NO175041B - Fremgangsmåte for fremstilling av et kalsiumholdig, farmasöytisk preparat - Google Patents
Fremgangsmåte for fremstilling av et kalsiumholdig, farmasöytisk preparat Download PDFInfo
- Publication number
- NO175041B NO175041B NO872712A NO872712A NO175041B NO 175041 B NO175041 B NO 175041B NO 872712 A NO872712 A NO 872712A NO 872712 A NO872712 A NO 872712A NO 175041 B NO175041 B NO 175041B
- Authority
- NO
- Norway
- Prior art keywords
- calcium
- acid
- organic
- preparation
- calcium carbonate
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 37
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims description 16
- 239000011575 calcium Substances 0.000 title claims description 16
- 229910052791 calcium Inorganic materials 0.000 title claims description 16
- 238000000034 method Methods 0.000 title claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 34
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 29
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 17
- 229960005069 calcium Drugs 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 15
- 159000000007 calcium salts Chemical class 0.000 claims description 14
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 10
- 229910001424 calcium ion Inorganic materials 0.000 claims description 10
- 150000001720 carbohydrates Chemical class 0.000 claims description 9
- 235000015165 citric acid Nutrition 0.000 claims description 9
- 235000003599 food sweetener Nutrition 0.000 claims description 9
- 239000003765 sweetening agent Substances 0.000 claims description 9
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 8
- 239000004227 calcium gluconate Substances 0.000 claims description 6
- 229960004494 calcium gluconate Drugs 0.000 claims description 6
- 235000013927 calcium gluconate Nutrition 0.000 claims description 6
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 235000013355 food flavoring agent Nutrition 0.000 claims description 5
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 3
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 3
- 235000010216 calcium carbonate Nutrition 0.000 claims description 3
- 239000000174 gluconic acid Substances 0.000 claims description 3
- 235000012208 gluconic acid Nutrition 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 239000001630 malic acid Substances 0.000 claims description 3
- 235000011090 malic acid Nutrition 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000011975 tartaric acid Substances 0.000 claims description 3
- 235000002906 tartaric acid Nutrition 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- YZQCXOFQZKCETR-UWVGGRQHSA-N Asp-Phe Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 YZQCXOFQZKCETR-UWVGGRQHSA-N 0.000 claims 1
- 229960003563 calcium carbonate Drugs 0.000 description 12
- 239000000203 mixture Substances 0.000 description 10
- 238000011282 treatment Methods 0.000 description 8
- 229960004106 citric acid Drugs 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 5
- 239000000123 paper Substances 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 108010011485 Aspartame Proteins 0.000 description 4
- 235000005979 Citrus limon Nutrition 0.000 description 4
- 244000131522 Citrus pyriformis Species 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 239000000605 aspartame Substances 0.000 description 4
- 235000010357 aspartame Nutrition 0.000 description 4
- 229960003438 aspartame Drugs 0.000 description 4
- LNMAXKMUGYXKPJ-UHFFFAOYSA-L calcium;1,1-dioxo-1,2-benzothiazol-2-id-3-one Chemical compound [Ca+2].C1=CC=C2C([O-])=NS(=O)(=O)C2=C1.C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 LNMAXKMUGYXKPJ-UHFFFAOYSA-L 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- PWKNEBQRTUXXLT-ZBHRUSISSA-L calcium lactate gluconate Chemical compound [Ca+2].CC(O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O PWKNEBQRTUXXLT-ZBHRUSISSA-L 0.000 description 3
- 239000007938 effervescent tablet Substances 0.000 description 3
- 239000011888 foil Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-M 1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-M 0.000 description 2
