NO154521C - Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive piperidinderivater. - Google Patents

Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive piperidinderivater.

Info

Publication number
NO154521C
NO154521C NO801014A NO801014A NO154521C NO 154521 C NO154521 C NO 154521C NO 801014 A NO801014 A NO 801014A NO 801014 A NO801014 A NO 801014A NO 154521 C NO154521 C NO 154521C
Authority
NO
Norway
Prior art keywords
preparation
therapeutically active
new therapeutically
analogy procedure
piperide
Prior art date
Application number
NO801014A
Other languages
English (en)
Norwegian (no)
Other versions
NO801014L (no
NO154521B (no
Inventor
Albert A Carr
Joseph E Dolfini
George J Wright
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21845568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO154521(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of NO801014L publication Critical patent/NO801014L/no
Publication of NO154521B publication Critical patent/NO154521B/no
Publication of NO154521C publication Critical patent/NO154521C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO801014A 1979-04-10 1980-04-09 Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive piperidinderivater. NO154521C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/028,813 US4254129A (en) 1979-04-10 1979-04-10 Piperidine derivatives

Publications (3)

Publication Number Publication Date
NO801014L NO801014L (no) 1980-10-13
NO154521B NO154521B (no) 1986-06-30
NO154521C true NO154521C (no) 1986-10-08

Family

ID=21845568

Family Applications (2)

Application Number Title Priority Date Filing Date
NO801014A NO154521C (no) 1979-04-10 1980-04-09 Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive piperidinderivater.
NO1998017C NO1998017I1 (no) 1979-04-10 1998-05-29 Fexofenadine

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1998017C NO1998017I1 (no) 1979-04-10 1998-05-29 Fexofenadine

Country Status (19)

Country Link
US (1) US4254129A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS55141469A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT376208B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU531146B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE882703A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1123438A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH643245A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3007498A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK153709C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES489934A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2453854A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL59158A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1143960B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (2) NL190580C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (2) NO154521C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ192653A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH17023A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE448726B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA80332B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR240018A1 (es) * 1987-10-07 1990-01-31 Merrell Pharma Inc Procedimiento para preparar una composicion que comprende derivados de piperidinoalcanol.
CN1053570C (zh) 1987-10-07 2000-06-21 默尔多药物公司 哌啶子基链烷醇的药用组合物-减充血剂复方的制备方法
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
AR245888A1 (es) * 1989-01-23 1994-03-30 Merrell Pharma Inc Procedimiento para la preparacion de una composicion farmaceutica liquida de derivados de piperidinoalcanol.
DE3917241A1 (de) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkan-derivate
US5190029A (en) * 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
TW198008B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1991-04-08 1993-01-11 Green Cross Corp
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
PT626968E (pt) * 1992-02-13 2002-03-28 Merrell Pharma Inc Derivados de piperidinilo tiaciclicos
US5631375A (en) * 1992-04-10 1997-05-20 Merrell Pharmaceuticals, Inc. Process for piperidine derivatives
CA2117892C (en) * 1992-04-10 2001-12-18 Chi-Hsin R. King 4-diphenylmethyl piperidine derivatives and process for their preparation
AU679910B2 (en) 1992-05-11 1997-07-17 Merrell Pharmaceuticals Inc. Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient
EP1688142A1 (en) † 1992-08-03 2006-08-09 Sepracor Inc. Terfenadine carboxylate and the treatment of dermal irritation
US5654433A (en) * 1993-01-26 1997-08-05 Merrell Pharmaceuticals Inc. Process for piperidine derivatives
EP0703902B1 (en) * 1993-06-24 1998-12-16 Albany Molecular Research, Inc. Process for the production of piperidine derivatives
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
CA2362337C (en) * 1993-06-25 2005-08-02 Merrell Pharmaceuticals Inc. Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate
CA2173467A1 (en) * 1993-10-25 1995-05-04 Keith D. Ertel A stable pharmaceutical composition of terfenadine and ibuprofen
DE69517810T2 (de) * 1994-05-16 2000-12-14 Merrell Pharmaceuticals Inc., Cincinnati Verfahren und diastereomere salze nützlich bei der racemattrennung von racemischer 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylphenyl essigsäure sowie entsprechende diastereomere salze
PT766668E (pt) 1994-05-18 2002-11-29 Aventis Pharma Inc Processos para a preparacao de formas anidras e hidratadas de derivados antihistaminicos da piperidina e de polimorfos e pseudomorfos destes
CN101337922A (zh) * 1994-05-18 2009-01-07 阿温蒂斯药物公司 抗组胺哌啶衍生物,其多晶形物和假同晶物的无水和水合物形式的制备方法
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
CN1067385C (zh) 1994-08-25 2001-06-20 默里尔药物公司 用于治疗变应性疾病的新的取代的哌啶类化合物
EP0812195B1 (en) * 1995-02-28 2002-10-30 Aventis Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol compounds
JPH11504650A (ja) * 1995-05-08 1999-04-27 ヘキスト・マリオン・ルセル・インコーポレイテツド アルファ−（置換アルキルフェニル）−４−（ヒドロキシジフェニルメチル）−１−ピペリジンブタノール誘導体、その製造および抗ヒスタミン剤、抗アレルギー剤および気管支拡張剤としてのその使用
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
ES2216191T3 (es) * 1997-03-11 2004-10-16 Aventis Pharmaceuticals Inc. Procedimiento para preparar acido 4-(4-(hidroxidifenil)-1-piperidinil)-1-hidroxibutil)-alfa,alfa-dimetilfenilacetico y derivados fosforilados.
US6451815B1 (en) 1997-08-14 2002-09-17 Aventis Pharmaceuticals Inc. Method of enhancing bioavailability of fexofenadine and its derivatives
CZ293666B6 (cs) * 1997-08-14 2004-06-16 Aventis Pharmaceuticals Inc. Farmaceutický prostředek se zvýšenou biodostupností antihistaminika a použití
EP0998272B1 (en) * 1997-08-26 2003-05-02 Aventis Pharmaceuticals Inc. Pharmaceutical composition for combination of piperidinoalkanol-decongestant
PT924196E (pt) * 1997-12-17 2003-11-28 Aventis Pharma Gmbh Procedimento para a alquilacao de derivados de alquil- ou benzilciano em presenca de trialquilaminas ou -fosfinas
DE69835103T2 (de) * 1997-12-23 2006-12-21 Schering Corp. Zusammensetzung zur behandlung von atemwegs- und hauterkrankungen mit mindestens einem leukotrienantagonist und mindestens einem antihistaminikum
US6194431B1 (en) * 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
DE69942876D1 (de) * 1998-07-02 2010-12-02 Aventisub Ii Inc Antihistaminische piperidinderivate und zwischenprodukte zu ihrer herstellung
AU2007200674C1 (en) * 1998-07-02 2011-02-24 Aventisub Llc Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6930197B2 (en) 1998-07-02 2005-08-16 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
GB9822170D0 (en) * 1998-10-13 1998-12-02 Danbioyst Uk Ltd Novel formulations of fexofenadine
IN191492B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1999-05-25 2003-12-06 Ranbaxy Lab Ltd
US6613906B1 (en) * 2000-06-06 2003-09-02 Geneva Pharmaceuticals, Inc. Crystal modification
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
CH695216A5 (de) * 2001-02-23 2006-01-31 Cilag Ag Verfahren zur Herstellung eines nicht hydratisierten Salzes eines Piperidinderivats und eine so erhältliche neue kristalline Form eines solchen Salzes.
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
HRP20030900A2 (en) * 2001-04-09 2005-08-31 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine hydrochloride
CA2450858C (en) * 2001-06-18 2009-04-07 Dr. Reddy's Laboratories Limited Novel crystalline forms of 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-.alpha.,.alpha.-dimethylbenzene acetic acid and its hydrochloride
US7700779B2 (en) * 2001-06-18 2010-04-20 Dr. Reddy's Laboratories Limited Crystalline forms of fexofenadine and its hydrochloride
EP1453509A2 (en) * 2001-11-08 2004-09-08 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine base
US20030158227A1 (en) * 2001-11-08 2003-08-21 Barnaba Krochmal Polymorphs of fexofenadine base
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
ES2239554T1 (es) * 2002-06-10 2005-10-01 Teva Pharmaceutical Industries Ltd. Forma xvi polimorfica de hidrocloruro de fexofenadina.
CN1741981A (zh) * 2002-12-16 2006-03-01 兰贝克赛实验室有限公司 非索那汀的制备方法
US20070106078A1 (en) * 2003-01-31 2007-05-10 Sharma Mukesh K Process for the preparation of fexofenadine
US20050065183A1 (en) * 2003-07-31 2005-03-24 Indranil Nandi Fexofenadine composition and process for preparing
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
GB0319935D0 (en) * 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
US20050256163A1 (en) * 2004-04-26 2005-11-17 Ilan Kor Crystalline forms of fexofenadine hydrochloride and processes for their preparation
WO2006008567A1 (en) * 2004-06-18 2006-01-26 Wockhardt Limited Pharmaceutical compositions for piperidinoalkanol compounds
ITMI20041568A1 (it) * 2004-07-30 2004-10-30 Dipharma Spa "polimorfi di fexofenadina base"
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US20060148851A1 (en) * 2004-09-28 2006-07-06 Shlomit Wizel Fexofenadine crystal form and processes for its preparation thereof
ES2617253T3 (es) 2004-11-24 2017-06-16 Meda Pharmaceuticals Inc. Composiciones que comprenden azelastina y métodos de uso de las mismas
US20070020330A1 (en) * 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
US8758816B2 (en) * 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
JP2008120684A (ja) * 2005-03-07 2008-05-29 Kumamoto Univ 抗アレルギー薬
MX2008001645A (es) * 2005-08-05 2008-04-07 Lupin Ltd Composiciones de fexofendina en suspension farmaceutica oral.
US20070088065A1 (en) * 2005-10-14 2007-04-19 Jie Du Metaxalone products, method of manufacture, and method of use
US20080292584A1 (en) * 2005-10-14 2008-11-27 Mutual Pharmaceutical Company, Inc. Metaxalone products, method of manufacture, and method of use
RU2283649C1 (ru) * 2005-10-27 2006-09-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтическая композиция для лечения аллергических заболеваний
WO2007049303A2 (en) * 2005-10-28 2007-05-03 Ind-Swift Laboratories Limited An improved process for the preparation of highly pure fexofenadine
US8067433B2 (en) 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
DOP2006000274A (es) * 2005-12-14 2007-10-15 Sanofi Aventis Us Llc Formulación de suspensión de fexofenadina
CN100443470C (zh) * 2006-07-21 2008-12-17 杭州保灵有限公司 一种依巴斯汀的制备方法
ITMI20061491A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
CA2826272A1 (en) 2007-04-13 2009-02-19 Southern Research Institute Anti-angiogenic agents and methods of use
ITMI20070987A1 (it) * 2007-05-16 2008-11-17 Dipharma Francis Srl Procedimento per la preparazione di composti chetonici
US20090076080A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched fexofenadine
US20090306135A1 (en) 2008-03-24 2009-12-10 Mukesh Kumar Sharma Stable amorphous fexofenadine hydrochloride
US20090306025A1 (en) * 2008-05-30 2009-12-10 Fairfield Clinical Trials, Llc Method and composition for skin inflammation and discoloration
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
CN101585805B (zh) * 2009-06-06 2011-07-06 浙江大学宁波理工学院 一种抗过敏药物非索非那定盐酸盐的制备方法
EP2289867A3 (en) 2009-08-19 2012-04-25 Jubilant Organosys Limited A process for producing 4-(4-halo-1-oxybutyl)-alpha,alpha-dimethylbenzene acetic acid or alkyl esters thereof
CN101671292B (zh) * 2009-10-10 2011-09-07 浙江大学宁波理工学院 盐酸非索非那定的合成方法
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
EP2371817A1 (en) * 2010-04-01 2011-10-05 Arevipharma GmbH Process for the preparation of 1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone and acid addition salts thereof
US9216955B2 (en) 2010-06-15 2015-12-22 Chemelectiva S.R.L. Polymorphic form of Fexofenadine hydrochloride, intermediates and process for its preparation
CN103702961A (zh) 2011-05-23 2014-04-02 赛诺菲 含有n-烷基的氘代化合物的制备方法
WO2013047725A1 (ja) 2011-09-29 2013-04-04 塩野義製薬株式会社 Ｐｇｄ２拮抗剤及びヒスタミン拮抗剤からなるアレルギー性鼻炎治療用医薬
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
CN102659667B (zh) * 2012-04-20 2013-08-14 浙江启明药业有限公司 一种非索非那定关键中间体的合成方法
CN103333100B (zh) * 2013-06-06 2016-04-06 池州东升药业有限公司 一种盐酸非索非那定的合成工艺
ITMI20131652A1 (it) 2013-10-07 2015-04-08 Dipharma Francis Srl Procedimento per la purificazione di derivati dell'acido 2-fenil-2-metil-propanoico
CN104557671B (zh) * 2013-10-10 2018-04-13 池州东升药业有限公司 一种非索非那定及中间体的合成方法
EP2949321A1 (en) 2014-05-26 2015-12-02 Sanovel Ilac Sanayi ve Ticaret A.S. Multilayer formulations of fexofenadine and montelukast
WO2016116555A1 (en) 2015-01-22 2016-07-28 Sanofi-Aventis Deutschland Gmbh Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile
PT3365327T (pt) 2015-10-22 2020-02-06 Sanofi Aventis Deutschland Processo para a preparação de fexofenadina e de intermediários usados no mesmo
GB2629127A (en) 2022-08-31 2024-10-23 Novumgen Ltd An orodispersible tablet of fexofenadine and its process of preparation
CN118714999A (zh) 2023-01-20 2024-09-27 欧彼乐医疗集团公司 不含对羟基苯甲酸酯的非索非那定制剂

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242169A (en) * 1969-04-09 1971-08-11 Ucb Sa Piperidine derivatives
BE794598A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3965257A (en) * 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
ZA728544B (en) * 1972-01-28 1974-02-27 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
BE794596A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Piperidinoalcanone-oximes substituees et leur procede de preparation
US3941795A (en) * 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US3931197A (en) * 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines

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NO1998017I1 (no) 1998-05-29
IT8048245A0 (it) 1980-03-24
CH643245A5 (de) 1984-05-30
CA1123438A (en) 1982-05-11
AT376208B (de) 1984-10-25
DE3007498C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-09-07
BE882703A (fr) 1980-07-31
JPH0132823B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-07-10
ES8103735A1 (es) 1981-03-16
DK153709C (da) 1988-12-27
NZ192653A (en) 1982-03-16
NL980013I2 (nl) 1998-10-01
IL59158A0 (en) 1980-05-30
JPS55141469A (en) 1980-11-05
AU5501680A (en) 1980-10-16
NO801014L (no) 1980-10-13
US4254129A (en) 1981-03-03
FR2453854A1 (fr) 1980-11-07
NO154521B (no) 1986-06-30
IT1143960B (it) 1986-10-29
SE8002634L (sv) 1980-10-11
ZA80332B (en) 1981-01-28
PH17023A (en) 1984-05-11
SE448726B (sv) 1987-03-16
DK132980A (da) 1980-10-11
IL59158A (en) 1984-04-30
NL190580B (nl) 1993-12-01
FR2453854B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1983-06-24
NL980013I1 (nl) 1998-06-02
AU531146B2 (en) 1983-08-11
DE3007498A1 (de) 1980-10-23
NL190580C (nl) 1994-05-02
DK153709B (da) 1988-08-22
ES489934A0 (es) 1981-03-16
ATA144880A (de) 1984-03-15
NL8000754A (nl) 1980-10-14

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