NO140858B - Analogifremgangsmaate ved fremstilling av terapeutisk aktive nye 2,4-diamino-5-benzyl-pyrimidinderivater - Google Patents
Analogifremgangsmaate ved fremstilling av terapeutisk aktive nye 2,4-diamino-5-benzyl-pyrimidinderivater Download PDFInfo
- Publication number
- NO140858B NO140858B NO743271A NO743271A NO140858B NO 140858 B NO140858 B NO 140858B NO 743271 A NO743271 A NO 743271A NO 743271 A NO743271 A NO 743271A NO 140858 B NO140858 B NO 140858B
- Authority
- NO
- Norway
- Prior art keywords
- diamino
- benzyl
- preparation
- channel
- analogical
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- XHPZVBGIPQQTQW-UHFFFAOYSA-N 5-benzylpyrimidine-2,4-diamine Chemical class NC1=NC(N)=NC=C1CC1=CC=CC=C1 XHPZVBGIPQQTQW-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 claims description 8
- 239000000428 dust Substances 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Analogifremgangsmåte ved fremstilling av terapeutisk aktive nye 2,4-diamino-5-benzyl-pyrimidinderivater.
Description
Anordning ved apparat for tilførsel og finfordeling av en væske i et gassformig medium.
Foreliggende oppfinnelse vedrører en
anordning ved et apparat for tilførsel og
finfordeling av en væske i et i en kanal
fremstrømmende gassformig medium i
henhold til påstand 2 i patent 87 484 (hovedpatentet). Ved anvendelsen av apparater av denne art har det i praksis vist seg
at virkningsgraden, når det gjelder væskens sønderdeling, nedsettes i betydelig
grad hvis gasshastigheten ligger nevne-verdig under den beregnede verdi. Da en
slik variasjon av gasshastigheten — som
følge av en variasjon i den tilførte gassmengde — i mange tilfelle ikke kan unn-gås, blir resultatet temmelig ujevnt, hva
enten væsken tilføres for å befukte det
gassformige medium eller for å agglome-rere og utskille støv som følger med gassen.
Oppfinnelsen, som tar sikte å eliminere
denne vanskelighet ved slike apparater,
utmerker seg ved at når gasskanalen er
utformet med et rektangulært tverrsnitt,
er minst én av de motstående vegger i den
avsmalnende del av gasskanalens utvidelse således understøttet og lagret at den
kan forstilles inn mot kanalens midtplan,
f. eks. ved hjelp av en skrue, for å mulig-gjøre en regulering av gjennomløpsarealet
på det sted hvor væskens finfordeling finner sted, og at den eller de tilsvarende vegger i utløpsledningen fra utvidelsen er inn-stillbare på lignende måte, i den hensikt
å muliggjøre en tilpasning av gjennom-løpsarealet til den aktuelle gassmengde.
Oppfinnelsen skal beskrives nærmere i tilslutning til tegningen som viser et apparat i henhold til oppfinnelsen.
På tegningen betegner 1 en tilførsels-kanal for et gassformig medium som skal befuktes eller renses for medfølgende støv. Denne kanal munner ut i en utvidelse 2 som er utstyrt med organer 3 for tilførsel av væske som skal tilføres og fordeles på den i hovedpatentet angitte måte. Utvidelsen er utført med en avsmalnende del 2a, til hvilken der slutter seg en etterføl-gende kanaldel 4. På overgangsstedet 5 danner den avsmalnende kanaldels vegger i hovedsaken 90° med strømningsretnin-gen for det gassformige medium for å til-veiebringe den tilsiktede strupning av gasstrømmen. Ifølge oppfinnelsen er veggdelen 2b og 4b i det viste tilfelle innstill-bart anordnet idet de er svingbart opp-hengt ved punktet 6. Forskyvningen be-virkes i det viste tilfelle ved hjelp av en skrue 7 som ved punktet 4a er svingbart forbundet med veggdelen 4b og står i inn-grep med en mutter 8 som er anbragt i en fast ytre vegg 9. Ved apparater med større dimensjoner utnyttes der for omstillingen hensiktsmessig flere skruespindler. I det tilfelle at bare veggdelen 2b er innstillbar er skruene selvsagt alene forbundet med denne veggdel.
Claims (1)
- Anordning ved apparat for tilførsel og finfordeling av en væske i et i en kanal fremstrømmende gassformig medium i henhold til påstand 2 i patent 87 484, karakterisert ved at når gasskanalen er utformet med et rektangulært tverrsnitt, er minst én av de motstående lang-siders vegger (2b) i den avsmalnende del (2a) av gasskanalens utvidelse således un-derstøttet og lageret at den kan forstillesinn mot kanalens midtplan, f. eks. ved hjelp av en skrue (7), for å muliggjøre en regulering av gjennomløpsarealet på det sted (5), hvor væskens finfordeling finner sted, og at den eller de tilsvarende vegger (4b) i utløpsledningen (4) fra utvidelsen (2) er innstillbar på lignende måte.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1305773A CH591456A5 (no) | 1973-09-12 | 1973-09-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO743271L NO743271L (no) | 1975-04-07 |
| NO140858B true NO140858B (no) | 1979-08-20 |
| NO140858C NO140858C (no) | 1979-11-28 |
Family
ID=4388903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO743271A NO140858C (no) | 1973-09-12 | 1974-09-11 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive nye 2,4-diamino-5-benzyl-pyrimidinderivater |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS6042238B2 (no) |
| AR (2) | AR207764A1 (no) |
| AT (1) | AT338797B (no) |
| BE (1) | BE819773A (no) |
| BR (1) | BR7407614D0 (no) |
| CA (1) | CA1037476A (no) |
| CH (1) | CH591456A5 (no) |
| CU (1) | CU34115A (no) |
| DD (2) | DD122785A5 (no) |
| DE (1) | DE2443682C2 (no) |
| DK (1) | DK135683B (no) |
| ES (7) | ES429949A1 (no) |
| FI (1) | FI58638C (no) |
| FR (1) | FR2242984B1 (no) |
| GB (3) | GB1484481A (no) |
| HK (1) | HK181A (no) |
| HU (1) | HU170427B (no) |
| IE (1) | IE40523B1 (no) |
| IL (1) | IL45510A (no) |
| LU (1) | LU70878A1 (no) |
| NL (1) | NL155827B (no) |
| NO (1) | NO140858C (no) |
| PH (1) | PH10643A (no) |
| PL (2) | PL99159B1 (no) |
| SE (1) | SE419443B (no) |
| SU (3) | SU577987A3 (no) |
| YU (3) | YU217874A (no) |
| ZA (1) | ZA745317B (no) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515948A (en) * | 1973-09-12 | 1985-05-07 | Hoffmann-La Roche Inc. | 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines |
| EP0001633A1 (en) * | 1977-10-18 | 1979-05-02 | The Wellcome Foundation Limited | Processes for preparing tri-heterocyclic substituted methanes and their conversion into further intermediates useful in the preparation of pharmacologically active compounds |
| CH639273A5 (de) | 1978-09-12 | 1983-11-15 | Hoffmann La Roche | Diuretische mittel. |
| JPS5888368A (ja) * | 1981-11-09 | 1983-05-26 | ザ・ウエルカム・フアウンデ−シヨン・リミテツド | ベンジルピリミジン誘導体の製造法 |
| DE3250132C2 (de) * | 1981-11-09 | 1997-01-16 | Mallinckrodt Veterinary Inc | Verfahren zur Herstellung von 2,4-Diamino-5-benzyl-pyrimidinen und neue Zwischenprodukte des Verfahrens |
| GB2180836A (en) * | 1985-09-27 | 1987-04-08 | William James Stephen Barker | Sunscreen |
| JPH0431685Y2 (no) * | 1987-06-01 | 1992-07-30 | ||
| CA1300166C (en) * | 1987-12-03 | 1992-05-05 | Alfredo Guerrato | Process for the preparation of a benzoic acid ester |
| US4900859A (en) * | 1987-12-03 | 1990-02-13 | Hoffman-La Roche Inc. | Process for 4-dimethylamino-3,5-dimethoxybenzaldehyde |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1103931B (de) * | 1957-02-21 | 1961-04-06 | Wellcome Found | Verfahren zur Herstellung von 2, 4-Diamino-5-benzylpyrimidinderivaten |
| US3485840A (en) * | 1964-11-12 | 1969-12-23 | Hoffmann La Roche | 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes |
-
1973
- 1973-09-12 CH CH1305773A patent/CH591456A5/xx not_active IP Right Cessation
-
1974
- 1974-01-01 AR AR255569A patent/AR207764A1/es active
- 1974-08-06 YU YU02178/74A patent/YU217874A/xx unknown
- 1974-08-19 ZA ZA00745317A patent/ZA745317B/xx unknown
- 1974-08-21 CA CA207,509A patent/CA1037476A/en not_active Expired
- 1974-08-21 IL IL45510A patent/IL45510A/xx unknown
- 1974-09-02 FI FI2561/74A patent/FI58638C/fi active
- 1974-09-03 NL NL7411685.A patent/NL155827B/xx not_active IP Right Cessation
- 1974-09-04 DK DK468374AA patent/DK135683B/da unknown
- 1974-09-06 PL PL1974195308A patent/PL99159B1/pl unknown
- 1974-09-06 PL PL1974173909A patent/PL97757B1/pl unknown
- 1974-09-09 IE IE1870/74A patent/IE40523B1/xx unknown
- 1974-09-09 SE SE7411382A patent/SE419443B/xx unknown
- 1974-09-09 PH PH16253A patent/PH10643A/en unknown
- 1974-09-10 LU LU70878A patent/LU70878A1/xx unknown
- 1974-09-10 DD DD190238A patent/DD122785A5/xx unknown
- 1974-09-10 FR FR7430568A patent/FR2242984B1/fr not_active Expired
- 1974-09-10 JP JP49103536A patent/JPS6042238B2/ja not_active Expired
- 1974-09-10 DD DD181015A patent/DD116824A5/xx unknown
- 1974-09-11 CU CU34115A patent/CU34115A/es unknown
- 1974-09-11 NO NO743271A patent/NO140858C/no unknown
- 1974-09-11 AT AT735174A patent/AT338797B/de not_active IP Right Cessation
- 1974-09-11 ES ES429949A patent/ES429949A1/es not_active Expired
- 1974-09-11 HU HUHO1718A patent/HU170427B/hu not_active IP Right Cessation
- 1974-09-11 BE BE148396A patent/BE819773A/xx not_active IP Right Cessation
- 1974-09-11 GB GB39617/74A patent/GB1484481A/en not_active Expired
- 1974-09-11 GB GB47894/76A patent/GB1484483A/en not_active Expired
- 1974-09-11 GB GB47893/76A patent/GB1484482A/en not_active Expired
- 1974-09-11 SU SU7402058406A patent/SU577987A3/ru active
- 1974-09-12 DE DE2443682A patent/DE2443682C2/de not_active Expired
- 1974-09-12 BR BR7614/74A patent/BR7407614D0/pt unknown
-
1975
- 1975-04-25 ES ES437011A patent/ES437011A1/es not_active Expired
- 1975-04-25 ES ES437008A patent/ES437008A1/es not_active Expired
- 1975-04-25 ES ES437012A patent/ES437012A1/es not_active Expired
- 1975-04-25 ES ES437009A patent/ES437009A1/es not_active Expired
- 1975-04-25 ES ES437007A patent/ES437007A1/es not_active Expired
- 1975-04-25 ES ES437013A patent/ES437013A1/es not_active Expired
- 1975-06-20 SU SU7502145932A patent/SU571189A3/ru active
- 1975-06-20 SU SU752145937A patent/SU609465A3/ru active
- 1975-06-30 AR AR259408A patent/AR211387Q/es unknown
-
1980
- 1980-11-27 YU YU3015/80A patent/YU37153B/xx unknown
- 1980-11-27 YU YU3016/80A patent/YU37154B/xx unknown
-
1981
- 1981-01-08 HK HK1/81A patent/HK181A/xx unknown
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