NO20063231L - Pyrido[2,3-D]pyrimidin-2,4-diaminer som PDE 2 inhibitorer - Google Patents

Pyrido[2,3-D]pyrimidin-2,4-diaminer som PDE 2 inhibitorer

Info

Publication number
NO20063231L
NO20063231L NO20063231A NO20063231A NO20063231L NO 20063231 L NO20063231 L NO 20063231L NO 20063231 A NO20063231 A NO 20063231A NO 20063231 A NO20063231 A NO 20063231A NO 20063231 L NO20063231 L NO 20063231L
Authority
NO
Norway
Prior art keywords
pde
pyrido
diamines
pyrimidine
inhibitors
Prior art date
Application number
NO20063231A
Other languages
English (en)
Norwegian (no)
Inventor
Andrew Ian Morrell
David Duane Thompson
Robert James Chambers
Thomas Arthur Beyer
Kelvin Lam
Mel Li
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20063231L publication Critical patent/NO20063231L/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20063231A 2003-12-16 2006-07-11 Pyrido[2,3-D]pyrimidin-2,4-diaminer som PDE 2 inhibitorer NO20063231L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52999403P 2003-12-16 2003-12-16
PCT/IB2004/004013 WO2005061497A1 (en) 2003-12-16 2004-12-06 Pyrido[2,3-d]pyrimidine-2,4-diamines as pde 2 inhibitors

Publications (1)

Publication Number Publication Date
NO20063231L true NO20063231L (no) 2006-07-11

Family

ID=34710150

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063231A NO20063231L (no) 2003-12-16 2006-07-11 Pyrido[2,3-D]pyrimidin-2,4-diaminer som PDE 2 inhibitorer

Country Status (39)

Country Link
US (1) US20070135457A1 (xx)
EP (1) EP1697356B1 (xx)
JP (1) JP4073944B2 (xx)
KR (1) KR100816179B1 (xx)
CN (1) CN100439366C (xx)
AP (1) AP2006003632A0 (xx)
AR (1) AR046766A1 (xx)
AT (1) ATE387446T1 (xx)
AU (1) AU2004303609A1 (xx)
BR (1) BRPI0417663A (xx)
CA (1) CA2549510A1 (xx)
CL (1) CL2008001920A1 (xx)
DE (1) DE602004012154T2 (xx)
DK (1) DK1697356T3 (xx)
EA (1) EA010424B1 (xx)
EC (1) ECSP066643A (xx)
ES (1) ES2299888T3 (xx)
GE (1) GEP20094720B (xx)
GT (1) GT200400268A (xx)
HN (1) HN2004000538A (xx)
HR (1) HRP20080142T3 (xx)
IL (1) IL175813A0 (xx)
IS (1) IS8474A (xx)
MA (1) MA28270A1 (xx)
MX (1) MXPA06006777A (xx)
NL (1) NL1027787C2 (xx)
NO (1) NO20063231L (xx)
PE (1) PE20050681A1 (xx)
PL (1) PL1697356T3 (xx)
PT (1) PT1697356E (xx)
RS (1) RS50575B (xx)
SI (1) SI1697356T1 (xx)
SV (1) SV2005001979A (xx)
TN (1) TNSN06186A1 (xx)
TW (1) TWI291961B (xx)
UA (1) UA83091C2 (xx)
UY (1) UY28671A1 (xx)
WO (1) WO2005061497A1 (xx)
ZA (1) ZA200604970B (xx)

