NO20045699L - Bisindolyl-maleimidderivater som kinaseinhibitorer - Google Patents
Bisindolyl-maleimidderivater som kinaseinhibitorerInfo
- Publication number
- NO20045699L NO20045699L NO20045699A NO20045699A NO20045699L NO 20045699 L NO20045699 L NO 20045699L NO 20045699 A NO20045699 A NO 20045699A NO 20045699 A NO20045699 A NO 20045699A NO 20045699 L NO20045699 L NO 20045699L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- kinase inhibitors
- kinase
- bisindolyl
- methods
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- 150000003924 bisindolylmaleimides Chemical class 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- DXGTUUQHTDOFFQ-UHFFFAOYSA-N [N].C1=CC=C2NC=CC2=C1 Chemical group [N].C1=CC=C2NC=CC2=C1 DXGTUUQHTDOFFQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940127263 dual kinase inhibitor Drugs 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000000771 oncological effect Effects 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003236 pyrrolines Chemical class 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Oncology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38593502P | 2002-06-05 | 2002-06-05 | |
| PCT/US2003/017569 WO2003104222A1 (en) | 2002-06-05 | 2003-06-04 | Bisindolyl-maleimid derivatives as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20045699L true NO20045699L (no) | 2005-01-28 |
Family
ID=29736126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20045699A NO20045699L (no) | 2002-06-05 | 2004-12-29 | Bisindolyl-maleimidderivater som kinaseinhibitorer |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6987110B2 (enExample) |
| EP (1) | EP1513830A1 (enExample) |
| JP (1) | JP2005531609A (enExample) |
| KR (1) | KR20050008787A (enExample) |
| CN (1) | CN1671694A (enExample) |
| AU (1) | AU2003238874A1 (enExample) |
| BR (1) | BR0311821A (enExample) |
| CA (1) | CA2488602A1 (enExample) |
| CR (1) | CR7606A (enExample) |
| IL (1) | IL165515A0 (enExample) |
| MX (1) | MXPA04012188A (enExample) |
| NO (1) | NO20045699L (enExample) |
| RU (1) | RU2004135382A (enExample) |
| WO (1) | WO2003104222A1 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2003117078A (ru) * | 2000-12-08 | 2004-12-10 | Орто-Макнейл Фармасьютикал, Инк. (Us) | Индазолил-замещенные соединения пирролина в качестве ингибиторов киназы |
| SE0302546D0 (sv) * | 2003-09-24 | 2003-09-24 | Astrazeneca Ab | New compounds |
| SE0200979D0 (sv) * | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
| ES2300573T3 (es) * | 2002-05-08 | 2008-06-16 | Janssen Pharmaceutica Nv | Inhibidores de cinasa sustituidos con pirrolina. |
| JP2005531607A (ja) * | 2002-06-05 | 2005-10-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼ阻害剤として置換ピロリン |
| CA2393720C (en) * | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
| AU2002951253A0 (en) * | 2002-09-06 | 2002-09-19 | Medvet Science Pty. Ltd. | A method of modulating cellular activity |
| CA2520590A1 (en) * | 2003-03-27 | 2004-11-04 | Janssen Pharmaceutica, N.V. | Substituted pyrroline kinase inhibitors |
| EA200600032A1 (ru) * | 2003-06-13 | 2006-06-30 | Янссен Фармацевтика Н.В. | Замещённые производные индазолил (индолил) малеимида в качестве ингибиторов киназ |
| EP1723427A2 (en) * | 2004-02-26 | 2006-11-22 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with glycogen synthase kinase 3 beta (gsk3b) |
| WO2005095983A1 (en) * | 2004-03-04 | 2005-10-13 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with protein kinase c, gamma (prkcg) |
| RU2413511C2 (ru) * | 2004-04-08 | 2011-03-10 | Новартис Аг | Ингибиторы протеинкиназы с, предназначенные для лечения аутоиммунных заболеваний и отторжения трансплантата |
| CA2560311A1 (en) * | 2004-04-08 | 2005-10-20 | Novartis Ag | Protein kinase c inhibitors for the treatment of autoimmune diseases and of transplant rejection |
| US20060079568A1 (en) * | 2004-05-21 | 2006-04-13 | The Texas A&M University System | Inhibition of atherosclerosis by diindolylmethane analogs |
| EP1662259A1 (en) * | 2004-11-25 | 2006-05-31 | Cellzome Ag | Use of Eph receptor inhibitors for the treatment of neurodegenerative diseases |
| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| AU2006255183B2 (en) * | 2005-06-08 | 2012-02-02 | Centocor, Inc. | A cellular therapy for ocular degeneration |
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| US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| EP1940411A4 (en) * | 2005-09-29 | 2008-10-29 | Janssen Pharmaceutica Nv | MACROHETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
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| WO2007123233A1 (ja) | 2006-04-25 | 2007-11-01 | Kyushu University, National University Corporation | 動脈硬化性疾患関連遺伝子、およびその利用 |
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| JP2008063278A (ja) * | 2006-09-07 | 2008-03-21 | Fujifilm Finechemicals Co Ltd | １−ピリジン−４−イル−インドール類の製造方法 |
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| AU2013368221B2 (en) | 2012-12-31 | 2018-11-01 | Janssen Biotech, Inc. | Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells |
| EP4219683A1 (en) | 2012-12-31 | 2023-08-02 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators |
| CA2949056C (en) | 2014-05-16 | 2025-10-07 | Janssen Biotech, Inc. | USE OF SMALL MOLECULES TO IMPROVE MAFA GENE EXPRESSION IN PANCREATIC ENDOCRINE CELLS |
| MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| CN105777751B (zh) * | 2016-04-26 | 2018-12-11 | 浙江工业大学 | 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用 |
| EP3920885A1 (en) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ227850A (en) | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
| GB8904161D0 (en) | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
| US5624949A (en) | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| AU1339895A (en) * | 1993-12-23 | 1995-07-10 | Eli Lilly And Company | Protein kinase c inhibitors |
| JP3258334B2 (ja) | 1996-03-20 | 2002-02-18 | イーライ・リリー・アンド・カンパニー | インドリルマレイミドの合成 |
| SE9603283D0 (sv) * | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
| EP1057484A4 (en) | 1998-02-23 | 2002-11-20 | Sagami Chem Res | INHIBITORS OF CELL DEATH |
| IL141080A0 (en) | 1998-07-30 | 2002-02-10 | Japan Tobacco Inc | Disubstituted maleimide derivatives and pharmaceutical compositions containing the same |
| DE69922526T2 (de) | 1998-10-08 | 2005-06-02 | Smithkline Beecham Plc, Brentford | 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) |
| WO2002010158A2 (en) | 2000-07-27 | 2002-02-07 | F. Hoffmann-La Roche Ag | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta |
| CA2428133C (en) | 2000-11-07 | 2009-12-29 | Novartis Ag | Indolylmaleimide derivatives as protein kinase c inhibitors |
-
2003
- 2003-06-04 US US10/454,069 patent/US6987110B2/en not_active Expired - Fee Related
- 2003-06-04 KR KR10-2004-7019678A patent/KR20050008787A/ko not_active Withdrawn
- 2003-06-04 RU RU2004135382/04A patent/RU2004135382A/ru not_active Application Discontinuation
- 2003-06-04 JP JP2004511292A patent/JP2005531609A/ja not_active Withdrawn
- 2003-06-04 EP EP03734389A patent/EP1513830A1/en not_active Withdrawn
- 2003-06-04 AU AU2003238874A patent/AU2003238874A1/en not_active Abandoned
- 2003-06-04 CA CA002488602A patent/CA2488602A1/en not_active Abandoned
- 2003-06-04 MX MXPA04012188A patent/MXPA04012188A/es unknown
- 2003-06-04 CN CNA038184788A patent/CN1671694A/zh active Pending
- 2003-06-04 BR BR0311821-5A patent/BR0311821A/pt not_active IP Right Cessation
- 2003-06-04 WO PCT/US2003/017569 patent/WO2003104222A1/en not_active Ceased
-
2004
- 2004-12-02 IL IL16551504A patent/IL165515A0/xx unknown
- 2004-12-06 CR CR7606A patent/CR7606A/es unknown
- 2004-12-29 NO NO20045699A patent/NO20045699L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003238874A1 (en) | 2003-12-22 |
| RU2004135382A (ru) | 2005-06-27 |
| JP2005531609A (ja) | 2005-10-20 |
| WO2003104222A1 (en) | 2003-12-18 |
| CR7606A (es) | 2009-01-16 |
| US6987110B2 (en) | 2006-01-17 |
| US20040059113A1 (en) | 2004-03-25 |
| CA2488602A1 (en) | 2003-12-18 |
| KR20050008787A (ko) | 2005-01-21 |
| EP1513830A1 (en) | 2005-03-16 |
| CN1671694A (zh) | 2005-09-21 |
| BR0311821A (pt) | 2005-04-05 |
| MXPA04012188A (es) | 2005-07-25 |
| IL165515A0 (en) | 2006-01-15 |
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