NO20030111L - Kjemokinreseptor-modulatorer, deres fremstilling og anvendelse - Google Patents
Kjemokinreseptor-modulatorer, deres fremstilling og anvendelseInfo
- Publication number
- NO20030111L NO20030111L NO20030111A NO20030111A NO20030111L NO 20030111 L NO20030111 L NO 20030111L NO 20030111 A NO20030111 A NO 20030111A NO 20030111 A NO20030111 A NO 20030111A NO 20030111 L NO20030111 L NO 20030111L
- Authority
- NO
- Norway
- Prior art keywords
- terminus
- chemokine receptor
- treatment
- terminal
- analogs
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Kjemokinreseptor-modulatorer omfattende en kjemisk modifisert karboksyl-terminus (C-terminus) og/eller amino-terminus (N- terminus) for å modulere potens og farmakokinetikkegenskaper, og fremgangsmåte for fremstilling og anvendelse er omtalt. Forbindelsene og fremgangsmåtene ifølge oppfinnelsen er eksemplifisert ved nye N-terminal, C-terminal og N/C-terminal analoger av CC og CXC kjemokiner. Kjemokinreseptor-modula-toranalogene ifølge oppfinnelsen er anvendbare for behandling av lidelser som involverer det naturlig forekommende kjemokin som analogene ifølge oppfinnelsen antagoniserer, slik som for behandling av HTV og AIDS relaterte lidelser og for behandling av astma, allergisk rhinitt, atopisk dermatitt, aterom/- aterosklerose, organtransplantatavstøtning og revmatoid artritt.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21768300P | 2000-07-12 | 2000-07-12 | |
PCT/US2001/021934 WO2002004499A1 (en) | 2000-07-12 | 2001-07-12 | Chemokine receptor modulators, production and use |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20030111D0 NO20030111D0 (no) | 2003-01-09 |
NO20030111L true NO20030111L (no) | 2003-03-12 |
Family
ID=22812056
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20030110A NO20030110L (no) | 2000-07-12 | 2003-01-09 | Polymer-modifiserte bioaktive syntetiske kjemokiner, fremgangsmåter for deres fremstilling og anvendelse |
NO20030111A NO20030111L (no) | 2000-07-12 | 2003-01-09 | Kjemokinreseptor-modulatorer, deres fremstilling og anvendelse |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20030110A NO20030110L (no) | 2000-07-12 | 2003-01-09 | Polymer-modifiserte bioaktive syntetiske kjemokiner, fremgangsmåter for deres fremstilling og anvendelse |
Country Status (14)
Country | Link |
---|---|
US (1) | US20050089970A1 (no) |
EP (2) | EP1307216A4 (no) |
JP (3) | JP2004502783A (no) |
KR (2) | KR20030036591A (no) |
CN (2) | CN1460023A (no) |
AU (2) | AU2002218769A1 (no) |
BR (2) | BR0112429A (no) |
CA (2) | CA2412150A1 (no) |
IL (2) | IL153789A0 (no) |
MX (2) | MXPA03000310A (no) |
NO (2) | NO20030110L (no) |
RU (1) | RU2003104024A (no) |
WO (2) | WO2002004015A1 (no) |
ZA (2) | ZA200300313B (no) |
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WO2004017999A1 (en) * | 2002-08-16 | 2004-03-04 | University Of Bern | Non-glycosylated polyacrylamide conjugates and their use for cytoprotection |
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US7166574B2 (en) | 2002-08-20 | 2007-01-23 | Biosurface Engineering Technologies, Inc. | Synthetic heparin-binding growth factor analogs |
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US7414028B1 (en) | 2004-02-04 | 2008-08-19 | Biosurface Engineering Technologies, Inc. | Growth factor analogs |
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US7528105B1 (en) | 2004-02-10 | 2009-05-05 | Biosurface Engineering Technologies | Heterodimeric chain synthetic heparin-binding growth factor analogs |
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EP1732942A4 (en) * | 2004-03-30 | 2008-12-03 | Amylin Pharmaceuticals Inc | SYNTHETIC CHEMOKINES, MANUFACTURING METHODS AND APPLICATIONS |
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CN110892990B (zh) * | 2019-10-11 | 2023-03-31 | 内蒙古伊利实业集团股份有限公司 | 益生菌益生元食用组合物及其应用 |
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JP4454152B2 (ja) * | 1998-07-22 | 2010-04-21 | オスプレイ・ファーマシューティカルズ・ユーエスエイ・インコーポレイテッド | 二次的組織損傷ならびにその他の炎症症状および疾患を治療する方法および組成物 |
JP2004508338A (ja) * | 2000-09-08 | 2004-03-18 | グリフォン セラピューティクス,インコーポレーテッド | ポリマー修飾合成タンパク質 |
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Also Published As
Publication number | Publication date |
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AU2001273387A1 (en) | 2002-01-21 |
KR20030036591A (ko) | 2003-05-09 |
CA2412162A1 (en) | 2002-01-17 |
CA2412150A1 (en) | 2002-01-17 |
EP1307216A4 (en) | 2005-01-12 |
KR20030032977A (ko) | 2003-04-26 |
RU2003104024A (ru) | 2004-06-27 |
NO20030111D0 (no) | 2003-01-09 |
AU2002218769A1 (en) | 2002-01-21 |
ZA200300312B (en) | 2004-02-04 |
CN1441808A (zh) | 2003-09-10 |
WO2002004499A1 (en) | 2002-01-17 |
EP1299415A1 (en) | 2003-04-09 |
JP2007302667A (ja) | 2007-11-22 |
EP1307216A1 (en) | 2003-05-07 |
BR0112428A (pt) | 2003-11-25 |
US20050089970A1 (en) | 2005-04-28 |
BR0112429A (pt) | 2003-12-30 |
CN1460023A (zh) | 2003-12-03 |
JP2004502783A (ja) | 2004-01-29 |
NO20030110L (no) | 2003-03-12 |
NO20030110D0 (no) | 2003-01-09 |
EP1299415A4 (en) | 2005-01-19 |
MXPA03000310A (es) | 2004-12-13 |
JP2004517040A (ja) | 2004-06-10 |
WO2002004015A9 (en) | 2003-08-07 |
MXPA03000311A (es) | 2004-12-13 |
ZA200300313B (en) | 2004-02-04 |
IL153785A0 (en) | 2003-07-31 |
IL153789A0 (en) | 2003-07-31 |
WO2002004015A1 (en) | 2002-01-17 |
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