NO177301C - Analogifremgangsmåte for fremstilling av terapeutisk aktive N-(aryloksyalkyl)heteroarylpiperidiner og -heteroarylpiperaziner - Google Patents
Analogifremgangsmåte for fremstilling av terapeutisk aktive N-(aryloksyalkyl)heteroarylpiperidiner og -heteroarylpiperazinerInfo
- Publication number
- NO177301C NO177301C NO902214A NO902214A NO177301C NO 177301 C NO177301 C NO 177301C NO 902214 A NO902214 A NO 902214A NO 902214 A NO902214 A NO 902214A NO 177301 C NO177301 C NO 177301C
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- alkyl
- chem
- alkoxy
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35441189A | 1989-05-19 | 1989-05-19 | |
| US45679089A | 1989-12-29 | 1989-12-29 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO902214D0 NO902214D0 (no) | 1990-05-18 |
| NO902214L NO902214L (no) | 1990-11-20 |
| NO177301B NO177301B (no) | 1995-05-15 |
| NO177301C true NO177301C (no) | 1995-08-23 |
Family
ID=26998389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO902214A NO177301C (no) | 1989-05-19 | 1990-05-18 | Analogifremgangsmåte for fremstilling av terapeutisk aktive N-(aryloksyalkyl)heteroarylpiperidiner og -heteroarylpiperaziner |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0402644B1 (cs) |
| JP (1) | JPH0662580B2 (cs) |
| KR (1) | KR0157308B1 (cs) |
| CN (2) | CN1086387C (cs) |
| AT (1) | ATE126512T1 (cs) |
| AU (1) | AU640653B2 (cs) |
| CA (1) | CA2017193C (cs) |
| CZ (1) | CZ282385B6 (cs) |
| DD (1) | DD300433A5 (cs) |
| DE (1) | DE69021645T2 (cs) |
| DK (1) | DK0402644T3 (cs) |
| ES (1) | ES2076253T3 (cs) |
| FI (2) | FI104072B1 (cs) |
| GR (1) | GR3017447T3 (cs) |
| HU (2) | HU218200B (cs) |
| IE (1) | IE68431B1 (cs) |
| IL (1) | IL94425A (cs) |
| NO (1) | NO177301C (cs) |
| NZ (1) | NZ233710A (cs) |
| PL (1) | PL163965B1 (cs) |
| PT (1) | PT94084B (cs) |
| RU (3) | RU2062776C1 (cs) |
| SK (1) | SK279474B6 (cs) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5561128A (en) * | 1989-05-19 | 1996-10-01 | Hoechst-Roussel Pharmaceuticals, Inc. | N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility |
| US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| DK203990D0 (da) * | 1990-08-24 | 1990-08-24 | Novo Nordisk As | Piperazinylderivater |
| US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
| US5177088A (en) * | 1991-04-17 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 3-(pyridinylamino)-indoles |
| TW241263B (cs) * | 1991-08-22 | 1995-02-21 | Hoechst Roussel Pharma | |
| NZ240863A (en) * | 1991-09-11 | 1995-04-27 | Mcneilab Inc | Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof |
| US5378714A (en) * | 1991-11-27 | 1995-01-03 | Novo Nordisk A/S | Antipsychotic piperidine derivatives |
| NZ245260A (en) * | 1991-11-27 | 1995-06-27 | Novo Nordisk As | Piperidine derivatives, preparation and pharmaceutical compositions thereof |
| WO1993013068A1 (fr) * | 1991-12-25 | 1993-07-08 | Zeria Pharmaceutical Co., Ltd. | Compose tricyclique et medicament renfermant ce compose |
| EP0665840A1 (en) * | 1992-10-23 | 1995-08-09 | MERCK SHARP & DOHME LTD. | Dopamine receptor subtype ligands |
| JPH08502508A (ja) * | 1992-10-23 | 1996-03-19 | メルク シヤープ エンド ドーム リミテツド | ドーパミンレセプターサブタイプリガンド |
| DK60793D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
| DK60593D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
| GB9318691D0 (en) * | 1993-09-09 | 1993-10-27 | Merck Sharp & Dohme | Therapeutic agents |
| EP0724572B1 (en) * | 1993-09-15 | 1998-12-16 | MERCK SHARP & DOHME LTD. | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands |
| JP3274579B2 (ja) * | 1995-01-12 | 2002-04-15 | 住友製薬株式会社 | 脳血管障害に伴う精神症候治療剤 |
| ES2101646B1 (es) * | 1995-04-12 | 1998-04-01 | Ferrer Int | Nuevo compuesto derivado del cromeno. |
| US5668148A (en) * | 1995-04-20 | 1997-09-16 | Merck & Co., Inc. | Alpha1a adrenergic receptor antagonists |
| CA2223011C (en) * | 1995-06-02 | 2007-01-09 | Synthelabo | Oxazolidinone derivatives, their preparation and therapeutical use |
