MD4178C1 - Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului - Google Patents

Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului

Info

Publication number
MD4178C1
MD4178C1 MDA20120023A MD20120023A MD4178C1 MD 4178 C1 MD4178 C1 MD 4178C1 MD A20120023 A MDA20120023 A MD A20120023A MD 20120023 A MD20120023 A MD 20120023A MD 4178 C1 MD4178 C1 MD 4178C1
Authority
MD
Moldova
Prior art keywords
diphenylimidazole
nitro
producing
compounds
coordinative
Prior art date
Application number
MDA20120023A
Other languages
English (en)
Russian (ru)
Other versions
MD4178B1 (ro
Inventor
Константин ИНДРИЧАН
Ирина ВОДЭ
Вадим ДРУЦЭ
Константин ТУРТЭ
Original Assignee
Институт Химии Академии Наук Молдовы
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт Химии Академии Наук Молдовы filed Critical Институт Химии Академии Наук Молдовы
Priority to MDA20120023A priority Critical patent/MD4178C1/ro
Publication of MD4178B1 publication Critical patent/MD4178B1/ro
Publication of MD4178C1 publication Critical patent/MD4178C1/ro

Links

Abstract

Invenţia se referă la domeniul chimiei, în particular la derivaţii 2-nitro-4,5-diarilimidazolului, care pot fi utilizaţi în calitate de compuşi biologic activi, catalizatori etc.Esenţa invenţiei constă în aceea că se propune un procedeu de obţinere a 2-nitro-4,5-difenilimidazolului prin reacţia de demetalare cu un acid mineral la pH≤2 în mediu apos a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol. După neutralizarea amestecului rezultat compusul-ţintă se extrage cu un solvent imiscibil cu apa şi se izolează din extract.Compuşii coordinativi iniţiali se pot obţine la interacţiunea 4,5-difenilimidazolului cu nitratul metalului respectiv în condiţii solvotermale cu nitrarea in situ a heterociclului.
MDA20120023A 2012-02-27 2012-02-27 Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului MD4178C1 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20120023A MD4178C1 (ro) 2012-02-27 2012-02-27 Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20120023A MD4178C1 (ro) 2012-02-27 2012-02-27 Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului

Publications (2)

Publication Number Publication Date
MD4178B1 MD4178B1 (ro) 2012-07-31
MD4178C1 true MD4178C1 (ro) 2013-02-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20120023A MD4178C1 (ro) 2012-02-27 2012-02-27 Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului

Country Status (1)

Country Link
MD (1) MD4178C1 (ro)

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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CN1736976A (zh) * 2005-08-30 2006-02-22 南京大学 硝酸铝在芳环硝化中的应用
WO2008070336A2 (en) * 2006-10-27 2008-06-12 Natural Pharmacia International, Inc. Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
US20100004460A1 (en) * 2007-01-23 2010-01-07 Pola Pharma Inc Method for producing 2-nitroimidazole derivative
MD4150B1 (ro) * 2011-10-11 2012-02-29 Inst De Chimie Al Academiei De Stiinte A Moldovei Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB700211A (en) * 1950-07-21 1953-11-25 Ciba Ltd Manufacture of azo dyestuffs
US4241060A (en) * 1977-08-19 1980-12-23 Hoffmann-La Roche Inc. Nitroimidazoles and compositions thereof
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles
US5008398A (en) * 1988-10-15 1991-04-16 Basf Aktiengesellschaft Preparation of p-nitrophenyl-imidazoles
EP0510036A1 (en) * 1990-01-12 1992-10-28 Rhone Poulenc Rorer Sa 2-SUBSTITUTED 4,5-DIPHENYLIMIDAZOLES.
RU2021249C1 (ru) * 1990-10-16 1994-10-15 Индивидуально-частное предприятие "Ост-Вест" Способ получения ароматических 1,2-дикетонов
WO1994019310A1 (en) * 1993-02-26 1994-09-01 Instituto Nacional De Engenharia E Tecnologia Industrial New process for the nitration of aromatic compounds in mild, non-corrosive conditions
CN1736976A (zh) * 2005-08-30 2006-02-22 南京大学 硝酸铝在芳环硝化中的应用
WO2008070336A2 (en) * 2006-10-27 2008-06-12 Natural Pharmacia International, Inc. Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
US7842278B2 (en) * 2006-10-27 2010-11-30 Natural Pharmacia International, Inc. Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
US20100004460A1 (en) * 2007-01-23 2010-01-07 Pola Pharma Inc Method for producing 2-nitroimidazole derivative
MD4150B1 (ro) * 2011-10-11 2012-02-29 Inst De Chimie Al Academiei De Stiinte A Moldovei Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective

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Title
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Publication number Publication date
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FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees