. Ltd. Novel polymorph of regadenoson
EP3080139A4 (en) * 2013-12-10 2017-09-06 Scinopharm Taiwan Ltd. A process for the preparation of regadenoson

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078779A2 (en) * 1999-06-22 2000-12-28 Cv Therapeutics, Inc. N-pyrazole a2a receptor agonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NIIYA K ET AL "2-(N'-ALKYLIDENEHYDRAZINO)ADENOSINES: POTENT AND SELECTIVE CORONARY VASODILATORS", J. of Medicinal Chemistry, American Chemical Society, 1992, vol. 35, nr. 24, side 4557-4561, xp000918397, ISSN: 0022-2623, Dated: 01.01.0001 *

Also Published As

Publication number Publication date
EP2581381A2 (en) 2013-04-17
JP2009525347A (ja) 2009-07-09
JP2013014620A (ja) 2013-01-24
AU2007212542A1 (en) 2007-08-16
IL252700A0 (en) 2017-08-31
IL193153A0 (en) 2009-02-11
KR20130130868A (ko) 2013-12-02
US20070265445A1 (en) 2007-11-15
CA2640089C (en) 2013-07-23
US7732595B2 (en) 2010-06-08
EP1989214A1 (en) 2008-11-12
CN102260311A (zh) 2011-11-30
USRE47301E1 (en) 2019-03-19
US20140213539A1 (en) 2014-07-31
NZ570239A (en) 2011-09-30
US20100179313A1 (en) 2010-07-15
JP5326156B2 (ja) 2013-10-30
SI1989214T1 (sl) 2016-10-28
WO2007092372A1 (en) 2007-08-16
KR101494125B1 (ko) 2015-02-16
RU2008131956A (ru) 2010-02-10
US20070225247A1 (en) 2007-09-27
JP2013010791A (ja) 2013-01-17
ES2593028T3 (es) 2016-12-05
PT1989214T (pt) 2016-09-22
US8268988B2 (en) 2012-09-18
RU2447081C2 (ru) 2012-04-10
US7671192B2 (en) 2010-03-02
KR20080090491A (ko) 2008-10-08
EP1989214B1 (en) 2016-06-22
IL193153A (en) 2017-06-29
PL1989214T3 (pl) 2017-07-31
US20120165350A1 (en) 2012-06-28
AU2007212542B2 (en) 2013-01-31
US20100267953A1 (en) 2010-10-21
EP1989214B8 (en) 2016-12-21
US20110257387A1 (en) 2011-10-20
HK1127358A1 (zh) 2009-09-25
EP2581381A3 (en) 2013-10-30
MX2010014060A (es) 2011-01-18
US8106183B2 (en) 2012-01-31
US7956179B2 (en) 2011-06-07
CA2640089A1 (en) 2007-08-16
US9085601B2 (en) 2015-07-21
NO341322B1 (no) 2017-10-09
US8524883B2 (en) 2013-09-03

Similar Documents

Publication Publication Date Title
NO20083395L (no) Fremgangsmåte for fremstilling av en A2A-adenosinreseptoragonist og dens polymorfer
NO20093543L (no) Fremgangsmate for fremstilling av en A2A-adenosinreseptoragonist og dens polymorfer
CL2008001896A1 (es) 3-dihalometil-1-metil-1h-pirazol-4-carbaldehidos; su proceso de preparacion usando un intermediario de hidrazona, que reacciona con un agente de vilsmeier; y el derivado de hidrazona usado.
DK2084287T3 (da) Fremgangsmåde til biologisk fremstilling af n-butanol med højt udbytte
NO20065321L (no) Fremgangsmate for fremstilling av clopidogrelhydrogensulfat polymorf for I
MX2009005463A (es) Proceso para sintetizar analogos cuaternarios de 4,5-epoxi-morfinano y aislar sus n-estereoisomeros.
NO20092692L (no) MAPK/ERK kinaseinhibitorer
NO20082121L (no) Imidazopyridinderivater som A2B-adenosinreseptorantagonister
PT2292607E (pt) Processo para a síntese de compostos orgânicos
EA201170618A1 (ru) Способ получения защищенных производных l-аланина
WO2006091896A3 (en) Pyridyl substituted xanthines
AU2015221439B2 (en) Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same
CY1113184T1 (el) Μεθοδος για την παρασκευη θεραπευτικως πολυτιμων παραγωγων τριφαινυλβουτενιου
BRPI0811500A2 (pt) Detecção de isômeros usando espectrometria de massa de derivatização diferencial.
NO20080468L (no) Diazepinokinoliner, synteser av disse samt intermediater
WO2011092504A3 (en) Biomarkers for schizophrenia
EA200801404A1 (ru) Новый способ получения 5-амино-3н-тиазоло[4,5-d]пиримидин-2-она
WO2007054784A8 (en) An improved process for the preparation of granisetron hydrochloride
ZA200709621B (en) Process for the synthesis of organic compounds
EP3977119A4 (en) HIGH PRECISION NANOPORES-BASED SINGLE MOLECULE SEQUENCING BY SYNTHESIS WITH LABELED NUCLEOTIDES
WO2010002662A8 (en) Enabling analysis of a survey source signal using a time-based visualization of the survey source signal
WO2009114313A3 (en) Methods for synthesizing antiviral compounds
EA200970406A1 (ru) СПОСОБ ПОЛУЧЕНИЯ 5-АЛКИЛ-7Н-ПИРРОЛО[2,3-d]ПИРИМИДИН-2-ОЛОВ
WO2011106373A3 (en) Arnt isoform 3 as a predictor of aminoflavone responsiveness in cancer cells
WO2010010412A3 (en) Method for the preparation of n-methyl-aryloxy-propanamine derivatives

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: CV THERAPEUTICS INC, US

CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: GILEAD SCIENCES, US