EP0233222A4
(en)
*
|
1985-07-19 |
1987-10-19 |
Armtech Ltd |
FIREARMS WITH DISC SHAPE CHARGER.
|
US7863444B2
(en)
*
|
1997-03-19 |
2011-01-04 |
Abbott Laboratories |
4-aminopyrrolopyrimidines as kinase inhibitors
|
US7223724B1
(en)
|
1999-02-08 |
2007-05-29 |
Human Genome Sciences, Inc. |
Use of vascular endothelial growth factor to treat photoreceptor cells
|
US6921763B2
(en)
*
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
AU8473401A
(en)
*
|
2000-08-04 |
2002-02-18 |
Human Genome Sciences, Inc. |
Vascular endothelial growth factor 2
|
MXPA03008560A
(es)
*
|
2001-03-22 |
2004-06-30 |
Abbot Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos.
|
DE60236646D1
(de)
*
|
2001-04-13 |
2010-07-22 |
Human Genome Sciences Inc |
Anti-VEGF-2 Antikörper
|
US20050232921A1
(en)
*
|
2001-04-13 |
2005-10-20 |
Rosen Craig A |
Vascular endothelial growth factor 2
|
EP1385862A4
(en)
*
|
2001-04-13 |
2005-03-02 |
Human Genome Sciences Inc |
VASCULAR ENDOTHEL GROWTH FACTOR 2
|
PL366934A1
(en)
|
2001-04-30 |
2005-02-07 |
Glaxo Group Limited |
Fused pyrimidines as antagonists of the corticotropin releasing factor (crf)
|
WO2003029209A2
(en)
*
|
2001-10-02 |
2003-04-10 |
Smithkline Beecham Corporation |
Chemical compounds
|
US20030187026A1
(en)
|
2001-12-13 |
2003-10-02 |
Qun Li |
Kinase inhibitors
|
US20030199525A1
(en)
*
|
2002-03-21 |
2003-10-23 |
Hirst Gavin C. |
Kinase inhibitors
|
US20030225273A1
(en)
*
|
2002-03-21 |
2003-12-04 |
Michaelides Michael R. |
Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
|
US6695881B2
(en)
|
2002-04-29 |
2004-02-24 |
Alcon, Inc. |
Accommodative intraocular lens
|
US7456222B2
(en)
*
|
2002-05-17 |
2008-11-25 |
Sequella, Inc. |
Anti tubercular drug: compositions and methods
|
US20040033986A1
(en)
*
|
2002-05-17 |
2004-02-19 |
Protopopova Marina Nikolaevna |
Anti tubercular drug: compositions and methods
|
US7652039B2
(en)
*
|
2002-05-17 |
2010-01-26 |
Sequella, Inc. |
Methods of use and compositions for the diagnosis and treatment of infectious disease
|
JP2006514918A
(ja)
*
|
2002-07-23 |
2006-05-18 |
スミスクライン ビーチャム コーポレーション |
キナーゼインヒビターとしてのピラゾロピリミジン
|
WO2004009602A1
(en)
*
|
2002-07-23 |
2004-01-29 |
Smithkline Beecham Corporation |
Pyrazolopyrimidines as kinase inhibitors
|
EP1523314A2
(en)
*
|
2002-07-23 |
2005-04-20 |
SmithKline Beecham Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
ATE323702T1
(de)
|
2002-08-06 |
2006-05-15 |
Astrazeneca Ab |
Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität
|
GB0226370D0
(en)
*
|
2002-11-12 |
2002-12-18 |
Novartis Ag |
Organic compounds
|
GB0230089D0
(en)
*
|
2002-12-24 |
2003-01-29 |
Astrazeneca Ab |
Therapeutic agents
|
PL377847A1
(pl)
|
2003-01-14 |
2006-02-20 |
Arena Pharmaceuticals Inc. |
1,2,3-Tripodstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu oraz profilaktyka i leczenie związanych z nim zaburzeń takich jak cukrzyca i hiperglikemia
|
US20050008640A1
(en)
*
|
2003-04-23 |
2005-01-13 |
Wendy Waegell |
Method of treating transplant rejection
|
US7429596B2
(en)
*
|
2003-06-20 |
2008-09-30 |
The Regents Of The University Of California |
1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
|
EA010023B1
(ru)
*
|
2003-07-14 |
2008-06-30 |
Арена Фармасьютикалз, Инк. |
Конденсированные арильные и гетероарильные производные в качестве модуляторов метаболизма и для профилактики и лечения расстройств, связанных с нарушением метаболизма
|
WO2005034857A2
(en)
*
|
2003-09-05 |
2005-04-21 |
Sequella, Inc. |
Methods and compositions comprising diamines as new anti-tubercular therapeutics
|
SG148161A1
(en)
|
2003-11-05 |
2008-12-31 |
Palingen Inc |
Enhanced b cell cytotoxicity of cdim binding antibody
|
GB0401334D0
(en)
*
|
2004-01-21 |
2004-02-25 |
Novartis Ag |
Organic compounds
|
JP2007520559A
(ja)
*
|
2004-02-03 |
2007-07-26 |
アボット・ラボラトリーズ |
治療薬としてのアミノベンゾオキサゾール類
|
EP1737865A1
(en)
*
|
2004-02-27 |
2007-01-03 |
F.Hoffmann-La Roche Ag |
Fused derivatives of pyrazole
|
MXPA06010667A
(es)
*
|
2004-03-19 |
2007-07-04 |
Penn State Res Found |
Metodos combinatorios y composiciones para el tratamiento de melanoma.
|
WO2005112936A1
(en)
*
|
2004-05-14 |
2005-12-01 |
The Regents Of The University Of Michigan |
Compositions and methods relating to protein kinase inhibitors
|
WO2005117932A1
(en)
*
|
2004-06-04 |
2005-12-15 |
The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations |
Bisubstrate inhibitors of protein tyrosine kinases as therapeutic agents
|
WO2006115509A2
(en)
|
2004-06-24 |
2006-11-02 |
Novartis Vaccines And Diagnostics Inc. |
Small molecule immunopotentiators and assays for their detection
|
EP1814913B1
(en)
|
2004-11-05 |
2015-08-19 |
IGM Biosciences, Inc. |
Antibody induced cell membrane wounding
|
EP1831225A2
(en)
|
2004-11-19 |
2007-09-12 |
The Regents of the University of California |
Anti-inflammatory pyrazolopyrimidines
|
DOP2006000009A
(es)
*
|
2005-01-13 |
2006-08-15 |
Arena Pharm Inc |
Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina
|
EP1932839A4
(en)
*
|
2005-09-06 |
2014-09-10 |
Shionogi & Co |
INDOLECARBOXYLATE ACID DERIVATIVE HAVING ANTAGONIST EFFECT OF THE PGD2 RECEPTOR
|
US20070072933A1
(en)
*
|
2005-09-26 |
2007-03-29 |
Peyman Gholam A |
Delivery of an ocular agent
|
EP2385053B1
(en)
|
2005-11-17 |
2013-10-02 |
OSI Pharmaceuticals, Inc. |
Intermediates for the preparation of fused bicyclic mTOR inhibitors
|
PE20070855A1
(es)
*
|
2005-12-02 |
2007-10-14 |
Bayer Pharmaceuticals Corp |
Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
|
US8338594B2
(en)
*
|
2005-12-02 |
2012-12-25 |
Bayer Healthcare Llc |
Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
|
MX2008007103A
(es)
*
|
2005-12-02 |
2008-09-12 |
Bayer Healthcare Llc |
Derivados 4-amino-pirrolotriazina sustituidos, útiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogenesis.
