ATA88878A - Verfahren zur herstellung von 4-hydroxy- pyrrolidin-2-on-derivaten - Google Patents

Verfahren zur herstellung von 4-hydroxy- pyrrolidin-2-on-derivaten

Info

Publication number
ATA88878A
ATA88878A AT88878A AT88878A ATA88878A AT A88878 A ATA88878 A AT A88878A AT 88878 A AT88878 A AT 88878A AT 88878 A AT88878 A AT 88878A AT A88878 A ATA88878 A AT A88878A
Authority
AT
Austria
Prior art keywords
pyrrolidin
hydroxy
derivatives
producing
Prior art date
Application number
AT88878A
Other languages
English (en)
Other versions
AT362782B (de
Inventor
Silvano Banfi
Renato Pellegata
Giorgio Pifferi
Mario Pinza
Original Assignee
Isf Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isf Spa filed Critical Isf Spa
Publication of ATA88878A publication Critical patent/ATA88878A/de
Application granted granted Critical
Publication of AT362782B publication Critical patent/AT362782B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B43—WRITING OR DRAWING IMPLEMENTS; BUREAU ACCESSORIES
    • B43K—IMPLEMENTS FOR WRITING OR DRAWING
    • B43K24/00—Mechanisms for selecting, projecting, retracting or locking writing units
    • B43K24/02—Mechanisms for selecting, projecting, retracting or locking writing units for locking a single writing unit in only fully projected or retracted positions
    • B43K24/08—Mechanisms for selecting, projecting, retracting or locking writing units for locking a single writing unit in only fully projected or retracted positions operated by push-buttons
    • B43K24/084—Mechanisms for selecting, projecting, retracting or locking writing units for locking a single writing unit in only fully projected or retracted positions operated by push-buttons with saw-like or analogous cams
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J115/00—Adhesives based on rubber derivatives
AT0088878A 1977-02-11 1978-02-08 Verfahren zur herstellung von 4-hydroxypyrrolidin-2-on-derivaten AT362782B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20227/77A IT1075280B (it) 1977-02-11 1977-02-11 Procedimento per la preparazione di derivati pirrolidinici

Publications (2)

Publication Number Publication Date
ATA88878A true ATA88878A (de) 1980-11-15
AT362782B AT362782B (de) 1981-06-10

Family

ID=11164931

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0088878A AT362782B (de) 1977-02-11 1978-02-08 Verfahren zur herstellung von 4-hydroxypyrrolidin-2-on-derivaten

Country Status (26)

Country Link
US (1) US4173569A (de)
JP (1) JPS53101367A (de)
AR (1) AR223958A1 (de)
AT (1) AT362782B (de)
AU (1) AU513992B2 (de)
BE (1) BE863883A (de)
CA (1) CA1087200A (de)
CH (1) CH637928A5 (de)
CS (1) CS214800B2 (de)
DE (2) DE2758937A1 (de)
DK (1) DK155733C (de)
ES (1) ES466856A1 (de)
FI (1) FI67695C (de)
FR (1) FR2380257A1 (de)
GB (1) GB1588075A (de)
HU (1) HU178587B (de)
IN (1) IN148327B (de)
IT (1) IT1075280B (de)
MX (1) MX5950E (de)
NL (1) NL190412C (de)
NO (1) NO148148C (de)
NZ (1) NZ186431A (de)
PL (1) PL112858B1 (de)
PT (1) PT67642A (de)
SU (1) SU755195A3 (de)
YU (1) YU40321B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
IT1206699B (it) * 1984-02-27 1989-04-27 Isf Spa Procedimento per preparare derivati di pirrolidone.
IT1173768B (it) * 1984-04-02 1987-06-24 Isf Spa Procedimento di preparazione di derivati 1-carbamoilmetilici di 4-idrossi-2-osso-pirrolidina nonche' di intermedi per ottenere tali composti
CH666483A5 (de) * 1985-01-16 1988-07-29 Lonza Ag Verfahren zur herstellung von thiotetronsaeure.
EP0223328B1 (de) 1985-07-26 1992-01-29 Denki Kagaku Kogyo Kabushiki Kaisha Verfahren zur Herstellung von Oxiracetam
CH668423A5 (de) * 1986-06-19 1988-12-30 Lonza Ag Verfahren zur herstellung von 4-alkoxy-3-pyrrolin-2-onen.
IL80071A0 (en) * 1985-09-24 1986-12-31 Lonza Ag Pyrrolidine acetamide derivatives
HU195773B (en) * 1985-09-24 1988-07-28 Lonza Ag Process for preparing alkyl esters of 4-alkoxy-3-pyrrolin-2-on-1-yl-acetic acid
CH666891A5 (de) * 1985-11-26 1988-08-31 Lonza Ag 4-alkoxy-2-oxo-pyrrolidin-1-yl-essigsaeure-c(1)-c(4)-alkylester, deren herstellung und verwendung.
CH668424A5 (de) * 1986-06-26 1988-12-30 Lonza Ag 4-benzyloxy-3-pyrrolin-2-on-l-yl-acetamid, dessen herstellung und verwendung.
CH668422A5 (de) * 1986-06-26 1988-12-30 Lonza Ag 4-benzyloxy-3-pyrrolin-2-on, dessen herstellung und verwendung zur synthese von tetramsaeure.
CH667655A5 (de) * 1986-09-24 1988-10-31 Lonza Ag Verfahren zur herstellung von 4-alkoxy-2(5h)-thiophenonen.
CH670644A5 (de) * 1986-12-18 1989-06-30 Lonza Ag
IT1215581B (it) * 1987-06-25 1990-02-14 Roussel Maestretti Spa Derivati della 1-benzil 2-oxo 5-alcossi pirrolidina, loro procedimento di preparazione e loro applicazione come prodotti medicinali.
DE3813416A1 (de) * 1988-04-21 1989-11-02 Hoechst Ag 3,4-dihydroxypyrrolidin-2-on-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung sowie die bei der herstellung anfallenden neuen zwischenprodukte
JPH02115162A (ja) * 1988-09-06 1990-04-27 Lonza Ag ５―アルキルテトラム酸およびその製造方法
FI95034C (fi) * 1989-03-15 1995-12-11 Lonza Ag Menetelmä 1,3-substituoidun tetrahydro-1H-tieno/3,4-d/-imidatsol-2(3H)-on-4-ylideenipentaanihappoesterin valmistamiseksi
CH680293A5 (de) * 1990-06-26 1992-07-31 Lonza Ag
GB9121289D0 (en) * 1991-10-08 1991-11-20 Isf Spa Composition and use
JP2969616B2 (ja) * 1994-11-24 1999-11-02 田辺製薬株式会社 ４−メルカプトピロリジン化合物の製法
EP0951468A4 (de) * 1996-11-22 2001-06-06 Mona Industries Inc Eine carboxylgruppe enthaltende silikonmonomere und -oligomere
US5679798A (en) * 1996-11-22 1997-10-21 Mona Industries, Inc. Silicone monomers having a carboxyl functional group thereon
KR100424393B1 (ko) * 2001-11-26 2004-03-24 한국화학연구원 옥시라세탐의 제조방법
JP4378326B2 (ja) * 2005-07-26 2009-12-02 キヤノン株式会社 駆動装置及び光量調節装置
DK3260118T3 (da) * 2008-10-16 2021-04-19 Univ Johns Hopkins Fremgangsmåder og sammensætninger til forbedring af kognitiv funktion
CN101747259B (zh) * 2008-12-18 2012-02-15 北京大学 氮杂糖类化合物及其合成方法及应用
CN101575309B (zh) * 2009-04-28 2011-05-18 中国医药集团总公司四川抗菌素工业研究所 合成(s)-奥拉西坦的方法
CN101704778B (zh) * 2009-09-30 2012-10-17 厦门市华兴化工有限公司 一种制备4-羟基吡咯烷酮-2-乙酰胺的方法
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
CA2904767C (en) 2013-03-15 2022-06-21 Agenebio, Inc. Methods and compositions for improving cognitive function
CN104513189B (zh) * 2014-12-19 2017-07-28 深圳市海滨制药有限公司 一种奥拉西坦中间体及其制备方法和应用
US20180147183A1 (en) * 2015-05-18 2018-05-31 Chongqing Runze Pharmaceutical Co., Ltd. Use of r-oxiracetam in pharmaceutical field
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
CN107973739B (zh) 2016-10-24 2020-03-20 重庆润泽医药有限公司 右旋奥拉西坦晶型ii及其制备方法和用途
EP3530650A4 (de) * 2016-10-24 2020-03-25 Chongqing Runze Pharmaceutical Company Limited Kristalline form von (r)-4-hydroxy-2-oxo-1-pyrrolidinacetamid, herstellungsverfahren dafür und verwendung davon
KR20190053253A (ko) 2016-10-24 2019-05-17 충칭 룬즈 파마슈티컬 컴퍼니 리미티드. 덱스트랄 옥시라세탐의 새로운 결정형, 이의 제조 방법 및 이의 용도
CN108299267A (zh) 2017-01-12 2018-07-20 重庆润泽医药有限公司 (r)-4-羟基-2-氧-1-吡咯烷乙酰胺的晶型及其制备方法和用途
CN114621128A (zh) * 2022-03-10 2022-06-14 成都百途医药科技有限公司 一种（s）-奥拉西坦的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
AR211398Q (es) 1975-08-13 1977-12-15 Isf Spa Un procedimiento para preparar derivados de ( -pirrolin -2- on -1- il)-acilamida

