GT200400268A - Pirido[2,3-d] pirimidina-2,4-diaminas como inhibidores de pde 2 - Google Patents
Pirido[2,3-d] pirimidina-2,4-diaminas como inhibidores de pde 2Info
- Publication number
- GT200400268A GT200400268A GT200400268A GT200400268A GT200400268A GT 200400268 A GT200400268 A GT 200400268A GT 200400268 A GT200400268 A GT 200400268A GT 200400268 A GT200400268 A GT 200400268A GT 200400268 A GT200400268 A GT 200400268A
- Authority
- GT
- Guatemala
- Prior art keywords
- pde
- inhibitors
- diaminas
- pirimidina
- pirido
- Prior art date
Links
- 229940121828 Phosphodiesterase 2 inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101100135858 Caenorhabditis elegans pde-2 gene Proteins 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 208000002815 pulmonary hypertension Diseases 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA GENERAL I EN LA QUE R1,R2,X,Y,N, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON UTILES COMO INHIBIDORES DE LA PDE 2 POR LO QUE SON DE UTILIDAD EN UNA AMPLIA VARIEDAD DE PATOLOGIAS TALES COMO OSTEOPOROSIS, HIPERTENSION PULMONAR, ANGIOGENESIS VASCULAR, DEMENCIA, ENTRE OTRAS MENCIONADAS EN LA SOLICITUD. T2004
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52999403P | 2003-12-16 | 2003-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT200400268A true GT200400268A (es) | 2005-09-20 |
Family
ID=34710150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200400268A GT200400268A (es) | 2003-12-16 | 2004-12-15 | Pirido[2,3-d] pirimidina-2,4-diaminas como inhibidores de pde 2 |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US20070135457A1 (es) |
| EP (1) | EP1697356B1 (es) |
| JP (1) | JP4073944B2 (es) |
| KR (1) | KR100816179B1 (es) |
| CN (1) | CN100439366C (es) |
| AP (1) | AP2006003632A0 (es) |
| AR (1) | AR046766A1 (es) |
| AT (1) | ATE387446T1 (es) |
| AU (1) | AU2004303609A1 (es) |
| BR (1) | BRPI0417663A (es) |
| CA (1) | CA2549510A1 (es) |
| CL (1) | CL2008001920A1 (es) |
| DE (1) | DE602004012154T2 (es) |
| DK (1) | DK1697356T3 (es) |
| EA (1) | EA010424B1 (es) |
| EC (1) | ECSP066643A (es) |
| ES (1) | ES2299888T3 (es) |
| GE (1) | GEP20094720B (es) |
| GT (1) | GT200400268A (es) |
| HN (1) | HN2004000538A (es) |
| HR (1) | HRP20080142T3 (es) |
| IL (1) | IL175813A0 (es) |
| IS (1) | IS8474A (es) |
| MA (1) | MA28270A1 (es) |
| MX (1) | MXPA06006777A (es) |
| NL (1) | NL1027787C2 (es) |
| NO (1) | NO20063231L (es) |
| PE (1) | PE20050681A1 (es) |
| PL (1) | PL1697356T3 (es) |
| PT (1) | PT1697356E (es) |
| RS (1) | RS50575B (es) |
| SI (1) | SI1697356T1 (es) |
| SV (1) | SV2005001979A (es) |
| TN (1) | TNSN06186A1 (es) |
| TW (1) | TWI291961B (es) |
| UA (1) | UA83091C2 (es) |
| UY (1) | UY28671A1 (es) |
| WO (1) | WO2005061497A1 (es) |
| ZA (1) | ZA200604970B (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7601713B2 (en) * | 2005-12-15 | 2009-10-13 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and their uses |
| EP2070541A4 (en) * | 2006-09-21 | 2011-04-13 | Toshiki Oguro | MEANS FOR PROMOTING REGENERATION OF HARD FABRIC |
| JP5472638B2 (ja) * | 2008-03-18 | 2014-04-16 | 日産化学工業株式会社 | １−（置換フェニル）−１−置換シリルエーテル、アルコールまたはケトンの製造方法および中間体 |
| WO2010062366A1 (en) * | 2008-10-31 | 2010-06-03 | Arginetix, Inc. | Compositions and methods of treating endothelial disorders |
| US8680116B2 (en) | 2009-07-22 | 2014-03-25 | Merck Sharp & Dohme Corp. | Quinolinone PDE2 inhibitors |
| US8440710B2 (en) | 2009-10-15 | 2013-05-14 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
| US9540379B2 (en) | 2011-01-31 | 2017-01-10 | Boehringer Ingelheim International Gmbh | (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases |
| EA201391558A1 (ru) | 2011-04-20 | 2014-05-30 | Глэксо Груп Лимитед | Тетрагидропиразоло[1,5-а]пиримидины как противотуберкулезные соединения |