| PT833820E (pt) * | 1995-06-06 | 2001-07-31 | Aventis Pharmaceuticals Inc Av | Derivados de benzisoxazol e indazol uteis como agentes antipsicoticos |
| US5880121A (en) * | 1996-01-05 | 1999-03-09 | Hoechst Marion Roussel Inc. | 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof |
| AU710059B2 (en) * | 1996-01-05 | 1999-09-09 | Aventis Pharmaceuticals Inc. | 4,5-dihydronaphth(1,2-C)isoxazoles and derivatives thereof having CNS activity |
| ES2144355B1 (es) * | 1997-12-30 | 2001-01-01 | Ferrer Int | Compuestos derivados del cromeno. |
| WO2001017993A1 (en) * | 1999-09-09 | 2001-03-15 | EGIS Gyógyszergyár Rt. | Alkylpiperidi nylbenzo [d] isoxazole derivatives having psychotropic activity, pharmaceutical compositions containing the same, and a process for the preparation of the active ingredient |
| AU2006201188B2 (en) * | 2001-02-05 | 2007-11-15 | Novartis Ag | New use of iloperidone |
| GB0102841D0 (en) * | 2001-02-05 | 2001-03-21 | Novartis Ag | Organic compounds |
| RU2265018C2 (ru) * | 2001-04-18 | 2005-11-27 | Эро-Селтик, С.А. | Производные бензимидазола и фармацевтические композиции на их основе |
| EP2305656B1 (en) | 2001-08-31 | 2012-10-24 | Novartis AG | Optical isomers of an iloperidone metabolite |
| EP1441727B1 (en) | 2001-10-30 | 2010-12-29 | Novartis AG | Depot formulations of iloperidone and a star polymer |
| US6995144B2 (en) * | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
| GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
| PL375981A1 (en) * | 2002-09-17 | 2005-12-12 | Warner-Lambert Company Llc | Heterocyclic substituted piperazines for the treatment of schizophrenia |
| EP1562919A1 (en) * | 2002-11-08 | 2005-08-17 | Warner-Lambert Company LLC | Phenylalkyl and pyridylalkyl piperazine derivatives |
| US7160888B2 (en) | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
| GB0322994D0 (en) * | 2003-10-01 | 2003-11-05 | Novartis Ag | Organic compounds |
| RU2283650C1 (ru) * | 2005-02-24 | 2006-09-20 | Закрытое Акционерное Общество "Канонфарма Продакшн" | Твердая лекарственная форма для улучшения мужской эректильной функции |
| DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| JP2010519171A (ja) | 2006-02-17 | 2010-06-03 | メモリー・ファーマシューティカルズ・コーポレイション | ５−ｈｔ６受容体親和性を有する化合物 |
| HRP20170027T1 (hr) | 2006-11-22 | 2017-03-10 | Clinical Research Associates, Llc | Postupci liječenja downovog sindroma, sindroma lomljivog kromosoma x i autizma |
| US8198305B2 (en) | 2007-04-13 | 2012-06-12 | Concert Pharmaceuticals Inc. | 1,2-benzisoxazol-3-yl compounds |
| CN101824030B (zh) * | 2009-03-04 | 2014-06-18 | 北京德众万全药物技术开发有限公司 | 一种伊潘立酮的制备方法 |
| FI2445502T4 (fi) | 2009-06-25 | 2023-01-13 | Heterosyklisiä yhdisteitä neurologisten ja psykologisten häiriöiden hoitamiseksi | |
| WO2011032404A1 (zh) * | 2009-09-19 | 2011-03-24 | 浙江华海药业股份有限公司 | 伊潘立酮的一种制备方法及结晶方法 |
| CN102030744B (zh) * | 2009-09-30 | 2013-04-17 | 天津药物研究院 | 伊潘立酮晶体、其制备方法及药物组合物 |
| US20120220776A1 (en) * | 2009-11-19 | 2012-08-30 | Symed Labs Limited | Process for the preparation of iloperidone using a novel intermediate |
| WO2011154860A1 (en) * | 2010-06-08 | 2011-12-15 | Alembic Pharmaceuticals Limited | An improved process for preparing iloperidone |
| CN102311430A (zh) * | 2010-06-29 | 2012-01-11 | 大道隆达（北京）医药科技发展有限公司 | 伊潘立酮的新晶态及其制备方法 |
| ITMI20101294A1 (it) * | 2010-07-14 | 2012-01-15 | Dipharma Francis Srl | Procedimento per la preparazione di iloperidone |
| US9000221B2 (en) | 2010-09-07 | 2015-04-07 | Symed Labs Limited | Processes for the preparation of 4′-[3-[4-(6-Fluoro-1 ,2-benzisoxazol-3-yl)piperidino]propoxy]-3′-methoxyacetophenone and intermediates thereof |
| WO2012063269A2 (en) | 2010-11-12 | 2012-05-18 | Cadila Healthcare Limited | Process for preparing iloperidone |
| EP2640391B1 (en) | 2010-11-15 | 2015-11-11 | Agenebio, Inc. | Pyridazine derivatives, compositions and methods for treating cognitive impairment |
| WO2012123963A2 (en) | 2011-02-24 | 2012-09-20 | Megafine Pharma (P) Ltd. | A process for preparation of iloperidone and amorphous co- precipitate of iloperidone with pharmaceutically acceptable excipient |
