FI70576C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-(3-amino-2-hydroxipropyl)-2-nitroimidazoler - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-(3-amino-2-hydroxipropyl)-2-nitroimidazoler Download PDF

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Publication number
FI70576C
FI70576C FI782530A FI782530A FI70576C FI 70576 C FI70576 C FI 70576C FI 782530 A FI782530 A FI 782530A FI 782530 A FI782530 A FI 782530A FI 70576 C FI70576 C FI 70576C
Authority
FI
Finland
Prior art keywords
formula
ethanol
nitro
methyl
imidazole
Prior art date
Application number
FI782530A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI782530A (fi
FI70576B (fi
Inventor
Carey Ernest Smithen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI782530A publication Critical patent/FI782530A/fi
Publication of FI70576B publication Critical patent/FI70576B/fi
Application granted granted Critical
Publication of FI70576C publication Critical patent/FI70576C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI782530A 1977-08-19 1978-08-18 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-(3-amino-2-hydroxipropyl)-2-nitroimidazoler FI70576C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB3490877 1977-08-19
GB3490877 1977-08-19
GB1953478 1978-05-15
GB1953478 1978-05-15

Publications (3)

Publication Number Publication Date
FI782530A FI782530A (fi) 1979-02-20
FI70576B FI70576B (fi) 1986-06-06
FI70576C true FI70576C (fi) 1986-09-24

Family

ID=26254111

Family Applications (1)

Application Number Title Priority Date Filing Date
FI782530A FI70576C (fi) 1977-08-19 1978-08-18 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-(3-amino-2-hydroxipropyl)-2-nitroimidazoler

Country Status (26)

Country Link
US (1) US4241060A (fr)
EP (1) EP0000928B1 (fr)
JP (1) JPS5444671A (fr)
AR (3) AR218325A1 (fr)
AT (1) AT364829B (fr)
AU (1) AU516443B2 (fr)
CA (1) CA1104133A (fr)
DE (2) DE2836073A1 (fr)
DK (1) DK155367C (fr)
ES (3) ES472661A1 (fr)
FI (1) FI70576C (fr)
FR (1) FR2400512A1 (fr)
GB (1) GB2003154A (fr)
GR (1) GR73055B (fr)
HU (1) HU179983B (fr)
IE (1) IE47132B1 (fr)
IL (1) IL55351A (fr)
IT (1) IT1098042B (fr)
MC (1) MC1210A1 (fr)
NL (1) NL7808597A (fr)
NO (1) NO151240C (fr)
NZ (1) NZ188140A (fr)
PH (1) PH16364A (fr)
PT (1) PT68441A (fr)
SE (1) SE7808773L (fr)
YU (1) YU41317B (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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DE2948884A1 (de) * 1979-12-05 1981-06-11 Basf Ag, 6700 Ludwigshafen 2-hydroxypropylimidazole, verfahren zu ihrer herstellung und verwendung als oelloesliche korrosionsinhibitoren
ZW8781A1 (en) * 1980-05-23 1981-12-16 Hoffmann La Roche 2-nitroimidazoles and preparation thereof
US4494547A (en) * 1981-03-30 1985-01-22 North Carolina Central University 2H-isoindolediones, their synthesis and use as radiosensitizers
US4537969A (en) * 1982-03-18 1985-08-27 Hoffmann-La Roche Inc. Imidazole derivatives
US4605744A (en) * 1982-03-18 1986-08-12 Hoffmann-La Roche Inc. Imidazole derivatives
JPH0649697B2 (ja) * 1982-05-27 1994-06-29 ブリティッシュ・テクノロジー・グループ・リミテッド 放射線治療または化学療法に有用な化合物
CA1227211A (fr) * 1982-05-27 1987-09-22 Israr Ahmed Nitro-imidazolylaziridinopropanols
US4742050B1 (en) * 1982-08-17 1994-06-28 Alpha Therapeutic Corp Sensitization of hypoxic tumor cells and control of growth thereof
WO1984000686A1 (fr) * 1982-08-17 1984-03-01 Sun Tech Inc Emulsions de perfluorocarbone, leur preparation et leur utilisation en therapie
US4889525A (en) * 1982-08-17 1989-12-26 Adamantech, Inc. Sensitization of hypoxic tumor cells and control of growth thereof
US5304654A (en) * 1987-06-10 1994-04-19 Yasunori Nishijima Fluorine-containing nitroimidazole compounds
CA1329206C (fr) * 1987-06-10 1994-05-03 Tsutomu Kagiya Derives nitroazole fluores et radiosensibilisant en contenant
JP2848602B2 (ja) * 1987-06-24 1999-01-20 京都大学長 新規含フッ素２−ニトロイミダゾールおよびそれを含む放射線増感剤
US4797397A (en) * 1987-07-31 1989-01-10 Warner-Lambert Company 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells
GB8728418D0 (en) * 1987-12-04 1988-01-13 Jenkins T C Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment
EP0319329B1 (fr) * 1987-12-04 1995-11-02 Btg International Limited Composés aromatiques ou hétéro-aromatiques nitro-substitués utilisables dans le traitement de cancer
US5086068A (en) * 1988-02-26 1992-02-04 Alberta Cancer Board Immunochemical detection of hypoxia in normal and tumor tissue
US5194624A (en) * 1988-05-23 1993-03-16 Fujisawa Pharmaceutical Co., Ltd. Intermediates for the preparation of compounds of antimicrobial activity
US4954515A (en) * 1988-11-25 1990-09-04 Warner-Lambert Company Haloalkylaminomethyl-2-nitro-1H-imidazoles
US5036096A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives
JPH02146288A (ja) * 1988-11-25 1990-06-05 Ebara Corp 内部圧縮を持つ容積型圧縮機
US5036089A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company 2-oxazolidinone derivatives of nitroimidazoles and pharmaceutical compositions useful as sensitizing agents
US5073639A (en) * 1988-11-25 1991-12-17 Warner-Lambert Company Process for the synthesis of novel and known nitroimidazoles which are useful as sensitizing agents
JP2799368B2 (ja) * 1990-01-10 1998-09-17 ポーラ化成工業株式会社 抗原虫剤
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
MX9304399A (es) * 1992-07-31 1994-02-28 Warner Lambert Co Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados.
US6855828B1 (en) 1992-11-19 2005-02-15 The Trustees Of The University Of Pennsylvania Detection of hypoxia
CA2149770C (fr) * 1992-11-19 2009-01-06 Cameron J. Koch Detection de l'hypoxie
US6252087B1 (en) 1992-11-19 2001-06-26 The Trustees Of The University Of Pennsylvania Nitroaromatic compounds for the detection of hypoxia
US5741800A (en) * 1993-06-22 1998-04-21 Knoll Aktiengesellachaft Azolyl-cyclic amine derivates with immunomodulatory activity
GB9312893D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
US5674693A (en) * 1994-03-18 1997-10-07 Natural Pharmacia International Inc. Derivatives of 2-nitro-imidazoles as hypoxic cell markers
US5972984A (en) * 1995-06-06 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US20050026974A1 (en) * 1996-02-08 2005-02-03 Trustees Of The University Of Pennsylvania Detection of hypoxia
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US8974363B2 (en) 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US8557298B2 (en) 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7608612B2 (en) * 2005-01-21 2009-10-27 Richard H. Matthews Radiosensitizer formulations and methods for use
US9056136B2 (en) * 2006-10-06 2015-06-16 Natural Pharmacia International, Inc. Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
US7842278B2 (en) * 2006-10-27 2010-11-30 Natural Pharmacia International, Inc. Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
MD4150C1 (ro) * 2011-10-11 2012-09-30 Институт Химии Академии Наук Молдовы Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective
MD4178C1 (ro) * 2012-02-27 2013-02-28 Институт Химии Академии Наук Молдовы Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului
JP2016525059A (ja) * 2013-07-16 2016-08-22 コーニング インコーポレイテッド 薄ガラスを曲げるための装置及び方法
CN108203411A (zh) * 2016-12-19 2018-06-26 曾舟华 一种高压合成甲硝唑的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA746007A (en) * 1966-11-08 W. Henry David 1-substituted-2-sulfonyl-5-nitroimidazoles
US3255201A (en) * 1965-04-09 1966-06-07 Hoffmann La Roche 2-nitroimidazoles
US3505349A (en) * 1966-04-18 1970-04-07 Hoffmann La Roche 2-nitro-imidazolyl-1-acetamides
CH512493A (de) * 1966-06-10 1971-09-15 Hoffmann La Roche Verfahren zur Herstellung von Imidazolderivaten
US3646057A (en) * 1969-04-06 1972-02-29 Hoffmann La Roche 2-nitroimidazoles
FR2260996A1 (en) * 1974-02-15 1975-09-12 Hoffmann La Roche (2-Nitro-1-imidazolyl)-carbamates - useful as germicides and antiproto-zoal agents
DE2410749A1 (de) * 1974-03-06 1975-09-11 Hoffmann La Roche 2-nitroimidazole
US4038410A (en) * 1974-03-14 1977-07-26 Schering Aktiengesellschaft Nitroimidazole derivatives and process for the preparation thereof