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JP5400388B2 (ja) * 2005-12-15 2014-01-29 ライジェル ファーマシューティカルズ, インコーポレイテッド キナーゼインヒビターおよびその利用
EP2070541A4 (en) * 2006-09-21 2011-04-13 Toshiki Oguro MEANS FOR PROMOTING REGENERATION OF HARD FABRIC
WO2009116577A1 (ja) * 2008-03-18 2009-09-24 日産化学工業株式会社 1-(置換フェニル)-1-置換シリルエーテル、アルコールまたはケトンの製造方法および中間体
US20120065165A1 (en) * 2008-10-31 2012-03-15 Arginetix, Inc Compositions and methods of treating endothelial disorders
WO2011011312A1 (en) 2009-07-22 2011-01-27 Merck Sharp & Dohme Corp. Quinolinone pde2 inhibitors
US8440710B2 (en) 2009-10-15 2013-05-14 Hoffmann-La Roche Inc. HSL inhibitors useful in the treatment of diabetes
US9540379B2 (en) 2011-01-31 2017-01-10 Boehringer Ingelheim International Gmbh (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
EP2699577A1 (en) 2011-04-20 2014-02-26 Glaxo Group Limited Tetrahydropyrazolo [1,5 -a]pyrimidine as anti -tuberculosis compounds
PE20142258A1 (es) 2012-04-25 2015-01-15 Takeda Pharmaceutical Compuesto heterociclico nitrogenado
WO2014010732A1 (ja) 2012-07-13 2014-01-16 武田薬品工業株式会社 複素環化合物
US20140045856A1 (en) 2012-07-31 2014-02-13 Boehringer Ingelheim International Gmbh 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
US9834520B2 (en) 2013-03-14 2017-12-05 Takeda Pharmaceutical Company Limited Heterocyclic compound
US10053468B2 (en) 2013-07-03 2018-08-21 Takeda Pharmaceutical Company Limited Heterocyclic compound
JP6411342B2 (ja) 2013-07-03 2018-10-24 武田薬品工業株式会社 アミド化合物
WO2015012328A1 (ja) * 2013-07-24 2015-01-29 武田薬品工業株式会社 複素環化合物
EP3087060B1 (en) 2013-12-23 2020-05-13 Merck Sharp & Dohme Corp. Pyrimidone carboxamide compounds as pde2 inhibitors
US9849132B2 (en) 2014-01-08 2017-12-26 Intra-Cellular Therapies, Inc. Products and pharmaceutical compositions
RU2712165C2 (ru) * 2014-08-01 2020-01-24 Фирмениш Са Твердая дисперсия амидных пищевых ароматизаторов
MX2017007377A (es) 2014-12-06 2017-11-06 Intra Cellular Therapies Inc Compuestos organicos.
BR112017012007B1 (pt) 2014-12-06 2022-11-01 Intra-Cellular Therapies, Inc Compostos orgânicos inibitórios de pde2, composições farmacêuticas compreendendo os ditos compostos e uso dos mesmos no tratamento de um distúrbio mediado por pde2
WO2016145614A1 (en) 2015-03-17 2016-09-22 Merck Sharp & Dohme Corp. Triazolyl pyrimidinone compounds as pde2 inhibitors
US10287269B2 (en) 2015-03-26 2019-05-14 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as PDE2 inhibitors
WO2016179059A1 (en) 2015-05-05 2016-11-10 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as pde2 inhibitors
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
WO2016191935A1 (en) 2015-05-29 2016-12-08 Merck Sharp & Dohme Corp. 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016192083A1 (en) * 2015-06-04 2016-12-08 Merck Sharp & Dohme Corp. Dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016209749A1 (en) 2015-06-25 2016-12-29 Merck Sharp & Dohme Corp. Substituted pyrazolo/imidazolo bicyclic compounds as pde2 inhibitors
WO2017000277A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Substituted triazolo bicycliccompounds as pde2 inhibitors
WO2017000276A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
EP3156405A1 (en) 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
GB201700814D0 (en) 2017-01-17 2017-03-01 Liverpool School Tropical Medicine Compounds
JP2021504466A (ja) 2017-11-23 2021-02-15 オスロ ウニヴェルシティ ホスピタル ホーエフ 頻脈の治療
CN109758458B (zh) * 2019-03-05 2021-02-23 中国人民解放军陆军军医大学第二附属医院 抑制Crif1与PKA相互作用的化合物的应用
US11648254B2 (en) 2021-03-02 2023-05-16 Kumquat Biosciences Inc. Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling
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Also Published As

Publication number Publication date
GT200400268A (es) 2005-09-20
ZA200604970B (en) 2007-11-28
NL1027787A1 (nl) 2005-06-21
DK1697356T3 (da) 2009-01-12
EA010424B1 (ru) 2008-08-29
KR100816179B1 (ko) 2008-03-28
AP2006003632A0 (en) 2006-06-30
EP1697356A1 (en) 2006-09-06
MA28270A1 (fr) 2006-11-01
PE20050681A1 (es) 2005-10-04
CA2549510A1 (en) 2005-07-07
DE602004012154D1 (de) 2008-04-10
UY28671A1 (es) 2005-07-29
HRP20080142T3 (en) 2008-06-30
ATE387446T1 (de) 2008-03-15
IS8474A (is) 2006-05-18
JP4073944B2 (ja) 2008-04-09
KR20060105776A (ko) 2006-10-11
CN1894245A (zh) 2007-01-10
PT1697356E (pt) 2008-05-05
UA83091C2 (xx) 2008-06-10
US20070135457A1 (en) 2007-06-14
CN100439366C (zh) 2008-12-03
EP1697356B1 (en) 2008-02-27
EA200600973A1 (ru) 2006-10-27
TWI291961B (en) 2008-01-01
ES2299888T3 (es) 2008-06-01
HN2004000538A (es) 2008-02-21
SV2005001979A (es) 2005-12-13
BRPI0417663A (pt) 2007-04-03
CL2008001920A1 (es) 2008-10-17
TW200522952A (en) 2005-07-16
AU2004303609A1 (en) 2005-07-07
AR046766A1 (es) 2005-12-21
GEP20094720B (en) 2009-06-25
WO2005061497A1 (en) 2005-07-07
PL1697356T3 (pl) 2008-07-31
ECSP066643A (es) 2006-10-25
JP2007513996A (ja) 2007-05-31
IL175813A0 (en) 2006-10-05
RS50575B (sr) 2010-05-07
NL1027787C2 (nl) 2006-03-09
SI1697356T1 (sl) 2008-06-30
MXPA06006777A (es) 2006-08-23
DE602004012154T2 (de) 2009-03-12
TNSN06186A1 (fr) 2007-11-15

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