NO170977C - Analogifremgangsmaate for fremstilling av terapeutisk aktive aryl-piperazinyl-etyl (eller butyl)-heterocykliske forbindelser - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive aryl-piperazinyl-etyl (eller butyl)-heterocykliske forbindelser

Info

Publication number
NO170977C
NO170977C NO880901A NO880901A NO170977C NO 170977 C NO170977 C NO 170977C NO 880901 A NO880901 A NO 880901A NO 880901 A NO880901 A NO 880901A NO 170977 C NO170977 C NO 170977C
Authority
NO
Norway
Prior art keywords
piperazinyl
butyl
ethyl
preparation
heterocyclic compounds
Prior art date
Application number
NO880901A
Other languages
English (en)
Norwegian (no)
Other versions
NO170977B (no
NO880901L (no
NO880901D0 (no
Inventor
Iii John Adams Lowe
Arthur Adam Nagel
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22202301&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO170977(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of NO880901D0 publication Critical patent/NO880901D0/no
Publication of NO880901L publication Critical patent/NO880901L/no
Publication of NO170977B publication Critical patent/NO170977B/no
Publication of NO170977C publication Critical patent/NO170977C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
NO880901A 1987-03-02 1988-03-01 Analogifremgangsmaate for fremstilling av terapeutisk aktive aryl-piperazinyl-etyl (eller butyl)-heterocykliske forbindelser NO170977C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8700423 1987-03-02

Publications (4)

Publication Number Publication Date
NO880901D0 NO880901D0 (no) 1988-03-01
NO880901L NO880901L (no) 1988-09-05
NO170977B NO170977B (no) 1992-09-28
NO170977C true NO170977C (no) 1993-01-06

Family

ID=22202301

Family Applications (2)

Application Number Title Priority Date Filing Date
NO880901A NO170977C (no) 1987-03-02 1988-03-01 Analogifremgangsmaate for fremstilling av terapeutisk aktive aryl-piperazinyl-etyl (eller butyl)-heterocykliske forbindelser
NO2002004C NO2002004I2 (no) 1987-03-02 2002-05-28 Ziprasidon

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2002004C NO2002004I2 (no) 1987-03-02 2002-05-28 Ziprasidon

Country Status (31)

Country Link
EP (1) EP0281309B1 (xx)
JP (1) JPH0710837B2 (xx)
KR (1) KR900003492B1 (xx)
CN (1) CN1015057B (xx)
AR (1) AR244673A1 (xx)
AT (1) ATE70833T1 (xx)
AU (1) AU583762B2 (xx)
BA (1) BA98296A (xx)
CA (1) CA1300139C (xx)
CZ (1) CZ281257B6 (xx)
DD (1) DD272077A5 (xx)
DE (3) DE10299021I1 (xx)
DK (1) DK173065B1 (xx)
EG (1) EG18398A (xx)
ES (1) ES2040838T3 (xx)
FI (1) FI91868C (xx)
GR (1) GR3003459T3 (xx)
HU (1) HU207860B (xx)
IE (1) IE60849B1 (xx)
IL (1) IL85495A (xx)
LU (1) LU90944I2 (xx)
MX (1) MX173362B (xx)
MY (1) MY103352A (xx)
NO (2) NO170977C (xx)
NZ (1) NZ223694A (xx)
PH (1) PH24119A (xx)
PL (1) PL157897B1 (xx)
PT (1) PT86866B (xx)
SU (1) SU1644716A3 (xx)
YU (1) YU46639B (xx)
ZA (1) ZA881447B (xx)

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US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
FR2631625B1 (fr) * 1988-05-17 1992-10-16 Synthelabo Derives de phenyl-6 piperazinylalkyl-3 1h,3h-pyrimidinedione-2,4, leur preparation et leur application en therapeutique
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
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WO1991000863A1 (en) * 1989-07-07 1991-01-24 Pfizer Inc. Heteroaryl piperazine antipsychotic agents
EP0429341A3 (en) * 1989-11-20 1991-11-13 Rhone-Poulenc Sante Heterocyclic derivatives, their preparation and pharmaceuticals containing them
FR2655042B1 (fr) * 1989-11-29 1994-01-21 Adir Cie Nouvelles benzothiazolinones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5166157A (en) * 1989-12-20 1992-11-24 Adir Et Compagnie Naphthyl piperazines useful as 5-HT1A receptor ligands
FR2655988B1 (fr) * 1989-12-20 1994-05-20 Adir Cie Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5166156A (en) * 1989-12-20 1992-11-24 Adir Et Compagnie Naphthyl piperazines useful as 5-HT1A receptor ligands
US5162321A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie 1-naphthyl piperazines useful as 5-HT1A receptor ligands
US5162324A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie Naphyl piperazines useful as 5-HT1A receptor ligands
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
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US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
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NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DK55192D0 (da) * 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater
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DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
CN1050604C (zh) * 1993-02-04 2000-03-22 明治制果株式会社 具有抗精神病作用的化合物
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GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
ES2083319B1 (es) * 1993-09-20 1997-01-16 Pfizer Monohidrato de clorhidrato de 5-(2-(4-(1,2-benzisotiazol-3-il)-1-piperazinil)-etil)-6-cloro-1,3-dihidro-2h-indol-2-ona.
FR2717807B1 (fr) * 1994-03-22 1996-04-19 Adir Nouvelles 6- [(4-arylalkyl-1-piperazino)alkyl] benzothiazolinones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
AU687155B2 (en) * 1994-03-22 1998-02-19 Les Laboratoires Servier Novel aminoalkyl benzothiazolinones, process for their preparation and the pharmaceutical compositions which contain them
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
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UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
IL126590A (en) * 1996-05-07 2001-11-25 Pfizer Trihydrate salt of -5 (-2 (-4 (1 (2, 2-benzothiazole - 3yl) -1-piperazinyl) ethyl) - 6-chloro-1, 3-dihydro-2 (1H) - indole - 2On (= Ziprasidone) and pharmaceutical preparations containing it
FR2755690B1 (fr) * 1996-11-08 1998-12-18 Adir Nouveaux derives aminomethyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6150366A (en) * 1998-06-15 2000-11-21 Pfizer Inc. Ziprasidone formulations
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JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
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JO2642B1 (en) 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
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CN101663299A (zh) 2007-04-23 2010-03-03 詹森药业有限公司 作为快速解离性多巴胺2受体拮抗剂的噻(二)唑类化合物
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JP5457450B2 (ja) 2008-07-31 2014-04-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 迅速解離性ドーパミン２受容体拮抗薬としてのピペラジン−１−イル−トリフルオロメチル−置換−ピリジン
DK2445502T4 (da) 2009-06-25 2022-11-28 Alkermes Pharma Ireland Ltd Heterocycliske forbindelser til behandling af neurologiske og psykologiske lidelser
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Also Published As

Publication number Publication date
DE10299021I2 (de) 2007-05-10
JPH0710837B2 (ja) 1995-02-08
IL85495A0 (en) 1988-07-31
CA1300139C (en) 1992-05-05
DK108388D0 (da) 1988-03-01
NO2002004I2 (no) 2007-02-12
MX10621A (es) 1993-09-01
NO170977B (no) 1992-09-28
DE10299021I1 (de) 2002-09-26
ATE70833T1 (de) 1992-01-15
FI880941A (fi) 1988-09-03
YU46639B (sh) 1994-01-20
HU207860B (en) 1993-06-28
BA98296A (bs) 2001-09-14
GR3003459T3 (en) 1993-02-17
AU1253788A (en) 1988-09-01
FI91868C (fi) 1994-08-25
IE60849B1 (en) 1994-08-24
ZA881447B (en) 1989-10-25
MY103352A (en) 1993-06-30
MX173362B (es) 1994-02-23
DK173065B1 (da) 1999-12-13
AR244673A1 (es) 1993-11-30
KR900003492B1 (ko) 1990-05-21
JPS63301861A (ja) 1988-12-08
ES2040838T3 (es) 1993-11-01
CN88101642A (zh) 1988-09-14
FI880941A0 (fi) 1988-03-01
IL85495A (en) 1993-05-13
SU1644716A3 (ru) 1991-04-23
NO880901L (no) 1988-09-05
IE880574L (en) 1988-09-02
PT86866B (pt) 1992-05-29
PT86866A (pt) 1988-03-01
PL157897B1 (pl) 1992-07-31
HUT50330A (en) 1990-01-29
CZ281257B6 (cs) 1996-07-17
PH24119A (en) 1990-03-05
EP0281309B1 (en) 1991-12-27
CZ131788A3 (en) 1996-05-15
CN1015057B (zh) 1991-12-11
DK108388A (da) 1988-09-03
DE3867089D1 (de) 1992-02-06
PL270925A1 (en) 1988-12-08
NO880901D0 (no) 1988-03-01
NZ223694A (en) 1990-02-26
AU583762B2 (en) 1989-05-04
FI91868B (fi) 1994-05-13
EG18398A (en) 1993-02-28
KR880011142A (ko) 1988-10-26
EP0281309A1 (en) 1988-09-07
DD272077A5 (de) 1989-09-27
LU90944I2 (fr) 2002-10-07
YU40688A (en) 1989-12-31

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