NO20015107L - En farmasöytisk formulering som innbefatter en trombininhibitor med lav molekylvekt og dens prodrug - Google Patents

En farmasöytisk formulering som innbefatter en trombininhibitor med lav molekylvekt og dens prodrug

Info

Publication number
NO20015107L
NO20015107L NO20015107A NO20015107A NO20015107L NO 20015107 L NO20015107 L NO 20015107L NO 20015107 A NO20015107 A NO 20015107A NO 20015107 A NO20015107 A NO 20015107A NO 20015107 L NO20015107 L NO 20015107L
Authority
NO
Norway
Prior art keywords
prodrug
molecular weight
low molecular
pharmaceutical formulation
thrombin inhibitor
Prior art date
Application number
NO20015107A
Other languages
English (en)
Norwegian (no)
Other versions
NO20015107D0 (no
Inventor
David Gustafsson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9901442A external-priority patent/SE523811C2/sv
Priority claimed from SE9904419A external-priority patent/SE9904419D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20015107D0 publication Critical patent/NO20015107D0/no
Publication of NO20015107L publication Critical patent/NO20015107L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
NO20015107A 1999-04-21 2001-10-19 En farmasöytisk formulering som innbefatter en trombininhibitor med lav molekylvekt og dens prodrug NO20015107L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9901442A SE523811C2 (sv) 1999-04-21 1999-04-21 Beredning innehållande en trombininhibitor med låg molekylvikt tillsammans med en prodrog av densamma
SE9904419A SE9904419D0 (sv) 1999-12-03 1999-12-03 New use
PCT/SE2000/000756 WO2000064470A1 (en) 1999-04-21 2000-04-19 A pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug

Publications (2)

Publication Number Publication Date
NO20015107D0 NO20015107D0 (no) 2001-10-19
NO20015107L true NO20015107L (no) 2001-10-19

Family

ID=26663557

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20015107A NO20015107L (no) 1999-04-21 2001-10-19 En farmasöytisk formulering som innbefatter en trombininhibitor med lav molekylvekt og dens prodrug

Country Status (29)

Country Link
US (3) US6962905B1 (ru)
EP (2) EP1200118B1 (ru)
JP (1) JP2002542298A (ru)
KR (1) KR20010110788A (ru)
CN (1) CN100377742C (ru)
AR (1) AR023510A1 (ru)
AT (1) ATE383868T1 (ru)
AU (1) AU754405B2 (ru)
BR (1) BR0009847A (ru)
CA (1) CA2371008A1 (ru)
CZ (1) CZ20013757A3 (ru)
DE (1) DE60037816T2 (ru)
DK (1) DK1200118T3 (ru)
EE (1) EE200100543A (ru)
ES (1) ES2298141T3 (ru)
HK (1) HK1045465B (ru)
HU (1) HUP0200955A3 (ru)
IL (1) IL145840A0 (ru)
IS (1) IS6111A (ru)
MY (1) MY128061A (ru)
NO (1) NO20015107L (ru)
NZ (1) NZ514827A (ru)
PL (1) PL201793B1 (ru)
PT (1) PT1200118E (ru)
RU (1) RU2252783C2 (ru)
SA (1) SA00210092B1 (ru)
SK (1) SK14962001A3 (ru)
TR (1) TR200103017T2 (ru)
WO (1) WO2000064470A1 (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9900070D0 (sv) 1999-01-13 1999-01-13 Astra Ab New use
AR023510A1 (es) * 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
US20020116222A1 (en) * 2000-10-22 2002-08-22 Standing Stone, Inc. Method and system for administering anticoagulation therapy
US6462021B1 (en) * 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
SE0101762D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab New use
SE0101932D0 (sv) * 2001-05-31 2001-05-31 Astrazeneca Ab Pharmaceutical combinations
SE0103590D0 (sv) 2001-10-26 2001-10-26 Astrazeneca Ab New Combination
WO2003076391A2 (de) 2002-03-11 2003-09-18 Curacyte Ag Hemmstoffe der urokinase, ihre herstellung und verwendung
SE0203349D0 (sv) * 2002-11-12 2002-11-12 Astrazeneca Ab New use
DE10301300B4 (de) 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
GB0306615D0 (en) * 2003-03-22 2003-04-30 Astrazeneca Ab New use
DE10342108A1 (de) * 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE102005044319A1 (de) 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
KR101955691B1 (ko) 2010-03-30 2019-03-07 베르선 코포레이션 트롬빈 억제제로서의 다중치환된 방향족 화합물
JP6479749B2 (ja) 2013-03-15 2019-03-06 ヴァーセオン コーポレイション トロンビン阻害剤としてのハロゲノピラゾール
RU2019101889A (ru) 2013-03-15 2019-03-28 Версеон Корпорейшн Полизамещенные ароматические соединения в качестве ингибиторов сериновых протеаз
WO2016044662A1 (en) 2014-09-17 2016-03-24 Verseon Corporation Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
EP3261639B1 (en) 2015-02-27 2022-08-24 Verseon International Corporation Substituted pyrazole compounds as serine protease inhibitors

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087380A (en) 1949-11-24 2000-07-11 Boehringer Ingelheim Pharma Kg Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
AU600226B2 (en) 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
ZA897514B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
US5518725A (en) 1989-09-25 1996-05-21 University Of Utah Research Foundation Vaccine compositions and method for induction of mucosal immune response via systemic vaccination
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
CZ333492A3 (en) 1991-11-12 1993-09-15 Lilly Co Eli Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
CA2131367A1 (en) 1992-03-04 1993-09-16 Sandor Bajusz New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
AU675981B2 (en) 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
TW257757B (ru) 1993-03-03 1995-09-21 Boehringer Mannheim Gmbh
JPH06340619A (ja) 1993-05-03 1994-12-13 Bristol Myers Squibb Co グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
US5643588A (en) * 1994-11-28 1997-07-01 The Procter & Gamble Company Diaper having a lotioned topsheet
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
US5707966A (en) 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5705487A (en) 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
DE4430757A1 (de) 1994-08-30 1996-03-07 Boehringer Mannheim Gmbh Neue 4-Aminopyridazine, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
DE4430755A1 (de) 1994-08-30 1996-03-07 Boehringer Mannheim Gmbh Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
MX9706069A (es) 1995-02-17 1997-10-31 Basf Ag Nuevos inhibidores de la trombina.
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
EP0820453A4 (en) 1995-04-04 2001-08-29 Merck & Co Inc THROMBIN INHIBITORS
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
WO1997001338A1 (en) 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
CZ92298A3 (cs) 1995-09-29 1998-07-15 3-Dimensional Pharmaceuticals, Inc. Inhibitory guanidin proteasy
DE69625230T2 (de) 1995-10-24 2003-09-04 Merck & Co., Inc. Thrombininhibitoren
TW541316B (en) * 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
GB9526273D0 (en) * 1995-12-21 1996-02-21 Astra Ab New prodrugs
JP2000503010A (ja) 1995-12-29 2000-03-14 スリー―ダイメンショナル・ファーマスーティカルス・インコーポレーテッド アミジノプロテアーゼ阻害剤
JP2000512616A (ja) 1996-02-22 2000-09-26 メルク エンド カンパニー インコーポレーテッド ピリジノントロンビンインヒビター
PL329441A1 (en) 1996-04-23 1999-03-29 Merck & Co Inc Pyrasinone-type thrombin inhibitors
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
WO1997047299A1 (en) 1996-06-12 1997-12-18 3-Dimensional Pharmaceuticals, Inc. Amidino and guanidino heterocyclic protease inhibitors
WO1997049404A1 (en) 1996-06-25 1997-12-31 Eli Lilly And Company Anticoagulant agents
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
DE19632773A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
PE121699A1 (es) 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
DE19727117A1 (de) 1997-06-26 1999-01-07 Boehringer Ingelheim Pharma Phenylalkylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE19753522A1 (de) 1997-12-03 1999-06-10 Boehringer Ingelheim Pharma Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
DE19754490A1 (de) 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
CA2317761A1 (en) 1998-01-26 1999-07-29 Basf Aktiengesellschaft Thrombin inhibitors
JP2002501044A (ja) 1998-01-26 2002-01-15 ビーエーエスエフ アクチェンゲゼルシャフト カリクレインプロテアーゼ阻害剤としての複素環アミジン
JP2002502844A (ja) 1998-02-03 2002-01-29 ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト ５員複素環縮合ベンゾ誘導体、その調製及び医薬品としてのそれらの使用
DE19816983A1 (de) 1998-04-17 1999-10-21 Boehringer Ingelheim Pharma Bicyclen, deren Herstellung und deren Verwendung als Arzneimittel
TWI248435B (en) 1998-07-04 2006-02-01 Boehringer Ingelheim Pharma Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
DE19834751A1 (de) 1998-08-01 2000-02-03 Boehringer Ingelheim Pharma Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
WO2000039102A1 (en) * 1998-12-23 2000-07-06 Du Pont Pharmaceuticals Company THROMBIN OR FACTOR Xa INHIBITORS
AR023510A1 (es) * 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.

Also Published As

Publication number Publication date
IL145840A0 (en) 2002-07-25
RU2252783C2 (ru) 2005-05-27
US20060009397A1 (en) 2006-01-12
EE200100543A (et) 2003-02-17
BR0009847A (pt) 2002-01-08
PT1200118E (pt) 2008-03-18
HK1045465A1 (en) 2002-11-29
HUP0200955A2 (en) 2002-09-28
WO2000064470A1 (en) 2000-11-02
MY128061A (en) 2007-01-31
CZ20013757A3 (cs) 2002-05-15
NO20015107D0 (no) 2001-10-19
EP1200118B1 (en) 2008-01-16
DE60037816T2 (de) 2009-01-08
AR023510A1 (es) 2002-09-04
AU754405B2 (en) 2002-11-14
CN1356908A (zh) 2002-07-03
ATE383868T1 (de) 2008-02-15
CA2371008A1 (en) 2000-11-02
US6962905B1 (en) 2005-11-08
DK1200118T3 (da) 2008-04-21
DE60037816D1 (de) 2008-03-06
PL351917A1 (en) 2003-06-30
ES2298141T3 (es) 2008-05-16
HK1045465B (zh) 2008-08-01
IS6111A (is) 2001-10-19
KR20010110788A (ko) 2001-12-13
SK14962001A3 (sk) 2002-06-04
JP2002542298A (ja) 2002-12-10
TR200103017T2 (tr) 2002-05-21
HUP0200955A3 (en) 2006-07-28
EP1200118A1 (en) 2002-05-02
AU4633600A (en) 2000-11-10
PL201793B1 (pl) 2009-05-29
SA00210092B1 (ar) 2006-11-11
NZ514827A (en) 2005-01-28
CN100377742C (zh) 2008-04-02
US20080113960A1 (en) 2008-05-15
EP1886691A3 (en) 2008-03-05
EP1886691A2 (en) 2008-02-13

Similar Documents

Publication Publication Date Title
NO20015107L (no) En farmasöytisk formulering som innbefatter en trombininhibitor med lav molekylvekt og dens prodrug
ITTO20010008A0 (it) Formulazione farmaceutica
FIU20000164U0 (fi) Uusi farmaseuttinen formulaatio
HUP0400202A3 (en) Imidazolidindion derivatives having metalloproteinase inhibitor effect, their use and pharmaceutical compositions containing them
PT1242087E (pt) Composicoes farmaceuticas
DK1329456T3 (da) Glucopyranosyloxybenzylbenzenderivater og medicinske sammensætninger indeholdende samme
NO20021253L (no) Kinolylpropylpiperidinderivater og deres anvendelse som antibakterielle midler
ATE336264T1 (de) Dispergierbare pharmazeutische zusammensetzungen
NO20016277L (no) Systemer og fremgangsmåter for aerolisering av farmasöytiske sammensetninger
NO20014702L (no) Diarylderivater og deres anvendelse som medikamenter
DK1267880T4 (da) Entecavir-formulering med lav dosis og anvendelse deraf
NO20025357L (no) Antranylamider og deres anvendelse som legemidler
NO20015897D0 (no) Indolylpiperidinderivater som antihistaminiske og antiallergiske midler
DK1268419T3 (da) Farmaceutisk aktive pyrrolidinderivater som BAX-inhibitorer
IS2841B (is) Samstæða hluta og lyfjasamsetningar
NO20034778L (no) Farmasöytiske sammensetninger for oral og topisk anvendelse
IS6723A (is) 10-arýl-11H-bensó[b]flúorenafleiður og hliðstæðurtil lyfjanotkunar
DK1387838T3 (da) Cyanoanthranylamid-derivater og deres anvendelse som lægemidler
PT1239832E (pt) Composicoes farmaceuticas
DK1150996T3 (da) Nye amidinobenzylaminderivater og deres anvendelse som thrombin-inhibitorer
NO20022022L (no) N-guanidinoalkylamider, deres fremstilling, deres anvendelse og farmasöytiske preparater omfattende disse
NO20041485L (no) Farmasoytisk formulering omfattende (R)-bicalutamid
IS6140A (is) Lyfjablanda sem inniheldur hemil karboxýpeptíðasaU og þrombínhemil
AR025867A1 (es) Formulacion portasdora farmaceutica
NO20024354L (no) N-deacetyltiocolchicin-derivater og farmasöytiske sammensetninger inneholdende dem

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application
FC2A Withdrawal, rejection or dismissal of laid open patent application