PE20142258A1 - Compuesto heterociclico nitrogenado - Google Patents

Compuesto heterociclico nitrogenado

Info

Publication number
PE20142258A1
PE20142258A1 PE2014001787A PE2014001787A PE20142258A1 PE 20142258 A1 PE20142258 A1 PE 20142258A1 PE 2014001787 A PE2014001787 A PE 2014001787A PE 2014001787 A PE2014001787 A PE 2014001787A PE 20142258 A1 PE20142258 A1 PE 20142258A1
Authority
PE
Peru
Prior art keywords
metoxy
heterocyclic compound
nitrogenated heterocyclic
trifluorometoxy
carboxamide
Prior art date
Application number
PE2014001787A
Other languages
English (en)
Inventor
Satoshi Mikami
Shinji Nakamura
Tomoko Ashizawa
Shigekazu Sasaki
Takahiko Taniguchi
Izumi Nomura
Masanori Kawasaki
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20142258A1 publication Critical patent/PE20142258A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Abstract

SE REFIERE A COMPUESTOS HETEROCICLICOS NITROGENADOS O UNA SAL DEL MISMO DE FORMULA (1) EN DONDE CADA SIMBOLO ES COMO SE DESCRIBE EN LA DESCRIPCION. SON COMPUESTOS PREFERIDOS: 7-METOXI-N-((1S)-2-METOXI-1-(4-(TRIFLUOROMETOXI)FENIL)ETIL)-2-OXO-2,3-DIHIDROPIRIDO[2,3-b]PIRAZINA-4(1H)-CARBOXAMIDA; N-((1S)-1-(3-FLUORO-4-(TRIFLUOROMETOXI)FENIL)-2-METOXIETIL)-7-METOXI-2-OXO-2,3-DIHIDROPIRIDO[2,3-b]PIRAZINA-4(1H)-CARBOXAMIDA; ENTRE OTROS. DICHOS COMPUESTOS TIENEN UNA ACCION INHIBIDORA SELECTIVA DE LA PDE2A, Y ES UTIL COMO AGENTE PARA LA PROFILAXIS O TRATAMIENTO DE ESQUIZOFRENIA, LA ENFERMEDAD DE ALZHEIMER
PE2014001787A 2012-04-25 2013-04-24 Compuesto heterociclico nitrogenado PE20142258A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012100374 2012-04-25
JP2012283470 2012-12-26

Publications (1)

Publication Number Publication Date
PE20142258A1 true PE20142258A1 (es) 2015-01-15

Family

ID=49483221

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001787A PE20142258A1 (es) 2012-04-25 2013-04-24 Compuesto heterociclico nitrogenado

Country Status (25)

Country Link
US (2) US9469637B2 (es)
EP (1) EP2848618B1 (es)
JP (1) JP6157455B2 (es)
KR (1) KR20150005936A (es)
AU (1) AU2013253516B2 (es)
BR (1) BR112014025711A8 (es)
CA (1) CA2869730A1 (es)
CL (1) CL2014002880A1 (es)
CO (1) CO7141410A2 (es)
CR (1) CR20140537A (es)
DO (1) DOP2014000243A (es)
EA (1) EA029892B1 (es)
GE (1) GEP20166554B (es)
HK (1) HK1203500A1 (es)
IL (1) IL235048B (es)
MX (1) MX361539B (es)
MY (1) MY173949A (es)
NZ (1) NZ631258A (es)
PE (1) PE20142258A1 (es)
PH (1) PH12014502396A1 (es)
SG (1) SG11201406552UA (es)
TN (1) TN2014000416A1 (es)
UA (1) UA115057C2 (es)
WO (1) WO2013161913A1 (es)
ZA (1) ZA201408644B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150005936A (ko) 2012-04-25 2015-01-15 다케다 야쿠힌 고교 가부시키가이샤 질소화 헤테로시클릭 화합물
EP2873669A4 (en) 2012-07-13 2015-11-25 Takeda Pharmaceutical HETEROCYCLIC COMPOUND
US9834520B2 (en) 2013-03-14 2017-12-05 Takeda Pharmaceutical Company Limited Heterocyclic compound
JP6427491B2 (ja) 2013-07-03 2018-11-21 武田薬品工業株式会社 複素環化合物
ES2950424T3 (es) 2013-07-03 2023-10-09 Takeda Pharmaceuticals Co Compuesto de amida
WO2015012328A1 (ja) * 2013-07-24 2015-01-29 武田薬品工業株式会社 複素環化合物
EP3061754A4 (en) * 2013-10-23 2017-03-22 Takeda Pharmaceutical Company Limited Heterocyclic compound
US9815796B2 (en) 2013-12-23 2017-11-14 Merck Sharp & Dohme Corp. Pyrimidone carboxamide compounds as PDE2 inhibitors
JP2017114764A (ja) * 2014-04-25 2017-06-29 武田薬品工業株式会社 片頭痛治療剤
WO2016145614A1 (en) 2015-03-17 2016-09-22 Merck Sharp & Dohme Corp. Triazolyl pyrimidinone compounds as pde2 inhibitors
WO2016154081A1 (en) 2015-03-26 2016-09-29 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as pde2 inhibitors
US10195201B2 (en) 2015-05-05 2019-02-05 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as PDE2 inhibitors
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
WO2016191935A1 (en) 2015-05-29 2016-12-08 Merck Sharp & Dohme Corp. 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016192083A1 (en) 2015-06-04 2016-12-08 Merck Sharp & Dohme Corp. Dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016209749A1 (en) 2015-06-25 2016-12-29 Merck Sharp & Dohme Corp. Substituted pyrazolo/imidazolo bicyclic compounds as pde2 inhibitors
WO2017000277A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Substituted triazolo bicycliccompounds as pde2 inhibitors
WO2017000276A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
AU2018371216A1 (en) 2017-11-23 2020-06-04 Oslo University Hospital Hf Treatment of tachycardia
EP3806888B1 (en) 2018-06-12 2024-01-31 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
CN113214172A (zh) * 2021-04-25 2021-08-06 西南大学 氟康唑中间体还原胺化产物的制备方法

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001938A1 (en) 1990-07-20 1992-02-06 City Of Hope Derivatization of c-terminal proline
DE4211239C2 (de) 1992-04-03 1995-11-16 Max Planck Gesellschaft Arzneimittel gegen Herz-Kreislauf-Erkrankungen
JPH06145169A (ja) 1992-09-17 1994-05-24 Nippon Soda Co Ltd 新規な含窒素５員環化合物、その製造方法及び有害生物防除剤
JP3601898B2 (ja) 1996-02-14 2004-12-15 俊隆 鍋島 薬物依存形成抑制剤
JPH11292877A (ja) 1998-04-09 1999-10-26 Yamanouchi Pharmaceut Co Ltd １，４−ジ置換ピリドピラジン誘導体
EP1146888A2 (en) 1998-10-15 2001-10-24 BioImage A/S Specific therapeutic interventions obtained by interference with redistribution and/or targetting
GB9826174D0 (en) 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
HUP0202150A3 (en) 1999-06-14 2003-10-28 Henry Ford Health System Detro Use of nitric oxide donors for inducing neurogenesis
US7655423B2 (en) 1999-06-14 2010-02-02 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
US7135498B1 (en) 1999-06-14 2006-11-14 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
FR2796947A1 (fr) 1999-07-30 2001-02-02 Aventis Pharma Sa Nouveaux derives 8-carbonyl chromanes, leur preparation et leur utilisation en therapeutique
WO2001032170A1 (en) 1999-09-13 2001-05-10 Swope David M Composition and method for decreasing neurologic symptomatology
WO2002009713A2 (de) 2000-08-01 2002-02-07 Bayer Aktiengesellschaft Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
US20020119978A1 (en) 2000-12-05 2002-08-29 Swope David M. Composition and method for decreasing neurologic symptomatology
DE10064105A1 (de) 2000-12-21 2002-06-27 Bayer Ag Neue Substituierte Imidazotriazinone
DE60234510D1 (de) 2001-04-16 2010-01-07 Eisai R&D Man Co Ltd 1h-indazolverbindungen die jnk hemmen
AU2003210447B2 (en) 2002-01-04 2008-02-07 Henry Ford Health System Nitric oxide donors for treatment of disease and injury
DE10224462A1 (de) 2002-06-03 2003-12-11 Bayer Ag Verwendung von cGMP stimulierenden Verbindungen
GB0230045D0 (en) 2002-12-23 2003-01-29 Glaxo Group Ltd Compounds
ATE412415T1 (de) 2002-10-30 2008-11-15 Via Pharmaceuticals Inc Inhibitoren der phosphodiesterase der zyklischen nucleotiden, mit einer benzodiazepinischen struktur, und deren verwendung in therapie
WO2004044234A1 (en) 2002-11-13 2004-05-27 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 2a (pde2a)
EP1581493A1 (en) 2002-12-30 2005-10-05 Eli Lilly And Company Factor xa inhibitors
US20060106037A1 (en) 2003-03-04 2006-05-18 Thomas Bar Purin-6-one-derivatives
GB2404658A (en) 2003-08-07 2005-02-09 Bayer Ag Quinoxalinone derivatives and their use in the treatment of diseases
WO2005035534A1 (ja) 2003-10-08 2005-04-21 Ono Pharmaceutical Co., Ltd. 複素ビシクロ環および複素トリシクロ環化合物およびその医薬
JP2005145840A (ja) 2003-11-12 2005-06-09 Nippon Soda Co Ltd 縮合ヘテロ環誘導体及び農園芸用殺菌剤
AP2006003632A0 (en) 2003-12-16 2006-06-30 Pfizer Prod Inc Pyridol[2,3-D] pyrimidine-2,4-Diamines as PDE 2 inhibitors
US20070111995A1 (en) 2003-12-19 2007-05-17 Allen David G Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors
US7879839B2 (en) 2004-07-29 2011-02-01 Merck Sharp & Dohme Corp. Potassium channel inhibitors
CN101103033B (zh) 2005-01-05 2010-08-04 尼科梅德有限责任公司 作为pde2抑制剂的三唑并酞嗪
JP5130053B2 (ja) 2005-01-05 2013-01-30 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング トリアゾロフタラジン
WO2007094755A2 (en) 2005-02-04 2007-08-23 Massachusetts Institute Of Technology Compositions and methods for modulating cognitive function
WO2007020521A1 (en) 2005-08-16 2007-02-22 Pharmacia & Upjohn Company Llc Pyridoyrazinones as pde-5 inhibitors
JP2009535393A (ja) 2006-05-01 2009-10-01 ファイザー・プロダクツ・インク 置換２−アミノ縮合複素環式化合物
TW200815436A (en) 2006-05-30 2008-04-01 Elbion Ag 4-amino-pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
TW200817400A (en) 2006-05-30 2008-04-16 Elbion Ag Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
WO2007146230A2 (en) 2006-06-14 2007-12-21 Merck & Co., Inc. Non-nucleoside reverse transcriptase inhibitors
DE102006048693A1 (de) 2006-10-14 2008-04-17 Bayer Healthcare Ag Inhibition der PDE2A
EP2120938A4 (en) 2006-12-20 2010-12-08 Merck Sharp & Dohme IMIDAZOPYRIDINE ANALOGUE AS CB2 RECEPTOR MODULATORS FOR THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES
KR20120107538A (ko) 2007-08-22 2012-10-02 아이알엠 엘엘씨 키나제 억제제로서의 5-(4-(할로알콕시)페닐)피리미딘-2-아민 화합물 및 조성물
CA2724077C (en) 2008-05-14 2016-04-26 Astellas Pharma Inc. Amide compound
WO2010054253A1 (en) * 2008-11-07 2010-05-14 Biotie Therapies Gmbh Triazine derivatives as inhibitors of phosphodiesterases
US20100120763A1 (en) 2008-11-07 2010-05-13 Wyeth Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases
ES2432070T3 (es) 2009-02-24 2013-11-29 Respiratorius Ab Diazaheteroarilos broncodilatadores novedosos
WO2011022213A1 (en) * 2009-08-17 2011-02-24 Merck Sharp & Dohme Corp. Amino tetrahydro-pyridopyrimidine pde10 inhibitors
HUE043536T2 (hu) 2009-10-06 2019-08-28 Millennium Pharm Inc PDK1 inhibitorként alkalmazható heterociklusos vegyületek
US9556201B2 (en) * 2009-10-29 2017-01-31 Glaxosmithkline Llc Bicyclic pyridines and analogs as sirtuin modulators
JP5760085B2 (ja) 2010-08-04 2015-08-05 武田薬品工業株式会社 縮合複素環化合物
US20130184462A1 (en) 2010-09-30 2013-07-18 Council Of Scientific & Industrial Research Method for predicting and modeling anti-psychotic activity using virtual screening model
US8927559B2 (en) 2010-10-11 2015-01-06 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as CRTH2 antagonists
US9265735B2 (en) 2010-11-30 2016-02-23 New York University Methods for screening to identify therapeutic agents for Alzheimer's disease and use thereof
JP5952829B2 (ja) 2010-12-23 2016-07-13 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｃｒｔｈ２受容体調節剤としてのキノキサリン類およびアザ−キノキサリン類
MX2013014082A (es) 2011-05-30 2014-03-21 Astellas Pharma Inc Compuestos de imidazopiridina.
JP2014522818A (ja) 2011-06-22 2014-09-08 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
US9212168B2 (en) 2011-11-03 2015-12-15 Theravance Biopharma R&D Ip, Llc Hepatitis C virus inhibitors
KR20150005936A (ko) 2012-04-25 2015-01-15 다케다 야쿠힌 고교 가부시키가이샤 질소화 헤테로시클릭 화합물
EP2873669A4 (en) 2012-07-13 2015-11-25 Takeda Pharmaceutical HETEROCYCLIC COMPOUND
WO2015012328A1 (ja) 2013-07-24 2015-01-29 武田薬品工業株式会社 複素環化合物

Also Published As

Publication number Publication date
UA115057C2 (uk) 2017-09-11
TN2014000416A1 (en) 2016-03-30
EA201491936A1 (ru) 2015-03-31
CO7141410A2 (es) 2014-12-12
US20150105373A1 (en) 2015-04-16
US20170129887A1 (en) 2017-05-11
HK1203500A1 (en) 2015-10-30
CN104245698A (zh) 2014-12-24
PH12014502396B1 (en) 2014-12-22
CA2869730A1 (en) 2013-10-31
DOP2014000243A (es) 2014-12-31
NZ631258A (en) 2016-11-25
EP2848618B1 (en) 2018-03-14
MX2014013011A (es) 2015-01-12
ZA201408644B (en) 2016-02-24
PH12014502396A1 (en) 2014-12-22
JPWO2013161913A1 (ja) 2015-12-24
IL235048B (en) 2018-11-29
AU2013253516A2 (en) 2015-04-02
BR112014025711A8 (pt) 2018-01-16
CL2014002880A1 (es) 2015-02-06
JP6157455B2 (ja) 2017-07-05
EP2848618A1 (en) 2015-03-18
KR20150005936A (ko) 2015-01-15
MX361539B (es) 2018-12-10
AU2013253516A1 (en) 2014-12-18
BR112014025711A2 (pt) 2017-07-04
GEP20166554B (en) 2016-10-10
CR20140537A (es) 2015-02-03
EP2848618A4 (en) 2015-11-11
WO2013161913A1 (ja) 2013-10-31
SG11201406552UA (en) 2014-11-27
US10017508B2 (en) 2018-07-10
AU2013253516B2 (en) 2017-10-12
MY173949A (en) 2020-02-28
US9469637B2 (en) 2016-10-18
EA029892B1 (ru) 2018-05-31

Similar Documents

Publication Publication Date Title
PE20142258A1 (es) Compuesto heterociclico nitrogenado
PH12020551315A1 (en) Benzoxazepin oxazolidinone compounds and methods of use
AR094918A1 (es) Compuestos de tetrahidropirrolotiazina como inhibidores de bace
TR201904455T4 (tr) Nükleer taşıma modülatörleri olarak 1,2,4-triazoller ve bunların kullanımları.
DOP2015000216A (es) Inhibidores de bromodominios tetraciclicos
EA201200174A1 (ru) Производные оксазина и их применение в качестве ингибиторов bace для лечения неврологических нарушений
PE20121617A1 (es) Derivados de oxazina como inhibidores de bace
EA201590748A1 (ru) Противовирусные соединения против rsv
PH12015500209A1 (en) Partially saturated nitrogen-containing heterocyclic compound
NZ723198A (en) Anthelmintic compounds and compositions and methods of using thereof
EA201590092A1 (ru) АЗОТСОДЕРЖАЩИЕ 5-ЧЛЕННЫЕ ГЕТЕРОЦИКЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ЯДЕРНОГО ОРФАНОВОГО РЕЦЕПТОРА RORγ
EA201490493A1 (ru) Пирано[3,2-d][1,3]тиазол в качестве ингибиторов гликозидазы
NZ627560A (en) Heterocyclic piperazine compounds and methods for their use
PE20151748A1 (es) Inhibidores de bace1
MY173573A (en) Pyridin-4-yl derivatives
PE20151718A1 (es) Compuestos piridinilpirazoloquinolina
PE20150709A1 (es) Benzamidas
NZ719185A (en) Crystalline forms of therapeutic compounds and uses thereof
PE20151062A1 (es) PIRIMIDO-[4,5-b]-QUINOLINA-4,5(3H,10H)-DIONAS COMO SUPRESORAS DE MUTACION SIN SENTIDO
EA201400822A1 (ru) Производные гетероциклических амидов в качестве антагонистов p2xрецептора
AR093527A1 (es) 6-((S)-1-1-[5-(2-HIDROXI-ETOXI)-PIRIDIN-2-IL]1H-PIRAZOL-3-IL-ETIL)-3H-1,3-BENZOTIAZOL-2-ONA COMO UN ANTAGONISTA DEL RECEPTOR AMPA DEPENDIENTE DE TARP-g 8
EA201491878A1 (ru) Замещенные ксантиновые производные
PH12016501645A1 (en) Aminopyrazolone derivative
EA201792558A1 (ru) Противогрибковый 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-триазол-1-ил)метил)-5-(2,4-дифторфенил)тетрагидрофуран-3-ил)метокси)-3-метилфенил)пиперазин-1-ил)-n-(2-гидроксициклогексил)бензамид или его фармацевтически приемлемая соль
EA201591300A1 (ru) Формы меглуминовой соли 2-((1r,4r)-4-(4-(5-(бензоксазол-2-иламино)пиридин-2-ил)фенил)циклогексил)уксусной кислоты и их применение в качестве ингибиторов dgat1

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed