NL155827B - Werkwijze voor de bereiding van antibacterieel werkzame benzylpyrimidinen, alsmede voor de bereiding van antibacterieel werkzame preparaten, die deze verbindingen bevatten, en de gevormde preparaten. - Google Patents

Werkwijze voor de bereiding van antibacterieel werkzame benzylpyrimidinen, alsmede voor de bereiding van antibacterieel werkzame preparaten, die deze verbindingen bevatten, en de gevormde preparaten.

Info

Publication number
NL155827B
NL155827B NL7411685.A NL7411685A NL155827B NL 155827 B NL155827 B NL 155827B NL 7411685 A NL7411685 A NL 7411685A NL 155827 B NL155827 B NL 155827B
Authority
NL
Netherlands
Prior art keywords
preparation
active
preparations
antibacterally
benzylpyrimidines
Prior art date
Application number
NL7411685.A
Other languages
English (en)
Dutch (nl)
Other versions
NL7411685A (nl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NL7411685A publication Critical patent/NL7411685A/xx
Publication of NL155827B publication Critical patent/NL155827B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NL7411685.A 1973-09-12 1974-09-03 Werkwijze voor de bereiding van antibacterieel werkzame benzylpyrimidinen, alsmede voor de bereiding van antibacterieel werkzame preparaten, die deze verbindingen bevatten, en de gevormde preparaten. NL155827B (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1305773A CH591456A5 (xx) 1973-09-12 1973-09-12

Publications (2)

Publication Number Publication Date
NL7411685A NL7411685A (nl) 1975-03-14
NL155827B true NL155827B (nl) 1978-02-15

Family

ID=4388903

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7411685.A NL155827B (nl) 1973-09-12 1974-09-03 Werkwijze voor de bereiding van antibacterieel werkzame benzylpyrimidinen, alsmede voor de bereiding van antibacterieel werkzame preparaten, die deze verbindingen bevatten, en de gevormde preparaten.

Country Status (28)

Country Link
JP (1) JPS6042238B2 (xx)
AR (2) AR207764A1 (xx)
AT (1) AT338797B (xx)
BE (1) BE819773A (xx)
BR (1) BR7407614D0 (xx)
CA (1) CA1037476A (xx)
CH (1) CH591456A5 (xx)
CU (1) CU34115A (xx)
DD (2) DD116824A5 (xx)
DE (1) DE2443682C2 (xx)
DK (1) DK135683B (xx)
ES (7) ES429949A1 (xx)
FI (1) FI58638C (xx)
FR (1) FR2242984B1 (xx)
GB (3) GB1484483A (xx)
HK (1) HK181A (xx)
HU (1) HU170427B (xx)
IE (1) IE40523B1 (xx)
IL (1) IL45510A (xx)
LU (1) LU70878A1 (xx)
NL (1) NL155827B (xx)
NO (1) NO140858C (xx)
PH (1) PH10643A (xx)
PL (2) PL97757B1 (xx)
SE (1) SE419443B (xx)
SU (3) SU577987A3 (xx)
YU (3) YU217874A (xx)
ZA (1) ZA745317B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
JPS5481278A (en) * 1977-10-18 1979-06-28 Wellcome Found Manufacture of triiseccaminomethane
CH639273A5 (de) * 1978-09-12 1983-11-15 Hoffmann La Roche Diuretische mittel.
DE3241134C2 (de) * 1981-11-09 1996-04-11 Mallinckrodt Veterinary Inc N Verfahren zur Herstellung von 2,4-Diamino-5-benzylpyrimidinen sowie Zwischenprodukte des Verfahrens
DE3250132C2 (de) * 1981-11-09 1997-01-16 Mallinckrodt Veterinary Inc Verfahren zur Herstellung von 2,4-Diamino-5-benzyl-pyrimidinen und neue Zwischenprodukte des Verfahrens
GB2180836A (en) * 1985-09-27 1987-04-08 William James Stephen Barker Sunscreen
JPH0431685Y2 (xx) * 1987-06-01 1992-07-30
US4900859A (en) * 1987-12-03 1990-02-13 Hoffman-La Roche Inc. Process for 4-dimethylamino-3,5-dimethoxybenzaldehyde
CA1300166C (en) * 1987-12-03 1992-05-05 Alfredo Guerrato Process for the preparation of a benzoic acid ester

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1103931B (de) * 1957-02-21 1961-04-06 Wellcome Found Verfahren zur Herstellung von 2, 4-Diamino-5-benzylpyrimidinderivaten
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes

Also Published As

Publication number Publication date
DE2443682A1 (de) 1975-03-20
YU37154B (en) 1984-08-31
DD116824A5 (xx) 1975-12-12
LU70878A1 (xx) 1976-08-19
ZA745317B (en) 1975-11-26
YU301680A (en) 1983-04-27
PL99159B1 (pl) 1978-06-30
CU21022L (en) 1981-09-09
FR2242984A1 (xx) 1975-04-04
YU217874A (en) 1982-06-18
DK135683C (xx) 1977-11-14
HK181A (en) 1981-01-16
ES437011A1 (es) 1977-04-01
IE40523B1 (en) 1979-06-20
SU577987A3 (ru) 1977-10-25
DE2443682C2 (de) 1983-11-10
YU37153B (en) 1984-08-31
AR211387Q (es) 1977-12-15
AU7263174A (en) 1976-02-26
BR7407614D0 (pt) 1975-07-08
BE819773A (fr) 1975-03-11
ES437013A1 (es) 1977-04-01
IE40523L (en) 1975-03-12
JPS5053385A (xx) 1975-05-12
SE419443B (sv) 1981-08-03
FI58638B (fi) 1980-11-28
GB1484482A (en) 1977-09-01
PH10643A (en) 1977-07-22
NO743271L (xx) 1975-04-07
SU571189A3 (ru) 1977-08-30
ES437008A1 (es) 1977-04-01
NO140858C (no) 1979-11-28
ES437012A1 (es) 1977-04-01
IL45510A0 (en) 1974-11-29
YU301580A (en) 1983-04-27
PL97757B1 (pl) 1978-03-30
DK468374A (xx) 1975-05-12
FI58638C (fi) 1981-03-10
DK135683B (da) 1977-06-06
FR2242984B1 (xx) 1977-11-04
DD122785A5 (xx) 1976-11-05
SE7411382L (xx) 1975-03-13
JPS6042238B2 (ja) 1985-09-20
CU34115A (es) 1983-10-04
AT338797B (de) 1977-09-12
CA1037476A (en) 1978-08-29
ES437007A1 (es) 1977-04-01
FI256174A (xx) 1975-03-13
GB1484483A (en) 1977-09-01
ES429949A1 (es) 1976-10-01
HU170427B (xx) 1977-06-28
AR207764A1 (es) 1976-10-29
ATA735174A (de) 1977-01-15
NL7411685A (nl) 1975-03-14
IL45510A (en) 1978-08-31
ES437009A1 (es) 1977-04-01
NO140858B (no) 1979-08-20
CH591456A5 (xx) 1977-09-15
GB1484481A (en) 1977-09-01
SU609465A3 (ru) 1978-05-30

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Owner name: F. HOFFMANN-LA ROCHE AG

V1 Lapsed because of non-payment of the annual fee
NL80 Information provided on patent owner name for an already discontinued patent

Owner name: HOFFMANN