NO148148C - Fremgangsmaate til fremstilling av terapeutisk aktive 4-hydroksy-2-pyrrolidinonderivater - Google Patents

Fremgangsmaate til fremstilling av terapeutisk aktive 4-hydroksy-2-pyrrolidinonderivater

Info

Publication number
NO148148C
NO148148C NO780464A NO780464A NO148148C NO 148148 C NO148148 C NO 148148C NO 780464 A NO780464 A NO 780464A NO 780464 A NO780464 A NO 780464A NO 148148 C NO148148 C NO 148148C
Authority
NO
Norway
Prior art keywords
pyrrolidinon
hydroxy
derivatives
procedure
preparation
Prior art date
Application number
NO780464A
Other languages
English (en)
Norwegian (no)
Other versions
NO148148B (no
NO780464L (no
Inventor
Silvano Banfi
Renato Pellegata
Giorgio Pifferi
Mario Pinza
Original Assignee
Isf Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isf Spa filed Critical Isf Spa
Publication of NO780464L publication Critical patent/NO780464L/no
Publication of NO148148B publication Critical patent/NO148148B/no
Publication of NO148148C publication Critical patent/NO148148C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B43—WRITING OR DRAWING IMPLEMENTS; BUREAU ACCESSORIES
    • B43K—IMPLEMENTS FOR WRITING OR DRAWING
    • B43K24/00—Mechanisms for selecting, projecting, retracting or locking writing units
    • B43K24/02—Mechanisms for selecting, projecting, retracting or locking writing units for locking a single writing unit in only fully projected or retracted positions
    • B43K24/08—Mechanisms for selecting, projecting, retracting or locking writing units for locking a single writing unit in only fully projected or retracted positions operated by push-buttons
    • B43K24/084—Mechanisms for selecting, projecting, retracting or locking writing units for locking a single writing unit in only fully projected or retracted positions operated by push-buttons with saw-like or analogous cams
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J115/00—Adhesives based on rubber derivatives
NO780464A 1977-02-11 1978-02-10 Fremgangsmaate til fremstilling av terapeutisk aktive 4-hydroksy-2-pyrrolidinonderivater NO148148C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20227/77A IT1075280B (it) 1977-02-11 1977-02-11 Procedimento per la preparazione di derivati pirrolidinici

Publications (3)

Publication Number Publication Date
NO780464L NO780464L (no) 1978-08-14
NO148148B NO148148B (no) 1983-05-09
NO148148C true NO148148C (no) 1983-08-17

Family

ID=11164931

Family Applications (1)

Application Number Title Priority Date Filing Date
NO780464A NO148148C (no) 1977-02-11 1978-02-10 Fremgangsmaate til fremstilling av terapeutisk aktive 4-hydroksy-2-pyrrolidinonderivater

Country Status (26)

Country Link
US (1) US4173569A (es)
JP (1) JPS53101367A (es)
AR (1) AR223958A1 (es)
AT (1) AT362782B (es)
AU (1) AU513992B2 (es)
BE (1) BE863883A (es)
CA (1) CA1087200A (es)
CH (1) CH637928A5 (es)
CS (1) CS214800B2 (es)
DE (2) DE2758939A1 (es)
DK (1) DK155733C (es)
ES (1) ES466856A1 (es)
FI (1) FI67695C (es)
FR (1) FR2380257A1 (es)
GB (1) GB1588075A (es)
HU (1) HU178587B (es)
IN (1) IN148327B (es)
IT (1) IT1075280B (es)
MX (1) MX5950E (es)
NL (1) NL190412C (es)
NO (1) NO148148C (es)
NZ (1) NZ186431A (es)
PL (1) PL112858B1 (es)
PT (1) PT67642A (es)
SU (1) SU755195A3 (es)
YU (1) YU40321B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
IT1206699B (it) * 1984-02-27 1989-04-27 Isf Spa Procedimento per preparare derivati di pirrolidone.
IT1173768B (it) * 1984-04-02 1987-06-24 Isf Spa Procedimento di preparazione di derivati 1-carbamoilmetilici di 4-idrossi-2-osso-pirrolidina nonche' di intermedi per ottenere tali composti
CH666483A5 (de) * 1985-01-16 1988-07-29 Lonza Ag Verfahren zur herstellung von thiotetronsaeure.
EP0223328B1 (en) 1985-07-26 1992-01-29 Denki Kagaku Kogyo Kabushiki Kaisha Process for producing oxiracetam
CH668423A5 (de) * 1986-06-19 1988-12-30 Lonza Ag Verfahren zur herstellung von 4-alkoxy-3-pyrrolin-2-onen.
HU195773B (en) * 1985-09-24 1988-07-28 Lonza Ag Process for preparing alkyl esters of 4-alkoxy-3-pyrrolin-2-on-1-yl-acetic acid
IL80071A0 (en) * 1985-09-24 1986-12-31 Lonza Ag Pyrrolidine acetamide derivatives
CH666891A5 (de) * 1985-11-26 1988-08-31 Lonza Ag 4-alkoxy-2-oxo-pyrrolidin-1-yl-essigsaeure-c(1)-c(4)-alkylester, deren herstellung und verwendung.
CH668424A5 (de) * 1986-06-26 1988-12-30 Lonza Ag 4-benzyloxy-3-pyrrolin-2-on-l-yl-acetamid, dessen herstellung und verwendung.
CH668422A5 (de) * 1986-06-26 1988-12-30 Lonza Ag 4-benzyloxy-3-pyrrolin-2-on, dessen herstellung und verwendung zur synthese von tetramsaeure.
CH667655A5 (de) * 1986-09-24 1988-10-31 Lonza Ag Verfahren zur herstellung von 4-alkoxy-2(5h)-thiophenonen.
CH670644A5 (es) * 1986-12-18 1989-06-30 Lonza Ag
IT1215581B (it) * 1987-06-25 1990-02-14 Roussel Maestretti Spa Derivati della 1-benzil 2-oxo 5-alcossi pirrolidina, loro procedimento di preparazione e loro applicazione come prodotti medicinali.
DE3813416A1 (de) * 1988-04-21 1989-11-02 Hoechst Ag 3,4-dihydroxypyrrolidin-2-on-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
DE58909320D1 (de) * 1988-09-06 1995-08-03 Lonza Ag Verfahren zur Herstellung von 5-Alkyltetramsäuren.
FI95034C (fi) * 1989-03-15 1995-12-11 Lonza Ag Menetelmä 1,3-substituoidun tetrahydro-1H-tieno/3,4-d/-imidatsol-2(3H)-on-4-ylideenipentaanihappoesterin valmistamiseksi
CH680293A5 (es) * 1990-06-26 1992-07-31 Lonza Ag
GB9121289D0 (en) * 1991-10-08 1991-11-20 Isf Spa Composition and use
JP2969616B2 (ja) * 1994-11-24 1999-11-02 田辺製薬株式会社 ４−メルカプトピロリジン化合物の製法
EP0951468A4 (en) * 1996-11-22 2001-06-06 Mona Industries Inc SILICONE MONOMERS AND OLIGOMERS CONTAINING A CARBOXYL FUNCTIONAL GROUP
US5679798A (en) * 1996-11-22 1997-10-21 Mona Industries, Inc. Silicone monomers having a carboxyl functional group thereon
KR100424393B1 (ko) * 2001-11-26 2004-03-24 한국화학연구원 옥시라세탐의 제조방법
JP4378326B2 (ja) * 2005-07-26 2009-12-02 キヤノン株式会社 駆動装置及び光量調節装置
DK3260118T3 (da) * 2008-10-16 2021-04-19 Univ Johns Hopkins Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion
CN101747259B (zh) * 2008-12-18 2012-02-15 北京大学 氮杂糖类化合物及其合成方法及应用
CN101575309B (zh) * 2009-04-28 2011-05-18 中国医药集团总公司四川抗菌素工业研究所 合成(s)-奥拉西坦的方法
CN101704778B (zh) * 2009-09-30 2012-10-17 厦门市华兴化工有限公司 一种制备4-羟基吡咯烷酮-2-乙酰胺的方法
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
DK2968220T3 (da) 2013-03-15 2021-06-14 Agenebio Inc Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
CN104513189B (zh) * 2014-12-19 2017-07-28 深圳市海滨制药有限公司 一种奥拉西坦中间体及其制备方法和应用
CN106166150A (zh) * 2015-05-18 2016-11-30 重庆润泽医药有限公司 右旋奥拉西坦在制药领域中的应用
CN107810002B (zh) 2015-05-22 2021-01-05 艾吉因生物股份有限公司 左乙拉西坦的延时释放药物组合物
JP2019531323A (ja) * 2016-10-24 2019-10-31 チョンキン ランゼ ファーマスーティカル カンパニー リミテッド （ｒ）−４−ヒドロキシ−２−オキソ−１−ピロリジンアセトアミドの結晶型、調製方法、用途
JP2019531314A (ja) 2016-10-24 2019-10-31 チョンキン ランゼ ファーマスーティカル カンパニー リミテッド 右旋性オキシラセタムの新しい結晶型、調製方法、用途
JP6957807B2 (ja) * 2016-10-24 2021-11-02 チョンキン ランゼ ファーマスーティカル カンパニー リミテッド 右旋性オキシラセタムの２型結晶、調製方法および用途
CN108299267A (zh) 2017-01-12 2018-07-20 重庆润泽医药有限公司 (r)-4-羟基-2-氧-1-吡咯烷乙酰胺的晶型及其制备方法和用途
CN114621128A (zh) * 2022-03-10 2022-06-14 成都百途医药科技有限公司 一种（s）-奥拉西坦的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR211398Q (es) 1975-08-13 1977-12-15 Isf Spa Un procedimiento para preparar derivados de ( -pirrolin -2- on -1- il)-acilamida
IT1045043B (it) 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici

Also Published As

Publication number Publication date
DK63178A (da) 1978-08-12
DE2758937C2 (es) 1988-07-07
FI67695B (fi) 1985-01-31
SU755195A3 (en) 1980-08-07
PT67642A (en) 1978-03-01
NL190412B (nl) 1993-09-16
ES466856A1 (es) 1978-10-01
JPS53101367A (en) 1978-09-04
DE2758937A1 (de) 1978-08-17
AU513992B2 (en) 1981-01-15
ATA88878A (de) 1980-11-15
YU30278A (en) 1983-01-21
NL190412C (nl) 1994-02-16
AT362782B (de) 1981-06-10
NO148148B (no) 1983-05-09
US4173569A (en) 1979-11-06
CS214800B2 (en) 1982-05-28
DK155733C (da) 1989-09-25
FI780407A (fi) 1978-08-12
NZ186431A (en) 1979-08-31
IN148327B (es) 1981-01-17
PL204549A1 (pl) 1979-03-12
CH637928A5 (de) 1983-08-31
HU178587B (en) 1982-05-28
GB1588075A (en) 1981-04-15
DE2758939A1 (de) 1978-08-17
NO780464L (no) 1978-08-14
JPS6338348B2 (es) 1988-07-29
MX5950E (es) 1984-09-06
IT1075280B (it) 1985-04-22
AR223958A1 (es) 1981-10-15
FR2380257A1 (fr) 1978-09-08
AU3309178A (en) 1979-08-16
YU40321B (en) 1985-12-31
FR2380257B1 (es) 1981-11-20
CA1087200A (en) 1980-10-07
NL7801500A (nl) 1978-08-15
BE863883A (fr) 1978-08-10
DK155733B (da) 1989-05-08
FI67695C (fi) 1985-05-10
PL112858B1 (en) 1980-11-29

Similar Documents

Publication Publication Date Title
NO148148C (no) Fremgangsmaate til fremstilling av terapeutisk aktive 4-hydroksy-2-pyrrolidinonderivater
NO782127L (no) Fremgangsmaate for fremstilling av fysiologisk aktive isoksazolo-pyridin-derivater
NO149962C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive imidazolderivater
NO155774C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive imidazo-diazepin-derivater.
NO147243C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive ftalanderivater
NO151240C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive nitroimidazoler
NO156611C (no) Analogifremgangsmaate for fremstilling av terapeutiske virksomme derivater av hydroksykarbonylfosfonsyre.
NO151321C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater
NO151463C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinazolinderivater
NO151411C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-aryloksy-2-hydroksy-3-alkylenaminopropan-derivater
NO148957C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive cyklopeptider
NO800881L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonderivater
NO782756L (no) Fremgangsmaate for fremstilling av terapeutisk aktive antrakinonderivater
NO144848C (no) Analogifremgangsmaate til fremstilling av terapeutisk virksomme 4-hydroksyfenylalkanolamin-derivater
NO149065C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzodiazepinderivater
NO149313C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridobenzodiazepiner
NO149037C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridobenzodiazepiner
NO148291C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive basisk substituerte teofyllinderivater
NO148454C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazolidin-dionderivater
NO148488C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive acyl-benzimidazol-2-derivater
NO780644L (no) Fremgangsmaate til fremstilling av terapeutisk virksomme 9-hydroksyetoksymetylguanin-derivater
NO780743L (no) Fremgangsmaate for fremstilling av farmakologisk aktive benzylpyrimidiner
NO784325L (no) Analogifremgangsmaate for fremstilling av farmasoeytisk aktive tetracyklononanderivater
NO794318L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive spiro-kinolyl-hydantoin-derivater
NO152556C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive antracen-biskarbonylhydrazoner