NO20002038L - Uløselige insulinsammensetninger - Google Patents
Uløselige insulinsammensetningerInfo
- Publication number
- NO20002038L NO20002038L NO20002038A NO20002038A NO20002038L NO 20002038 L NO20002038 L NO 20002038L NO 20002038 A NO20002038 A NO 20002038A NO 20002038 A NO20002038 A NO 20002038A NO 20002038 L NO20002038 L NO 20002038L
- Authority
- NO
- Norway
- Prior art keywords
- acylated
- insulin
- nph
- preparations
- present
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6310497P | 1997-10-24 | 1997-10-24 | |
US8893098P | 1998-06-11 | 1998-06-11 | |
PCT/US1998/022434 WO1999021578A1 (en) | 1997-10-24 | 1998-10-22 | Insoluble insulin compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20002038D0 NO20002038D0 (no) | 2000-04-18 |
NO20002038L true NO20002038L (no) | 2000-06-26 |
Family
ID=26743043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20002038A NO20002038L (no) | 1997-10-24 | 2000-04-18 | Uløselige insulinsammensetninger |
Country Status (21)
Country | Link |
---|---|
US (3) | US6268335B1 (hu) |
EP (1) | EP1039920A4 (hu) |
JP (2) | JP2001521004A (hu) |
KR (1) | KR20010024556A (hu) |
CN (1) | CN1276731A (hu) |
AR (1) | AR020047A1 (hu) |
AU (2) | AU747926B2 (hu) |
BR (1) | BR9813111A (hu) |
CA (2) | CA2306905A1 (hu) |
CO (1) | CO4970769A1 (hu) |
EA (1) | EA200000453A1 (hu) |
HR (1) | HRP20000236A2 (hu) |
HU (1) | HUP0004169A3 (hu) |
ID (1) | ID24890A (hu) |
IL (1) | IL134901A0 (hu) |
NO (1) | NO20002038L (hu) |
PE (1) | PE123799A1 (hu) |
PL (1) | PL340255A1 (hu) |
SV (1) | SV1998000125A (hu) |
TR (1) | TR200001050T2 (hu) |
WO (2) | WO1999021573A1 (hu) |
Families Citing this family (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6444641B1 (en) | 1997-10-24 | 2002-09-03 | Eli Lilly Company | Fatty acid-acylated insulin analogs |
CO4970787A1 (es) * | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
US7169889B1 (en) * | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
CN1406131A (zh) * | 2000-12-25 | 2003-03-26 | 株式会社资生堂 | 活化交感神经的香料组合物 |
US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US20020155614A1 (en) * | 2001-02-21 | 2002-10-24 | Tomlinson Andrew J. | Peptide esterification |
US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
US6828305B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
EP1432430A4 (en) * | 2001-08-28 | 2006-05-10 | Lilly Co Eli | PREMIXTURES OF GLP-1 AND BASALINSULIN |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6913903B2 (en) * | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6770625B2 (en) | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7030082B2 (en) * | 2001-09-07 | 2006-04-18 | Nobex Corporation | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith |
PT1429731E (pt) * | 2001-09-19 | 2007-04-30 | Elan Pharma Int Ltd | Formulações de insulina nanoparticulada |
AU2002346491A1 (en) * | 2001-12-19 | 2003-07-09 | Eli Lilly And Company | Crystalline compositions for controlling blood glucose |
IL161848A0 (en) * | 2001-12-20 | 2005-11-20 | Lilly Co Eli | Insulin moldecule having protracted time action |
US20040038864A1 (en) * | 2002-06-27 | 2004-02-26 | Per Balschmidt | Use of dimethyl sulfone as isotonicity agent |
US20060258561A1 (en) * | 2003-03-13 | 2006-11-16 | Novo Nordisk A/S | Novel NPH insulin preparations |
JP2006519791A (ja) * | 2003-03-13 | 2006-08-31 | ノボ ノルディスク アクティーゼルスカブ | 新規なnphインスリン製剤 |