| WO2012153341A1 (en) | 2011-05-12 | 2012-11-15 | Arch Pharmalabs Limited | A process for the preparation of iloperidone and pharmaceutically acceptable salts thereof |
| WO2012164516A1 (en) | 2011-06-03 | 2012-12-06 | Lupin Limited | Process for the preparation of iloperidone |
| ITMI20120511A1 (it) * | 2012-03-29 | 2013-09-30 | Procos Spa | Processo one-pot per la sintesi di iloperidone |
| EP3610890A1 (en) | 2012-11-14 | 2020-02-19 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| CN106068256B (zh) | 2013-12-20 | 2020-10-23 | 艾吉因生物股份有限公司 | 用于治疗认知损害的苯并二氮杂*衍生物、组合物和方法 |
| EA036844B1 (ru) | 2015-06-19 | 2020-12-28 | Эйджинбайо, Инк. | Производные бензодиазепина, композиции и способы для лечения когнитивного нарушения |
| BR112019012821A2 (pt) | 2016-12-19 | 2019-11-26 | Agenebio Inc | derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo |
| US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| NZ772066A (en) | 2018-06-19 | 2025-05-30 | Agenebio Inc | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| JP2025529834A (ja) | 2022-08-19 | 2025-09-09 | エージンバイオ， インコーポレイテッド | 認知障害を処置するためのベンゾアゼピン誘導体、組成物および方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4366162A (en) * | 1977-11-09 | 1982-12-28 | Ab Ferrosan | Aryl ethers of N-alkyl-piperidines and acid addition salts thereof |
| US4355037A (en) * | 1981-11-12 | 1982-10-19 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidyl)-1,2-benzisoxales |
| FR2537133A1 (fr) * | 1982-12-07 | 1984-06-08 | Rhone Poulenc Sante | Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent |
| US4458076A (en) * | 1983-05-31 | 1984-07-03 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidinyl)-1,2-benzisothiazoles |
| HU198036B (en) * | 1983-08-22 | 1989-07-28 | Hoechst Roussel Pharma | Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them |
| US4590196A (en) * | 1984-08-23 | 1986-05-20 | Bristol-Myers Company | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
-
1990
- 1990-05-16 AT AT90109208T patent/ATE126512T1/de not_active IP Right Cessation
- 1990-05-16 DE DE69021645T patent/DE69021645T2/de not_active Expired - Lifetime
- 1990-05-16 ES ES90109208T patent/ES2076253T3/es not_active Expired - Lifetime
- 1990-05-16 EP EP90109208A patent/EP0402644B1/en not_active Expired - Lifetime
- 1990-05-16 DK DK90109208.0T patent/DK0402644T3/da active
- 1990-05-17 SK SK2425-90A patent/SK279474B6/sk not_active IP Right Cessation
- 1990-05-17 DD DD340772A patent/DD300433A5/de unknown
- 1990-05-17 NZ NZ233710A patent/NZ233710A/en unknown
- 1990-05-17 CZ CS902425A patent/CZ282385B6/cs not_active IP Right Cessation
- 1990-05-17 IL IL9442590A patent/IL94425A/en not_active IP Right Cessation
- 1990-05-17 FI FI902449A patent/FI104072B1/fi active IP Right Grant
- 1990-05-18 PT PT94084A patent/PT94084B/pt not_active IP Right Cessation
- 1990-05-18 CA CA002017193A patent/CA2017193C/en not_active Expired - Lifetime
- 1990-05-18 KR KR1019900007102A patent/KR0157308B1/ko not_active Expired - Lifetime
- 1990-05-18 RU SU904743876A patent/RU2062776C1/ru active
- 1990-05-18 IE IE180990A patent/IE68431B1/en not_active IP Right Cessation
- 1990-05-18 JP JP2127090A patent/JPH0662580B2/ja not_active Expired - Lifetime
- 1990-05-18 HU HU090/90A patent/HU218200B/hu unknown
- 1990-05-18 RU RU95115403A patent/RU2147583C1/ru active
- 1990-05-18 NO NO902214A patent/NO177301C/no not_active IP Right Cessation
- 1990-05-18 PL PL90285247A patent/PL163965B1/pl unknown
- 1990-05-19 CN CN90103721A patent/CN1086387C/zh not_active Expired - Lifetime
- 1990-05-23 AU AU55770/90A patent/AU640653B2/en not_active Expired
-
1995
- 1995-06-29 HU HU95P/P00576P patent/HU211853A9/hu unknown
- 1995-09-20 GR GR950402573T patent/GR3017447T3/el unknown
-
1999
- 1999-09-02 FI FI991869A patent/FI19991869L/fi unknown
- 1999-12-20 RU RU99126501/15A patent/RU2239434C2/ru active
-
2000
- 2000-11-06 CN CNB00130979XA patent/CN1223348C/zh not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |