EP0000928B1 - Neue Nitroimidazole und diese enthaltende pharmazeutische Präparate sowie deren Herstellung - Google Patents
Neue Nitroimidazole und diese enthaltende pharmazeutische Präparate sowie deren Herstellung Download PDFInfo
- Publication number
- EP0000928B1 EP0000928B1 EP78100690A EP78100690A EP0000928B1 EP 0000928 B1 EP0000928 B1 EP 0000928B1 EP 78100690 A EP78100690 A EP 78100690A EP 78100690 A EP78100690 A EP 78100690A EP 0000928 B1 EP0000928 B1 EP 0000928B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- nitro
- ethanol
- methyl
- aryl
- imidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 0 CCC1C(C)CC*1 Chemical compound CCC1C(C)CC*1 0.000 description 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to new nitroimidazoles, a process for their preparation and pharmaceutical preparations containing these compounds.
- lower alkyl means a straight or branched chain alkyl group preferably having 1 to 6 carbon atoms, such as methyl, ethyl, propyl, isopropyl, butyl, tert-butyl, pentyl and hexyl.
- hydroxy lower alkyl groups are hydroxymethyl, 2-hydroxyethyl, 2-hydroxypropyl, 3-hydroxypropyl and 2-hydroxybutyl.
- lower cycloalkyl means cycloalkyl groups, preferably having up to 6 carbon atoms, such as cyclopropyl, cyclopentyl and cyclohexyl.
- aryl means the phenyl group or the mono- or polysubstituted, preferably mono- or polysubstituted phenyl group, where the substituents can be halogens (ie fluorine, chlorine, bromine or iodine) trifluoromethyl, lower alkyl, lower alkoxy, nitro and amino.
- aryl-lower alkyl denotes a lower alkyl radical substituted by an aryl group.
- aryl-lower alkyl groups are benzyl, 4-chlorobenzyl, phenethyl and phenylpropyl.
- saturated heteromonocyclic rings which are formed from the substituents R 1 and R 2 together with the nitrogen atom and which can carry a hydroxyl group on a C atom which is not directly adjacent to the nitrogen atom are pyrrolidino, piperidino, 3-hydroxypyrrolidino, 4-hydroxy-piperidino and 3-hydroxy-hexahydro-1 H-azepino.
- saturated heteromonocyclic rings which are formed from the substituents R I and R 2 together with the nitrogen atom to which they are attached and which may contain a further oxygen, sulfur or nitrogen atom which may optionally be substituted as indicated above , are piperazino, N-methylpiperazino, N- (2-hydroxyethyl) piperazino, morpholino and thiamorpholino.
- lower alkoxy means a straight or branched chain alkoxy group with preferably 1-6 carbon atoms, such as methoxy or ethoxy.
- nitroimidazoles of the present invention are compounds of the formula I in which R I is hydrogen, lower alkyl, hydroxy-lower alkyl, aryl or aryl-lower alkyl, R 2 is lower alkyl, hydroxy-lower alkyl, aryl or aryl-lower alkyl or R 1 and R 2 together with the nitrogen atom to which they are attached represent a 5-, 6- or 7-membered saturated heteromonocyclic ring which may contain another oxygen, sulfur or nitrogen atom which may be replaced by a lower alkyl, hydroxy-lower alkyl , Aryl or aryl-lower alkyl group can be substituted, as well as their acid addition salts.
- a particularly interesting group of nitroimidazole derivatives of the present invention are those compounds of the formula in which R 1 and R 2 together with the nitrogen atom to which they are attached represent a 6-membered heteromonocyclic ring which may contain a further oxygen or nitrogen atom, which is optionally substituted by a lower alkyl group, and their acid addition salts.
- the reaction of an epoxide of formula II with an amine of formula III according to process variant (a) can be carried out in the presence or absence of an inert organic solvent.
- Suitable inert organic solvents are lower alkanols (e.g. methanol and ethanol), dimethylformamide or dimethylacetamide.
- an excess of an amine of formula III can be used as a solvent.
- Pressure and temperature during the reaction are not critical; the reaction can be carried out at room temperature and under atmospheric pressure or else at elevated temperature and / or elevated pressure. In a preferred embodiment, the reaction is carried out at a temperature of about 50 ° C. to the reflux temperature of the reaction mixture and under normal pressure.
