NO20050755L - Fremgangsmate for fremstilling av ketokarotenoider i plantefrukt - Google Patents

Fremgangsmate for fremstilling av ketokarotenoider i plantefrukt

Info

Publication number
NO20050755L
NO20050755L NO20050755A NO20050755A NO20050755L NO 20050755 L NO20050755 L NO 20050755L NO 20050755 A NO20050755 A NO 20050755A NO 20050755 A NO20050755 A NO 20050755A NO 20050755 L NO20050755 L NO 20050755L
Authority
NO
Norway
Prior art keywords
ketocarotenoids
preparation
plant fruit
genetically modified
modified organisms
Prior art date
Application number
NO20050755A
Other languages
English (en)
Inventor
Christel Renate Schopfer
Ralf Flachmann
Karin Herbers
Irene Kunze
Matt Sauer
Martin Klebsattel
Original Assignee
Sungene Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10238979A external-priority patent/DE10238979A1/de
Priority claimed from DE10238978A external-priority patent/DE10238978A1/de
Priority claimed from DE2002138980 external-priority patent/DE10238980A1/de
Priority claimed from DE2002153112 external-priority patent/DE10253112A1/de
Priority claimed from DE2002158971 external-priority patent/DE10258971A1/de
Application filed by Sungene Gmbh & Co Kgaa filed Critical Sungene Gmbh & Co Kgaa
Publication of NO20050755L publication Critical patent/NO20050755L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40—Colouring or decolouring of foods
    • A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
    • A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B61/00—Dyes of natural origin prepared from natural sources, e.g. vegetable sources
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
    • C12N15/823—Reproductive tissue-specific promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/825—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving pigment biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
    • Y02A40/81—Aquaculture, e.g. of fish
    • Y02A40/818—Alternative feeds for fish, e.g. in aquacultures

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Animal Husbandry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Insects & Arthropods (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Birds (AREA)
  • Physiology (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fodder In General (AREA)

Abstract

Oppfinnelsen angår en metode for fremstilling av ketokarotenoider ved dyrking av genetisk modifisert planter som fremviser en ketolaseaktivitet i frukter.
NO20050755A 2002-08-20 2005-02-11 Fremgangsmate for fremstilling av ketokarotenoider i plantefrukt NO20050755L (no)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE10238979A DE10238979A1 (de) 2002-08-20 2002-08-20 Verfahren zur Herstellung von Zeaxanthin und/oder dessen biosynthetischen Zwischen- und/oder Folgeprodukten
DE10238978A DE10238978A1 (de) 2002-08-20 2002-08-20 Verfahren zur Herstellung von Ketocarotinoiden in Früchten von Pflanzen
DE2002138980 DE10238980A1 (de) 2002-08-20 2002-08-20 Verfahren zur Herstellung von Ketocarotinoiden in Blütenblättern von Pflanzen
DE2002153112 DE10253112A1 (de) 2002-11-13 2002-11-13 Verfahren zur Herstellung von Ketocarotinoiden in genetisch veränderten Organismen
DE2002158971 DE10258971A1 (de) 2002-12-16 2002-12-16 Verwendung von astaxanthinhaltigen Pflanzen oder Pflanzenteilen der Gattung Tagetes als Futtermittel
PCT/EP2003/009107 WO2004018695A2 (de) 2002-08-20 2003-08-18 Verfahren zur herstellung von ketocarotinoiden in früchten von pflanzen

Publications (1)

Publication Number Publication Date
NO20050755L true NO20050755L (no) 2005-05-19

Family

ID=31950810

Family Applications (5)

Application Number Title Priority Date Filing Date
NO20050598A NO20050598L (no) 2002-08-20 2005-02-03 Fremsgangmate for fremstilling av zeaxantin og/eller biosyntetiske mellomprodukter og/eller folgeprodukter derav
NO20050705A NO20050705L (no) 2002-08-20 2005-02-09 Fremgangsmate for fremstilling av ketokarotinoider i blomsterblader fra planter
NO20050704A NO20050704L (no) 2002-08-20 2005-02-09 Anvendelse av astaxantin-inneholdende planter eller deler av planter av slekten Tagetes som dyrefor
NO20050703A NO20050703L (no) 2002-08-20 2005-02-09 Fremgangsmate for fremstilling av ketokarotinoider i genetisk modifiserte organismer
NO20050755A NO20050755L (no) 2002-08-20 2005-02-11 Fremgangsmate for fremstilling av ketokarotenoider i plantefrukt

Family Applications Before (4)

Application Number Title Priority Date Filing Date
NO20050598A NO20050598L (no) 2002-08-20 2005-02-03 Fremsgangmate for fremstilling av zeaxantin og/eller biosyntetiske mellomprodukter og/eller folgeprodukter derav
NO20050705A NO20050705L (no) 2002-08-20 2005-02-09 Fremgangsmate for fremstilling av ketokarotinoider i blomsterblader fra planter
NO20050704A NO20050704L (no) 2002-08-20 2005-02-09 Anvendelse av astaxantin-inneholdende planter eller deler av planter av slekten Tagetes som dyrefor
NO20050703A NO20050703L (no) 2002-08-20 2005-02-09 Fremgangsmate for fremstilling av ketokarotinoider i genetisk modifiserte organismer

Country Status (12)

Country Link
US (5) US20060031963A1 (no)
EP (5) EP1531683B1 (no)
CN (1) CN1675367A (no)
AT (1) ATE484198T1 (no)
AU (5) AU2003258623A1 (no)
CA (5) CA2496133A1 (no)
DE (1) DE50313184D1 (no)
IL (4) IL166507A0 (no)
MX (5) MXPA05001659A (no)
NO (5) NO20050598L (no)
WO (5) WO2004018695A2 (no)
ZA (1) ZA200602230B (no)

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US20060107352A1 (en) * 2002-08-20 2006-05-18 Sungene Gmbh & Co. Kgaa Transgenic expression cassettes for expression of nucleic acids in the plant blooms
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EP1532256A1 (de) * 2002-08-20 2005-05-25 Sungene GmbH & Co. KGaA VERFAHREN ZUR HERSTELLUNG VON &bgr;-CAROTINOIDEN
EP1554388A1 (de) * 2002-10-11 2005-07-20 Sungene GmbH & Co. KGaA Transgene expressionskassetten zur expression von nukleinsäuren in der pflanzlichen blüte
DE10300649A1 (de) * 2003-01-09 2004-07-22 Basf Ag Verfahren zur Herstellung von Ketocarotinoiden durch Kultivierung von genetisch veränderten Organismen
EP1780281B1 (en) * 2004-06-04 2013-12-11 Kirin Holdings Kabushiki Kaisha Method of producing astaxanthin or metabolic product thereof by using carotenoid ketolase and carotenoid hydroxylase genes
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BRPI0806029A2 (pt) * 2007-07-19 2009-11-10 Biosigma Sa plasmìdeos para transformação de bactérias do gênero aciditiobacillus spp. e método de transformação
US20090093015A1 (en) * 2007-10-09 2009-04-09 Kemin Foods, L.C. Beta-cryptoxanthin production using a novel lycopene beta-monocyclase gene
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WO2010079032A1 (en) * 2008-12-17 2010-07-15 Basf Plant Science Gmbh Production of ketocarotenoids in plants
KR101983115B1 (ko) * 2011-08-08 2019-05-29 에볼바 에스아 사프란 화합물의 재조합 생성을 위한 방법 및 물질
CN114748605A (zh) 2011-11-29 2022-07-15 普罗克拉拉生物科学股份有限公司 噬菌体基因3蛋白组合物及作为淀粉样蛋白结合剂的用途
ES2558953B1 (es) * 2015-11-23 2016-11-18 Universitat De Lleida Maíz enriquecido en antioxidantes para mejorar la calidad nutricional del huevo
JP2019165635A (ja) * 2016-08-10 2019-10-03 味の素株式会社 Ｌ−アミノ酸の製造法
US10004253B1 (en) * 2017-09-05 2018-06-26 Jose-Odon Torres-Quiroga Method for increasing the health condition of crustaceans in aquaculture, survival rate and pigmentation
CN112458103B (zh) * 2021-01-28 2022-09-30 青岛农业大学 一种调控辣椒红素积累的基因CaBBX20及其应用

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CA2496133A1 (en) * 2002-08-20 2004-03-04 Sungene Gmbh & Co. Kgaa Method for the production of ketocarotinoids in flower petals on plants
DE10300649A1 (de) * 2003-01-09 2004-07-22 Basf Ag Verfahren zur Herstellung von Ketocarotinoiden durch Kultivierung von genetisch veränderten Organismen
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Also Published As

Publication number Publication date
MXPA05001948A (es) 2005-09-08
MXPA05001899A (es) 2005-08-29
WO2004018693A3 (de) 2004-12-09
WO2004018695A3 (de) 2004-10-14
ATE484198T1 (de) 2010-10-15
US20060112451A1 (en) 2006-05-25
WO2004017749A3 (de) 2004-10-14
ZA200602230B (en) 2007-05-30
AU2003264062A1 (en) 2004-03-11
WO2004018693A2 (de) 2004-03-04
EP1531683B1 (de) 2010-10-13
MXPA05001659A (es) 2005-07-22
US7385123B2 (en) 2008-06-10
US7381541B2 (en) 2008-06-03
AU2003260424A1 (en) 2004-03-11
NO20050703L (no) 2005-05-09
CA2495235A1 (en) 2004-03-04
EP1532266A2 (de) 2005-05-25
CN1675367A (zh) 2005-09-28
DE50313184D1 (de) 2010-11-25
EP1531683A2 (de) 2005-05-25
WO2004018695A2 (de) 2004-03-04
MXPA05001944A (es) 2005-06-22
IL166771A0 (en) 2006-01-15
EP1542945A2 (de) 2005-06-22
AU2003260423A1 (en) 2004-03-11
WO2004018694A2 (de) 2004-03-04
WO2004017749A2 (de) 2004-03-04
MXPA05001811A (es) 2005-10-19
EP1532264A2 (de) 2005-05-25
WO2004018694A3 (de) 2004-09-10
NO20050598L (no) 2005-04-07
NO20050705L (no) 2005-05-18
US20070094749A1 (en) 2007-04-26
CA2495444A1 (en) 2004-03-04
WO2004018385A3 (de) 2004-10-21
NO20050704L (no) 2005-05-13
US20050281909A1 (en) 2005-12-22
AU2003253416A1 (en) 2004-03-11
CA2496133A1 (en) 2004-03-04
AU2003258623A1 (en) 2004-03-11
IL166507A0 (en) 2006-01-15
AU2003264062B2 (en) 2008-01-03
CA2496207A1 (en) 2004-03-04
CA2495878A1 (en) 2004-03-04
IL166770A0 (en) 2006-01-15
IL166767A0 (en) 2006-01-15
US20060031963A1 (en) 2006-02-09
US20060253927A1 (en) 2006-11-09
WO2004018385A2 (de) 2004-03-04
EP1532265A2 (de) 2005-05-25

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