US20050054818A1 (en) * | 2003-07-02 | 2005-03-10 | Brader Mark Laurence | Crystalline compositions for controlling blood glucose |
JP2007520441A (ja) * | 2003-07-25 | 2007-07-26 | コンジュシェム,インコーポレイティド | 持続性インスリン誘導体及びその方法 |
EP2107069B1 (en) | 2003-08-05 | 2013-01-16 | Novo Nordisk A/S | Novel insulin derivatives |
WO2005054291A1 (en) * | 2003-12-03 | 2005-06-16 | Novo Nordisk A/S | Single-chain insulin |
US7605123B2 (en) * | 2004-07-19 | 2009-10-20 | Biocon Ltd. | Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof |
ES2391776T3 (es) | 2004-11-22 | 2012-11-29 | Novo Nordisk A/S | Formulaciones solubles, estables conteniendo insulina con una sal de protamina |
EP1679065A1 (en) * | 2005-01-07 | 2006-07-12 | OctoPlus Sciences B.V. | Controlled release compositions for interferon based on PEGT/PBT block copolymers |
US20100216690A1 (en) * | 2005-03-18 | 2010-08-26 | Novo Nordisk A/S | Pegylated Single-Chain Insulin |
PT1969004E (pt) | 2005-12-28 | 2011-11-25 | Novo Nordisk As | Composições que compreendem uma insulina acilada e zinco e método para criar tais composições |
WO2007081824A2 (en) * | 2006-01-06 | 2007-07-19 | Case Western Reserve University | Fibrillation resistant proteins |
US8927015B2 (en) * | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
US20100160209A1 (en) * | 2006-05-10 | 2010-06-24 | Smithkline Beecham Corporation | Composition and Method for Increasing Cell Permeability of a Compound |
WO2007135118A1 (en) * | 2006-05-24 | 2007-11-29 | Novo Nordisk A/S | Soluble, stable insulin-containing formulations |
EP2049149B1 (en) | 2006-07-31 | 2015-04-15 | Novo Nordisk A/S | Pegylated extended insulins |
KR101729986B1 (ko) | 2006-09-22 | 2017-04-25 | 노보 노르디스크 에이/에스 | 프로테아제 내성 인슐린 유사체 |
EP2074140B8 (en) * | 2006-10-04 | 2015-10-28 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
CN101674812B (zh) | 2007-04-30 | 2013-12-11 | 诺沃-诺迪斯克有限公司 | 干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物 |
JP5552046B2 (ja) | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー/エス | インスリン誘導体を含有する薬学的製剤 |
AU2008288413B2 (en) * | 2007-08-15 | 2013-09-26 | Novo Nordisk A/S | Insulin analogues with an acyl and aklylene glycol moiety |
JP5868594B2 (ja) | 2007-10-16 | 2016-02-24 | バイオコン・リミテッドBiocon Limited | 経口投与可能な固形医薬組成物及びそのプロセス |
CN102007143B (zh) * | 2008-01-09 | 2015-08-26 | 塞诺菲-安万特德国有限公司 | 具有超延迟时效特征的新型胰岛素衍生物 |
AU2009203810B2 (en) * | 2008-01-09 | 2013-07-25 | Sanofi-Aventis Deutschland Gmbh | Novel insulin derivatives having an extremely delayed time-action profile |
DE102008003566A1 (de) * | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
ES2618073T3 (es) | 2008-03-14 | 2017-06-20 | Novo Nordisk A/S | Análogos de insulina estabilizados frente a proteasas |
DK2910570T3 (en) | 2008-03-18 | 2017-01-30 | Novo Nordisk As | Protease-stabilized acylated insulin analogues. |
US8993516B2 (en) * | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
BRPI0911571A2 (pt) * | 2008-04-22 | 2018-04-03 | Univ Case Western Reserve | método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira |
KR20120129875A (ko) | 2008-07-31 | 2012-11-28 | 케이스 웨스턴 리저브 유니버시티 | 염소화 아미노산을 갖는 인슐린 유사체 |
US9200053B2 (en) | 2008-07-31 | 2015-12-01 | Case Western Reserve University | Insulin analogues containing penta-fluoro-Phenylalanine at position B24 |
PT3228320T (pt) | 2008-10-17 | 2020-03-26 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
EP2352513B1 (en) | 2008-10-30 | 2016-09-14 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
WO2010088286A1 (en) | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
KR20110104081A (ko) | 2009-01-28 | 2011-09-21 | 스마트쎌스, 인크. | 제어 약물 전달을 위한 접합체 기재 시스템 |
US20100198188A1 (en) * | 2009-02-05 | 2010-08-05 | Abbott Diabetes Care Inc. | Devices and Methods for Metering Insoluble Active Agent Particles |
WO2010107519A1 (en) | 2009-03-20 | 2010-09-23 | Smartcells, Inc. | Terminally-functionalized conjugates and uses thereof |
EP2451472A1 (de) * | 2009-07-06 | 2012-05-16 | Sanofi-Aventis Deutschland GmbH | Hitze- und schüttelstabile insulinzubereitungen |
TW201113032A (en) * | 2009-07-06 | 2011-04-16 | Sanofi Aventis Deutschland | Slow-acting insulin preparations |
US8399407B2 (en) * | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
PT2498801T (pt) | 2009-11-13 | 2018-05-02 | Sanofi Aventis Deutschland | Composição farmacêutica compreendendo despro36exendin-4(1-39)-lys6-nh2 e metionina |
RU2537239C2 (ru) | 2009-11-13 | 2014-12-27 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая композиция, включающая агонист glp-1, инсулин и метионин |
US9445992B2 (en) | 2009-11-25 | 2016-09-20 | Arisgen Sa | Mucosal delivery compositions comprising a peptide complexed with a crown compound and/or a counter ion |
US9079975B2 (en) * | 2009-12-11 | 2015-07-14 | Case Western Reserve University | Insulin analogues with chlorinated amino acids |
AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
CN102985440B (zh) | 2010-06-23 | 2016-10-26 | 诺沃-诺迪斯克有限公司 | 包含额外的二硫键的胰岛素衍生物 |
RU2546520C2 (ru) | 2010-08-30 | 2015-04-10 | Санофи-Авентис Дойчланд Гмбх | Применение ave0010 для производства лекарственного средства для лечения сахарного диабета 2 типа |
RU2013123515A (ru) | 2010-10-27 | 2014-12-10 | Ново Нордиск А/С | Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
WO2012171994A1 (en) | 2011-06-15 | 2012-12-20 | Novo Nordisk A/S | Multi substituted insulins |
ES2550357T3 (es) | 2011-08-29 | 2015-11-06 | Sanofi-Aventis Deutschland Gmbh | Combinación farmacéutica para su uso en el control glucémico en pacientes de diabetes de tipo 2 |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
CN104364260B (zh) | 2012-04-11 | 2017-02-22 | 诺和诺德股份有限公司 | 胰岛素制剂 |
WO2014088836A1 (en) | 2012-12-03 | 2014-06-12 | Merck Sharp & Dohme Corp. | O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues |
TWI641381B (zh) | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
ES2709339T3 (es) | 2013-04-03 | 2019-04-16 | Sanofi Sa | Tratamiento de la diabetes mellitus mediante formulaciones de insulinas de acción prolongada |
US10137172B2 (en) | 2013-04-30 | 2018-11-27 | Novo Nordisk A/S | Administration regime |
CA2926701A1 (en) | 2013-10-07 | 2015-04-16 | Novo Nordisk A/S | Novel derivative of an insulin analogue |
EP3091964A1 (en) * | 2014-01-09 | 2016-11-16 | Sanofi | Stabilized pharmaceutical formulations of insulin aspart |
CN105960249B (zh) | 2014-01-09 | 2021-03-16 | 赛诺菲 | 胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂 |
CA2932875A1 (en) | 2014-01-09 | 2015-07-16 | Sanofi | Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives |
AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
CA2957714A1 (en) * | 2014-08-11 | 2016-02-18 | Albany Medical College | Myristoylated leptin-related peptides and uses thereof |
CN107108716A (zh) | 2014-10-06 | 2017-08-29 | 卡斯西部储备大学 | 双相性单链胰岛素类似物 |
HUE062573T2 (hu) | 2014-12-12 | 2023-11-28 | Sanofi Aventis Deutschland | Glargin inzulin/lixiszenatid rögzített arányú készítmény |
CN105884879A (zh) * | 2015-01-26 | 2016-08-24 | 漳州博欣生物技术有限公司 | 一种胰岛素类似物的化学合成方法 |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
US11352406B2 (en) * | 2015-08-25 | 2022-06-07 | Novo Nordisk A/S | Insulin derivatives and the medical uses hereof |
CN105597087B (zh) * | 2016-01-06 | 2019-04-26 | 山东新时代药业有限公司 | 一种甘精胰岛素注射液及其制备方法 |
CA3035850A1 (en) * | 2016-09-06 | 2018-03-15 | Chemical & Biopharmaceutical Laboratories Of Patras S.A. | Proinsulin derivatives |
JP2020504714A (ja) | 2016-12-05 | 2020-02-13 | ニューリタス リミテッド | ペプチドwkdeagkplvkを含む組成物 |
EP3329930A1 (en) | 2016-12-05 | 2018-06-06 | Nuritas Limited | Pharmaceuctical compositions |
HUE055231T2 (hu) | 2016-12-16 | 2021-11-29 | Novo Nordisk As | Inzulint tartalmazó gyógyászati készítmények |
US20200147215A1 (en) * | 2017-04-24 | 2020-05-14 | Simon H. Friedman | Drug conjugates with photocleavable solubility modulators |
JOP20190273A1 (ar) * | 2017-05-26 | 2019-11-24 | Lilly Co Eli | مركب إنسولين معالج بأسيل |
EP3740212A4 (en) | 2017-12-18 | 2021-10-27 | Merck Sharp & Dohme Corp. | CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY |
EP3727424A4 (en) | 2017-12-18 | 2021-10-27 | Merck Sharp & Dohme Corp. | CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN RELEASE |
WO2019222221A1 (en) * | 2018-05-14 | 2019-11-21 | Dance Biopharm Inc. | Insulin formulations for reconstitution into high concentration liquid solutions |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
EP3894391A1 (en) | 2018-12-11 | 2021-10-20 | Sanofi | Peptide binder |
CN110063932A (zh) * | 2019-04-12 | 2019-07-30 | 浙江大学 | 一种多肽蛋白类药物的缓释组合物制剂及其制备方法 |
AR120717A1 (es) | 2019-12-11 | 2022-03-09 | Novo Nordisk As | Análogos de insulina y usos de los mismos |
AU2021247169A1 (en) | 2020-03-31 | 2022-10-20 | Protomer Technologies Inc. | Conjugates for selective responsiveness to vicinal diols |
WO2021231676A1 (en) | 2020-05-15 | 2021-11-18 | Eli Lilly And Company | Extended time action acylated insulin compounds |
KR20230110505A (ko) | 2020-11-19 | 2023-07-24 | 프로토머 테크놀로지스 인크. | 방향족 붕소-함유 화합물 및 인슐린 유사체 |
WO2022125587A1 (en) * | 2020-12-07 | 2022-06-16 | Case Western Reserve University | Acylated single-chain insulin analogues |
TW202409070A (zh) | 2022-05-18 | 2024-03-01 | 美商普羅托莫科技公司 | 芳族含硼化合物及相關胰島素類似物 |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2538018A (en) | 1944-04-04 | 1951-01-16 | Nordisk Insulinlab | Crystalline product of insulin and alkaline protein and process of making it |
US2801953A (en) | 1952-02-28 | 1957-08-06 | Hoechst Ag | Process of preparing crystallized insulin preparations |
US2849370A (en) | 1953-06-04 | 1958-08-26 | Novo Terapeutisk Labortorium A | Injectable insulin preparations with protracted effect and process of producing same |
US3102077A (en) | 1953-08-19 | 1963-08-27 | Christensen Henry Marinus | Preparation of insulin containing 2.75 to 8 percent zinc content |
US3060093A (en) | 1957-07-18 | 1962-10-23 | Nordisk Insulinlab | Slowly acting insulin preparation in crystalline form and method of preparation |