Also Published As

Publication number Publication date
AR223958A1 (es) 1981-10-15
PL112858B1 (en) 1980-11-29
GB1588075A (en) 1981-04-15
FR2380257B1 (de) 1981-11-20
JPS53101367A (en) 1978-09-04
NL190412B (nl) 1993-09-16
CA1087200A (en) 1980-10-07
NL190412C (nl) 1994-02-16
IT1075280B (it) 1985-04-22
NO148148B (no) 1983-05-09
FI67695B (fi) 1985-01-31
SU755195A3 (en) 1980-08-07
DE2758937A1 (de) 1978-08-17
JPS6338348B2 (de) 1988-07-29
DK155733B (da) 1989-05-08
DE2758939A1 (de) 1978-08-17
NZ186431A (en) 1979-08-31
MX5950E (es) 1984-09-06
FI67695C (fi) 1985-05-10
DK63178A (da) 1978-08-12
FR2380257A1 (fr) 1978-09-08
CS214800B2 (en) 1982-05-28
HU178587B (en) 1982-05-28
YU30278A (en) 1983-01-21
PT67642A (en) 1978-03-01
NO148148C (no) 1983-08-17
AU3309178A (en) 1979-08-16
NL7801500A (nl) 1978-08-15
NO780464L (no) 1978-08-14
ES466856A1 (es) 1978-10-01
YU40321B (en) 1985-12-31
AU513992B2 (en) 1981-01-15
BE863883A (fr) 1978-08-10
CH637928A5 (de) 1983-08-31
IN148327B (de) 1981-01-17
FI780407A (fi) 1978-08-12
AT362782B (de) 1981-06-10
US4173569A (en) 1979-11-06
DK155733C (da) 1989-09-25
PL204549A1 (pl) 1979-03-12
DE2758937C2 (de) 1988-07-07

Similar Documents

Publication Publication Date Title
AT362782B (de) Verfahren zur herstellung von 4-hydroxypyrrolidin-2-on-derivaten
AT367438B (de) Verfahren zur herstellung von oligoimiden
AT362781B (de) Verfahren zur herstellung von 4-hydroxypyrrolidin-2-on-derivaten
AT356096B (de) Verfahren zur herstellung von furokumarinen
AT358548B (de) Verfahren zur herstellung von 2-aethylhexanol
AT358559B (de) Verfahren zur herstellung von o-methallyloxy- phenol
AT360504B (de) Verfahren zur herstellung von m-chloranilinen
AT356643B (de) Verfahren zur herstellung von acylcyaniden
AT377741B (de) Verfahren zur herstellung von chlordioxid
AT360154B (de) Verfahren zur herstellung von aminoglycosid- -antibiotka
AT347440B (de) Verfahren zur herstellung von benzoylcyanid
AT356642B (de) Verfahren zur herstellung von acylcyaniden
AT360648B (de) Verfahren zur herstellung von p-hydroxy-alpha- -aminobenzylpenicillin
AT363625B (de) Verfahren zur herstellung von 21-hydroxy-20methyl-pregnan-derivaten
AT366695B (de) Verfahren zur herstellung von 3-brommethyl-3cephemsulfoxydderivaten
AT366036B (de) Verfahren zur herstellung von 3-pyridazonen
AT352104B (de) Verfahren zur herstellung von n-cyanoalkyl-p- halogenphenoxy-isobutyramiden
AT359483B (de) Verfahren zur herstellung von benzoylcyanid
AT365590B (de) Verfahren zur herstellung von apovincamin
AT368500B (de) Verfahren zur herstellung von ergolin-derivaten
AT362369B (de) Verfahren zur herstellung von furocumarin- derivaten
AT359510B (de) Verfahren zur herstellung von benzylpyrimidinen
AT358021B (de) Verfahren zur herstellung von benzoylcyanid
AT361497B (de) Verfahren zur herstellung von alkylthiosemi- carbaziden
ATA617079A (de) Verfahren zur herstellung von 1-dethia-1-oxacephemderivaten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties