NO173015C - Analogifremgangsmaate til fremstilling av pyrido(1,2-a)pyrimidin-3-piperidinyl-1,2-benzisoksazoler - Google Patents
Analogifremgangsmaate til fremstilling av pyrido(1,2-a)pyrimidin-3-piperidinyl-1,2-benzisoksazolerInfo
- Publication number
- NO173015C NO173015C NO894411A NO894411A NO173015C NO 173015 C NO173015 C NO 173015C NO 894411 A NO894411 A NO 894411A NO 894411 A NO894411 A NO 894411A NO 173015 C NO173015 C NO 173015C
- Authority
- NO
- Norway
- Prior art keywords
- piperidinyl
- benzisoxazols
- pyrido
- pyrimidin
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26785788A | 1988-11-07 | 1988-11-07 |
Publications (4)
Publication Number | Publication Date |
---|---|
NO894411D0 NO894411D0 (no) | 1989-11-06 |
NO894411L NO894411L (no) | 1990-05-08 |
NO173015B NO173015B (no) | 1993-07-05 |
NO173015C true NO173015C (no) | 1993-10-13 |
Family
ID=23020416
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO894411A NO173015C (no) | 1988-11-07 | 1989-11-06 | Analogifremgangsmaate til fremstilling av pyrido(1,2-a)pyrimidin-3-piperidinyl-1,2-benzisoksazoler |
NO2007017C NO2007017I2 (no) | 1988-11-07 | 2007-12-21 | 3-[2-[4-(6-fluor-1,2-benzoksazol-3-yl)-1-piperidinyl]etyl]-6,7,8,9-tetrahydro-9-hydroksy-2-metyl-4H-pyridol]1,2-a]pyrimidin-4-on(palperidone) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO2007017C NO2007017I2 (no) | 1988-11-07 | 2007-12-21 | 3-[2-[4-(6-fluor-1,2-benzoksazol-3-yl)-1-piperidinyl]etyl]-6,7,8,9-tetrahydro-9-hydroksy-2-metyl-4H-pyridol]1,2-a]pyrimidin-4-on(palperidone) |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0368388B1 (fr) |
JP (1) | JP2758045B2 (fr) |
KR (1) | KR0146053B1 (fr) |
AT (1) | ATE122349T1 (fr) |
AU (1) | AU614437B2 (fr) |
CA (1) | CA2000786C (fr) |
CL (1) | CL43432B (fr) |
CY (2) | CY1926A (fr) |
DE (2) | DE68922577T2 (fr) |
DK (1) | DK169923B1 (fr) |
ES (1) | ES2075036T3 (fr) |
FI (1) | FI92201C (fr) |
HK (1) | HK131696A (fr) |
IE (1) | IE66370B1 (fr) |
IL (1) | IL92208A0 (fr) |
LU (1) | LU91362I2 (fr) |
NL (1) | NL300298I2 (fr) |
NO (2) | NO173015C (fr) |
NZ (1) | NZ231062A (fr) |
PT (1) | PT92206B (fr) |
ZA (1) | ZA898436B (fr) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9008850D0 (en) * | 1990-04-19 | 1990-06-13 | Janssen Pharmaceutica Nv | Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones |
AU672182B2 (en) * | 1991-11-27 | 1996-09-26 | Novo Nordisk A/S | Piperidine derivatives and their use in treating psychosis |
US5378714A (en) * | 1991-11-27 | 1995-01-03 | Novo Nordisk A/S | Antipsychotic piperidine derivatives |
ES2050069B1 (es) * | 1992-07-10 | 1994-12-16 | Vita Invest Sa | Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona. |
DK60793D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
DK60593D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
ES2236700T3 (es) | 1993-11-19 | 2005-07-16 | Janssen Pharmaceutica N.V. | 1,2-benzazoles microencapsulados. |
SI0730594T1 (en) * | 1993-11-23 | 1999-12-31 | Janssen Pharmaceutica N.V. | 9-HYDROXY-PYRIDO (1,2-a)PYRIMIDIN-4-ONE ETHER DERIVATIVES |
ES2085234B1 (es) * | 1994-02-24 | 1997-01-16 | Vita Invest Sa | Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. |
TW487572B (en) * | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
