HK1036808A1 - Novel insulin analogs with enhanced zinc binding - Google Patents

Novel insulin analogs with enhanced zinc binding

Info

Publication number
HK1036808A1
HK1036808A1 HK01107736.3A HK01107736A HK1036808A1 HK 1036808 A1 HK1036808 A1 HK 1036808A1 HK 01107736 A HK01107736 A HK 01107736A HK 1036808 A1 HK1036808 A1 HK 1036808A1
Authority
HK
Hong Kong
Prior art keywords
insulin analogs
zinc binding
novel insulin
enhanced zinc
enhanced
Prior art date
Application number
HK01107736.3A
Other languages
English (en)
Inventor
Johann Ertl
Paul Habermann
Karl Geisen
Gerhard Seipke
Axel Wollmer
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of HK1036808A1 publication Critical patent/HK1036808A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK01107736.3A 1998-06-06 2001-11-06 Novel insulin analogs with enhanced zinc binding HK1036808A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19825447A DE19825447A1 (de) 1998-06-06 1998-06-06 Neue Insulinanaloga mit erhöhter Zinkbildung
PCT/EP1999/003490 WO1999064598A2 (de) 1998-06-06 1999-05-21 Neue insulinanaloga mit erhöhter zinkbindung

Publications (1)

Publication Number Publication Date
HK1036808A1 true HK1036808A1 (en) 2002-01-18

Family

ID=7870213

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01107736.3A HK1036808A1 (en) 1998-06-06 2001-11-06 Novel insulin analogs with enhanced zinc binding

Country Status (24)

Country Link
US (1) US6686177B1 (xx)
EP (1) EP1084248B1 (xx)
JP (1) JP4402296B2 (xx)
KR (1) KR100649339B1 (xx)
CN (1) CN1304450B (xx)
AR (1) AR019852A1 (xx)
AT (1) ATE334201T1 (xx)
AU (1) AU757275B2 (xx)
BR (1) BR9910978A (xx)
CA (1) CA2330183C (xx)
CZ (1) CZ301377B6 (xx)
DE (2) DE19825447A1 (xx)
DK (1) DK1084248T3 (xx)
ES (1) ES2268871T3 (xx)
HK (1) HK1036808A1 (xx)
HU (1) HU228908B1 (xx)
MX (1) MXPA00011456A (xx)
NO (1) NO329956B1 (xx)
PL (1) PL198190B1 (xx)
PT (1) PT1084248E (xx)
RU (1) RU2225723C2 (xx)
TR (1) TR200003606T2 (xx)
WO (1) WO1999064598A2 (xx)
ZA (1) ZA200006835B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
US6852694B2 (en) 2001-02-21 2005-02-08 Medtronic Minimed, Inc. Stabilized insulin formulations
US20040038864A1 (en) * 2002-06-27 2004-02-26 Per Balschmidt Use of dimethyl sulfone as isotonicity agent
EP2626368B1 (en) * 2004-07-19 2016-12-21 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
BRPI0818004B8 (pt) * 2007-10-16 2021-05-25 Biocon Ltd composição farmacêutica sólida administrável por via oral e o processo da mesma.
PL2597103T3 (pl) * 2007-11-16 2017-04-28 Novo Nordisk A/S Stabilne kompozycje farmaceutyczne zawierające liraglutyd i degludec
PL219335B1 (pl) * 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
ES2552636T3 (es) * 2008-07-31 2015-12-01 Case Western Reserve University Insulina estabilizada por halógenos
WO2011103575A1 (en) * 2010-02-22 2011-08-25 Case Western Reserve University Long-acting insulin analogue preparations in soluble and crystalline forms
PL222975B1 (pl) 2012-05-23 2016-09-30 Inst Biotechnologii I Antybiotyków Analog insuliny lub jego farmaceutycznie dopuszczalna sól, kompozycja farmaceutyczna o przedłużonym działaniu terapeutycznym oraz zastosowanie analogu insuliny
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
US10562951B2 (en) 2015-03-10 2020-02-18 Merck Sharp & Dohme Corp. Process for preparing recombinant insulin using microfiltration
UY36870A (es) * 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI78616C (fi) 1982-02-05 1989-09-11 Novo Industri As Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
DE3326472A1 (de) 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3440988A1 (de) 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
US4569794A (en) * 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
US5008241A (en) 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DE3526995A1 (de) 1985-07-27 1987-02-05 Hoechst Ag Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DE3541856A1 (de) 1985-11-27 1987-06-04 Hoechst Ag Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
DE3636903A1 (de) 1985-12-21 1987-07-02 Hoechst Ag Fusionsproteine mit eukaryotischem ballastanteil
CA1340522C (en) 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
DE3805150A1 (de) 1987-04-11 1988-10-20 Hoechst Ag Gentechnologisches verfahren zur herstellung von polypeptiden
DE4012818A1 (de) 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3726655A1 (de) 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
DE3739347A1 (de) 1987-11-20 1989-06-01 Hoechst Ag Verfahren zur selektiven spaltung von fusionsproteinen
DK257988D0 (da) * 1988-05-11 1988-05-11 Novo Industri As Nye peptider
DE58906966D1 (de) 1988-06-23 1994-03-24 Hoechst Ag Mini-Proinsulin, seine Herstellung und Verwendung.
DE3827533A1 (de) 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
GR1005153B (el) 1989-08-29 2006-03-13 The General Hospital Corporation Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους.
US5358857A (en) 1989-08-29 1994-10-25 The General Hospital Corp. Method of preparing fusion proteins
US5227293A (en) 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
DK0600372T3 (da) 1992-12-02 1997-08-11 Hoechst Ag Fremgangsmåde til fremstilling af proinsulin med korrekt forbundne cystinbroer.
ATE176482T1 (de) * 1993-06-21 1999-02-15 Novo Nordisk As Asp-b28-insulinkristalle
JP3014764B2 (ja) * 1993-09-17 2000-02-28 ノボ ノルディスク アクティーゼルスカブ アシル化インスリン
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
ATE264871T1 (de) * 1996-07-26 2004-05-15 Aventis Pharma Gmbh Insulinderivate mit erhöhter zinkbindung
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung

Also Published As

Publication number Publication date
HUP0102217A2 (hu) 2001-10-28
PT1084248E (pt) 2006-11-30
ZA200006835B (en) 2001-07-09
JP2002517247A (ja) 2002-06-18
RU2225723C2 (ru) 2004-03-20
CA2330183C (en) 2009-10-20
US6686177B1 (en) 2004-02-03
DE19825447A1 (de) 1999-12-09
EP1084248B1 (de) 2006-07-26
WO1999064598A3 (de) 2000-03-16
PL198190B1 (pl) 2008-06-30
KR20010052635A (ko) 2001-06-25
DE59913711D1 (de) 2006-09-07
KR100649339B1 (ko) 2006-11-24
HUP0102217A3 (en) 2004-04-28
CZ20004525A3 (cs) 2001-04-11
CA2330183A1 (en) 1999-12-16
CZ301377B6 (cs) 2010-02-03
CN1304450B (zh) 2012-10-10
BR9910978A (pt) 2001-02-13
AU757275B2 (en) 2003-02-13
NO20006177D0 (no) 2000-12-05
WO1999064598A2 (de) 1999-12-16
MXPA00011456A (es) 2002-10-17
AU4145499A (en) 1999-12-30
JP4402296B2 (ja) 2010-01-20
NO329956B1 (no) 2011-01-31
NO20006177L (no) 2000-12-05
PL345898A1 (en) 2002-01-14
EP1084248A2 (de) 2001-03-21
TR200003606T2 (tr) 2001-06-21
ES2268871T3 (es) 2007-03-16
DK1084248T3 (da) 2006-11-20
CN1304450A (zh) 2001-07-18
HU228908B1 (hu) 2013-06-28
AR019852A1 (es) 2002-03-20
ATE334201T1 (de) 2006-08-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20160521