HUP0102217A2 - Megnövelt cinkmegkötő képességű új inzulinanalógok - Google Patents

Megnövelt cinkmegkötő képességű új inzulinanalógok

Info

Publication number
HUP0102217A2
HUP0102217A2 HU0102217A HUP0102217A HUP0102217A2 HU P0102217 A2 HUP0102217 A2 HU P0102217A2 HU 0102217 A HU0102217 A HU 0102217A HU P0102217 A HUP0102217 A HU P0102217A HU P0102217 A2 HUP0102217 A2 HU P0102217A2
Authority
HU
Hungary
Prior art keywords
insulin analogs
zinc binding
analogs
novel insulin
enhanced zinc
Prior art date
Application number
HU0102217A
Other languages
English (en)
Inventor
Johann Ertl
Karl Geisen
Paul Habermann
Gerhard Seipke
Axel Wollmer
Original Assignee
Aventis Pharma Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh. filed Critical Aventis Pharma Deutschland Gmbh.
Publication of HUP0102217A2 publication Critical patent/HUP0102217A2/hu
Publication of HUP0102217A3 publication Critical patent/HUP0102217A3/hu
Publication of HU228908B1 publication Critical patent/HU228908B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány nagy cink-megkötőképességű inzulinanalógokra, azokelőállítási eljárására, az inzulinanalógok stabil cink-komplexeire,valamint ilyen analógokat, illetve komplexeket tartalmazó, késleltetvemegjelenő inzulinaktivitású gyógyászati készítményekre vonatkozik,amelyek különösen I és II típusú diabetes mellitus kezelésérealkalmazhatók. A találmány szerinti inzulinanalógok az (I) általánosképletnek felelnek meg. Ó
HU0102217A 1998-06-06 1999-05-21 Megnövelt cink-megkötõképességû új inzulinanalógok HU228908B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19825447A DE19825447A1 (de) 1998-06-06 1998-06-06 Neue Insulinanaloga mit erhöhter Zinkbildung
PCT/EP1999/003490 WO1999064598A2 (de) 1998-06-06 1999-05-21 Neue insulinanaloga mit erhöhter zinkbindung

Publications (3)

Publication Number Publication Date
HUP0102217A2 true HUP0102217A2 (hu) 2001-10-28
HUP0102217A3 HUP0102217A3 (en) 2004-04-28
HU228908B1 HU228908B1 (hu) 2013-06-28

Family

ID=7870213

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0102217A HU228908B1 (hu) 1998-06-06 1999-05-21 Megnövelt cink-megkötõképességû új inzulinanalógok

Country Status (24)

Country Link
US (1) US6686177B1 (hu)
EP (1) EP1084248B1 (hu)
JP (1) JP4402296B2 (hu)
KR (1) KR100649339B1 (hu)
CN (1) CN1304450B (hu)
AR (1) AR019852A1 (hu)
AT (1) ATE334201T1 (hu)
AU (1) AU757275B2 (hu)
BR (1) BR9910978A (hu)
CA (1) CA2330183C (hu)
CZ (1) CZ301377B6 (hu)
DE (2) DE19825447A1 (hu)
DK (1) DK1084248T3 (hu)
ES (1) ES2268871T3 (hu)
HK (1) HK1036808A1 (hu)
HU (1) HU228908B1 (hu)
MX (1) MXPA00011456A (hu)
NO (1) NO329956B1 (hu)
PL (1) PL198190B1 (hu)
PT (1) PT1084248E (hu)
RU (1) RU2225723C2 (hu)
TR (1) TR200003606T2 (hu)
WO (1) WO1999064598A2 (hu)
ZA (1) ZA200006835B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
AU2002248464A1 (en) 2001-02-21 2002-09-12 Medtronic Minimed, Inc. Stabilized insulin formulations
US20040038864A1 (en) * 2002-06-27 2004-02-26 Per Balschmidt Use of dimethyl sulfone as isotonicity agent
EP2626368B1 (en) 2004-07-19 2016-12-21 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
RU2453332C2 (ru) * 2007-10-16 2012-06-20 Байокон Лимитид Твердая фармацевтическая композиция (варианты) и способ контроля концентрации глюкозы с ее помощью, способ получения твердой фармацевтической композиции (варианты), таблетка (варианты) и способ получения амфорных частиц
ES2430042T3 (es) * 2007-11-16 2013-11-18 Novo Nordisk A/S Composiciones farmacéuticas estables que comprenden liraglutida y degludec
PL219335B1 (pl) 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
MY158627A (en) * 2008-07-31 2016-10-31 Univ Case Western Reserve Halogen-stabilized insulin
WO2011103575A1 (en) * 2010-02-22 2011-08-25 Case Western Reserve University Long-acting insulin analogue preparations in soluble and crystalline forms
PL222975B1 (pl) 2012-05-23 2016-09-30 Inst Biotechnologii I Antybiotyków Analog insuliny lub jego farmaceutycznie dopuszczalna sól, kompozycja farmaceutyczna o przedłużonym działaniu terapeutycznym oraz zastosowanie analogu insuliny
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
WO2016144658A1 (en) * 2015-03-10 2016-09-15 Merck Sharp & Dohme Corp. Process for preparing recombinant insulin using microfiltration
UY36870A (es) * 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI78616C (fi) 1982-02-05 1989-09-11 Novo Industri As Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
DE3326472A1 (de) 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3440988A1 (de) 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
US4569794A (en) 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
US5008241A (en) 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DE3526995A1 (de) 1985-07-27 1987-02-05 Hoechst Ag Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DE3636903A1 (de) 1985-12-21 1987-07-02 Hoechst Ag Fusionsproteine mit eukaryotischem ballastanteil
DE3541856A1 (de) 1985-11-27 1987-06-04 Hoechst Ag Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
CA1340522C (en) 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
DE3805150A1 (de) 1987-04-11 1988-10-20 Hoechst Ag Gentechnologisches verfahren zur herstellung von polypeptiden
DE4012818A1 (de) 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3726655A1 (de) 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
DE3739347A1 (de) 1987-11-20 1989-06-01 Hoechst Ag Verfahren zur selektiven spaltung von fusionsproteinen
DK257988D0 (da) * 1988-05-11 1988-05-11 Novo Industri As Nye peptider
ES2061797T3 (es) 1988-06-23 1994-12-16 Hoechst Ag Mini-proinsulina, su preparacion y empleo.
DE3827533A1 (de) 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5227293A (en) 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
US5358857A (en) 1989-08-29 1994-10-25 The General Hospital Corp. Method of preparing fusion proteins
IL95495A (en) 1989-08-29 1996-10-16 Hoechst Ag Fusion proteins their preparation and use
DE59305396D1 (de) 1992-12-02 1997-03-20 Hoechst Ag Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
DK0705275T3 (da) * 1993-06-21 1999-09-20 Novo Nordisk As AspB28-insulin-krystaller
WO1995007931A1 (en) * 1993-09-17 1995-03-23 Novo Nordisk A/S Acylated insulin
DE4405179A1 (de) 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
ATE264871T1 (de) * 1996-07-26 2004-05-15 Aventis Pharma Gmbh Insulinderivate mit erhöhter zinkbindung
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung

Also Published As

Publication number Publication date
AU4145499A (en) 1999-12-30
TR200003606T2 (tr) 2001-06-21
NO20006177D0 (no) 2000-12-05
PL345898A1 (en) 2002-01-14
ES2268871T3 (es) 2007-03-16
JP4402296B2 (ja) 2010-01-20
KR20010052635A (ko) 2001-06-25
CZ20004525A3 (cs) 2001-04-11
NO329956B1 (no) 2011-01-31
DK1084248T3 (da) 2006-11-20
EP1084248B1 (de) 2006-07-26
ATE334201T1 (de) 2006-08-15
US6686177B1 (en) 2004-02-03
CZ301377B6 (cs) 2010-02-03
DE19825447A1 (de) 1999-12-09
KR100649339B1 (ko) 2006-11-24
WO1999064598A2 (de) 1999-12-16
JP2002517247A (ja) 2002-06-18
MXPA00011456A (es) 2002-10-17
HUP0102217A3 (en) 2004-04-28
CN1304450A (zh) 2001-07-18
CA2330183C (en) 2009-10-20
DE59913711D1 (de) 2006-09-07
ZA200006835B (en) 2001-07-09
HU228908B1 (hu) 2013-06-28
BR9910978A (pt) 2001-02-13
AR019852A1 (es) 2002-03-20
EP1084248A2 (de) 2001-03-21
PL198190B1 (pl) 2008-06-30
CA2330183A1 (en) 1999-12-16
HK1036808A1 (en) 2002-01-18
PT1084248E (pt) 2006-11-30
WO1999064598A3 (de) 2000-03-16
CN1304450B (zh) 2012-10-10
RU2225723C2 (ru) 2004-03-20
AU757275B2 (en) 2003-02-13
NO20006177L (no) 2000-12-05

Similar Documents

Publication Publication Date Title
HUP0102217A2 (hu) Megnövelt cinkmegkötő képességű új inzulinanalógok
IL127352A0 (en) Pyridyl alkene- and pyridyl alkine-acid amides as cytostatics and immunosupressives
HUP0004169A2 (hu) Oldhatatlan inzulinkészítmények és eljárás ezek előállítására
AR010385A1 (es) Compuesto derivado de propiofenona, proceso para su preparacion, composicion farmaceutica que lo contiene y uso de dicho compuesto.
HUP0100243A2 (hu) Inzulint és/vagy inzulin-analógokat és azok származékait tartalmazó oldhatatlan készítmények, eljárás azok előállítására és alkalmazásuk a vércukor szintjének szabályozására
TNSN05244A1 (en) Novel diphenyl azetidinone with improved physiological characteristics, corresponding production method, medicaments containing said compound and use of the latter
MY117785A (en) New 3-aryl-2-hydroxypropionic acid derivatives i
MY122383A (en) Cyclic boroproline compounds
MY126527A (en) Novel dihydropyrimidines
MY128441A (en) Bipiperidine derivatives as modulators of ccr3 activity and as h1 antogonists
PL346520A1 (en) Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
DE69434590D1 (de) Maltose-Trehalose-konvertierendes Enzym, dessen Herstellung und Verwendung
SE8804570D0 (sv) New ciclosporin crystal form process for its produktion pharmaceutical compositions containing it and its use
MY135920A (en) New phenalkyloxy-phenyl derivatives
ES8705414A1 (es) Un procedimiento para preparar laudanos
EP1026157A3 (en) Method for the synthesis of huperzine A and analogs thereof and compounds useful therein
HUT68589A (en) The cyclodextrin cluster complexes of taxol, taxotere, or taxus, process for their production, and use of them
LT2004074A (en) Matricines metalproteinazes inhibuojanti kompozicija neoplazinems ligoms gydyti
TW261615B (hu)
SE9904421D0 (sv) New compounds
YU68702A (sh) Novi lhrh-antagonisti, njihova proizvodnja i upotreba kao leka
AP2001002377A0 (en) Substituted phenoxyacetic acids.
GB8727099D0 (en) Compositions containing melantonin/homologues
EP0775157A4 (en) HUMAN-PORPHYRIN SERUMALBUMIN COMPLEXES THAT CAN BIND OXYGEN AND THEIR THERAPEUTIC USES
TR200101083T2 (tr) (7alfa,17alfa)-17-hidroksi- 7-metil-19-nor-17-pregn-5 (10)-en-20-in-3-on içeren yüksek saflıkta bileşim.

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees