NO175939C - Analogifremgangsmåte for fremstilling av terapeutisk aktiv N1-(1,2-cis-2-halogencyklopropyl)-substituerte pyridonkarboksylsyrederivater, eller et farmasöytisk akseptabelt salt derav, eventuelt i en stereoisomerisk form - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktiv N1-(1,2-cis-2-halogencyklopropyl)-substituerte pyridonkarboksylsyrederivater, eller et farmasöytisk akseptabelt salt derav, eventuelt i en stereoisomerisk form

Info

Publication number
NO175939C
NO175939C NO891698A NO891698A NO175939C NO 175939 C NO175939 C NO 175939C NO 891698 A NO891698 A NO 891698A NO 891698 A NO891698 A NO 891698A NO 175939 C NO175939 C NO 175939C
Authority
NO
Norway
Prior art keywords
preparation
therapeutically active
analogous process
halogenocydopropyl
cis
Prior art date
Application number
NO891698A
Other languages
English (en)
Norwegian (no)
Other versions
NO175939B (no
NO891698D0 (no
NO891698L (no
Inventor
Isao Hayakawa
Yoichi Kimura
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of NO891698D0 publication Critical patent/NO891698D0/no
Publication of NO891698L publication Critical patent/NO891698L/no
Publication of NO175939B publication Critical patent/NO175939B/no
Publication of NO175939C publication Critical patent/NO175939C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
NO891698A 1988-04-27 1989-04-25 Analogifremgangsmåte for fremstilling av terapeutisk aktiv N1-(1,2-cis-2-halogencyklopropyl)-substituerte pyridonkarboksylsyrederivater, eller et farmasöytisk akseptabelt salt derav, eventuelt i en stereoisomerisk form NO175939C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10462588 1988-04-27
JP29698488 1988-11-24

Publications (4)

Publication Number Publication Date
NO891698D0 NO891698D0 (no) 1989-04-25
NO891698L NO891698L (no) 1989-10-30
NO175939B NO175939B (no) 1994-09-26
NO175939C true NO175939C (no) 1995-01-04

Family

ID=26445063

Family Applications (1)

Application Number Title Priority Date Filing Date
NO891698A NO175939C (no) 1988-04-27 1989-04-25 Analogifremgangsmåte for fremstilling av terapeutisk aktiv N1-(1,2-cis-2-halogencyklopropyl)-substituerte pyridonkarboksylsyrederivater, eller et farmasöytisk akseptabelt salt derav, eventuelt i en stereoisomerisk form

Country Status (26)

Country Link
US (4) US5587386A (ja)
EP (1) EP0341493B1 (ja)
JP (5) JP2714597B2 (ja)
KR (1) KR0184614B1 (ja)
CN (1) CN1033751C (ja)
AT (1) ATE182145T1 (ja)
AU (1) AU625414B2 (ja)
BG (1) BG61122B2 (ja)
CA (1) CA1340801C (ja)
DE (1) DE68929030T2 (ja)
DK (1) DK175467B1 (ja)
ES (1) ES2135372T3 (ja)
FI (1) FI96947C (ja)
GR (1) GR3031365T3 (ja)
HK (1) HK1002108A1 (ja)
HU (1) HU211136A9 (ja)
IL (1) IL90062A (ja)
LV (1) LV10092B (ja)
MY (1) MY105136A (ja)
NO (1) NO175939C (ja)
NZ (1) NZ228893A (ja)
PT (1) PT90377B (ja)
RU (1) RU2075475C1 (ja)
SG (1) SG48036A1 (ja)
UA (1) UA29378C2 (ja)
YU (1) YU48432B (ja)