Also Published As

Publication number Publication date
JPS5444671A (en) 1979-04-09
ES472661A1 (es) 1979-02-16
GR73055B (fr) 1984-01-26
IT7826792A0 (it) 1978-08-16
GB2003154A (en) 1979-03-07
NO782813L (no) 1979-02-20
IE781453L (en) 1979-02-19
AR218325A1 (es) 1980-05-30
US4241060A (en) 1980-12-23
NZ188140A (en) 1981-01-23
EP0000928B1 (fr) 1981-03-18
NO151240C (no) 1985-03-06
MC1210A1 (fr) 1979-05-18
FI782530A (fi) 1979-02-20
YU41317B (en) 1987-02-28
FR2400512B1 (fr) 1980-07-04
JPS6220187B2 (fr) 1987-05-06
FR2400512A1 (fr) 1979-03-16
DK366678A (da) 1979-02-20
AT364829B (de) 1981-11-25
NL7808597A (nl) 1979-02-21
AR220216A1 (es) 1980-10-15
ATA601078A (de) 1981-04-15
ES478051A1 (es) 1979-10-16
ES478052A1 (es) 1979-10-16
IL55351A0 (en) 1978-10-31
AU3891578A (en) 1980-02-21
HU179983B (en) 1983-01-28
EP0000928A1 (fr) 1979-03-07
IT1098042B (it) 1985-08-31
AR218553A1 (es) 1980-06-13
CA1104133A (fr) 1981-06-30
NO151240B (no) 1984-11-26
DE2836073A1 (de) 1979-03-01
SE7808773L (sv) 1979-02-20
DK155367B (da) 1989-04-03
PH16364A (en) 1983-09-08
AU516443B2 (en) 1981-06-04
IE47132B1 (en) 1983-12-28
DK155367C (da) 1989-08-14
YU195378A (en) 1983-01-21
FI70576B (fi) 1986-06-06
IL55351A (en) 1982-07-30
DE2860546D1 (en) 1981-04-16
PT68441A (fr) 1978-09-01

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Owner name: F. HOFFMANN-LA ROCHE AG