| NZ631258A (en) | 2012-04-25 | 2016-11-25 | Takeda Pharmaceuticals Co | Nitrogenated heterocyclic compound |
| US9527841B2 (en) | 2012-07-13 | 2016-12-27 | Takeda Pharmaceutical Company Limited | Substituted pyrido[2,3-b]pyrazines as phosphodiesterase 2A inhibitors |
| US20140045856A1 (en) | 2012-07-31 | 2014-02-13 | Boehringer Ingelheim International Gmbh | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes |
| US9834520B2 (en) | 2013-03-14 | 2017-12-05 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP3018126A4 (en) | 2013-07-03 | 2016-12-07 | Takeda Pharmaceuticals Co | HETEROCYCLIC COMPOUND |
| EP3018123B1 (en) | 2013-07-03 | 2023-05-10 | Takeda Pharmaceutical Company Limited | Amide compound |
| WO2015012328A1 (ja) * | 2013-07-24 | 2015-01-29 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3087060B1 (en) | 2013-12-23 | 2020-05-13 | Merck Sharp & Dohme Corp. | Pyrimidone carboxamide compounds as pde2 inhibitors |
| EP3091983B1 (en) | 2014-01-08 | 2019-10-02 | Intra-Cellular Therapies, Inc. | Pharmaceutical compositions comprising a pde-1 inhibitor and a pde-2 inhibitor |
| MX2017000713A (es) * | 2014-08-01 | 2017-05-01 | Firmenich & Cie | Dispersion solida de compuestos con sabor de amida. |
| BR112017012005B1 (pt) | 2014-12-06 | 2023-04-04 | Intra-Cellular Therapies, Inc | Compostos orgânicos inibidores de pde2, composições farmacêuticas compreendendo os ditos compostos e uso dos mesmos no tratamento de um distúrbio mediado por pde2 |
| EP3226870B1 (en) | 2014-12-06 | 2019-09-25 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2016145614A1 (en) | 2015-03-17 | 2016-09-22 | Merck Sharp & Dohme Corp. | Triazolyl pyrimidinone compounds as pde2 inhibitors |
| WO2016154081A1 (en) | 2015-03-26 | 2016-09-29 | Merck Sharp & Dohme Corp. | Pyrazolyl pyrimidinone compounds as pde2 inhibitors |
| WO2016179059A1 (en) | 2015-05-05 | 2016-11-10 | Merck Sharp & Dohme Corp. | Heteroaryl-pyrimidinone compounds as pde2 inhibitors |
| WO2016183741A1 (en) | 2015-05-15 | 2016-11-24 | Merck Sharp & Dohme Corp. | Pyrimidinone amide compounds as pde2 inhibitors |
| WO2016191935A1 (en) | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| WO2016192083A1 (en) | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| EP3313852B1 (en) * | 2015-06-25 | 2021-01-20 | Merck Sharp & Dohme Corp. | Substituted pyrazolo/imidazolo bicyclic compounds as pde2 inhibitors |
| WO2017000277A1 (en) * | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Substituted triazolo bicycliccompounds as pde2 inhibitors |
| WO2017000276A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic compounds as pde2 inhibitors |
| EP3156405A1 (en) | 2015-10-13 | 2017-04-19 | Boehringer Ingelheim International GmbH | Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide |
| GB201700814D0 (en) * | 2017-01-17 | 2017-03-01 | Liverpool School Tropical Medicine | Compounds |
| WO2019101970A1 (en) | 2017-11-23 | 2019-05-31 | Oslo University Hospital Hf | Treatment of tachycardia |
| CN109758458B (zh) * | 2019-03-05 | 2021-02-23 | 中国人民解放军陆军军医大学第二附属医院 | 抑制Crif1与PKA相互作用的化合物的应用 |
| US11648254B2 (en) | 2021-03-02 | 2023-05-16 | Kumquat Biosciences Inc. | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling |
| US11912708B2 (en) | 2022-04-20 | 2024-02-27 | Kumquat Biosciences Inc. | Macrocyclic heterocycles and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2749344A (en) * | 1953-01-02 | 1956-06-05 | Burroughs Wellcome Co | Pyrimidine compounds |
| US3021332A (en) * | 1954-01-04 | 1962-02-13 | Burroughs Wellcome Co | Pyrido (2, 3-d) pyrimidine compounds and method of making |
| US2926166A (en) * | 1954-01-04 | 1960-02-23 | Burroughs Wellcome Co | Pyrido (2, 3-d) pyrimidine compounds and method of making |
| US2924599A (en) * | 1956-07-16 | 1960-02-09 | Anchor Chemical Company Ltd | Derivatives of 1:3:5-triazanaphthalene |
| US2937284A (en) * | 1958-05-01 | 1960-05-17 | Burroughs Wellcome Co | 2, 4-diamino-5, 6-dialkylpyrido (2, 3-d) pyrimidines and method |
| US3288792A (en) * | 1962-07-05 | 1966-11-29 | Burroughs Wellcome Co | Method of preparing 2, 4-diamino-6-alkylpyrido (2, 3-d) pyrimidines |
| DE3422824A1 (de) * | 1984-06-20 | 1986-01-02 | Celamerck Gmbh & Co Kg, 6507 Ingelheim | Neue herbizid wirksame sulfonylharnstoffe |
| US6194166B1 (en) * | 1993-05-24 | 2001-02-27 | Takara Shuzo Co., Ltd. | Gene regulating aureobasidin sensitivity |
| US5547954A (en) * | 1994-05-26 | 1996-08-20 | Fmc Corporation | 2,4-Diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides |
| US6262059B1 (en) * | 1995-06-07 | 2001-07-17 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with quinazoline derivatives |
| US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| PE20030008A1 (es) * | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
-
2004
- 2004-12-06 EA EA200600973A patent/EA010424B1/ru not_active IP Right Cessation
- 2004-12-06 DE DE602004012154T patent/DE602004012154T2/de not_active Expired - Fee Related
- 2004-12-06 KR KR1020067011800A patent/KR100816179B1/ko not_active IP Right Cessation
- 2004-12-06 AU AU2004303609A patent/AU2004303609A1/en not_active Abandoned
- 2004-12-06 UA UAA200606683A patent/UA83091C2/ru unknown
- 2004-12-06 CA CA002549510A patent/CA2549510A1/en not_active Abandoned
- 2004-12-06 MX MXPA06006777A patent/MXPA06006777A/es active IP Right Grant
- 2004-12-06 PT PT04801323T patent/PT1697356E/pt unknown
- 2004-12-06 AT AT04801323T patent/ATE387446T1/de not_active IP Right Cessation
- 2004-12-06 ES ES04801323T patent/ES2299888T3/es active Active
- 2004-12-06 US US10/595,766 patent/US20070135457A1/en not_active Abandoned
- 2004-12-06 DK DK04801323T patent/DK1697356T3/da active
- 2004-12-06 GE GEAP20049461A patent/GEP20094720B/en unknown
- 2004-12-06 PL PL04801323T patent/PL1697356T3/pl unknown
- 2004-12-06 JP JP2006544574A patent/JP4073944B2/ja not_active Expired - Fee Related
- 2004-12-06 EP EP04801323A patent/EP1697356B1/en active Active
- 2004-12-06 BR BRPI0417663-4A patent/BRPI0417663A/pt not_active IP Right Cessation
- 2004-12-06 CN CNB2004800376743A patent/CN100439366C/zh not_active Expired - Fee Related
- 2004-12-06 RS RSP-2008/0172A patent/RS50575B/sr unknown
- 2004-12-06 SI SI200430637T patent/SI1697356T1/sl unknown
- 2004-12-06 WO PCT/IB2004/004013 patent/WO2005061497A1/en active Application Filing
- 2004-12-06 AP AP2006003632A patent/AP2006003632A0/xx unknown
- 2004-12-15 TW TW093138972A patent/TWI291961B/zh active
- 2004-12-15 UY UY28671A patent/UY28671A1/es not_active Application Discontinuation
- 2004-12-15 GT GT200400268A patent/GT200400268A/es unknown
- 2004-12-15 AR ARP040104668A patent/AR046766A1/es not_active Application Discontinuation
- 2004-12-15 NL NL1027787A patent/NL1027787C2/nl not_active IP Right Cessation
- 2004-12-16 SV SV2004001979A patent/SV2005001979A/es not_active Application Discontinuation
- 2004-12-16 HN HN2004000538A patent/HN2004000538A/es unknown
-
2005
- 2005-01-03 PE PE2005000028A patent/PE20050681A1/es not_active Application Discontinuation
-
2006
- 2006-05-18 IS IS8474A patent/IS8474A/is unknown
- 2006-05-22 IL IL175813A patent/IL175813A0/en unknown
- 2006-06-15 ZA ZA200604970A patent/ZA200604970B/en unknown
- 2006-06-15 EC EC2006006643A patent/ECSP066643A/es unknown
- 2006-06-16 MA MA29113A patent/MA28270A1/fr unknown
- 2006-06-16 TN TNP2006000186A patent/TNSN06186A1/fr unknown
- 2006-07-11 NO NO20063231A patent/NO20063231L/no not_active Application Discontinuation
-
2008
- 2008-03-28 HR HR20080142T patent/HRP20080142T3/xx unknown
- 2008-06-27 CL CL200801920A patent/CL2008001920A1/es unknown
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