WO2007054784A8 - An improved process for the preparation of granisetron hydrochloride - Google Patents

An improved process for the preparation of granisetron hydrochloride

Info

Publication number
WO2007054784A8
WO2007054784A8 PCT/IB2006/003146 IB2006003146W WO2007054784A8 WO 2007054784 A8 WO2007054784 A8 WO 2007054784A8 IB 2006003146 W IB2006003146 W IB 2006003146W WO 2007054784 A8 WO2007054784 A8 WO 2007054784A8
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
granisetron hydrochloride
relates
granisetron
Prior art date
Application number
PCT/IB2006/003146
Other languages
French (fr)
Other versions
WO2007054784A1 (en
Inventor
Hitesh Chandraprakash Sharma
Siripragada Mahender Rao
Shanmuga Sundaram Bharan Kumar
Original Assignee
Orchid Chemicals & Pharm Ltd
Hitesh Chandraprakash Sharma
Siripragada Mahender Rao
Shanmuga Sundaram Bharan Kumar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharm Ltd, Hitesh Chandraprakash Sharma, Siripragada Mahender Rao, Shanmuga Sundaram Bharan Kumar filed Critical Orchid Chemicals & Pharm Ltd
Publication of WO2007054784A1 publication Critical patent/WO2007054784A1/en
Publication of WO2007054784A8 publication Critical patent/WO2007054784A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of Granisetron hydrochloride of formula (I). More particularly this invention relates to the preparation of Granisetron hydrochloride using methyl isobutyl ketone (MIBK) as a single solvent in presence of an organic base such as triethylamine.
PCT/IB2006/003146 2005-11-10 2006-11-08 An improved process for the preparation of granisetron hydrochloride WO2007054784A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1643CH2005 2005-11-10
IN1643/CHE/2005 2005-11-10

Publications (2)

Publication Number Publication Date
WO2007054784A1 WO2007054784A1 (en) 2007-05-18
WO2007054784A8 true WO2007054784A8 (en) 2007-08-09

Family

ID=38023004

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003146 WO2007054784A1 (en) 2005-11-10 2006-11-08 An improved process for the preparation of granisetron hydrochloride

Country Status (1)

Country Link
WO (1) WO2007054784A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080242696A1 (en) * 2007-03-27 2008-10-02 Chemagis Ltd. Crystalline granisetron base and production process therefor
WO2010022052A1 (en) * 2008-08-19 2010-02-25 Scinopharm Taiwan, Ltd. Polymorphic form of granisetron hydrochloride and methods of making the same
CN103159765B (en) * 2011-12-15 2015-06-24 北京嘉林药业股份有限公司 Indisetron purification method suitable for industrialization
CN115372487B (en) * 2021-05-18 2023-10-10 成都倍特得诺药业有限公司 HPLC determination method for impurity E in granisetron hydrochloride

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3650772T2 (en) * 1985-04-27 2003-04-03 F. Hoffmann-La Roche Ag, Basel Derivatives of indazole-3-carboxamide and -3-carboxylic acid
US7060841B2 (en) * 2003-06-03 2006-06-13 Chemagis Ltd. Process for preparing 1-methylindazole-3-carboxylic acid

Also Published As

Publication number Publication date
WO2007054784A1 (en) 2007-05-18

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