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HU208005B (en) * 1990-02-19 1993-07-28 Kyorin Seiyaku Kk Process for producing optically active 8-methoxy-quinolone-carboxylic acid derivatives and pharmaceutical compositions containing them
MY109714A (en) * 1990-10-18 1997-04-30 Daiichi Seiyaku Co Process for preparing 8-chloroquinolone derivatives
WO1992021659A1 (en) * 1991-05-28 1992-12-10 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivative
ATE184603T1 (de) * 1991-06-19 1999-10-15 Pfizer Azaspirochinolone als antibakterielle wirkstoffe
KR960011370B1 (ko) * 1991-12-31 1996-08-22 재단법인 한국화학연구소 스피로알킬아민 유도체와 그의 제조방법
NO301165B1 (no) * 1992-12-25 1997-09-22 Daiichi Seiyaku Co Bicykliske aminderivater og antibakterielle midler inneholdende disse
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
EP0773214A4 (en) * 1994-07-18 1998-04-15 Ube Industries TRIFLUORMETHYLQUINOLINE CARBONIC ACID DERIVATIVES
EP1304329B1 (en) * 1995-02-02 2008-10-15 Daiichi Sankyo Company, Limited Pyridonecarboxylic acid derivatives and their use as antibacterial agents
WO1996024593A1 (fr) * 1995-02-07 1996-08-15 Daiichi Pharmaceutical Co., Ltd. Derives spiro heterocycliques
JPH09124556A (ja) 1995-08-30 1997-05-13 Dai Ichi Seiyaku Co Ltd ハロゲン化シクロプロパン誘導体の製造方法
ES2258780T3 (es) * 1995-11-22 2006-09-01 Daiichi Pharmaceutical Co., Ltd. Derivados de aminocicloalquilpirrolidina sustituidos.
US6121285A (en) 1995-11-22 2000-09-19 Daiichi Pharmaceutical Co., Ltd. Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives
CA2242242C (en) * 1996-02-09 2001-08-07 Toyama Chemical Co., Ltd. Quinolonecarboxylic acid derivatives or salts thereof
ID16655A (id) 1996-04-24 1997-10-30 Daiichi Seiyaku Co Turunan-turunan sikloalkilaminometilpirolidina
AU1040597A (en) * 1996-12-04 1998-06-29 Daiichi Pharmaceutical Co., Ltd. Substituted aminomethylpyrrolidine derivatives
ES2244248T3 (es) * 1998-11-24 2005-12-01 Daiichi Pharmaceutical Co., Ltd. Derivados de aminometilpirrolidina sustituidos por cicloalquilos.
EP1182202B1 (en) 1999-03-10 2004-06-02 Daiichi Pharmaceutical Co., Ltd. Aminomethylpyrrolidine derivatives having aromatic substituents
KR100768034B1 (ko) 1999-03-17 2007-10-17 다이이찌 세이야꾸 가부시기가이샤 의약 조성물
EP1262477B1 (en) * 2000-02-09 2008-09-03 Daiichi Sankyo Company, Limited Anti-acid-fast bacterial agents containing pyridonecarboxylic acids as the active ingredient
CA2408806A1 (en) 2000-03-31 2001-10-04 Masayasu Sekiguchi Quinolonecarboxylic acid derivative
WO2001080858A1 (fr) * 2000-04-24 2001-11-01 Daiichi Pharmaceutical Co., Ltd. Preparation liquide stable
AU2001276748A1 (en) * 2000-08-08 2002-02-18 Daiichi Pharmaceutical Co., Ltd. Highly absorbable solid preparation
CN100422170C (zh) * 2002-05-17 2008-10-01 第一制药株式会社 喹诺酮羧酸衍生物的制备方法
WO2004060851A1 (ja) * 2003-01-07 2004-07-22 Daiichi Pharmaceutical Co., Ltd. 還元的脱ハロゲン化方法
US7085154B2 (en) * 2003-06-03 2006-08-01 Samsung Electronics Co., Ltd. Device and method for pulse width control in a phase change memory device
EP1757598A4 (en) 2004-05-13 2010-07-21 Daiichi Seiyaku Co SUBSTITUTED PYRROLIDINE DERIVATIVE
JP5063032B2 (ja) * 2005-05-19 2012-10-31 第一三共株式会社 トリ−、テトラ−置換−３−アミノピロリジン誘導体
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
US7928232B2 (en) 2005-05-20 2011-04-19 Daiichi Sankyo Company, Limited Method for producing asymmetric tetrasubstituted carbon atom-containing compound
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
TWI386401B (zh) * 2006-03-27 2013-02-21 Daiichi Seiyaku Co 醫藥用水合物
NZ577214A (en) 2007-01-05 2011-11-25 Daiichi Sankyo Co Ltd Fused substituted aminopyrrolidine derivatives useful as antibacterial reagents
WO2010005003A1 (ja) 2008-07-11 2010-01-14 住友化学株式会社 （１ｓ，２ｒ）－２－クロロ－２－フルオロシクロプロパンカルボン酸の製造方法
FR2961207B1 (fr) * 2010-06-09 2013-01-18 Oreal Utilisation d'un derive de 4- carboxy 2-pyrrolidinone comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant ; nouveaux composes
CN103467448B (zh) * 2013-09-18 2015-04-15 浙江司太立制药股份有限公司 7-(3-氨基-4-烷氧亚胺基-1-哌啶基)-1-[(1r,2s)-2-氟环丙基]喹诺酮羧酸类化合物及其制备方法
EP2957561A1 (en) * 2014-06-18 2015-12-23 Université Paris 6 Pierre et Marie Curie UPMC Novel fluoroquinolones and use thereof to treat bacterial infections
CN105330590B (zh) * 2015-10-15 2018-09-25 广州市朗启医药科技有限责任公司 西他沙星五元环侧链中间体的制备方法
CN109912504B (zh) * 2019-04-04 2020-11-10 山东省联合农药工业有限公司 一种喹啉羧酸类化合物及其制备方法与用途

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AU5427286A (en) * 1985-03-08 1986-09-11 Kyorin Pharmaceutical Co. Ltd. 7-(1-pyrrolidinyl)-3-quinolinecarboxylic acid derivatives
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Also Published As

Publication number Publication date
JP2714597B2 (ja) 1998-02-16
MY105136A (en) 1994-08-30
NO175939B (no) 1994-09-26
AU625414B2 (en) 1992-07-09
PT90377A (pt) 1989-11-10
EP0341493A3 (en) 1990-12-19
HU211136A9 (en) 1995-10-30
FI891980A (fi) 1989-10-28
IL90062A0 (en) 1989-12-15
YU87589A (en) 1990-12-31
HK1002108A1 (en) 1998-07-31
KR900016205A (ko) 1990-11-12
DK175467B1 (da) 2004-11-01
JPH11124380A (ja) 1999-05-11
EP0341493A2 (en) 1989-11-15
US5767127A (en) 1998-06-16
DK205789D0 (da) 1989-04-27
CN1033751C (zh) 1997-01-08
DE68929030D1 (de) 1999-08-19
YU48432B (sh) 1998-07-10
CA1340801C (en) 1999-10-26
IL90062A (en) 1994-10-07
BG61122B2 (bg) 1996-11-29
JPH11124367A (ja) 1999-05-11
DE68929030T2 (de) 2000-03-23
NO891698D0 (no) 1989-04-25
LV10092B (en) 1995-02-20
ES2135372T3 (es) 1999-11-01
FI891980A0 (fi) 1989-04-26
JP2917010B2 (ja) 1999-07-12
UA29378C2 (uk) 2000-11-15
USRE41149E1 (en) 2010-02-23
RU2075475C1 (ru) 1997-03-20
CN1037507A (zh) 1989-11-29
DK205789A (da) 1989-10-28
FI96947B (fi) 1996-06-14
ATE182145T1 (de) 1999-07-15
NZ228893A (en) 1990-06-26
KR0184614B1 (ko) 1999-05-01
US5587386A (en) 1996-12-24
PT90377B (pt) 1994-09-30
FI96947C (fi) 1996-09-25
JP2903292B2 (ja) 1999-06-07
GR3031365T3 (en) 2000-01-31
JPH07300416A (ja) 1995-11-14
EP0341493B1 (en) 1999-07-14
JPH1067779A (ja) 1998-03-10
AU3370289A (en) 1989-11-02
JPH02231475A (ja) 1990-09-13
NO891698L (no) 1989-10-30
SG48036A1 (en) 1998-04-17
US6031102A (en) 2000-02-29

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