- the condensation of a compound of formula IV (azomycin) with an epoxide of formula V according to process variant (b) is carried out in the presence of a base.
- Catalytic amounts of the base are preferably used, although larger amounts can also be used.
- Preferred bases are alkali metal carbonates (e.g. sodium carbonate or potassium carbonate), although other bases such as alkali metal hydroxides (e.g. sodium hydroxide or potassium hydroxide) can also be used.
- the condensation is conveniently carried out in the presence of an inert organic solvent, e.g. B. a lower alkanol (z. B. methanol or ethanol) performed.
- the condensation can also be carried out at room temperature and under higher pressure, it is preferably carried out at elevated temperature, in particular at the reflux temperature of the reaction mixture, and under atmospheric pressure.
- a halohydrin of the formula VI When a halohydrin of the formula VI is reacted with an amine of the formula 111 according to process variant (c), at least one mole of amine is advantageously used per mole of halohydrin.
- the reaction is conveniently carried out in the presence of an acid-binding agent such as an alkali metal carbonate (e.g. sodium carbonate or potassium carbonate) or a tertiary organic amine (e.g. pyridine) or, preferably, in the presence of excess amine of the formula III.
- an acid-binding agent such as an alkali metal carbonate (e.g. sodium carbonate or potassium carbonate) or a tertiary organic amine (e.g. pyridine) or, preferably, in the presence of excess amine of the formula III.
- an acid-binding agent such as an alkali metal carbonate (e.g. sodium carbonate or potassium carbonate) or a tertiary organic amine (e.g
- the reaction expediently takes place in the presence of an inert organic solvent, for example a lower alkanol (for example methanol or ethanol).
- an inert organic solvent for example a lower alkanol (for example methanol or ethanol).
- the temperature and pressure during the reaction are not critical. It can be carried out at room temperature and under normal pressure or at elevated temperature and under pressure. In a preferred embodiment, the reaction is carried out at elevated temperature, in particular at the reflux temperature of the reaction mixture, and under normal pressure. Chlorohydrin is used as the preferred halohydrin of the formula VI.
- the compounds of formula I can be converted into acid addition salts, e.g. B. by reaction with an inorganic acid such as a hydrohalic acid (e.g. HCl or HBr), sulfuric acid, nitric acid or phosphoric acid or with an organic acid such as acetic acid, citric acid, maleic acid, malic acid, fumaric acid, succinic acid, methanesulfonic acid or paratoluenesulfonic acid.
- Physiologically acceptable acid addition salts especially the hydrochlorides, are preferred.
- Physiologically unacceptable acid addition salts can be converted into physiologically acceptable acid addition salts by treatment with a base and subsequent reaction with be converted to a physiologically acceptable acid.
- the starting compounds of the formulas II to VI are known compounds.
- the compounds of the formula and their physiologically tolerated acid addition salts can be used as so-called "radiosensitizers" for sensitizing hypoxic cells to radiation, in particular in connection with the treatment of hypoxic tumor cells by radiation.
- radiosensitizers for sensitizing hypoxic cells to radiation, in particular in connection with the treatment of hypoxic tumor cells by radiation.
- the effectiveness of the compounds of the formula and their physiologically tolerable acid addition salts as radiosensitizers for hypoxic cells can be demonstrated in an in vitro experiment on hypoxic Chinese hamster V 79 cells (cf.
- the compounds of the formula and their physiologically acceptable acid addition salts can also be used to control infections caused by protozoa, in particular infections caused by Trichomonas vaginalis.
- the compounds of the invention can be used as pharmaceutical preparations with direct or delayed release of the active ingredient in a mixture with one for enteral, e.g. B. oral or parenteral application of suitable organic or inorganic inert carrier material, such as.
- suitable organic or inorganic inert carrier material such as.
- water gelatin, gum arabic, milk sugar, starch, magnesium stearate, talc, vegetable oils, polyalkylene glycols or petroleum jelly
- the preparations can be in solid form, e.g. B. as tablets, dragees, suppositories, capsules; in semi-solid form, e.g. B. as ointments; or in liquid form, e.g. B. present as solutions, suspensions or emulsions.
- the preparations can also contain other therapeutically valuable compounds.