US6028083A (en) * | 1997-07-25 | 2000-02-22 | Hoechst Marion Roussel, Inc. | Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol |
UA72189C2 (uk) * | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
ES2141671B1 (es) * | 1997-12-26 | 2001-01-01 | Vita Invest Sa | Compuesto pirimidinico activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. |
US6500833B1 (en) | 1998-05-18 | 2002-12-31 | Sepracor Inc. | (+)-Hydroxyrisperidone compositions and methods |
WO1999059589A1 (fr) * | 1998-05-18 | 1999-11-25 | Sepracor Inc. | Compositions d'hydroxyrisperidone (-) et methodes associees |
WO2000010572A1 (fr) * | 1998-08-18 | 2000-03-02 | Sepracor Inc. | Utilisation de l'hydroxyrisperidone pour la fabrication d'un medicament destine au traitement et a la prevention des psychoses, des vomissements et des syndromes de sevrage a l'alcool et a la nicotine |
ES2197801B1 (es) | 2002-03-05 | 2005-03-16 | Ferrer Internacional,S.A | Procedimiento de obtencion de la 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il) piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a ) pirimidin-4-ona. |
KR20040025224A (ko) * | 2002-09-18 | 2004-03-24 | 주식회사 대웅 | 2-(2-메틸-4-옥소-6,7,8,9-테트라하이드로-4H-피리도[1,2-a]피리미딘-3-일)아세트알데히드 및 그 제조방법 |
CN100390146C (zh) | 2002-11-13 | 2008-05-28 | 斯索恩有限公司 | 制备利培酮的方法和用于该方法的中间体 |
CN101014601B (zh) * | 2004-09-09 | 2011-09-14 | 詹森药业有限公司 | 制备9-羟基-3-(2-羟基乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮及其晶体 |
US20070197591A1 (en) | 2005-12-12 | 2007-08-23 | Sandra Boom | Use of paliperidone for the treatment of a mental disorder in a psychiatric patient with reduced hepatic function |
US20080177067A1 (en) | 2006-08-14 | 2008-07-24 | Ben-Zion Dolitzky | Crystal forms of 9-hydroxy-risperidone (paliperidone) |
EP2133352A3 (fr) * | 2006-08-14 | 2010-01-13 | Teva Pharmaceutical Industries Ltd. | Forme cristalline de la 9-hydroxy-rispéridone (palipéridone) |
EP2133351A3 (fr) * | 2006-08-14 | 2010-01-13 | Teva Pharmaceutical Industries Ltd. | Forme cristalline de la 9-hydroxy-rispéridone (palipéridone) |
KR20090079189A (ko) * | 2006-08-23 | 2009-07-21 | 테바 파마슈티컬 인더스트리즈 리미티드 | Cmhtp 및 이의 중간체의 합성 방법 |
US7820816B2 (en) | 2006-08-23 | 2010-10-26 | Teva Pharmaceutical Industries Ltd. | Process for the synthesis of CMHTP and intermediates thereof |
CN101600716A (zh) * | 2007-01-08 | 2009-12-09 | 阿特维斯集团公司 | 用于制备9-羟基-3-(2-氯乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮盐酸盐的改进方法 |
KR101244185B1 (ko) * | 2007-04-19 | 2013-03-25 | 유씬 리 | 정신 장애 치료용 신규 화합물, 그의 제조 방법 및 용도 |
WO2009010988A1 (fr) * | 2007-07-19 | 2009-01-22 | Natco Pharma Limited | Procédé amélioré, industriellement viable pour la préparation de palipéridone de haute pureté |
WO2009015828A1 (fr) * | 2007-07-27 | 2009-02-05 | Synthon B.V. | Dérivés de palipéridone |
WO2009045489A2 (fr) * | 2007-10-03 | 2009-04-09 | Teva Pharmaceutical Industries Ltd. | Procédé de synthèse de cmhtp, un intermédiaire de la palipéridone |
JP2010540676A (ja) * | 2007-10-09 | 2010-12-24 | シプラ・リミテッド | パリペリドン及びその医薬として許容し得る塩の製造方法、並びに該方法に使用する中間体 |
EP2235009B1 (fr) * | 2007-12-10 | 2013-10-30 | Synthon B.V. | Synthèse de palipéridone |
US20100311969A1 (en) * | 2008-02-05 | 2010-12-09 | Watson Pharma Private Limited | Process For Preparation of Paliperidone |
US20110087024A1 (en) * | 2008-04-21 | 2011-04-14 | Glenmark House | process for the preparation of paliperidone intermediates |
US8309717B2 (en) | 2008-05-29 | 2012-11-13 | Inke, S.A. | Process to prepare paliperidone and intermediates thereof |
EP2300467A4 (fr) * | 2008-06-16 | 2012-04-25 | Msn Lab Ltd | Nouveaux procédés améliorés de préparation de la palipéridone |
WO2010003703A2 (fr) * | 2008-07-11 | 2010-01-14 | Synthon B.V. | Palipéridone cétone |
EP2321311B1 (fr) * | 2008-07-11 | 2012-09-19 | Synthon B.V. | Synthèse de palipéridone |
SI22856A (sl) * | 2008-07-31 | 2010-02-26 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Proces za pripravo paliperidona |
EP2161019A1 (fr) | 2008-09-05 | 2010-03-10 | KRKA, D.D., Novo Mesto | Composition pharmaceutique multi-particules à libération prolongée comportant de la palipéridone |
EP2199293A1 (fr) | 2008-12-22 | 2010-06-23 | Chemo Ibérica, S.A. | Procédé à étape unique pour la préparation de palipéridone en son sel d'oxalate |
EP2202234A1 (fr) | 2008-12-24 | 2010-06-30 | Laboratorios Lesvi, S.L. | Purification de la palipéridone |
SI2275423T1 (sl) | 2009-07-13 | 2012-06-29 | Krka D.D., Novo Mesto | Postopek za sintezo paliperidona |
WO2011018246A2 (fr) | 2009-08-13 | 2011-02-17 | Synthon B.V. | Composition de palipéridone à libération contrôlée |
EP2343296A1 (fr) | 2009-12-01 | 2011-07-13 | Chemo Ibérica, S.A. | Procédé pour la purification de la palipéridone |
WO2011074017A1 (fr) * | 2009-12-17 | 2011-06-23 | Alkem Laboratories Ltd. | Nouveau procédé de préparation de palipéridone |
US8088594B2 (en) * | 2010-03-16 | 2012-01-03 | Saladax Biomedical Inc. | Risperidone immunoassay |
WO2012035554A1 (fr) * | 2010-09-14 | 2012-03-22 | Megafine Pharma (P) Ltd. | Procédé amélioré de préparation de palipéridone très pure |
JP5916746B2 (ja) | 2010-11-15 | 2016-05-11 | エージンバイオ, インコーポレイテッド | 認知障害を処置するためのピリダジン誘導体、組成物、および方法 |
CN102153552B (zh) * | 2011-03-01 | 2012-08-22 | 吉林大学 | 两种帕潘立酮药物共晶及其制备方法 |
CN102206210B (zh) * | 2011-04-01 | 2014-07-02 | 常州市第四制药厂有限公司 | 一种6-氟-3-(4-哌啶基)-1,2-苯并异噁唑盐酸盐的生产方法 |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
CN106068256B (zh) | 2013-12-20 | 2020-10-23 | 艾吉因生物股份有限公司 | 用于治疗认知损害的苯并二氮杂*衍生物、组合物和方法 |
EP3310785A4 (fr) | 2015-06-19 | 2018-12-26 | Agenebio, Inc. | Dérivés de benzodiazépine, compositions et méthodes de traitement de la déficience cognitive |
BR112019012821A2 (pt) | 2016-12-19 | 2019-11-26 | Agenebio Inc | derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo |
US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
WO2019162746A1 (fr) * | 2018-02-21 | 2019-08-29 | Zenvision Pharma Llp | Nouveaux dérivés de palipéridone et leur procédé de préparation |
CA3104478A1 (fr) | 2018-06-19 | 2019-12-26 | Agenebio, Inc. | Derives de benzodiazepine, compositions, et methodes de traitement de deficience cognitive |
WO2024039886A1 (fr) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Dérivés de benzoazépine, compositions et méthodes de traitement de déficience cognitive |
CN116003404A (zh) * | 2022-12-14 | 2023-04-25 | 杭州同舟生物技术有限公司 | 一种利培酮人工半抗原、人工抗原及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4342870A (en) * | 1980-03-28 | 1982-08-03 | Janssen Pharmaceutica N.V. | Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives |
US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
-
1989
- 1989-10-16 CA CA002000786A patent/CA2000786C/fr not_active Expired - Lifetime
- 1989-10-18 NZ NZ231062A patent/NZ231062A/xx unknown
- 1989-10-30 CY CY192689A patent/CY1926A/xx unknown
- 1989-10-30 AT AT89202724T patent/ATE122349T1/de active
- 1989-10-30 EP EP89202724A patent/EP0368388B1/fr not_active Expired - Lifetime
- 1989-10-30 ES ES89202724T patent/ES2075036T3/es not_active Expired - Lifetime
- 1989-10-30 DE DE68922577T patent/DE68922577T2/de not_active Expired - Lifetime
- 1989-10-30 DE DE122007000081C patent/DE122007000081I2/de active Active
- 1989-11-03 IL IL92208A patent/IL92208A0/xx not_active IP Right Cessation
- 1989-11-06 IE IE356489A patent/IE66370B1/en not_active IP Right Cessation
- 1989-11-06 DK DK551989A patent/DK169923B1/da not_active IP Right Cessation
- 1989-11-06 FI FI895261A patent/FI92201C/fi active Protection Beyond IP Right Term
- 1989-11-06 ZA ZA898436A patent/ZA898436B/xx unknown
- 1989-11-06 PT PT92206A patent/PT92206B/pt not_active IP Right Cessation
- 1989-11-06 NO NO894411A patent/NO173015C/no not_active IP Right Cessation
- 1989-11-06 AU AU44436/89A patent/AU614437B2/en not_active Expired
- 1989-11-07 JP JP1289842A patent/JP2758045B2/ja not_active Expired - Lifetime
- 1989-11-07 KR KR1019890016114A patent/KR0146053B1/ko not_active IP Right Cessation
-
1996
- 1996-07-18 HK HK131696A patent/HK131696A/xx not_active IP Right Cessation
-
2004
- 2004-05-20 CL CL200401183A patent/CL43432B/es active
-
2007
- 2007-09-12 LU LU91362C patent/LU91362I2/fr unknown
- 2007-10-15 CY CY200700025C patent/CY2007025I2/el unknown
- 2007-10-17 NL NL300298C patent/NL300298I2/nl unknown
- 2007-12-21 NO NO2007017C patent/NO2007017I2/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO173015C (no) | Analogifremgangsmaate til fremstilling av pyrido(1,2-a)pyrimidin-3-piperidinyl-1,2-benzisoksazoler | |
FI900085A (fi) | Menetelmä terapeuttisesti käyttökelpoisten N-(pyrimidin- ja kondensoitu pyrimidin-4-oni)etyyli-piperidiini- ja piperatsiinijohdannaisten valmistamiseksi | |
IL74017A0 (en) | N-(4-piperidinyl)bicyclic condensed 2-imidazolamine derivatives,their preparation and pharmaceutical compositions containing them | |
NO176051C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-piperazinylbenzazol-derivater | |
AU1810988A (en) | Novel n-(4-piperidinyl)bicyclic condensed 2-imidazolamine derivatives | |
NO176608C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-piperidinylindazol-derivater |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
SPCF | Filing of supplementary protection certificate |
Free format text: PRODUCT NAME: INVEGA - SE VEDLAGTE PREPARATOMTALE; NAT. REG. NO/DATE: 06/06522-15 20070717 Spc suppl protection certif: 2007017 Filing date: 20071221 |
|
MK1K | Patent expired | ||
SPCG | Granted supplementary protection certificate |
Free format text: PRODUCT NAME: INVEGA - SE VEDLAGTE PREPARATOMTALE; NAT. REG. NO/DATE: 06/06522-15 20070717 Spc suppl protection certif: 2007017 Filing date: 20071221 Extension date: 20141106 |
|
SPCX | Expiry of an spc |
Spc suppl protection certif: 2007017 Effective date: 20141106 |