DE60204463D1 - Substituierte 8-Arylchinoline als PDE4-Hemmer - Google Patents

Substituierte 8-Arylchinoline als PDE4-Hemmer

Info

Publication number
DE60204463D1
DE60204463D1 DE60204463T DE60204463T DE60204463D1 DE 60204463 D1 DE60204463 D1 DE 60204463D1 DE 60204463 T DE60204463 T DE 60204463T DE 60204463 T DE60204463 T DE 60204463T DE 60204463 D1 DE60204463 D1 DE 60204463D1
Authority
DE
Germany
Prior art keywords
sup
arylquinolines
pde4 inhibitors
substituted
arthritis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60204463T
Other languages
English (en)
Other versions
DE60204463T2 (de
Inventor
Daniel Dube
Yves Girard
Dwight Macdonald
Anthony Mastracchio
Michel Gallant
Patrick Lacombe
Denis Deschenes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Canada Inc
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Publication of DE60204463D1 publication Critical patent/DE60204463D1/de
Application granted granted Critical
Publication of DE60204463T2 publication Critical patent/DE60204463T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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    • C07D215/14—Radicals substituted by oxygen atoms
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    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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DE60204463T 2001-06-27 2002-06-26 Substituierte 8-Arylchinoline als PDE4-Hemmer Expired - Fee Related DE60204463T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30122001P 2001-06-27 2001-06-27
US301220P 2001-06-27
US30347201P 2001-07-06 2001-07-06
US303472P 2001-07-06
PCT/CA2002/000953 WO2003002118A1 (en) 2001-06-27 2002-06-26 Substituted 8-arylquinoline pde4 inhibitors

Publications (2)

Publication Number Publication Date
DE60204463D1 true DE60204463D1 (de) 2005-07-07
DE60204463T2 DE60204463T2 (de) 2006-05-18

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DE60204463T Expired - Fee Related DE60204463T2 (de) 2001-06-27 2002-06-26 Substituierte 8-Arylchinoline als PDE4-Hemmer

Country Status (9)

Country Link
US (1) US6919353B2 (de)
EP (1) EP1404330B1 (de)
JP (1) JP2005501822A (de)
AT (1) ATE296630T1 (de)
AU (1) AU2002344885C1 (de)
CA (1) CA2450686A1 (de)
DE (1) DE60204463T2 (de)
ES (1) ES2242036T3 (de)
WO (1) WO2003002118A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2479069A1 (en) * 2002-03-18 2003-09-25 Merck Frosst Canada & Co./Merck Frosst Canada & Cie Hetero-bridge substituted 8-arylquinoline pde4 inhibitors
WO2004026794A2 (en) * 2002-09-17 2004-04-01 Merck & Co., Inc. Removal of aldehyde impurity by reactive polystyrene resin
JP2006524638A (ja) * 2003-04-30 2006-11-02 メルク フロスト カナダ リミテツド ８−（３−ビアリール）フェニルキノリン系ホスホジエステラーゼ−４阻害薬
EP1732900A4 (de) * 2004-03-25 2007-12-12 Synta Pharmaceuticals Corp Acrylnitrilderivate für entzündungs- und immunspezifische verwendungen
CN100425591C (zh) * 2005-09-26 2008-10-15 山东大学 含有磺酰基二苯基乙烯桥化合物及其制法和药物应用
CA2628570A1 (en) 2005-11-09 2007-05-18 Combinatorx, Incorporated Methods, compositions, and kits for the treatment of medical conditions
ATE535244T1 (de) 2006-07-05 2011-12-15 Nycomed Gmbh Kombination aus atorvastatin mit einem phosphodiesterase-4-hemmer zur behandlung von entzündlichen lungenerkrankungen
RU2474581C2 (ru) 2007-12-26 2013-02-10 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Способ получения замещенных гетероциклом производных пиридина
US8367829B2 (en) 2010-05-10 2013-02-05 Gilead Sciences, Inc. Bi-functional pyrazolopyridine compounds
EP2569285A1 (de) 2010-05-10 2013-03-20 Gilead Sciences, Inc. Bifunktionelle chinolinderivate
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AU2002344885B2 (en) 2006-06-29
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EP1404330A1 (de) 2004-04-07
DE60204463T2 (de) 2006-05-18
WO2003002118A1 (en) 2003-01-09
ES2242036T3 (es) 2005-11-01
CA2450686A1 (en) 2003-01-09
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JP2005501822A (ja) 2005-01-20
AU2002344885C1 (en) 2006-11-09

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