NO20053774L - Rekombinant VHH enkelt domene antilegeme av camelidade mot von Willebrand faktor (vWF) eller mot kollagen. - Google Patents

Rekombinant VHH enkelt domene antilegeme av camelidade mot von Willebrand faktor (vWF) eller mot kollagen.

Info

Publication number
NO20053774L
NO20053774L NO20053774A NO20053774A NO20053774L NO 20053774 L NO20053774 L NO 20053774L NO 20053774 A NO20053774 A NO 20053774A NO 20053774 A NO20053774 A NO 20053774A NO 20053774 L NO20053774 L NO 20053774L
Authority
NO
Norway
Prior art keywords
vwf
polypeptides
single domain
domain antibody
camelidade
Prior art date
Application number
NO20053774A
Other languages
English (en)
Other versions
NO337265B1 (no
Inventor
Karen Silence
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/BE2003/000192 external-priority patent/WO2004041862A2/en
Priority claimed from PCT/BE2003/000190 external-priority patent/WO2004041867A2/en
Priority claimed from PCT/BE2003/000189 external-priority patent/WO2005044858A1/en
Application filed by Ablynx Nv filed Critical Ablynx Nv
Publication of NO20053774L publication Critical patent/NO20053774L/no
Publication of NO337265B1 publication Critical patent/NO337265B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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Abstract

Sammendrag Foreliggende oppfinnelse angår polypeptider omfattende minst ett enkeltdomene antistoff rettet mot vWF, vWF Al domene, Al domene av aktivert vWF, vWF A3 domene, gpIb og/eller kollagen, homologer av nevnte polypeptider, og/eller funksjonelle deler av nevnte polypeptider, for behandlingen av betingelser som krever en modulering av blodplate-mediert aggregering og som overvinner problemene ifølge kjent teknikk. Et videre aspekt ifølge foreliggende oppfinnelse er fremgangsmåter for produksjon av nevnte polypeptider, fremgangsmåter for å belegge anordninger med slike polypeptider benyttet i medisinske prosedyrer (f.eks. PCTA, stenting), fremgangsmåter og sett for skreening for midler som modulerer blodplate-mediert aggregering og sett for diagnostisering av sykdommer relatert til blodplate-mediert aggregering.
NO20053774A 2003-01-10 2005-08-08 Et polypeptidkonstrukt rettet mot von Willebrand faktor, anvendelse av polypeptidkonstruktet, sammensetninger omfattende polypeptidkonstruktet, og fremgangsmåte for dets fremstilling. NO337265B1 (no)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
EP03447005 2003-01-10
EPPCT/EP03/06581 2003-06-23
EPPCT/EP03/07313 2003-07-08
PCT/BE2003/000192 WO2004041862A2 (en) 2002-11-08 2003-11-07 Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
PCT/BE2003/000190 WO2004041867A2 (en) 2002-11-08 2003-11-07 Camelidae antibodies against imminoglobulin e and use thereof for the treatment of allergic disorders
PCT/BE2003/000194 WO2004041863A2 (en) 2002-11-08 2003-11-07 Single domain antibodies directed against interferon- gamma and uses therefor
PCT/BE2003/000193 WO2004041865A2 (en) 2002-11-08 2003-11-07 Stabilized single domain antibodies
PCT/BE2003/000189 WO2005044858A1 (en) 2003-11-07 2003-11-07 Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor
BEPCT/BE03/00206 2003-12-01
BEPCT/BE03/00191 2003-12-02
PCT/BE2004/000002 WO2004062551A2 (en) 2003-01-10 2004-01-09 RECOMBINANT VHH SINGLE DOMAIN ANTIBODY FROM CAMELIDAE AGAINST VON WILLEBRAND FACTOR (vWF) OR AGAINST COLLAGEN

Publications (2)

Publication Number Publication Date
NO20053774L true NO20053774L (no) 2005-08-31
NO337265B1 NO337265B1 (no) 2016-02-29

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Application Number Title Priority Date Filing Date
NO20053774A NO337265B1 (no) 2003-01-10 2005-08-08 Et polypeptidkonstrukt rettet mot von Willebrand faktor, anvendelse av polypeptidkonstruktet, sammensetninger omfattende polypeptidkonstruktet, og fremgangsmåte for dets fremstilling.

Country Status (15)

Country Link
US (3) US9028816B2 (no)
EP (2) EP1587838B1 (no)
JP (1) JP2006517789A (no)
KR (2) KR20050092029A (no)
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