- the pharmaceutical preparations can be prepared in the manner familiar to any person skilled in the art by mixing one of the compounds according to the invention as an active ingredient with an inert, solid or liquid carrier suitable for therapeutic administration, and if necessary bringing the mixture into a special galenical form.
- the compounds according to the invention can be administered orally at a dosage of about 20 to 60 mg per kg of body weight and day. In general, however, the total dose administered during a treatment should not exceed about 200 mg per kg body weight and day.
- the compounds according to the invention can also be administered orally at a daily dosage of about 20 to 60 mg per kg of body weight.
- the pharmaceutical preparation described above can be produced in a manner known per se, if possible with the exclusion of light, and should be kept in the dark.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3490877 | 1977-08-19 | ||
GB3490877 | 1977-08-19 | ||
GB1953478 | 1978-05-15 | ||
GB1953478 | 1978-05-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0000928A1 EP0000928A1 (de) | 1979-03-07 |
EP0000928B1 true EP0000928B1 (de) | 1981-03-18 |
Family
ID=26254111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP78100690A Expired EP0000928B1 (de) | 1977-08-19 | 1978-08-17 | Neue Nitroimidazole und diese enthaltende pharmazeutische Präparate sowie deren Herstellung |
Country Status (26)
Country | Link |
---|---|
US (1) | US4241060A (no) |
EP (1) | EP0000928B1 (no) |
JP (1) | JPS5444671A (no) |
AR (3) | AR218325A1 (no) |
AT (1) | AT364829B (no) |
AU (1) | AU516443B2 (no) |
CA (1) | CA1104133A (no) |
DE (2) | DE2860546D1 (no) |
DK (1) | DK155367C (no) |
ES (3) | ES472661A1 (no) |
FI (1) | FI70576C (no) |
FR (1) | FR2400512A1 (no) |
GB (1) | GB2003154A (no) |
GR (1) | GR73055B (no) |
HU (1) | HU179983B (no) |
IE (1) | IE47132B1 (no) |
IL (1) | IL55351A (no) |
IT (1) | IT1098042B (no) |
MC (1) | MC1210A1 (no) |
NL (1) | NL7808597A (no) |
NO (1) | NO151240C (no) |
NZ (1) | NZ188140A (no) |
PH (1) | PH16364A (no) |
PT (1) | PT68441A (no) |
SE (1) | SE7808773L (no) |
YU (1) | YU41317B (no) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2948884A1 (de) * | 1979-12-05 | 1981-06-11 | Basf Ag, 6700 Ludwigshafen | 2-hydroxypropylimidazole, verfahren zu ihrer herstellung und verwendung als oelloesliche korrosionsinhibitoren |
ZW8781A1 (en) * | 1980-05-23 | 1981-12-16 | Hoffmann La Roche | 2-nitroimidazoles and preparation thereof |
US4494547A (en) * | 1981-03-30 | 1985-01-22 | North Carolina Central University | 2H-isoindolediones, their synthesis and use as radiosensitizers |
US4605744A (en) * | 1982-03-18 | 1986-08-12 | Hoffmann-La Roche Inc. | Imidazole derivatives |
US4537969A (en) * | 1982-03-18 | 1985-08-27 | Hoffmann-La Roche Inc. | Imidazole derivatives |
CA1227211A (en) * | 1982-05-27 | 1987-09-22 | Israr Ahmed | Nitro imidazolyl aziridino propanols |
EP0095906B1 (en) * | 1982-05-27 | 1986-10-22 | National Research Development Corporation | Improvements relating to compounds useful in radiotherapy or chemotherapy |
US4742050B1 (en) * | 1982-08-17 | 1994-06-28 | Alpha Therapeutic Corp | Sensitization of hypoxic tumor cells and control of growth thereof |
NL8320264A (nl) * | 1982-08-17 | 1984-07-02 | Sun Tech Inc | Perfluorkoolstof-emulsies, hun bereiding en hun toepassing in de therapie. |
US4889525A (en) * | 1982-08-17 | 1989-12-26 | Adamantech, Inc. | Sensitization of hypoxic tumor cells and control of growth thereof |
CA1329206C (en) * | 1987-06-10 | 1994-05-03 | Tsutomu Kagiya | Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same |
US5304654A (en) * | 1987-06-10 | 1994-04-19 | Yasunori Nishijima | Fluorine-containing nitroimidazole compounds |
JP2848602B2 (ja) * | 1987-06-24 | 1999-01-20 | 京都大学長 | 新規含フッ素2−ニトロイミダゾールおよびそれを含む放射線増感剤 |
US4797397A (en) * | 1987-07-31 | 1989-01-10 | Warner-Lambert Company | 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells |
GB8728418D0 (en) * | 1987-12-04 | 1988-01-13 | Jenkins T C | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
ES2080726T3 (es) * | 1987-12-04 | 1996-02-16 | British Tech Group | Compuestos aromaticos o heteroaromaticos nitrosustituidos para su utilizacion en el tratamiento del cancer. |
US5086068A (en) * | 1988-02-26 | 1992-02-04 | Alberta Cancer Board | Immunochemical detection of hypoxia in normal and tumor tissue |
US5194624A (en) * | 1988-05-23 | 1993-03-16 | Fujisawa Pharmaceutical Co., Ltd. | Intermediates for the preparation of compounds of antimicrobial activity |
US5073639A (en) * | 1988-11-25 | 1991-12-17 | Warner-Lambert Company | Process for the synthesis of novel and known nitroimidazoles which are useful as sensitizing agents |
JPH02146288A (ja) * | 1988-11-25 | 1990-06-05 | Ebara Corp | 内部圧縮を持つ容積型圧縮機 |
US5036096A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives |
US4954515A (en) * | 1988-11-25 | 1990-09-04 | Warner-Lambert Company | Haloalkylaminomethyl-2-nitro-1H-imidazoles |
US5036089A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | 2-oxazolidinone derivatives of nitroimidazoles and pharmaceutical compositions useful as sensitizing agents |
JP2799368B2 (ja) * | 1990-01-10 | 1998-09-17 | ポーラ化成工業株式会社 | 抗原虫剤 |
GB9127304D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
MX9304399A (es) * | 1992-07-31 | 1994-02-28 | Warner Lambert Co | Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados. |
US6252087B1 (en) | 1992-11-19 | 2001-06-26 | The Trustees Of The University Of Pennsylvania | Nitroaromatic compounds for the detection of hypoxia |
US6855828B1 (en) | 1992-11-19 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Detection of hypoxia |
DE69332741T2 (de) * | 1992-11-19 | 2003-10-02 | Univ Pennsylvania | Nachweis von hypoxia |
US5741800A (en) * | 1993-06-22 | 1998-04-21 | Knoll Aktiengesellachaft | Azolyl-cyclic amine derivates with immunomodulatory activity |
GB9312893D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
US5674693A (en) * | 1994-03-18 | 1997-10-07 | Natural Pharmacia International Inc. | Derivatives of 2-nitro-imidazoles as hypoxic cell markers |
US5972984A (en) * | 1995-06-06 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US20050026974A1 (en) * | 1996-02-08 | 2005-02-03 | Trustees Of The University Of Pennsylvania | Detection of hypoxia |
US6331286B1 (en) | 1998-12-21 | 2001-12-18 | Photogen, Inc. | Methods for high energy phototherapeutics |
US8974363B2 (en) | 1997-12-11 | 2015-03-10 | Provectus Pharmatech, Inc. | Topical medicaments and methods for photodynamic treatment of disease |
US8557298B2 (en) | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
US20020001567A1 (en) * | 1998-12-21 | 2002-01-03 | Photogen, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
US7384623B1 (en) | 1998-12-21 | 2008-06-10 | Provectus Pharmatech, Inc. | High energy phototherapeutic agents |
US8470296B2 (en) * | 1998-12-21 | 2013-06-25 | Provectus Pharmatech, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
EP1838305A1 (en) * | 2005-01-21 | 2007-10-03 | Richard H. Matthews | Radiosensitizer formulations comprising nitrohistidine derivatives |
US9056136B2 (en) * | 2006-10-06 | 2015-06-16 | Natural Pharmacia International, Inc. | Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia |
US7842278B2 (en) * | 2006-10-27 | 2010-11-30 | Natural Pharmacia International, Inc. | Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof |
MD4150C1 (ro) * | 2011-10-11 | 2012-09-30 | Институт Химии Академии Наук Молдовы | Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective |
MD4178C1 (ro) * | 2012-02-27 | 2013-02-28 | Институт Химии Академии Наук Молдовы | Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului |
US20160145139A1 (en) * | 2013-07-16 | 2016-05-26 | Corning Incorporated | System and method for bending thin glass |
CN108203411A (zh) * | 2016-12-19 | 2018-06-26 | 曾舟华 | 一种高压合成甲硝唑的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA746007A (en) * | 1966-11-08 | W. Henry David | 1-substituted-2-sulfonyl-5-nitroimidazoles | |
US3255201A (en) * | 1965-04-09 | 1966-06-07 | Hoffmann La Roche | 2-nitroimidazoles |
US3505349A (en) * | 1966-04-18 | 1970-04-07 | Hoffmann La Roche | 2-nitro-imidazolyl-1-acetamides |
CH512492A (de) * | 1966-06-10 | 1971-09-15 | Hoffmann La Roche | Verfahren zur Herstellung von Imidazolderivaten |
US3646057A (en) * | 1969-04-06 | 1972-02-29 | Hoffmann La Roche | 2-nitroimidazoles |
FR2260996A1 (en) * | 1974-02-15 | 1975-09-12 | Hoffmann La Roche | (2-Nitro-1-imidazolyl)-carbamates - useful as germicides and antiproto-zoal agents |
DE2410749A1 (de) * | 1974-03-06 | 1975-09-11 | Hoffmann La Roche | 2-nitroimidazole |
US4038410A (en) * | 1974-03-14 | 1977-07-26 | Schering Aktiengesellschaft | Nitroimidazole derivatives and process for the preparation thereof |
-
1978
- 1978-07-20 IE IE1453/78A patent/IE47132B1/en not_active IP Right Cessation
- 1978-08-03 US US05/930,622 patent/US4241060A/en not_active Expired - Lifetime
- 1978-08-14 IL IL55351A patent/IL55351A/xx unknown
- 1978-08-14 NZ NZ188140A patent/NZ188140A/xx unknown
- 1978-08-15 YU YU1953/78A patent/YU41317B/xx unknown
- 1978-08-15 AU AU38915/78A patent/AU516443B2/en not_active Expired
- 1978-08-16 MC MC781318A patent/MC1210A1/xx unknown
- 1978-08-16 IT IT26792/78A patent/IT1098042B/it active
- 1978-08-16 PH PH21502A patent/PH16364A/en unknown
- 1978-08-17 DE DE7878100690T patent/DE2860546D1/de not_active Expired
- 1978-08-17 GR GR57019A patent/GR73055B/el unknown
- 1978-08-17 JP JP9958278A patent/JPS5444671A/ja active Granted
- 1978-08-17 DE DE19782836073 patent/DE2836073A1/de not_active Withdrawn
- 1978-08-17 CA CA309,523A patent/CA1104133A/en not_active Expired
- 1978-08-17 EP EP78100690A patent/EP0000928B1/de not_active Expired
- 1978-08-18 HU HU78HO2096A patent/HU179983B/hu not_active IP Right Cessation
- 1978-08-18 ES ES472661A patent/ES472661A1/es not_active Expired
- 1978-08-18 DK DK366678A patent/DK155367C/da not_active IP Right Cessation
- 1978-08-18 NO NO782813A patent/NO151240C/no unknown
- 1978-08-18 GB GB7833921A patent/GB2003154A/en not_active Withdrawn
- 1978-08-18 AT AT0601078A patent/AT364829B/de not_active IP Right Cessation
- 1978-08-18 PT PT68441A patent/PT68441A/pt unknown
- 1978-08-18 FR FR7824132A patent/FR2400512A1/fr active Granted
- 1978-08-18 SE SE7808773A patent/SE7808773L/xx unknown
- 1978-08-18 AR AR273353A patent/AR218325A1/es active
- 1978-08-18 FI FI782530A patent/FI70576C/fi not_active IP Right Cessation
- 1978-08-18 NL NL7808597A patent/NL7808597A/xx not_active Application Discontinuation
-
1979
- 1979-02-24 ES ES478052A patent/ES478052A1/es not_active Expired
- 1979-02-24 ES ES478051A patent/ES478051A1/es not_active Expired
- 1979-07-26 AR AR277480A patent/AR218553A1/es active
- 1979-07-26 AR AR277479A patent/AR220216A1/es active
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