SE419443B - Forfarande for framstellning av nya 2,4 diamino-5-bensylpyrimidinderivat - Google Patents

Forfarande for framstellning av nya 2,4 diamino-5-bensylpyrimidinderivat

Info

Publication number
SE419443B
SE419443B SE7411382A SE7411382A SE419443B SE 419443 B SE419443 B SE 419443B SE 7411382 A SE7411382 A SE 7411382A SE 7411382 A SE7411382 A SE 7411382A SE 419443 B SE419443 B SE 419443B
Authority
SE
Sweden
Prior art keywords
diamino
procedure
preparing new
benzylpyrimidine derivatives
benzylpyrimidine
Prior art date
Application number
SE7411382A
Other languages
English (en)
Other versions
SE7411382L (sv
Inventor
I Kompis
G Rey-Bellet
G Zanetti
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SE7411382L publication Critical patent/SE7411382L/xx
Publication of SE419443B publication Critical patent/SE419443B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
SE7411382A 1973-09-12 1974-09-09 Forfarande for framstellning av nya 2,4 diamino-5-bensylpyrimidinderivat SE419443B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1305773A CH591456A5 (sv) 1973-09-12 1973-09-12

Publications (2)

Publication Number Publication Date
SE7411382L SE7411382L (sv) 1975-03-13
SE419443B true SE419443B (sv) 1981-08-03

Family

ID=4388903

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7411382A SE419443B (sv) 1973-09-12 1974-09-09 Forfarande for framstellning av nya 2,4 diamino-5-bensylpyrimidinderivat

Country Status (28)

Country Link
JP (1) JPS6042238B2 (sv)
AR (2) AR207764A1 (sv)
AT (1) AT338797B (sv)
BE (1) BE819773A (sv)
BR (1) BR7407614D0 (sv)
CA (1) CA1037476A (sv)
CH (1) CH591456A5 (sv)
CU (1) CU34115A (sv)
DD (2) DD116824A5 (sv)
DE (1) DE2443682C2 (sv)
DK (1) DK135683B (sv)
ES (7) ES429949A1 (sv)
FI (1) FI58638C (sv)
FR (1) FR2242984B1 (sv)
GB (3) GB1484483A (sv)
HK (1) HK181A (sv)
HU (1) HU170427B (sv)
IE (1) IE40523B1 (sv)
IL (1) IL45510A (sv)
LU (1) LU70878A1 (sv)
NL (1) NL155827B (sv)
NO (1) NO140858C (sv)
PH (1) PH10643A (sv)
PL (2) PL97757B1 (sv)
SE (1) SE419443B (sv)
SU (3) SU577987A3 (sv)
YU (3) YU217874A (sv)
ZA (1) ZA745317B (sv)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
JPS5481278A (en) * 1977-10-18 1979-06-28 Wellcome Found Manufacture of triiseccaminomethane
CH639273A5 (de) 1978-09-12 1983-11-15 Hoffmann La Roche Diuretische mittel.
DE3250132C2 (de) * 1981-11-09 1997-01-16 Mallinckrodt Veterinary Inc Verfahren zur Herstellung von 2,4-Diamino-5-benzyl-pyrimidinen und neue Zwischenprodukte des Verfahrens
JPS5888368A (ja) * 1981-11-09 1983-05-26 ザ・ウエルカム・フアウンデ−シヨン・リミテツド ベンジルピリミジン誘導体の製造法
GB2180836A (en) * 1985-09-27 1987-04-08 William James Stephen Barker Sunscreen
JPH0431685Y2 (sv) * 1987-06-01 1992-07-30
US4900859A (en) * 1987-12-03 1990-02-13 Hoffman-La Roche Inc. Process for 4-dimethylamino-3,5-dimethoxybenzaldehyde
CA1300166C (en) * 1987-12-03 1992-05-05 Alfredo Guerrato Process for the preparation of a benzoic acid ester

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1103931B (de) * 1957-02-21 1961-04-06 Wellcome Found Verfahren zur Herstellung von 2, 4-Diamino-5-benzylpyrimidinderivaten
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes

Also Published As

Publication number Publication date
ES437009A1 (es) 1977-04-01
HU170427B (sv) 1977-06-28
JPS6042238B2 (ja) 1985-09-20
NO140858B (no) 1979-08-20
LU70878A1 (sv) 1976-08-19
CH591456A5 (sv) 1977-09-15
SU609465A3 (ru) 1978-05-30
AT338797B (de) 1977-09-12
FI256174A (sv) 1975-03-13
YU301580A (en) 1983-04-27
ES429949A1 (es) 1976-10-01
YU301680A (en) 1983-04-27
ES437012A1 (es) 1977-04-01
IL45510A (en) 1978-08-31
YU37153B (en) 1984-08-31
PH10643A (en) 1977-07-22
ES437008A1 (es) 1977-04-01
ES437013A1 (es) 1977-04-01
SE7411382L (sv) 1975-03-13
AR207764A1 (es) 1976-10-29
AR211387Q (es) 1977-12-15
CA1037476A (en) 1978-08-29
DD122785A5 (sv) 1976-11-05
JPS5053385A (sv) 1975-05-12
AU7263174A (en) 1976-02-26
DD116824A5 (sv) 1975-12-12
GB1484481A (en) 1977-09-01
FI58638C (fi) 1981-03-10
ZA745317B (en) 1975-11-26
ATA735174A (de) 1977-01-15
SU577987A3 (ru) 1977-10-25
FI58638B (fi) 1980-11-28
NL155827B (nl) 1978-02-15
GB1484482A (en) 1977-09-01
CU21022L (en) 1981-09-09
IL45510A0 (en) 1974-11-29
NO140858C (no) 1979-11-28
GB1484483A (en) 1977-09-01
CU34115A (es) 1983-10-04
HK181A (en) 1981-01-16
DK135683C (sv) 1977-11-14
ES437011A1 (es) 1977-04-01
ES437007A1 (es) 1977-04-01
DK135683B (da) 1977-06-06
BR7407614D0 (pt) 1975-07-08
DE2443682C2 (de) 1983-11-10
FR2242984A1 (sv) 1975-04-04
PL99159B1 (pl) 1978-06-30
DK468374A (sv) 1975-05-12
IE40523B1 (en) 1979-06-20
IE40523L (en) 1975-03-12
NO743271L (sv) 1975-04-07
SU571189A3 (ru) 1977-08-30
DE2443682A1 (de) 1975-03-20
BE819773A (fr) 1975-03-11
YU37154B (en) 1984-08-31
YU217874A (en) 1982-06-18
NL7411685A (nl) 1975-03-14
FR2242984B1 (sv) 1977-11-04
PL97757B1 (pl) 1978-03-30

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