NO177318C - Fremgangsmåte for fremstilling av prorennin og human-anafylatoksin C5a i Y. lipolytica, samt plasmider til fremstillingen - Google Patents

Fremgangsmåte for fremstilling av prorennin og human-anafylatoksin C5a i Y. lipolytica, samt plasmider til fremstillingen

Info

Publication number
NO177318C
NO177318C NO864148A NO864148A NO177318C NO 177318 C NO177318 C NO 177318C NO 864148 A NO864148 A NO 864148A NO 864148 A NO864148 A NO 864148A NO 177318 C NO177318 C NO 177318C
Authority
NO
Norway
Prior art keywords
lipolytica
heterologous
xpr2
plasmids
preparation
Prior art date
Application number
NO864148A
Other languages
English (en)
Norwegian (no)
Other versions
NO864148L (no
NO177318B (no
NO864148D0 (no
Inventor
Lance Steven Davidow
John Robert Dezeeuw
Arthur Ernest Franke
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO864148D0 publication Critical patent/NO864148D0/no
Publication of NO864148L publication Critical patent/NO864148L/no
Priority to NO923616A priority Critical patent/NO178793C/no
Publication of NO177318B publication Critical patent/NO177318B/no
Publication of NO177318C publication Critical patent/NO177318C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Treatment Of Sludge (AREA)
  • Magnetic Ceramics (AREA)
  • Peptides Or Proteins (AREA)
  • Paper (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
  • Fodder In General (AREA)
  • Noodles (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
NO864148A 1985-10-18 1986-10-17 Fremgangsmåte for fremstilling av prorennin og human-anafylatoksin C5a i Y. lipolytica, samt plasmider til fremstillingen NO177318C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO923616A NO178793C (no) 1985-10-18 1992-09-17 Fremgangsmåte for fremstilling av en Yarrowia lipolytica-transformant som ikke produserer alkalisk protease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78920685A 1985-10-18 1985-10-18
US06/841,121 US4937189A (en) 1985-10-18 1986-03-18 Expression and secretion of heterologous proteins by Yarrowia lipolytica transformants

Publications (4)

Publication Number Publication Date
NO864148D0 NO864148D0 (no) 1986-10-17
NO864148L NO864148L (no) 1987-04-21
NO177318B NO177318B (no) 1995-05-15
NO177318C true NO177318C (no) 1995-08-23

Family

ID=27120892

Family Applications (2)

Application Number Title Priority Date Filing Date
NO864148A NO177318C (no) 1985-10-18 1986-10-17 Fremgangsmåte for fremstilling av prorennin og human-anafylatoksin C5a i Y. lipolytica, samt plasmider til fremstillingen
NO923616A NO178793C (no) 1985-10-18 1992-09-17 Fremgangsmåte for fremstilling av en Yarrowia lipolytica-transformant som ikke produserer alkalisk protease

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO923616A NO178793C (no) 1985-10-18 1992-09-17 Fremgangsmåte for fremstilling av en Yarrowia lipolytica-transformant som ikke produserer alkalisk protease

Country Status (24)

Country Link
US (1) US4937189A (fr)
EP (1) EP0220864B1 (fr)
JP (1) JP3096297B2 (fr)
KR (1) KR900008950B1 (fr)
CN (3) CN1034428C (fr)
AT (1) ATE86302T1 (fr)
AU (1) AU586041B2 (fr)
CA (1) CA1340837C (fr)
DD (7) DD267995A5 (fr)
DE (1) DE3687878T2 (fr)
DK (1) DK496886A (fr)
EG (1) EG18142A (fr)
ES (1) ES2038966T3 (fr)
FI (1) FI90352C (fr)
HU (1) HU209150B (fr)
IE (1) IE59774B1 (fr)
IL (7) IL99893A (fr)
NO (2) NO177318C (fr)
NZ (1) NZ217985A (fr)
PH (3) PH27026A (fr)
PL (2) PL154427B1 (fr)
PT (1) PT83562B (fr)
RU (2) RU2157845C2 (fr)
YU (2) YU46412B (fr)

Families Citing this family (39)

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JPH082304B2 (ja) * 1987-12-17 1996-01-17 オリエンタル酵母工業株式会社 プラスミドとその製造方法
FR2626584B1 (fr) * 1988-01-28 1990-07-13 Agronomique Inst Nat Rech Sequence ars efficace chez yarrowia lipolytica et procede pour sa preparation
EP0382332A3 (fr) * 1989-01-06 1990-11-14 Collaborative Research Inc. Mutants modifiés de Saccharomyces cerevisiae à hypersécrétion
JPH0669365B2 (ja) * 1989-05-22 1994-09-07 株式会社ミドリ十字 アルブミン遺伝子を含むプラスミド、形質転換体、形質転換体の製造方法、アルブミンの製造方法
EP0402226A1 (fr) * 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Vecteurs de transformation de la levure yarrowia
JPH08508892A (ja) * 1993-09-02 1996-09-24 ファイザー・インク． 多重組込みベクター及びヤロウィア・リポリティカ形質転換体
US5837499A (en) * 1993-12-06 1998-11-17 Ciba-Geigy Corporation DNA encoding C5A receptor antagonists having substantially no agonist activity and methods of expressing same
US5807824A (en) * 1993-12-06 1998-09-15 Ciba-Geigy Corporation C5A receptor antagonists having substantially no agonist activity
DE19513152A1 (de) 1995-04-07 1996-10-10 Bundesrep Deutschland Verwendung eines "Immundefizienzvirus-supprimierenden Lymphokins (ISL)" zur Hemmung der Virusvermehrung, insbesondere von Retroviren
AU6125096A (en) * 1995-06-05 1996-12-24 Novartis Ag C5a receptor antagonists having substantially no agonist activity and methods for preparation
EP0747484A1 (fr) 1995-06-08 1996-12-11 Institut National De La Recherche Agronomique (Inra) Séquences activatrices en amont et séquences promotrices recombinantes fonctionelles dans yarrowia et vecteurs les contenant
EP0922109A1 (fr) 1996-05-21 1999-06-16 Novo Nordisk A/S Nouveaux promoteurs de levures convenant au clonage d'expression dans la levure et expression heterologue de proteines dans la levure
FR2782733B1 (fr) 1998-09-01 2002-02-08 Agronomique Inst Nat Rech Procede de transformation non-homologue de yarrowia lipolytica
US20110059496A1 (en) * 2003-06-25 2011-03-10 E. I. Du Pont De Nemours And Company Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
US7459546B2 (en) 2003-06-25 2008-12-02 E.I. Du Pont De Nemours And Company Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase regulatory sequences for gene expression in oleaginous yeast
US7259255B2 (en) * 2003-06-25 2007-08-21 E. I. Du Pont De Nemours And Company Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
US7202356B2 (en) * 2003-11-14 2007-04-10 E. I. Du Pont De Nemours And Company Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast
US7264949B2 (en) * 2004-09-15 2007-09-04 E.I. Du Pont De Nemours And Company Glycerol-3-phosphate o-acyltransferase promoter for gene expression in oleaginous yeast
US20060094102A1 (en) * 2004-11-04 2006-05-04 Zhixiong Xue Ammonium transporter promoter for gene expression in oleaginous yeast
EP2371967B1 (fr) 2005-03-18 2015-06-03 DSM IP Assets B.V. Production de caroténoïdes dans des levures oléagineuses et des champignons
WO2008042338A2 (fr) 2006-09-28 2008-04-10 Microbia, Inc. Production de caroténoïdes dans des levures et des champignons oléagineux
FR2927089B1 (fr) * 2008-02-05 2011-03-25 Inst Nat De La Rech Agronomique Inra Procede d'integration ciblee de multicopies d'un gene d'interet dans une souche de yarrowia
US8597931B2 (en) * 2008-07-11 2013-12-03 Institut National De La Recherche Agronomique (Inra) Mutant yeast strains capable of accumulating a large quantity of lipids
FR2962133B1 (fr) 2010-07-01 2014-09-12 Agronomique Inst Nat Rech Optimisation de la synthese et de l'accumulation de lipides
JP2014503216A (ja) * 2010-12-30 2014-02-13 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー スクロース利用のための、ヤロウィア・リポリティカ（Ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）におけるサッカロミセス・セレビシア（Ｓａｃｃｈａｒｏｍｙｃｅｓｃｅｒｅｖｉｓｉａｅ）ＳＵＣ２遺伝子の使用
WO2012135773A1 (fr) 2011-03-31 2012-10-04 E. I. Du Pont De Nemours And Company Régions promotrices de diacylglycérol acyltransférase d'yarrowia pour l'expression du gène dans la levure
EP2694657A1 (fr) 2011-04-05 2014-02-12 E. I. Du Pont de Nemours and Company Régions promotrices du cytochrome p450 hydroxylant les n-alcanes dérivées d'yarrowia pour l'expression génique dans la levure
WO2012138612A1 (fr) 2011-04-07 2012-10-11 E. I. Du Pont De Nemours And Company Régions promotrices de 2,4-diénoyl-coa réductase peroxysomale de yarrowia pour l'expression génique dans la levure
GB201106188D0 (en) * 2011-04-12 2011-05-25 Csir Production of extracellular polypeptides
FR3002774A1 (fr) 2013-03-04 2014-09-05 Agronomique Inst Nat Rech Levures mutantes ayant une production accrue de lipides et d'acide citrique
FR3005317B1 (fr) 2013-05-02 2016-03-18 Agronomique Inst Nat Rech Levures mutantes capables de produire un acide gras inhabituel
EA035512B1 (ru) 2014-01-31 2020-06-29 ДСМ АйПи АССЕТС Б.В. Промоторы, подходящие для экспрессии гетерологичных генов в дрожжах
US20170145449A1 (en) 2014-06-11 2017-05-25 Institut National De La Recherche Agronomique Improved lipid accumulation in Yarrowia lipolytica strains by overexpression of hexokinase and new strains thereof
WO2016075314A1 (fr) 2014-11-13 2016-05-19 Institut National De La Recherche Agronomique Identification de facteurs de transcription de yarrowia lipolytica affectant la production de proteines
FR3028527A1 (fr) 2014-11-13 2016-05-20 Pivert Identification de facteurs de transcription de yarrowia lipolytica
WO2017100158A1 (fr) 2015-12-11 2017-06-15 Danisco Us Inc. Procédés et compositions pour modification de génome médiée par nucléase augmentée et effets hors-site cible réduits
EP3390631B1 (fr) 2015-12-18 2020-04-08 Danisco US Inc. Procédés et compositions pour l'expression d'arn de guidage à base d'arnt
WO2017194424A1 (fr) 2016-05-10 2017-11-16 Institut National De La Recherche Agronomique Souches de levure mutante à production améliorée d'érythritol ou d'érythrulose
EP3348647A1 (fr) 2017-01-13 2018-07-18 Institut National De La Recherche Agronomique Souche de levure mutant capable de produir acides gras a chaîne moyenne

