NO151240C - Analogifremgangsmaate til fremstilling av terapeutisk aktive nitroimidazoler - Google Patents
Analogifremgangsmaate til fremstilling av terapeutisk aktive nitroimidazolerInfo
- Publication number
- NO151240C NO151240C NO782813A NO782813A NO151240C NO 151240 C NO151240 C NO 151240C NO 782813 A NO782813 A NO 782813A NO 782813 A NO782813 A NO 782813A NO 151240 C NO151240 C NO 151240C
- Authority
- NO
- Norway
- Prior art keywords
- nitroimidazoles
- preparation
- therapeutic active
- analogy procedure
- analogy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3490877 | 1977-08-19 | ||
GB1953478 | 1978-05-15 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO782813L NO782813L (no) | 1979-02-20 |
NO151240B NO151240B (no) | 1984-11-26 |
NO151240C true NO151240C (no) | 1985-03-06 |
Family
ID=26254111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO782813A NO151240C (no) | 1977-08-19 | 1978-08-18 | Analogifremgangsmaate til fremstilling av terapeutisk aktive nitroimidazoler |
Country Status (26)
Country | Link |
---|---|
US (1) | US4241060A (no) |
EP (1) | EP0000928B1 (no) |
JP (1) | JPS5444671A (no) |
AR (3) | AR218325A1 (no) |
AT (1) | AT364829B (no) |
AU (1) | AU516443B2 (no) |
CA (1) | CA1104133A (no) |
DE (2) | DE2836073A1 (no) |
DK (1) | DK155367C (no) |
ES (3) | ES472661A1 (no) |
FI (1) | FI70576C (no) |
FR (1) | FR2400512A1 (no) |
GB (1) | GB2003154A (no) |
GR (1) | GR73055B (no) |
HU (1) | HU179983B (no) |
IE (1) | IE47132B1 (no) |
IL (1) | IL55351A (no) |
IT (1) | IT1098042B (no) |
MC (1) | MC1210A1 (no) |
NL (1) | NL7808597A (no) |
NO (1) | NO151240C (no) |
NZ (1) | NZ188140A (no) |
PH (1) | PH16364A (no) |
PT (1) | PT68441A (no) |
SE (1) | SE7808773L (no) |
YU (1) | YU41317B (no) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2948884A1 (de) * | 1979-12-05 | 1981-06-11 | Basf Ag, 6700 Ludwigshafen | 2-hydroxypropylimidazole, verfahren zu ihrer herstellung und verwendung als oelloesliche korrosionsinhibitoren |
ZW8781A1 (en) * | 1980-05-23 | 1981-12-16 | Hoffmann La Roche | 2-nitroimidazoles and preparation thereof |
US4494547A (en) * | 1981-03-30 | 1985-01-22 | North Carolina Central University | 2H-isoindolediones, their synthesis and use as radiosensitizers |
US4605744A (en) * | 1982-03-18 | 1986-08-12 | Hoffmann-La Roche Inc. | Imidazole derivatives |
US4537969A (en) * | 1982-03-18 | 1985-08-27 | Hoffmann-La Roche Inc. | Imidazole derivatives |
GB2123816B (en) * | 1982-05-27 | 1986-03-19 | Nat Res Dev | Nitrolmidazole derivatives |
CA1227211A (en) * | 1982-05-27 | 1987-09-22 | Israr Ahmed | Nitro imidazolyl aziridino propanols |
AU559559B2 (en) * | 1982-08-17 | 1987-03-12 | Suntech, Inc. | Perfluorocarbon emulsions and their preparation and use in therapy |
US4742050B1 (en) * | 1982-08-17 | 1994-06-28 | Alpha Therapeutic Corp | Sensitization of hypoxic tumor cells and control of growth thereof |
US4889525A (en) * | 1982-08-17 | 1989-12-26 | Adamantech, Inc. | Sensitization of hypoxic tumor cells and control of growth thereof |
US5304654A (en) * | 1987-06-10 | 1994-04-19 | Yasunori Nishijima | Fluorine-containing nitroimidazole compounds |
CA1329206C (en) * | 1987-06-10 | 1994-05-03 | Tsutomu Kagiya | Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same |
JP2848602B2 (ja) * | 1987-06-24 | 1999-01-20 | 京都大学長 | 新規含フッ素2−ニトロイミダゾールおよびそれを含む放射線増感剤 |
US4797397A (en) * | 1987-07-31 | 1989-01-10 | Warner-Lambert Company | 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells |
ATE129703T1 (de) * | 1987-12-04 | 1995-11-15 | British Tech Group | Nitro substituierte aromatische und heteroaromatische verbindungen für krebsbehandlungen. |
GB8728418D0 (en) * | 1987-12-04 | 1988-01-13 | Jenkins T C | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
US5086068A (en) * | 1988-02-26 | 1992-02-04 | Alberta Cancer Board | Immunochemical detection of hypoxia in normal and tumor tissue |
US5194624A (en) * | 1988-05-23 | 1993-03-16 | Fujisawa Pharmaceutical Co., Ltd. | Intermediates for the preparation of compounds of antimicrobial activity |
US5036096A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives |
US5036089A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | 2-oxazolidinone derivatives of nitroimidazoles and pharmaceutical compositions useful as sensitizing agents |
US5073639A (en) * | 1988-11-25 | 1991-12-17 | Warner-Lambert Company | Process for the synthesis of novel and known nitroimidazoles which are useful as sensitizing agents |
US4954515A (en) * | 1988-11-25 | 1990-09-04 | Warner-Lambert Company | Haloalkylaminomethyl-2-nitro-1H-imidazoles |
JPH02146288A (ja) * | 1988-11-25 | 1990-06-05 | Ebara Corp | 内部圧縮を持つ容積型圧縮機 |
JP2799368B2 (ja) * | 1990-01-10 | 1998-09-17 | ポーラ化成工業株式会社 | 抗原虫剤 |
GB9127304D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
MX9304399A (es) * | 1992-07-31 | 1994-02-28 | Warner Lambert Co | Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados. |
US6855828B1 (en) | 1992-11-19 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Detection of hypoxia |
WO1994011348A1 (en) * | 1992-11-19 | 1994-05-26 | The Trustees Of The University Of Pennsylvania | Detection of hypoxia |
US6252087B1 (en) | 1992-11-19 | 2001-06-26 | The Trustees Of The University Of Pennsylvania | Nitroaromatic compounds for the detection of hypoxia |
US5741800A (en) * | 1993-06-22 | 1998-04-21 | Knoll Aktiengesellachaft | Azolyl-cyclic amine derivates with immunomodulatory activity |
GB9312893D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
US5674693A (en) * | 1994-03-18 | 1997-10-07 | Natural Pharmacia International Inc. | Derivatives of 2-nitro-imidazoles as hypoxic cell markers |
US5972984A (en) * | 1995-06-06 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US20050026974A1 (en) * | 1996-02-08 | 2005-02-03 | Trustees Of The University Of Pennsylvania | Detection of hypoxia |
US6331286B1 (en) | 1998-12-21 | 2001-12-18 | Photogen, Inc. | Methods for high energy phototherapeutics |
US8974363B2 (en) | 1997-12-11 | 2015-03-10 | Provectus Pharmatech, Inc. | Topical medicaments and methods for photodynamic treatment of disease |
US8557298B2 (en) | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
US20020001567A1 (en) * | 1998-12-21 | 2002-01-03 | Photogen, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
US8470296B2 (en) * | 1998-12-21 | 2013-06-25 | Provectus Pharmatech, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
US7384623B1 (en) | 1998-12-21 | 2008-06-10 | Provectus Pharmatech, Inc. | High energy phototherapeutic agents |
EP1838305A1 (en) * | 2005-01-21 | 2007-10-03 | Richard H. Matthews | Radiosensitizer formulations comprising nitrohistidine derivatives |
US9056136B2 (en) * | 2006-10-06 | 2015-06-16 | Natural Pharmacia International, Inc. | Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia |
US7842278B2 (en) * | 2006-10-27 | 2010-11-30 | Natural Pharmacia International, Inc. | Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof |
MD4150C1 (ro) * | 2011-10-11 | 2012-09-30 | Институт Химии Академии Наук Молдовы | Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective |
MD4178C1 (ro) * | 2012-02-27 | 2013-02-28 | Институт Химии Академии Наук Молдовы | Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului |
JP2016525059A (ja) * | 2013-07-16 | 2016-08-22 | コーニング インコーポレイテッド | 薄ガラスを曲げるための装置及び方法 |
CN108203411A (zh) * | 2016-12-19 | 2018-06-26 | 曾舟华 | 一种高压合成甲硝唑的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA746007A (en) * | 1966-11-08 | W. Henry David | 1-substituted-2-sulfonyl-5-nitroimidazoles | |
US3255201A (en) * | 1965-04-09 | 1966-06-07 | Hoffmann La Roche | 2-nitroimidazoles |
US3505349A (en) * | 1966-04-18 | 1970-04-07 | Hoffmann La Roche | 2-nitro-imidazolyl-1-acetamides |
CH513879A (de) * | 1966-06-10 | 1971-10-15 | Hoffmann La Roche | Verfahren zur Herstellung von Imidazolderivaten |
US3646057A (en) * | 1969-04-06 | 1972-02-29 | Hoffmann La Roche | 2-nitroimidazoles |
FR2260996A1 (en) * | 1974-02-15 | 1975-09-12 | Hoffmann La Roche | (2-Nitro-1-imidazolyl)-carbamates - useful as germicides and antiproto-zoal agents |
DE2410749A1 (de) * | 1974-03-06 | 1975-09-11 | Hoffmann La Roche | 2-nitroimidazole |
US4038410A (en) * | 1974-03-14 | 1977-07-26 | Schering Aktiengesellschaft | Nitroimidazole derivatives and process for the preparation thereof |
-
1978
- 1978-07-20 IE IE1453/78A patent/IE47132B1/en not_active IP Right Cessation
- 1978-08-03 US US05/930,622 patent/US4241060A/en not_active Expired - Lifetime
- 1978-08-14 NZ NZ188140A patent/NZ188140A/xx unknown
- 1978-08-14 IL IL55351A patent/IL55351A/xx unknown
- 1978-08-15 AU AU38915/78A patent/AU516443B2/en not_active Expired
- 1978-08-15 YU YU1953/78A patent/YU41317B/xx unknown
- 1978-08-16 PH PH21502A patent/PH16364A/en unknown
- 1978-08-16 IT IT26792/78A patent/IT1098042B/it active
- 1978-08-16 MC MC781318A patent/MC1210A1/xx unknown
- 1978-08-17 DE DE19782836073 patent/DE2836073A1/de not_active Withdrawn
- 1978-08-17 CA CA309,523A patent/CA1104133A/en not_active Expired
- 1978-08-17 DE DE7878100690T patent/DE2860546D1/de not_active Expired
- 1978-08-17 JP JP9958278A patent/JPS5444671A/ja active Granted
- 1978-08-17 GR GR57019A patent/GR73055B/el unknown
- 1978-08-17 EP EP78100690A patent/EP0000928B1/de not_active Expired
- 1978-08-18 FI FI782530A patent/FI70576C/fi not_active IP Right Cessation
- 1978-08-18 AR AR273353A patent/AR218325A1/es active
- 1978-08-18 ES ES472661A patent/ES472661A1/es not_active Expired
- 1978-08-18 AT AT0601078A patent/AT364829B/de not_active IP Right Cessation
- 1978-08-18 GB GB7833921A patent/GB2003154A/en not_active Withdrawn
- 1978-08-18 NO NO782813A patent/NO151240C/no unknown
- 1978-08-18 SE SE7808773A patent/SE7808773L/xx unknown
- 1978-08-18 DK DK366678A patent/DK155367C/da not_active IP Right Cessation
- 1978-08-18 NL NL7808597A patent/NL7808597A/xx not_active Application Discontinuation
- 1978-08-18 FR FR7824132A patent/FR2400512A1/fr active Granted
- 1978-08-18 HU HU78HO2096A patent/HU179983B/hu not_active IP Right Cessation
- 1978-08-18 PT PT68441A patent/PT68441A/pt unknown
-
1979
- 1979-02-24 ES ES478052A patent/ES478052A1/es not_active Expired
- 1979-02-24 ES ES478051A patent/ES478051A1/es not_active Expired
- 1979-07-26 AR AR277480A patent/AR218553A1/es active
- 1979-07-26 AR AR277479A patent/AR220216A1/es active
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