DE1793517C3 (de) | 1968-09-28 | 1974-12-05 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | N(Al),N(B29>Bis-(tert.-butyloxycarbonyl)-insulin und Verfahren zu seiner Herstellung |
US3950517A (en) | 1970-05-08 | 1976-04-13 | National Research Development Corporation | Insulin derivatives |
US3869437A (en) | 1970-05-08 | 1975-03-04 | Nat Res Dev | Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin |
GB1381274A (en) | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
US3868358A (en) | 1971-04-30 | 1975-02-25 | Lilly Co Eli | Protamine-insulin product |
US3865325A (en) | 1971-07-02 | 1975-02-11 | Dylaker Computer Systems Inc | Flexible tape reel |
US3907763A (en) | 1972-03-01 | 1975-09-23 | Bayer Ag | Insulin derivatives crosslinked by a dicarboxylic acid moiety |
US4183849A (en) | 1975-01-15 | 1980-01-15 | Nordisk Insulinlaboratorium | Therapeutic insulin preparation and a process for the production of a stable insulin preparation with protracted effect |
JPS55138393A (en) | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | Semisynthesis of insulin |
JPS55138391A (en) | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | New synthetic method of peptide derivative |
US4343898A (en) | 1980-02-11 | 1982-08-10 | Novo Industri A/S | Process for preparing esters of human insulin |
DE3101382A1 (de) | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten" |
DK353781A (da) | 1981-08-10 | 1983-02-11 | Novo Industri As | Fremgangsmaade til fremstilling af insulinderivater |
CA1174623A (en) | 1981-09-15 | 1984-09-18 | Finn H. Andresen | Process for preparing human insulin or b-30 esters thereof |
DE3326473A1 (de) | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
US4946828A (en) * | 1985-03-12 | 1990-08-07 | Novo Nordisk A/S | Novel insulin peptides |
PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
JPH01254699A (ja) | 1988-04-05 | 1989-10-11 | Kodama Kk | インスリン誘導体及びその用途 |
US5149777A (en) | 1988-07-20 | 1992-09-22 | Novo Nordisk A/S | Human insulin analogs and preparations containing them |
DE3837825A1 (de) * | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
JPH04502465A (ja) | 1988-12-23 | 1992-05-07 | ノボ ノルディスク アクティーゼルスカブ | ヒトインシュリン類似物質 |
US5514646A (en) | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
IL93282A (en) | 1989-02-09 | 1995-08-31 | Lilly Co Eli | Insulin analogues |
DK134189D0 (da) | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
DK72793D0 (da) * | 1993-06-21 | 1993-06-21 | Novo Nordisk As | Nyt produkt |
ATE176482T1 (de) | 1993-06-21 | 1999-02-15 | Novo Nordisk As | Asp-b28-insulinkristalle |
PT792290E (pt) | 1993-09-17 | 2002-01-30 | Novo Nordisk As | Insulina acilada |
US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
US5597893A (en) | 1994-10-31 | 1997-01-28 | Eli Lilly And Company | Preparation of stable insulin analog crystals |
US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
US5646242A (en) * | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
WO1996029344A1 (en) | 1995-03-17 | 1996-09-26 | Novo Nordisk A/S | Insulin derivatives |
US5700904A (en) * | 1995-06-07 | 1997-12-23 | Eli Lilly And Company | Preparation of an acylated protein powder |
US5877153A (en) | 1996-06-11 | 1999-03-02 | Commonwealth Biotechnologies Inc. | Heparin-binding peptides |
CZ297682B6 (cs) | 1996-06-20 | 2007-03-07 | Novo Nordisk A/S | Vodný inzulinový prípravek a zpusob jeho prípravy |
US5948751A (en) | 1996-06-20 | 1999-09-07 | Novo Nordisk A/S | X14-mannitol |
AU5749198A (en) | 1997-02-07 | 1998-08-26 | Novo Nordisk A/S | Crystallisation of proteins |
ZA989744B (en) | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
-
1998
- 1998-10-22 BR BR9813111-7A patent/BR9813111A/pt not_active IP Right Cessation
- 1998-10-22 CA CA002306905A patent/CA2306905A1/en not_active Abandoned
- 1998-10-22 ID IDW20000748A patent/ID24890A/id unknown
- 1998-10-22 WO PCT/US1998/022313 patent/WO1999021573A1/en not_active Application Discontinuation
- 1998-10-22 CA CA002306877A patent/CA2306877A1/en not_active Abandoned
- 1998-10-22 US US09/177,685 patent/US6268335B1/en not_active Expired - Lifetime
- 1998-10-22 CN CN98810334A patent/CN1276731A/zh active Pending
- 1998-10-22 HU HU0004169A patent/HUP0004169A3/hu unknown
- 1998-10-22 TR TR2000/01050T patent/TR200001050T2/xx unknown
- 1998-10-22 AU AU11166/99A patent/AU747926B2/en not_active Ceased
- 1998-10-22 AU AU11117/99A patent/AU1111799A/en not_active Abandoned
- 1998-10-22 EP EP98953852A patent/EP1039920A4/en not_active Withdrawn
- 1998-10-22 PE PE1998000996A patent/PE123799A1/es not_active Application Discontinuation
- 1998-10-22 SV SV1998000125A patent/SV1998000125A/es unknown
- 1998-10-22 JP JP2000517731A patent/JP2001521004A/ja not_active Withdrawn
- 1998-10-22 JP JP2000517736A patent/JP2001521006A/ja not_active Withdrawn
- 1998-10-22 EA EA200000453A patent/EA200000453A1/ru unknown
- 1998-10-22 KR KR1020007004395A patent/KR20010024556A/ko not_active Application Discontinuation
- 1998-10-22 IL IL13490198A patent/IL134901A0/xx unknown
- 1998-10-22 PL PL98340255A patent/PL340255A1/xx not_active Application Discontinuation
- 1998-10-22 CO CO98061475A patent/CO4970769A1/es unknown
- 1998-10-22 AR ARP980105267A patent/AR020047A1/es unknown
- 1998-10-22 WO PCT/US1998/022434 patent/WO1999021578A1/en not_active Application Discontinuation
-
2000
- 2000-04-18 NO NO20002038A patent/NO20002038L/no not_active Application Discontinuation
- 2000-04-21 HR HR20000236A patent/HRP20000236A2/hr not_active Application Discontinuation
-
2001
- 2001-01-17 US US09/761,903 patent/US6465426B2/en not_active Expired - Fee Related
- 2001-12-06 US US10/010,038 patent/US20020082199A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO20002038D0 (no) | 2000-04-18 |
SV1998000125A (es) | 1999-05-24 |
IL134901A0 (en) | 2001-05-20 |
CO4970769A1 (es) | 2000-11-07 |
AR020047A1 (es) | 2002-04-10 |
WO1999021578A1 (en) | 1999-05-06 |
ID24890A (id) | 2000-08-31 |
JP2001521004A (ja) | 2001-11-06 |
US20010036916A1 (en) | 2001-11-01 |
AU1116699A (en) | 1999-05-17 |
BR9813111A (pt) | 2000-08-15 |
CA2306905A1 (en) | 1999-05-06 |
HUP0004169A3 (en) | 2001-06-28 |
AU747926B2 (en) | 2002-05-30 |
HUP0004169A2 (hu) | 2001-05-28 |
EP1039920A1 (en) | 2000-10-04 |
KR20010024556A (ko) | 2001-03-26 |
CA2306877A1 (en) | 1999-05-06 |
AU1111799A (en) | 1999-05-17 |
EA200000453A1 (ru) | 2000-10-30 |
EP1039920A4 (en) | 2003-05-28 |
JP2001521006A (ja) | 2001-11-06 |
WO1999021573A1 (en) | 1999-05-06 |
CN1276731A (zh) | 2000-12-13 |
HRP20000236A2 (en) | 2001-02-28 |
US6465426B2 (en) | 2002-10-15 |
PE123799A1 (es) | 1999-12-13 |
PL340255A1 (en) | 2001-01-29 |
US20020082199A1 (en) | 2002-06-27 |
US6268335B1 (en) | 2001-07-31 |
TR200001050T2 (tr) | 2000-08-21 |
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