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US4394443A (en) * 1980-12-18 1983-07-19 Yale University Method for cloning genes
US4666847A (en) * 1981-01-16 1987-05-19 Collaborative Research, Inc. Recombinant DNA means and method
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US4546082A (en) * 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
NZ207926A (en) * 1983-04-25 1988-04-29 Genentech Inc Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
IN163393B (fr) * 1983-10-06 1988-09-17 Pfizer
US4628033A (en) * 1983-10-06 1986-12-09 Pfizer Inc. Novel host strain for transformation of Yarrowia lipolytica
EP0166659B1 (fr) * 1984-06-26 1989-08-30 Institut National De La Recherche Agronomique (Inra) Vecteurs de transformation de la levure yarrowia lipolytica, procédé de transformation et levure transformée

Also Published As

Publication number Publication date
PL154427B1 (en) 1991-08-30
FI90352C (fi) 1994-01-25
IL99893A0 (en) 1992-08-18
PH27171A (en) 1993-04-02
YU46412B (sh) 1993-10-20
DD267995A5 (de) 1989-05-17
IL99892A (en) 1993-02-21
AU6416186A (en) 1987-05-14
IE59774B1 (en) 1994-04-06
PH27198A (en) 1993-04-16
DE3687878D1 (de) 1993-04-08
YU177386A (en) 1989-04-30
AU586041B2 (en) 1989-06-29
DD269397A5 (de) 1989-06-28
EG18142A (en) 1992-08-30
RU2157845C2 (ru) 2000-10-20
IL80297A0 (en) 1987-01-30
US4937189A (en) 1990-06-26
NO178793B (no) 1996-02-26
IE862754L (en) 1987-04-18
DD269396A5 (de) 1989-06-28
EP0220864B1 (fr) 1993-03-03
PL261912A1 (en) 1987-10-19
IL99894A (en) 1993-02-21
KR870004138A (ko) 1987-05-07
NO864148L (no) 1987-04-21
IL99892A0 (en) 1992-08-18
KR900008950B1 (ko) 1990-12-15
DD267996A5 (de) 1989-05-17
FI864206A0 (fi) 1986-10-17
DD267997A5 (de) 1989-05-17
IL99893A (en) 1993-02-21
YU124588A (en) 1989-08-31
JP3096297B2 (ja) 2000-10-10
RU2069694C1 (ru) 1996-11-27
NO923616D0 (no) 1992-09-17
PL155850B1 (en) 1992-01-31
HUT43632A (en) 1987-11-30
YU46571B (sh) 1993-11-16
FI864206A (fi) 1987-04-19
CN1138632A (zh) 1996-12-25
NO923616L (no) 1987-04-21
EP0220864A1 (fr) 1987-05-06
PH27026A (en) 1993-02-01
HU209150B (en) 1994-03-28
NZ217985A (en) 1991-06-25
DK496886D0 (da) 1986-10-17
DD276886A5 (de) 1990-03-14
ATE86302T1 (de) 1993-03-15
NO177318B (no) 1995-05-15
DE3687878T2 (de) 1993-07-15
IL80297A (en) 1993-02-21
IL99894A0 (en) 1992-08-18
JPS63164889A (ja) 1988-07-08
PT83562B (pt) 1989-05-31
CN1034428C (zh) 1997-04-02
PT83562A (en) 1986-11-01
DD267998A5 (de) 1989-05-17
CN1069346C (zh) 2001-08-08
CN86106522A (zh) 1987-09-16
CA1340837C (fr) 1999-12-07
CN1141339A (zh) 1997-01-29
DK496886A (da) 1987-06-11
FI90352B (fi) 1993-10-15
ES2038966T3 (es) 1993-08-16
NO178793C (no) 1996-06-05
NO864148D0 (no) 1986-10-17

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