MD4150C1 - Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective - Google Patents
Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respectiveInfo
- Publication number
- MD4150C1 MD4150C1 MDA20110087A MD20110087A MD4150C1 MD 4150 C1 MD4150 C1 MD 4150C1 MD A20110087 A MDA20110087 A MD A20110087A MD 20110087 A MD20110087 A MD 20110087A MD 4150 C1 MD4150 C1 MD 4150C1
- Authority
- MD
- Moldova
- Prior art keywords
- diphenylimidazole
- nitrates
- nitro
- compounds
- producing
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- CPHGOBGXZQKCKI-UHFFFAOYSA-N 4,5-diphenyl-1h-imidazole Chemical compound N1C=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 CPHGOBGXZQKCKI-UHFFFAOYSA-N 0.000 title abstract 3
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 title abstract 3
- XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical compound [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 title abstract 3
- STGHAEAHYGLKLG-UHFFFAOYSA-N 2-nitro-4,5-diphenyl-1h-imidazole Chemical compound N1C([N+](=O)[O-])=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 STGHAEAHYGLKLG-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002184 metal Substances 0.000 title abstract 2
- 229910052751 metal Inorganic materials 0.000 title abstract 2
- 150000002739 metals Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000002823 nitrates Chemical class 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 150000002500 ions Chemical class 0.000 abstract 3
- 230000009920 chelation Effects 0.000 abstract 2
- 238000006396 nitration reaction Methods 0.000 abstract 2
- YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical compound [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 229910001960 metal nitrate Inorganic materials 0.000 abstract 1
- 230000000802 nitrating effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000004957 nitroimidazoles Chemical class 0.000 abstract 1
- 239000013110 organic ligand Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Catalysts (AREA)
Abstract
Invenţia se referă la chimia compuşilor coordinativi cu liganzi organici din clasa nitroimidazolilor, care pot fi utilizaţi în calitate de compuşi biologic activi, catalizatori etc.Esenţa invenţiei constă în aceea că se propune un procedeu de obţinere a compuşilor coordinativi ai unor biometale, aşa ca Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol la interacţiunea 4,5-difenilimidazolului cu nitraţii de Co(II), Ni(II) şi Zn(II), în metanol pur sau cu un conţinut mic de apă. În condiţii solvotermale (170°C, 3 ore) nucleul heterociclic al 4,5-difenilimidazolului este nitrat în poziţia C2, iar ionii metalelor iniţiale se leagă cu produsul nitrării prin chelatare, cu implicarea grupei nitro şi a unui atom de azot din nucleul heterociclic. Totodată solventul (metanolul) completează sfera de coordinare a ionului central.Rezultatul invenţiei constă în aceea că în condiţiile solvotermale se produce concomitent nitrarea nucleului heterociclic şi coordinarea produsului reacţiei, totodată nitraţii metalelor servesc ca agenţi de nitrare neacizi şi ca sursă de ioni centrali pentru chelatarea cu nitroimidazolul rezultant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20110087A MD4150C1 (ro) | 2011-10-11 | 2011-10-11 | Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20110087A MD4150C1 (ro) | 2011-10-11 | 2011-10-11 | Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4150B1 MD4150B1 (ro) | 2012-02-29 |
| MD4150C1 true MD4150C1 (ro) | 2012-09-30 |
Family
ID=45815372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20110087A MD4150C1 (ro) | 2011-10-11 | 2011-10-11 | Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4150C1 (ro) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4178C1 (ro) * | 2012-02-27 | 2013-02-28 | Институт Химии Академии Наук Молдовы | Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului |
Citations (9)
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| US4241060A (en) * | 1977-08-19 | 1980-12-23 | Hoffmann-La Roche Inc. | Nitroimidazoles and compositions thereof |
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| EP0510036A1 (en) * | 1990-01-12 | 1992-10-28 | Rhone Poulenc Rorer Sa | 2-SUBSTITUTED 4,5-DIPHENYLIMIDAZOLES. |
| WO1994019310A1 (en) * | 1993-02-26 | 1994-09-01 | Instituto Nacional De Engenharia E Tecnologia Industrial | New process for the nitration of aromatic compounds in mild, non-corrosive conditions |
| RU2021249C1 (ru) * | 1990-10-16 | 1994-10-15 | Индивидуально-частное предприятие "Ост-Вест" | Способ получения ароматических 1,2-дикетонов |
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| US20100004460A1 (en) * | 2007-01-23 | 2010-01-07 | Pola Pharma Inc | Method for producing 2-nitroimidazole derivative |
-
2011
- 2011-10-11 MD MDA20110087A patent/MD4150C1/ro not_active IP Right Cessation
Patent Citations (10)
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|---|---|---|---|---|
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| US4199592A (en) * | 1978-08-29 | 1980-04-22 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-nitroimidazoles |
| US5008398A (en) * | 1988-10-15 | 1991-04-16 | Basf Aktiengesellschaft | Preparation of p-nitrophenyl-imidazoles |
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| RU2021249C1 (ru) * | 1990-10-16 | 1994-10-15 | Индивидуально-частное предприятие "Ост-Вест" | Способ получения ароматических 1,2-дикетонов |
| WO1994019310A1 (en) * | 1993-02-26 | 1994-09-01 | Instituto Nacional De Engenharia E Tecnologia Industrial | New process for the nitration of aromatic compounds in mild, non-corrosive conditions |
| CN1736976A (zh) * | 2005-08-30 | 2006-02-22 | 南京大学 | 硝酸铝在芳环硝化中的应用 |
| WO2008070336A2 (en) * | 2006-10-27 | 2008-06-12 | Natural Pharmacia International, Inc. | Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof |
| US7842278B2 (en) * | 2006-10-27 | 2010-11-30 | Natural Pharmacia International, Inc. | Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof |
| US20100004460A1 (en) * | 2007-01-23 | 2010-01-07 | Pola Pharma Inc | Method for producing 2-nitroimidazole derivative |
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| Эйхгорн Г. Неорганическая химия, Мир, Москва, 1978, том 1, том 2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD4150B1 (ro) | 2012-02-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |