IS8474A - Pýridó[2,3-d]pýrimidín-2,4-díamín sem PDE 2 latar - Google Patents

Pýridó[2,3-d]pýrimidín-2,4-díamín sem PDE 2 latar

Info

Publication number
IS8474A
IS8474A IS8474A IS8474A IS8474A IS 8474 A IS8474 A IS 8474A IS 8474 A IS8474 A IS 8474A IS 8474 A IS8474 A IS 8474A IS 8474 A IS8474 A IS 8474A
Authority
IS
Iceland
Prior art keywords
pde
pyrido
pyrimidine
diamine
leaves
Prior art date
Application number
IS8474A
Other languages
English (en)
Inventor
Arthur Beyer Thomas
James Chambers Robert
Lam Kelvin
Li Mei
Ian Morrell Andrew
Duane Thompson David
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of IS8474A publication Critical patent/IS8474A/is

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IS8474A 2003-12-16 2006-05-18 Pýridó[2,3-d]pýrimidín-2,4-díamín sem PDE 2 latar IS8474A (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52999403P 2003-12-16 2003-12-16
PCT/IB2004/004013 WO2005061497A1 (en) 2003-12-16 2004-12-06 Pyrido[2,3-d]pyrimidine-2,4-diamines as pde 2 inhibitors

Publications (1)

Publication Number Publication Date
IS8474A true IS8474A (is) 2006-05-18

Family

ID=34710150

Family Applications (1)

Application Number Title Priority Date Filing Date
IS8474A IS8474A (is) 2003-12-16 2006-05-18 Pýridó[2,3-d]pýrimidín-2,4-díamín sem PDE 2 latar

Country Status (39)

Country Link
US (1) US20070135457A1 (is)
EP (1) EP1697356B1 (is)
JP (1) JP4073944B2 (is)
KR (1) KR100816179B1 (is)
CN (1) CN100439366C (is)
AP (1) AP2006003632A0 (is)
AR (1) AR046766A1 (is)
AT (1) ATE387446T1 (is)
AU (1) AU2004303609A1 (is)
BR (1) BRPI0417663A (is)
CA (1) CA2549510A1 (is)
CL (1) CL2008001920A1 (is)
DE (1) DE602004012154T2 (is)
DK (1) DK1697356T3 (is)
EA (1) EA010424B1 (is)
EC (1) ECSP066643A (is)
ES (1) ES2299888T3 (is)
GE (1) GEP20094720B (is)
GT (1) GT200400268A (is)
HN (1) HN2004000538A (is)
HR (1) HRP20080142T3 (is)
IL (1) IL175813A0 (is)
IS (1) IS8474A (is)
MA (1) MA28270A1 (is)
MX (1) MXPA06006777A (is)
NL (1) NL1027787C2 (is)
NO (1) NO20063231L (is)
PE (1) PE20050681A1 (is)
PL (1) PL1697356T3 (is)
PT (1) PT1697356E (is)
RS (1) RS50575B (is)
SI (1) SI1697356T1 (is)
SV (1) SV2005001979A (is)
TN (1) TNSN06186A1 (is)
TW (1) TWI291961B (is)
UA (1) UA83091C2 (is)
UY (1) UY28671A1 (is)
WO (1) WO2005061497A1 (is)
ZA (1) ZA200604970B (is)

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ES2562428T3 (es) * 2005-12-15 2016-03-04 Rigel Pharmaceuticals, Inc. Inhibidores de cinasa y sus usos
KR20090098783A (ko) * 2006-09-21 2009-09-17 토시키 오구로 경조직 재생 촉진제
WO2009116577A1 (ja) * 2008-03-18 2009-09-24 日産化学工業株式会社 1-(置換フェニル)-1-置換シリルエーテル、アルコールまたはケトンの製造方法および中間体
US20120065165A1 (en) * 2008-10-31 2012-03-15 Arginetix, Inc Compositions and methods of treating endothelial disorders
US8680116B2 (en) 2009-07-22 2014-03-25 Merck Sharp & Dohme Corp. Quinolinone PDE2 inhibitors
US8440710B2 (en) 2009-10-15 2013-05-14 Hoffmann-La Roche Inc. HSL inhibitors useful in the treatment of diabetes
US9540379B2 (en) 2011-01-31 2017-01-10 Boehringer Ingelheim International Gmbh (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
CN103596958A (zh) 2011-04-20 2014-02-19 葛兰素集团有限公司 用作抗结核病化合物的四氢吡唑并[1,5-a]嘧啶
WO2013161913A1 (ja) 2012-04-25 2013-10-31 武田薬品工業株式会社 含窒素複素環化合物
EP2873669A4 (en) 2012-07-13 2015-11-25 Takeda Pharmaceutical HETEROCYCLIC COMPOUND
US20140045856A1 (en) 2012-07-31 2014-02-13 Boehringer Ingelheim International Gmbh 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
EP2975031A4 (en) 2013-03-14 2017-04-19 Takeda Pharmaceutical Company Limited Heterocyclic compound
US10053468B2 (en) 2013-07-03 2018-08-21 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2015002230A1 (ja) 2013-07-03 2015-01-08 武田薬品工業株式会社 アミド化合物
EP3026051A4 (en) * 2013-07-24 2017-03-08 Takeda Pharmaceutical Company Limited Heterocyclic compound
EP3087060B1 (en) 2013-12-23 2020-05-13 Merck Sharp & Dohme Corp. Pyrimidone carboxamide compounds as pde2 inhibitors
JP6696904B2 (ja) 2014-01-08 2020-05-20 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 製剤および医薬組成物
WO2016016276A1 (en) * 2014-08-01 2016-02-04 Firmenich Sa Solid dispersion of amide flavor compounds
EP3226870B1 (en) 2014-12-06 2019-09-25 Intra-Cellular Therapies, Inc. Organic compounds
CA2969597C (en) 2014-12-06 2023-10-24 Intra-Cellular Therapies, Inc. 1h-pyrazolo[4,3-c][1,5]naphthyridin-4(5h)-one compounds and their use as pde2 inhibitors
WO2016145614A1 (en) 2015-03-17 2016-09-22 Merck Sharp & Dohme Corp. Triazolyl pyrimidinone compounds as pde2 inhibitors
EP3285581B1 (en) 2015-03-26 2021-08-11 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as pde2 inhibitors
US10195201B2 (en) 2015-05-05 2019-02-05 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as PDE2 inhibitors
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
WO2016191935A1 (en) 2015-05-29 2016-12-08 Merck Sharp & Dohme Corp. 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016192083A1 (en) 2015-06-04 2016-12-08 Merck Sharp & Dohme Corp. Dihydropyrazolopyrimidinone compounds as pde2 inhibitors
EP3313852B1 (en) * 2015-06-25 2021-01-20 Merck Sharp & Dohme Corp. Substituted pyrazolo/imidazolo bicyclic compounds as pde2 inhibitors
WO2017000276A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
WO2017000277A1 (en) * 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Substituted triazolo bicycliccompounds as pde2 inhibitors
EP3156405A1 (en) 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
GB201700814D0 (en) * 2017-01-17 2017-03-01 Liverpool School Tropical Medicine Compounds
EP3713572A1 (en) 2017-11-23 2020-09-30 Oslo University Hospital HF Treatment of tachycardia
CN109758458B (zh) * 2019-03-05 2021-02-23 中国人民解放军陆军军医大学第二附属医院 抑制Crif1与PKA相互作用的化合物的应用
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Also Published As

Publication number Publication date
TW200522952A (en) 2005-07-16
SI1697356T1 (sl) 2008-06-30
EP1697356B1 (en) 2008-02-27
GEP20094720B (en) 2009-06-25
CN100439366C (zh) 2008-12-03
CN1894245A (zh) 2007-01-10
DE602004012154T2 (de) 2009-03-12
CL2008001920A1 (es) 2008-10-17
TWI291961B (en) 2008-01-01
AU2004303609A1 (en) 2005-07-07
UY28671A1 (es) 2005-07-29
KR20060105776A (ko) 2006-10-11
EA200600973A1 (ru) 2006-10-27
HRP20080142T3 (en) 2008-06-30
JP2007513996A (ja) 2007-05-31
GT200400268A (es) 2005-09-20
MXPA06006777A (es) 2006-08-23
AR046766A1 (es) 2005-12-21
NL1027787A1 (nl) 2005-06-21
KR100816179B1 (ko) 2008-03-28
EA010424B1 (ru) 2008-08-29
NL1027787C2 (nl) 2006-03-09
BRPI0417663A (pt) 2007-04-03
NO20063231L (no) 2006-07-11
DE602004012154D1 (de) 2008-04-10
PE20050681A1 (es) 2005-10-04
RS50575B (sr) 2010-05-07
UA83091C2 (en) 2008-06-10
PT1697356E (pt) 2008-05-05
ATE387446T1 (de) 2008-03-15
HN2004000538A (es) 2008-02-21
ES2299888T3 (es) 2008-06-01
ZA200604970B (en) 2007-11-28
EP1697356A1 (en) 2006-09-06
JP4073944B2 (ja) 2008-04-09
CA2549510A1 (en) 2005-07-07
AP2006003632A0 (en) 2006-06-30
WO2005061497A1 (en) 2005-07-07
TNSN06186A1 (fr) 2007-11-15
IL175813A0 (en) 2006-10-05
MA28270A1 (fr) 2006-11-01
DK1697356T3 (da) 2009-01-12
US20070135457A1 (en) 2007-06-14
SV2005001979A (es) 2005-12-13
ECSP066643A (es) 2006-10-25
PL1697356T3 (pl) 2008-07-31

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