MC1210A1 - Nouveaux nitroimidazoles et procede pour leur preparation - Google Patents
Nouveaux nitroimidazoles et procede pour leur preparationInfo
- Publication number
- MC1210A1 MC1210A1 MC781318A MC1318A MC1210A1 MC 1210 A1 MC1210 A1 MC 1210A1 MC 781318 A MC781318 A MC 781318A MC 1318 A MC1318 A MC 1318A MC 1210 A1 MC1210 A1 MC 1210A1
- Authority
- MC
- Monaco
- Prior art keywords
- nitroimidazoles
- preparation
- new
- new nitroimidazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3490877 | 1977-08-19 | ||
GB1953478 | 1978-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
MC1210A1 true MC1210A1 (fr) | 1979-05-18 |
Family
ID=26254111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MC781318A MC1210A1 (fr) | 1977-08-19 | 1978-08-16 | Nouveaux nitroimidazoles et procede pour leur preparation |
Country Status (26)
Country | Link |
---|---|
US (1) | US4241060A (fr) |
EP (1) | EP0000928B1 (fr) |
JP (1) | JPS5444671A (fr) |
AR (3) | AR218325A1 (fr) |
AT (1) | AT364829B (fr) |
AU (1) | AU516443B2 (fr) |
CA (1) | CA1104133A (fr) |
DE (2) | DE2860546D1 (fr) |
DK (1) | DK155367C (fr) |
ES (3) | ES472661A1 (fr) |
FI (1) | FI70576C (fr) |
FR (1) | FR2400512A1 (fr) |
GB (1) | GB2003154A (fr) |
GR (1) | GR73055B (fr) |
HU (1) | HU179983B (fr) |
IE (1) | IE47132B1 (fr) |
IL (1) | IL55351A (fr) |
IT (1) | IT1098042B (fr) |
MC (1) | MC1210A1 (fr) |
NL (1) | NL7808597A (fr) |
NO (1) | NO151240C (fr) |
NZ (1) | NZ188140A (fr) |
PH (1) | PH16364A (fr) |
PT (1) | PT68441A (fr) |
SE (1) | SE7808773L (fr) |
YU (1) | YU41317B (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2948884A1 (de) * | 1979-12-05 | 1981-06-11 | Basf Ag, 6700 Ludwigshafen | 2-hydroxypropylimidazole, verfahren zu ihrer herstellung und verwendung als oelloesliche korrosionsinhibitoren |
ZW8781A1 (en) * | 1980-05-23 | 1981-12-16 | Hoffmann La Roche | 2-nitroimidazoles and preparation thereof |
US4494547A (en) * | 1981-03-30 | 1985-01-22 | North Carolina Central University | 2H-isoindolediones, their synthesis and use as radiosensitizers |
US4537969A (en) * | 1982-03-18 | 1985-08-27 | Hoffmann-La Roche Inc. | Imidazole derivatives |
US4605744A (en) * | 1982-03-18 | 1986-08-12 | Hoffmann-La Roche Inc. | Imidazole derivatives |
CA1227211A (fr) * | 1982-05-27 | 1987-09-22 | Israr Ahmed | Nitro-imidazolylaziridinopropanols |
GB2123816B (en) * | 1982-05-27 | 1986-03-19 | Nat Res Dev | Nitrolmidazole derivatives |
US4889525A (en) * | 1982-08-17 | 1989-12-26 | Adamantech, Inc. | Sensitization of hypoxic tumor cells and control of growth thereof |
US4742050B1 (en) * | 1982-08-17 | 1994-06-28 | Alpha Therapeutic Corp | Sensitization of hypoxic tumor cells and control of growth thereof |
WO1984000686A1 (fr) * | 1982-08-17 | 1984-03-01 | Sun Tech Inc | Emulsions de perfluorocarbone, leur preparation et leur utilisation en therapie |
JP2848602B2 (ja) * | 1987-06-24 | 1999-01-20 | 京都大学長 | 新規含フッ素2−ニトロイミダゾールおよびそれを含む放射線増感剤 |
CA1329206C (fr) * | 1987-06-10 | 1994-05-03 | Tsutomu Kagiya | Derives nitroazole fluores et radiosensibilisant en contenant |
US5304654A (en) * | 1987-06-10 | 1994-04-19 | Yasunori Nishijima | Fluorine-containing nitroimidazole compounds |
US4797397A (en) * | 1987-07-31 | 1989-01-10 | Warner-Lambert Company | 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells |
AU625314B2 (en) * | 1987-12-04 | 1992-07-09 | British Technology Group Limited | Nitro-substituted aromatic or hetero-aromatic compounds for use in cancer treatment |
GB8728418D0 (en) * | 1987-12-04 | 1988-01-13 | Jenkins T C | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
US5086068A (en) * | 1988-02-26 | 1992-02-04 | Alberta Cancer Board | Immunochemical detection of hypoxia in normal and tumor tissue |
US5194624A (en) * | 1988-05-23 | 1993-03-16 | Fujisawa Pharmaceutical Co., Ltd. | Intermediates for the preparation of compounds of antimicrobial activity |
JPH02146288A (ja) * | 1988-11-25 | 1990-06-05 | Ebara Corp | 内部圧縮を持つ容積型圧縮機 |
US5036096A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives |
US5073639A (en) * | 1988-11-25 | 1991-12-17 | Warner-Lambert Company | Process for the synthesis of novel and known nitroimidazoles which are useful as sensitizing agents |
US5036089A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | 2-oxazolidinone derivatives of nitroimidazoles and pharmaceutical compositions useful as sensitizing agents |
US4954515A (en) * | 1988-11-25 | 1990-09-04 | Warner-Lambert Company | Haloalkylaminomethyl-2-nitro-1H-imidazoles |
JP2799368B2 (ja) * | 1990-01-10 | 1998-09-17 | ポーラ化成工業株式会社 | 抗原虫剤 |
GB9127304D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
MX9304399A (es) * | 1992-07-31 | 1994-02-28 | Warner Lambert Co | Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados. |
WO1994011348A1 (fr) * | 1992-11-19 | 1994-05-26 | The Trustees Of The University Of Pennsylvania | Detection de l'hypoxie |
US6855828B1 (en) | 1992-11-19 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Detection of hypoxia |
US6252087B1 (en) | 1992-11-19 | 2001-06-26 | The Trustees Of The University Of Pennsylvania | Nitroaromatic compounds for the detection of hypoxia |
GB9312893D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
US5741800A (en) * | 1993-06-22 | 1998-04-21 | Knoll Aktiengesellachaft | Azolyl-cyclic amine derivates with immunomodulatory activity |
US5674693A (en) * | 1994-03-18 | 1997-10-07 | Natural Pharmacia International Inc. | Derivatives of 2-nitro-imidazoles as hypoxic cell markers |
US5972984A (en) * | 1995-06-06 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US20050026974A1 (en) * | 1996-02-08 | 2005-02-03 | Trustees Of The University Of Pennsylvania | Detection of hypoxia |
US6331286B1 (en) | 1998-12-21 | 2001-12-18 | Photogen, Inc. | Methods for high energy phototherapeutics |
US8974363B2 (en) | 1997-12-11 | 2015-03-10 | Provectus Pharmatech, Inc. | Topical medicaments and methods for photodynamic treatment of disease |
US8557298B2 (en) | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
US8470296B2 (en) * | 1998-12-21 | 2013-06-25 | Provectus Pharmatech, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
US7384623B1 (en) | 1998-12-21 | 2008-06-10 | Provectus Pharmatech, Inc. | High energy phototherapeutic agents |
US20020001567A1 (en) * | 1998-12-21 | 2002-01-03 | Photogen, Inc. | Intracorporeal medicaments for high energy phototherapeutic treatment of disease |
EP1838305A1 (fr) * | 2005-01-21 | 2007-10-03 | Richard H. Matthews | Formulations radiosensibilisantes comprenant des derives de nitrohistidine |
US9056136B2 (en) * | 2006-10-06 | 2015-06-16 | Natural Pharmacia International, Inc. | Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia |
US7842278B2 (en) * | 2006-10-27 | 2010-11-30 | Natural Pharmacia International, Inc. | Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof |
MD4150C1 (ro) * | 2011-10-11 | 2012-09-30 | Институт Химии Академии Наук Молдовы | Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective |
MD4178C1 (ro) * | 2012-02-27 | 2013-02-28 | Институт Химии Академии Наук Молдовы | Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului |
KR20160030537A (ko) * | 2013-07-16 | 2016-03-18 | 코닝 인코포레이티드 | 얇은 유리를 구부리기 위한 방법 및 기기 |
CN108203411A (zh) * | 2016-12-19 | 2018-06-26 | 曾舟华 | 一种高压合成甲硝唑的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA746007A (en) * | 1966-11-08 | W. Henry David | 1-substituted-2-sulfonyl-5-nitroimidazoles | |
US3255201A (en) * | 1965-04-09 | 1966-06-07 | Hoffmann La Roche | 2-nitroimidazoles |
US3505349A (en) * | 1966-04-18 | 1970-04-07 | Hoffmann La Roche | 2-nitro-imidazolyl-1-acetamides |
CH512493A (de) * | 1966-06-10 | 1971-09-15 | Hoffmann La Roche | Verfahren zur Herstellung von Imidazolderivaten |
US3646057A (en) * | 1969-04-06 | 1972-02-29 | Hoffmann La Roche | 2-nitroimidazoles |
FR2260996A1 (en) * | 1974-02-15 | 1975-09-12 | Hoffmann La Roche | (2-Nitro-1-imidazolyl)-carbamates - useful as germicides and antiproto-zoal agents |
DE2410749A1 (de) * | 1974-03-06 | 1975-09-11 | Hoffmann La Roche | 2-nitroimidazole |
US4038410A (en) * | 1974-03-14 | 1977-07-26 | Schering Aktiengesellschaft | Nitroimidazole derivatives and process for the preparation thereof |
-
1978
- 1978-07-20 IE IE1453/78A patent/IE47132B1/en not_active IP Right Cessation
- 1978-08-03 US US05/930,622 patent/US4241060A/en not_active Expired - Lifetime
- 1978-08-14 IL IL55351A patent/IL55351A/xx unknown
- 1978-08-14 NZ NZ188140A patent/NZ188140A/xx unknown
- 1978-08-15 AU AU38915/78A patent/AU516443B2/en not_active Expired
- 1978-08-15 YU YU1953/78A patent/YU41317B/xx unknown
- 1978-08-16 MC MC781318A patent/MC1210A1/fr unknown
- 1978-08-16 PH PH21502A patent/PH16364A/en unknown
- 1978-08-16 IT IT26792/78A patent/IT1098042B/it active
- 1978-08-17 JP JP9958278A patent/JPS5444671A/ja active Granted
- 1978-08-17 DE DE7878100690T patent/DE2860546D1/de not_active Expired
- 1978-08-17 DE DE19782836073 patent/DE2836073A1/de not_active Withdrawn
- 1978-08-17 EP EP78100690A patent/EP0000928B1/fr not_active Expired
- 1978-08-17 GR GR57019A patent/GR73055B/el unknown
- 1978-08-17 CA CA309,523A patent/CA1104133A/fr not_active Expired
- 1978-08-18 SE SE7808773A patent/SE7808773L/xx unknown
- 1978-08-18 ES ES472661A patent/ES472661A1/es not_active Expired
- 1978-08-18 AR AR273353A patent/AR218325A1/es active
- 1978-08-18 AT AT0601078A patent/AT364829B/de not_active IP Right Cessation
- 1978-08-18 NO NO782813A patent/NO151240C/no unknown
- 1978-08-18 PT PT68441A patent/PT68441A/pt unknown
- 1978-08-18 GB GB7833921A patent/GB2003154A/en not_active Withdrawn
- 1978-08-18 HU HU78HO2096A patent/HU179983B/hu not_active IP Right Cessation
- 1978-08-18 NL NL7808597A patent/NL7808597A/xx not_active Application Discontinuation
- 1978-08-18 DK DK366678A patent/DK155367C/da not_active IP Right Cessation
- 1978-08-18 FI FI782530A patent/FI70576C/fi not_active IP Right Cessation
- 1978-08-18 FR FR7824132A patent/FR2400512A1/fr active Granted
-
1979
- 1979-02-24 ES ES478051A patent/ES478051A1/es not_active Expired
- 1979-02-24 ES ES478052A patent/ES478052A1/es not_active Expired
- 1979-07-26 AR AR277480A patent/AR218553A1/es active
- 1979-07-26 AR AR277479A patent/AR220216A1/es active
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
YP | Annual fee paid |