|
EP1973917B1
(en)
*
|
2005-12-29 |
2015-06-10 |
AbbVie Inc. |
Protein kinase inhibitors
|
WO2007087068A2
(en)
|
2006-01-13 |
2007-08-02 |
Pharmacyclics, Inc. |
Inhibitors of tyrosine kinases and uses thereof
|
WO2007094962A2
(en)
*
|
2006-02-09 |
2007-08-23 |
Athersys, Inc. |
Pyrazoles for the treatment of obesity and other cns disorders
|
EP2001880A2
(en)
*
|
2006-03-07 |
2008-12-17 |
Array Biopharma, Inc. |
Heterobicyclic pyrazole compounds and methods of use
|
EA200870409A1
(ru)
|
2006-04-04 |
2009-04-28 |
Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния |
Антагонисты киназы pi3
|
NL2000613C2
(nl)
*
|
2006-05-11 |
2007-11-20 |
Pfizer Prod Inc |
Triazoolpyrazinederivaten.
|
GB0610242D0
(en)
*
|
2006-05-23 |
2006-07-05 |
Novartis Ag |
Organic compounds
|
PT2526933E
(pt)
*
|
2006-09-22 |
2015-06-23 |
Pharmacyclics Inc |
Inibidores da tirosina-quinase de bruton
|
CA2668286C
(en)
*
|
2006-11-03 |
2014-09-16 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
US20100150863A1
(en)
|
2006-12-20 |
2010-06-17 |
Bayer Pharmaceuticals Corporation |
Hydroxy methyl phenyl pyrazolyl urea compound useful in treatment of cancer
|
WO2008082856A1
(en)
*
|
2006-12-26 |
2008-07-10 |
Pharmacyclics, Inc. |
Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
|
WO2008089307A2
(en)
*
|
2007-01-18 |
2008-07-24 |
Lexicon Pharmaceuticals, Inc. |
Delta 5 desaturase inhibitors for the treatment of pain, inflammation and cancer
|
US20080200458A1
(en)
*
|
2007-01-18 |
2008-08-21 |
Joseph Barbosa |
Methods and compositions for the treatment of body composition disorders
|
US20120101113A1
(en)
|
2007-03-28 |
2012-04-26 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
IL295053A
(en)
|
2007-03-28 |
2022-09-01 |
Pharmacyclics Llc |
Broton tyrosine kinase inhibitors
|
BRPI0814423B1
(pt)
|
2007-07-17 |
2022-04-19 |
Plexxikon, Inc |
Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos
|
CN101801965B
(zh)
*
|
2007-08-17 |
2014-07-30 |
株式会社Lg生命科学 |
作为细胞坏死抑制剂的吲哚化合物
|
WO2009046448A1
(en)
|
2007-10-04 |
2009-04-09 |
Intellikine, Inc. |
Chemical entities and therapeutic uses thereof
|
MX2010007418A
(es)
|
2008-01-04 |
2010-11-12 |
Intellikine Inc |
Ciertas entidades quimicas, composiciones y metodos.
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
US20110020326A1
(en)
*
|
2008-03-04 |
2011-01-27 |
Children's Medical Center Corporation |
Method of treating polycystic kidney disease
|
US8993580B2
(en)
|
2008-03-14 |
2015-03-31 |
Intellikine Llc |
Benzothiazole kinase inhibitors and methods of use
|
US8637542B2
(en)
|
2008-03-14 |
2014-01-28 |
Intellikine, Inc. |
Kinase inhibitors and methods of use
|
US20090281054A1
(en)
*
|
2008-05-06 |
2009-11-12 |
Venkata Reddy |
Compositions and methods comprising capuramycin analogues
|
US20100101977A1
(en)
*
|
2008-06-05 |
2010-04-29 |
United Comb & Novelty Corporation |
Stackable Packaging For Lipped Containers
|
BRPI0915231A2
(pt)
|
2008-07-08 |
2018-06-12 |
Intellikine Inc |
compostos inibidores de quinase e métodos de uso
|
US20110224223A1
(en)
|
2008-07-08 |
2011-09-15 |
The Regents Of The University Of California, A California Corporation |
MTOR Modulators and Uses Thereof
|
US8946239B2
(en)
|
2008-07-10 |
2015-02-03 |
Duquesne University Of The Holy Spirit |
Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
|
AU2009270856B2
(en)
|
2008-07-16 |
2013-07-25 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors
|
WO2010036380A1
(en)
|
2008-09-26 |
2010-04-01 |
Intellikine, Inc. |
Heterocyclic kinase inhibitors
|
DK2358720T3
(en)
*
|
2008-10-16 |
2016-06-06 |
Univ California |
Heteroarylkinaseinhibitorer fused-ring
|
AU2009308687A1
(en)
*
|
2008-11-03 |
2010-05-06 |
Chemocentryx, Inc. |
Compounds for the treatment of osteoporosis and cancers
|
US8476282B2
(en)
|
2008-11-03 |
2013-07-02 |
Intellikine Llc |
Benzoxazole kinase inhibitors and methods of use
|
CN102448459A
(zh)
*
|
2009-04-15 |
2012-05-09 |
意大利癌症研究国立研究所基金会 |
多激酶抑制剂在治疗血管渗透性过高中的用途
|
CA2760791C
(en)
|
2009-05-07 |
2017-06-20 |
Intellikine, Inc. |
Heterocyclic compounds and uses thereof
|
GEP201706639B
(en)
|
2009-08-17 |
2017-03-27 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
US20120157451A1
(en)
*
|
2009-08-28 |
2012-06-21 |
Genentech, Inc |
Raf inhibitor compounds and methods of use thereof
|
US7718662B1
(en)
|
2009-10-12 |
2010-05-18 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
|
US8980899B2
(en)
|
2009-10-16 |
2015-03-17 |
The Regents Of The University Of California |
Methods of inhibiting Ire1
|
US9180127B2
(en)
|
2009-12-29 |
2015-11-10 |
Dana-Farber Cancer Institute, Inc. |
Type II Raf kinase inhibitors
|
EP3378854B1
(en)
|
2010-01-27 |
2022-12-21 |
Arena Pharmaceuticals, Inc. |
Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
|
MX2012009208A
(es)
*
|
2010-02-08 |
2012-09-07 |
Msd Oss Bv |
Compuestos de 8-metil-1-fenil-imidazol[1, 5-a]pirazina.
|
EP2571357B1
(en)
|
2010-05-21 |
2016-07-06 |
Infinity Pharmaceuticals, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
US9096531B2
(en)
|
2010-05-24 |
2015-08-04 |
Toa Eiyo Ltd. |
Fused imidazole derivative
|
EA201890869A3
(ru)
|
2010-06-03 |
2019-03-29 |
Фармасайкликс, Инк. |
Применение ингибиторов тирозинкиназы брутона (btk)
|
BR112013008100A2
(pt)
|
2010-09-22 |
2016-08-09 |
Arena Pharm Inc |
"moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles."
|
WO2012064973A2
(en)
|
2010-11-10 |
2012-05-18 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
AR084824A1
(es)
|
2011-01-10 |
2013-06-26 |
Intellikine Inc |
Procesos para preparar isoquinolinonas y formas solidas de isoquinolinonas
|
US8889684B2
(en)
*
|
2011-02-02 |
2014-11-18 |
Boehringer Ingelheim International Gmbh |
Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors
|
AR085397A1
(es)
|
2011-02-23 |
2013-09-25 |
Intellikine Inc |
Combinacion de inhibidores de quinasa y sus usos
|
SI2710005T1
(sl)
|
2011-05-17 |
2017-03-31 |
Principia Biopharma Inc. |
Zaviralci tirozinske kinaze
|
US9376438B2
(en)
|
2011-05-17 |
2016-06-28 |
Principia Biopharma, Inc. |
Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
|
EP2726634B1
(en)
|
2011-07-01 |
2017-02-22 |
Dana-Farber Cancer Institute, Inc. |
Discovery of a somatic mutation in myd88 gene in lymphoplasmacytic lymphoma
|
WO2013010136A2
(en)
|
2011-07-13 |
2013-01-17 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
CN103946226A
(zh)
|
2011-07-19 |
2014-07-23 |
无限药品股份有限公司 |
杂环化合物及其应用
|
EP2548877A1
(en)
*
|
2011-07-19 |
2013-01-23 |
MSD Oss B.V. |
4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
|
AU2012284088B2
(en)
|
2011-07-19 |
2015-10-08 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
WO2013032591A1
(en)
|
2011-08-29 |
2013-03-07 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
AU2012341028C1
(en)
*
|
2011-09-02 |
2017-10-19 |
Mount Sinai School Of Medicine |
Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
|
ES2627820T3
(es)
|
2011-09-13 |
2017-07-31 |
Pharmacyclics, Inc. |
Formulaciones de inhibidor de histona desacetilasa en combinación con bendamustina y usos de las mismas
|
AU2012340200B2
(en)
|
2011-11-17 |
2017-10-12 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-Jun-N-Terminal Kinase (JNK)
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
MX363819B
(es)
|
2012-02-08 |
2019-04-03 |
Igm Biosciences Inc |
Uniones a cdim y sus usos.
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
CN104379586B
(zh)
*
|
2012-05-31 |
2018-01-16 |
制药科学公司 |
蛋白激酶抑制剂
|
CA3015208C
(en)
|
2012-06-04 |
2024-01-02 |
Pharmacyclics Llc |
Crystalline forms of a bruton's tyrosine kinase inhibitor
|
US8828998B2
(en)
|
2012-06-25 |
2014-09-09 |
Infinity Pharmaceuticals, Inc. |
Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
|
GB201211309D0
(en)
*
|
2012-06-26 |
2012-08-08 |
Fujifilm Mfg Europe Bv |
Process for preparing membranes
|
CN104704129A
(zh)
|
2012-07-24 |
2015-06-10 |
药品循环公司 |
与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
|
JP6327713B2
(ja)
|
2012-07-27 |
2018-05-23 |
国立研究開発法人理化学研究所 |
急性骨髄性白血病の治療又は再発抑制剤
|
DK3181567T3
(da)
|
2012-09-10 |
2019-06-11 |
Principia Biopharma Inc |
Pyrazolopyrimidinforbindelser som kinasehæmmere
|
WO2014052669A1
(en)
|
2012-09-26 |
2014-04-03 |
The Regents Of The University Of California |
Modulation of ire1
|
WO2014063068A1
(en)
|
2012-10-18 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
WO2014063061A1
(en)
|
2012-10-19 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
WO2014063054A1
(en)
|
2012-10-19 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
|
BR112015011171A2
(pt)
|
2012-11-15 |
2017-07-11 |
Pharmacyclics Inc |
compostos de pirrolopirimidina como inibidores da quinase
|
RU2654692C2
(ru)
|
2012-12-07 |
2018-05-22 |
Венаторкс Фармасьютикалс, Инк. |
Ингибиторы бета-лактамаз
|
WO2014110442A1
(en)
|
2013-01-10 |
2014-07-17 |
VenatoRx Pharmaceuticals, Inc. |
Beta-lactamase inhibitors
|
WO2014122474A1
(en)
|
2013-02-07 |
2014-08-14 |
Takeda Pharmaceutical Company Limited |
Piperidin-1 -yl and azepin-1 -yl carboxylates as muscarinic m4 receptor agonists
|
KR102311329B1
(ko)
*
|
2013-03-15 |
2021-10-14 |
얀센 파마슈티카 엔.브이. |
약제를 제조하기 위한 방법 및 중간체
|
US9481667B2
(en)
|
2013-03-15 |
2016-11-01 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
CN105209042B
(zh)
|
2013-03-22 |
2019-03-08 |
米伦纽姆医药公司 |
催化性mtorc 1/2抑制剂与选择性极光a激酶抑制剂的组合
|
US8957080B2
(en)
|
2013-04-09 |
2015-02-17 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
MX367918B
(es)
|
2013-04-25 |
2019-09-11 |
Beigene Ltd |
Compuestos heterociclicos fusionados como inhibidores de proteina quinasa.
|
US9421208B2
(en)
|
2013-08-02 |
2016-08-23 |
Pharmacyclics Llc |
Methods for the treatment of solid tumors
|
ES2709509T3
(es)
|
2013-08-12 |
2019-04-16 |
Pharmacyclics Llc |
Procedimientos para el tratamiento de cáncer amplificado por HER2
|
SG11201601844TA
(en)
|
2013-09-13 |
2016-04-28 |
Beigene Ltd |
Anti-pd1 antibodies and their use as therapeutics and diagnostics
|
CA2925124A1
(en)
|
2013-09-30 |
2015-04-02 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
WO2015051241A1
(en)
|
2013-10-04 |
2015-04-09 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
JP6466924B2
(ja)
|
2013-10-04 |
2019-02-06 |
インフィニティー ファーマシューティカルズ, インコーポレイテッド |
複素環式化合物及びその使用
|
JP6491202B2
(ja)
|
2013-10-18 |
2019-03-27 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
サイクリン依存性キナーゼ7(cdk7)の多環阻害剤
|
ES2676734T3
(es)
|
2013-10-18 |
2018-07-24 |
Syros Pharmaceuticals, Inc. |
Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas
|
CA2928721C
(en)
|
2013-10-25 |
2020-12-22 |
Pharmacyclics Llc |
Use of ibrutinib for treating and preventing chronic graft versus host disease
|
AP2016009297A0
(en)
|
2014-02-03 |
2016-06-30 |
Cadila Healthcare Ltd |
Novel heterocyclic compounds
|
US10449210B2
(en)
*
|
2014-02-13 |
2019-10-22 |
Ligand Pharmaceuticals Inc. |
Prodrug compounds and their uses
|
CN112353806A
(zh)
|
2014-02-21 |
2021-02-12 |
普林斯匹亚生物制药公司 |
Btk抑制剂的盐和固体形式
|
US9775844B2
(en)
|
2014-03-19 |
2017-10-03 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
WO2015143400A1
(en)
|
2014-03-20 |
2015-09-24 |
Pharmacyclics, Inc. |
Phospholipase c gamma 2 and resistance associated mutations
|
US20150320755A1
(en)
|
2014-04-16 |
2015-11-12 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
WO2015164614A1
(en)
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Janus kinase inhibitors and uses thereof
|
WO2015164604A1
(en)
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged janus kinase inhibitors and uses thereof
|
GB201410430D0
(en)
|
2014-06-11 |
2014-07-23 |
Redx Pharma Ltd |
Compounds
|
JP6526189B2
(ja)
|
2014-07-03 |
2019-06-05 |
ベイジーン リミテッド |
抗pd−l1抗体並びにその治療及び診断のための使用
|
AU2015296215A1
(en)
|
2014-08-01 |
2017-03-23 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
US9545407B2
(en)
|
2014-08-07 |
2017-01-17 |
Pharmacyclics Llc |
Formulations of a bruton's tyrosine kinase inhibitor
|
US9708348B2
(en)
|
2014-10-03 |
2017-07-18 |
Infinity Pharmaceuticals, Inc. |
Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
|
ITRM20140620A1
(it)
|
2014-10-30 |
2016-04-30 |
Lead Discovery Siena S R L |
Compounds and uses thereof
|
UY36390A
(es)
|
2014-11-05 |
2016-06-01 |
Flexus Biosciences Inc |
Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
|
JP2017538678A
(ja)
|
2014-11-05 |
2017-12-28 |
フレクサス・バイオサイエンシーズ・インコーポレイテッドFlexus Biosciences, Inc. |
免疫調節剤
|
CN104478884A
(zh)
*
|
2014-12-05 |
2015-04-01 |
广东东阳光药业有限公司 |
一种中间体的制备方法
|
PT3233103T
(pt)
|
2014-12-18 |
2021-01-18 |
Principia Biopharma Inc |
Tratamento de pênfigo
|
JP6736253B2
(ja)
*
|
2014-12-22 |
2020-08-05 |
ザ チャイニーズ ユニバーシティ オブ ホンコン |
体細胞から多能性幹細胞を作製するための機械的操作とプログラミンの併用
|
US10167451B2
(en)
|
2014-12-22 |
2019-01-01 |
The Chinese University Of Hong Kong |
Combinational use of mechanical manipulation and programin derivatives to increase Oct4, Sox2, or Nanog expression in fibroblasts
|
EP3236959A4
(en)
|
2014-12-23 |
2018-04-25 |
Dana Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
AU2016205361C1
(en)
|
2015-01-06 |
2021-04-08 |
Arena Pharmaceuticals, Inc. |
Methods of treating conditions related to the S1P1 receptor
|
CN105777755A
(zh)
*
|
2015-01-07 |
2016-07-20 |
常州百敖威生物科技有限公司 |
一种伊鲁替尼中间体3-碘-1h-吡唑并[3,4-d]嘧啶-4-胺的制备方法
|
KR20170122220A
(ko)
|
2015-03-03 |
2017-11-03 |
파마싸이클릭스 엘엘씨 |
브루톤 타이로신 키나제 저해제의 약제학적 제제
|
CA2978518C
(en)
|
2015-03-27 |
2023-11-21 |
Nathanael S. Gray |
Inhibitors of cyclin-dependent kinases
|
AU2016276963C1
(en)
|
2015-06-12 |
2021-08-05 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
SI3310760T1
(sl)
|
2015-06-22 |
2023-02-28 |
Arena Pharmaceuticals, Inc. |
Kristalinična L-argininska sol (R)-2-(7-(4-ciklopentil-3-(trifluorometil)benziloksi)-1,2,3,4- tetrahidrociklo-penta(b)indol-3-il)ocetne kisline za uporabo pri motnjah, povezanih z receptorjem S1P1
|
TW201718572A
(zh)
|
2015-06-24 |
2017-06-01 |
普林斯匹亞生物製藥公司 |
酪胺酸激酶抑制劑
|
CA2996978A1
(en)
|
2015-09-09 |
2017-03-16 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
CA2998469A1
(en)
|
2015-09-14 |
2017-03-23 |
Infinity Pharmaceuticals, Inc. |
Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
|
AU2016322063A1
(en)
|
2015-09-16 |
2018-04-12 |
Loxo Oncology, Inc. |
Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer
|
CA3008488C
(en)
|
2015-12-16 |
2023-10-10 |
Loxo Oncology, Inc. |
Compounds useful as kinase inhibitors
|
WO2017161116A1
(en)
|
2016-03-17 |
2017-09-21 |
Infinity Pharmaceuticals, Inc. |
Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
|
US10919914B2
(en)
|
2016-06-08 |
2021-02-16 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
SG11201811237WA
(en)
|
2016-06-24 |
2019-01-30 |
Infinity Pharmaceuticals Inc |
Combination therapies
|
CA3028169A1
(en)
|
2016-06-29 |
2018-01-04 |
Principia Biopharma Inc. |
Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
|
WO2018007885A1
(en)
|
2016-07-05 |
2018-01-11 |
Beigene, Ltd. |
COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER
|
CA3033827A1
(en)
|
2016-08-16 |
2018-02-22 |
Beigene, Ltd. |
Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl )-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide,preparation, and uses thereof
|
EP4353747A3
(en)
|
2016-08-19 |
2024-06-26 |
BeiGene Switzerland GmbH |
Combination of zanubrutinib with an anti-cd20 or an anti-pd-1 antibody for use in treating cancer
|
WO2018137681A1
(en)
|
2017-01-25 |
2018-08-02 |
Beigene, Ltd. |
Crystalline forms of (s) -7- (1- (but-2-ynoyl) piperidin-4-yl) -2- (4-phenoxyphenyl) -4, 5, 6, 7-tetrahy dropyrazolo [1, 5-a] pyrimidine-3-carboxamide, preparation, and uses thereof
|
KR20190116416A
(ko)
|
2017-02-16 |
2019-10-14 |
아레나 파마슈티칼스, 인크. |
원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
|
EP3645569A4
(en)
|
2017-06-26 |
2021-03-24 |
BeiGene, Ltd. |
IMMUNOTHERAPY FOR LIVER CELL CARCINOMA
|
CN110997677A
(zh)
|
2017-08-12 |
2020-04-10 |
百济神州有限公司 |
具有改进的双重选择性的Btk抑制剂
|
US11786529B2
(en)
|
2017-11-29 |
2023-10-17 |
Beigene Switzerland Gmbh |
Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
|
US11970482B2
(en)
|
2018-01-09 |
2024-04-30 |
Ligand Pharmaceuticals Inc. |
Acetal compounds and therapeutic uses thereof
|
CN108299311A
(zh)
*
|
2018-02-28 |
2018-07-20 |
杭州福斯特药业有限公司 |
一种5-溴-2-氯-n-环戊基嘧啶-4-胺的制备方法
|
CN111171035B
(zh)
*
|
2018-11-13 |
2021-03-30 |
山东大学 |
4-苯氧基苯基吡唑并嘧啶酰胺衍生物的制备方法和应用
|
CN111454268B
(zh)
*
|
2019-01-18 |
2023-09-08 |
明慧医药(上海)有限公司 |
作为布鲁顿酪氨酸激酶抑制剂的环状分子
|
CA3143508A1
(en)
*
|
2019-06-24 |
2020-12-30 |
Dana-Farber Cancer Institute, Inc. |
Hck degraders and uses thereof
|
CN110511225B
(zh)
*
|
2019-08-19 |
2023-07-18 |
杭州中美华东制药有限公司 |
一种伊布替尼中间体的合成方法
|
WO2021038540A1
(en)
|
2019-08-31 |
2021-03-04 |
Sun Pharma Advanced Research Company Limited |
Cycloalkylidene carboxylic acids and derivatives as btk inhibitors
|
JP2022548696A
(ja)
|
2019-09-18 |
2022-11-21 |
武田薬品工業株式会社 |
血漿カリクレインインヒビター及びその使用
|
US20220395509A1
(en)
*
|
2019-10-08 |
2022-12-15 |
Dana-Farber Cancer Institute, Inc. |
A pyrazolopyrimidine derivative as a hck inhibitor for use in therapy, in particular myd88 mutated diseases
|
CN112961158B
(zh)
*
|
2020-03-05 |
2022-07-01 |
四川大学华西医院 |
氨基嘧啶并吡唑/吡咯类衍生物及其制备方法和用途
|
AU2020436612A1
(en)
|
2020-03-16 |
2022-09-01 |
Flash Therapeutics, Llc |
Compounds for treating or inhibiting recurrence of acute myeloid leukemia
|
EP4247795A1
(en)
|
2020-11-18 |
2023-09-27 |
Deciphera Pharmaceuticals, LLC |
Gcn2 and perk kinase inhibitors and methods of use thereof
|
WO2022197763A1
(en)
*
|
2021-03-17 |
2022-09-22 |
Shire Human Genetic Therapies, Inc. |
Inhibitors of plasma kallikrein
|
US11786531B1
(en)
|
2022-06-08 |
2023-10-17 |
Beigene Switzerland Gmbh |
Methods of treating B-cell proliferative disorder
|
CN115650986A
(zh)
*
|
2022-10-22 |
2023-01-31 |
浙江工业大学 |
肉桂酰氨基吡唑并[3,4-d]嘧啶类化合物及其制备和应用
|