- 208000001132 Osteoporosis Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 206010043376 Tetanus Diseases 0.000 description 2
- 229940041131 calcium lactate gluconate Drugs 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 229910002012 Aerosil® Inorganic materials 0.000 description 1
- 206010027654 Allergic conditions Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 102000055006 Calcitonin Human genes 0.000 description 1
- 108060001064 Calcitonin Proteins 0.000 description 1
- 206010006956 Calcium deficiency Diseases 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 208000013038 Hypocalcemia Diseases 0.000 description 1
- 241001516739 Platonia insignis Species 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 240000001890 Ribes hudsonianum Species 0.000 description 1
- 235000016954 Ribes hudsonianum Nutrition 0.000 description 1
- 235000001466 Ribes nigrum Nutrition 0.000 description 1
- 240000007651 Rubus glaucus Species 0.000 description 1
- 235000011034 Rubus glaucus Nutrition 0.000 description 1
- 235000009122 Rubus idaeus Nutrition 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229960004543 anhydrous citric acid Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000008122 artificial sweetener Substances 0.000 description 1
- 235000021311 artificial sweeteners Nutrition 0.000 description 1
- XTPLQANXHDDXIH-UHFFFAOYSA-N azanium;1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound N.C1=CC=C2C(=O)NS(=O)(=O)C2=C1 XTPLQANXHDDXIH-UHFFFAOYSA-N 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
- 229960004015 calcitonin Drugs 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000007580 dry-mixing Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000000705 hypocalcaemia Effects 0.000 description 1
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
- 239000007968 orange flavor Substances 0.000 description 1
- 235000015205 orange juice Nutrition 0.000 description 1
- 208000005368 osteomalacia Diseases 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-N sodium;hydron;carbonate Chemical compound [Na+].OC(O)=O UIIMBOGNXHQVGW-UHFFFAOYSA-N 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8609515A FR2600893B1 (fr) | 1986-07-01 | 1986-07-01 | Nouvelles compositions pharmaceutiques a base de sels de calcium |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO872712D0 NO872712D0 (no) | 1987-06-29 |
| NO872712L NO872712L (no) | 1988-01-04 |
| NO175041B true NO175041B (no) | 1994-05-16 |
| NO175041C NO175041C (sv) | 1994-08-24 |
Family
ID=9336917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO872712A NO175041B (no) | 1986-07-01 | 1987-06-29 | Fremgangsmåte for fremstilling av et kalsiumholdig, farmasöytisk preparat |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4867977A (sv) |
| JP (1) | JPS6322522A (sv) |
| KR (1) | KR950014449B1 (sv) |
| AT (1) | AT392588B (sv) |
| AU (1) | AU597992B2 (sv) |
| BE (1) | BE1007686A4 (sv) |
| CA (1) | CA1305057C (sv) |
| CH (1) | CH674935A5 (sv) |
| CY (1) | CY1684A (sv) |
| DE (1) | DE3720510C2 (sv) |
| DK (1) | DK173508B1 (sv) |
| ES (1) | ES2006192A6 (sv) |
| FI (1) | FI89329C (sv) |
| FR (1) | FR2600893B1 (sv) |
| GB (1) | GB2192131B (sv) |
| GR (1) | GR871015B (sv) |
| HK (1) | HK80393A (sv) |
| HU (1) | HU199283B (sv) |
| IE (1) | IE60430B1 (sv) |
| IL (1) | IL83032A (sv) |
| IT (1) | IT1216829B (sv) |
| LU (1) | LU86932A1 (sv) |
| MY (1) | MY101750A (sv) |
| NL (1) | NL194749C (sv) |
| NO (1) | NO175041B (sv) |
| NZ (1) | NZ220898A (sv) |
| PH (1) | PH25430A (sv) |
| PT (1) | PT85212B (sv) |
| SE (1) | SE502567C2 (sv) |
| SG (1) | SG123192G (sv) |
| ZA (1) | ZA874769B (sv) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH621486A5 (sv) * | 1977-01-27 | 1981-02-13 | Fischer Artur | |
| JP2665764B2 (ja) * | 1988-04-20 | 1997-10-22 | 日水製薬株式会社 | カルシウム水溶液剤 |
| EP0346866A3 (en) * | 1988-06-16 | 1990-07-11 | Biochemie Gesellschaft M.B.H. | Composition for the prophylaxis of osteoporosis |
| WO1993012672A1 (en) * | 1991-12-26 | 1993-07-08 | The Procter & Gamble Company | Storage stable calcium-supplemented beverage concentrates |
| ATE198122T1 (de) * | 1992-10-21 | 2001-01-15 | Procter & Gamble | Konzentrierte, bioverfügbare kalziumquelle |
| JP3199743B2 (ja) * | 1992-10-21 | 2001-08-20 | ザ、プロクター、エンド、ギャンブル、カンパニー | カルシウムを補給した貯蔵安定な飲料用濃縮プレミックス及びシロップ |
| WO1994008471A1 (en) * | 1992-10-21 | 1994-04-28 | The Procter & Gamble Company | Sweetener containing a concentrated bioavailable calcium source |
| DE19503190A1 (de) * | 1995-02-01 | 1996-08-08 | Dietl Hans | Mittel zur Beeinflussung von Störungen der Knochenbildung |
| US5942255A (en) * | 1996-07-15 | 1999-08-24 | The University Of Memphis | Methods of enhancing lean tissue mass and bone mineral content and compositions therefor |
| US6235322B1 (en) * | 1999-03-09 | 2001-05-22 | Mintech, Inc. | Highly soluble and stable mineral supplements containing calcium and magnesium |
| BRPI0215795B1 (pt) * | 2002-06-27 | 2018-07-17 | Torres Buendia Manuel | processo de fabricação de gliconolactato de cálcio |
| US20040048925A1 (en) * | 2002-09-09 | 2004-03-11 | Wiley David B. | Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives |
| US20040106678A1 (en) * | 2002-09-17 | 2004-06-03 | Dobbins Thomas A | Compositions for the parenteral administration of calcium and magnesium |
| JP2007523664A (ja) * | 2003-04-23 | 2007-08-23 | フェリング ベスローテン フェンノートシャップ | 医薬組成物用サシェ |
| US20040258818A1 (en) * | 2003-06-20 | 2004-12-23 | Kraft Foods Holdings, Inc. | Reduced acidic flavor in acidified starch products |
| US7198653B2 (en) | 2003-07-31 | 2007-04-03 | Delavau Llc | Calcium carbonate granulation |
| US20050089502A1 (en) * | 2003-08-21 | 2005-04-28 | Todd Schansberg | Effervescent delivery system |
| US7323201B2 (en) * | 2004-06-08 | 2008-01-29 | Tate & Lyle Ingredients Americas, Inc. | Highly soluble form of tricalcium citrate, and methods of its making and use |
| US9138414B1 (en) | 2006-09-15 | 2015-09-22 | Delavau Llc | Calcium supplement having enhanced absorption |
| US20090298946A1 (en) * | 2008-06-02 | 2009-12-03 | Cleavelin Cody R | Local Anesthetic Deactivation |
| WO2019126262A1 (en) * | 2017-12-20 | 2019-06-27 | Dsm Ip Assets B.V. | Materials and methods for dietary calcium supplementation of animals |
| AU2020400638A1 (en) * | 2019-12-12 | 2022-06-23 | Alberta Veterinary Laboratories Ltd. | Choline bolus compositions for ruminants |
| CN113749205B (zh) * | 2021-09-09 | 2024-08-06 | 山东凯翔生物科技股份有限公司 | 一种葡萄糖酸钙-葡萄糖酸复合粉的制备方法 |
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|---|---|---|---|---|
| US1526981A (en) * | 1923-02-02 | 1925-02-17 | Upjohn Co | Effervescent alkali compound and process of manufacturing and preparing the same |
| US1616587A (en) * | 1926-08-25 | 1927-02-08 | Upjohn Co | Method of manufacturing effervescent alkali compounds |
| US1765867A (en) * | 1928-12-15 | 1930-06-24 | Henry G Granger | Method for making candy |
| US2603569A (en) * | 1950-01-23 | 1952-07-15 | Joseph G Alther | Effervescent drink concentrate |
| US2639238A (en) * | 1952-07-02 | 1953-05-19 | Joseph G Alther | Effervescent drink concentrate |
| US3082091A (en) * | 1956-07-03 | 1963-03-19 | Pierre F Smith | Effervescing composition in particle form |
| US3061445A (en) * | 1959-04-30 | 1962-10-30 | Abbott Lab | Effervescent sweetening tablet |
| US3105792A (en) * | 1960-11-29 | 1963-10-01 | Warner Lambert Pharmaceutical | Stable effervescent compositions and method of preparing same |
| US3241977A (en) * | 1962-01-02 | 1966-03-22 | Gen Foods Corp | Effervescent beverage powders |
| US3328304A (en) * | 1964-07-31 | 1967-06-27 | Guardian Chemical Corp | Chelating agents and methods for their manufacture |
| US3489572A (en) * | 1966-04-04 | 1970-01-13 | Benjamin Eisenstadt | Sweetening composition |
| AU2332470A (en) * | 1969-12-15 | 1972-06-15 | Sandoz Patents Limited | Improvements in or relating to organic compounds |
| US3939289A (en) * | 1973-04-02 | 1976-02-17 | General Foods Corporation | Dry carbonation source for a beverage concentrate and method of preparing the same |
| US3965273A (en) * | 1973-04-02 | 1976-06-22 | General Foods Corporation | Dry carbonation source and method for preparing the same, and dry carbonated beverage concentrate |
| US4237147A (en) * | 1974-01-04 | 1980-12-02 | Monsanto Company | Stabilized amorphous calcium carbonate |
| US3949098A (en) * | 1974-06-05 | 1976-04-06 | Nabisco, Inc. | Nutritious orange drink concentrate, process and drink resultant therefrom |
| US4009292A (en) * | 1975-02-26 | 1977-02-22 | General Foods Corporation | Effervescent dipeptide sweetener tablets |
| US4206244A (en) * | 1978-02-06 | 1980-06-03 | Persian Delight, Inc. | Dry mix for preparing a carbonated yogurt |
| JPS5585385A (en) * | 1978-12-22 | 1980-06-27 | Mitsuma Miyoshi | Powdered food and drink |
| JPS57122925A (en) * | 1981-01-26 | 1982-07-31 | Ajinomoto Co Inc | Tablet composition |
| US4551342A (en) * | 1983-02-01 | 1985-11-05 | The Procter & Gamble Company | Beverages containing specific cation-edible acid mixtures for improved flavor impression |
| JPS59166057A (ja) * | 1983-03-14 | 1984-09-19 | Ajinomoto Co Inc | ジペプチド甘味料含有発泡錠剤の製造法 |
| US4678661A (en) * | 1983-09-28 | 1987-07-07 | Gerhard Gergely | Effervescent composition and method of making same |
| US4725427A (en) * | 1984-03-13 | 1988-02-16 | Albion International, Inc. | Effervescent vitamin-mineral granule preparation |
| US4647453A (en) * | 1984-10-18 | 1987-03-03 | Peritain, Ltd. | Treatment for tissue degenerative inflammatory disease |
| US4760138A (en) * | 1984-12-13 | 1988-07-26 | Nestec S. A. | Carbonating agents and their preparation |
| JPS62501843A (ja) * | 1985-02-19 | 1987-07-23 | ボ−ド・オブ・リ−ジェンツ・ザ・ユニバ−シティ−・オブ・テキサス・システム | 食事のカルシウム補足によるオステオポロ−シス抑制 |
| US4772467A (en) * | 1985-02-19 | 1988-09-20 | Board Of Regents, U T Systems | Osteoporosis inhibition by dietary calcium supplementation |
| US4650669A (en) * | 1985-07-30 | 1987-03-17 | Miles Laboratories, Inc. | Method to make effervescent calcium tablets and calcium tablets produced thereby |
-
1986
- 1986-07-01 FR FR8609515A patent/FR2600893B1/fr not_active Expired - Lifetime
-
1987
- 1987-06-19 NL NL8701440A patent/NL194749C/nl not_active IP Right Cessation
- 1987-06-19 HU HU872808A patent/HU199283B/hu not_active IP Right Cessation
- 1987-06-20 DE DE3720510A patent/DE3720510C2/de not_active Expired - Fee Related
- 1987-06-25 IT IT8748100A patent/IT1216829B/it active
- 1987-06-25 BE BE8700715A patent/BE1007686A4/fr not_active IP Right Cessation
- 1987-06-26 CH CH2389/87A patent/CH674935A5/fr not_active IP Right Cessation
- 1987-06-26 LU LU86932A patent/LU86932A1/fr unknown
- 1987-06-26 US US07/067,311 patent/US4867977A/en not_active Expired - Fee Related
- 1987-06-26 MY MYPI87000905A patent/MY101750A/en unknown
- 1987-06-29 FI FI872871A patent/FI89329C/sv not_active IP Right Cessation
- 1987-06-29 IE IE173087A patent/IE60430B1/en not_active IP Right Cessation
- 1987-06-29 NO NO872712A patent/NO175041B/no unknown
- 1987-06-29 GR GR871015A patent/GR871015B/el unknown
- 1987-06-29 GB GB8715216A patent/GB2192131B/en not_active Expired - Lifetime
- 1987-06-29 DK DK198703334A patent/DK173508B1/da not_active IP Right Cessation
- 1987-06-29 AU AU74913/87A patent/AU597992B2/en not_active Ceased
- 1987-06-30 PT PT85212A patent/PT85212B/pt unknown
- 1987-06-30 JP JP62165136A patent/JPS6322522A/ja active Pending
- 1987-06-30 AT AT1641/87A patent/AT392588B/de not_active IP Right Cessation
- 1987-06-30 CA CA000540958A patent/CA1305057C/en not_active Expired - Lifetime
- 1987-06-30 IL IL83032A patent/IL83032A/xx not_active IP Right Cessation
- 1987-06-30 PH PH35475A patent/PH25430A/en unknown
- 1987-06-30 SE SE8702712A patent/SE502567C2/sv not_active IP Right Cessation
- 1987-06-30 NZ NZ220898A patent/NZ220898A/en unknown
- 1987-07-01 ZA ZA874769A patent/ZA874769B/xx unknown
- 1987-07-01 ES ES8701924A patent/ES2006192A6/es not_active Expired
- 1987-07-01 KR KR1019870007049A patent/KR950014449B1/ko not_active IP Right Cessation
-
1992
- 1992-12-09 SG SG1231/92A patent/SG123192G/en unknown
-
1993
- 1993-08-05 HK HK803/93A patent/HK80393A/xx not_active IP Right Cessation
- 1993-10-10 CY CY1684A patent/CY1684A/xx unknown
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