FR2516081B1 - Synthese de benzylpyrimidines et produits intermediaires pour cette synthese - Google Patents
Synthese de benzylpyrimidines et produits intermediaires pour cette syntheseInfo
- Publication number
- FR2516081B1 FR2516081B1 FR8218670A FR8218670A FR2516081B1 FR 2516081 B1 FR2516081 B1 FR 2516081B1 FR 8218670 A FR8218670 A FR 8218670A FR 8218670 A FR8218670 A FR 8218670A FR 2516081 B1 FR2516081 B1 FR 2516081B1
- Authority
- FR
- France
- Prior art keywords
- synthesis
- benzylpyrimidines
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31964381A | 1981-11-09 | 1981-11-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2516081A1 FR2516081A1 (fr) | 1983-05-13 |
FR2516081B1 true FR2516081B1 (fr) | 1987-05-29 |
Family
ID=23243118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8218670A Expired FR2516081B1 (fr) | 1981-11-09 | 1982-11-08 | Synthese de benzylpyrimidines et produits intermediaires pour cette synthese |
Country Status (5)
Country | Link |
---|---|
JP (4) | JPS5888368A (fr) |
CH (4) | CH664959A5 (fr) |
DE (1) | DE3241134C2 (fr) |
FR (1) | FR2516081B1 (fr) |
GB (3) | GB2109375B (fr) |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE323746C (de) | 1919-10-30 | 1920-08-04 | Huebner Johannes | Feuerschutzapparat fuer kinematographische Projektionsapparate |
AT323745B (de) * | 1971-04-16 | 1975-07-25 | Wellcome Found | Verfahren zur herstellung von neuen 2,4-diamino-5-benzylpyrimidinen bzw. deren salzen |
GB1401612A (en) * | 1971-04-16 | 1975-07-16 | Wellcome Found | 2,4-diamino-5-benzylpyrimidines and preparations thereof |
CH592066A5 (fr) * | 1973-02-26 | 1977-10-14 | Hoffmann La Roche | |
US3923807A (en) * | 1973-09-10 | 1975-12-02 | Takeda Chemical Industries Ltd | 6-Aminouracil derivatives |
CH591456A5 (fr) * | 1973-09-12 | 1977-09-15 | Hoffmann La Roche | |
US4008236A (en) * | 1975-07-31 | 1977-02-15 | Abbott Laboratories | 2,4-Diamino-5-benzylpyrimidines |
JPS5353385A (en) * | 1976-10-26 | 1978-05-15 | Seiko Epson Corp | Clocking device |
GR71725B (fr) * | 1977-11-10 | 1983-06-22 | Hoffmann La Roche | |
CH639273A5 (de) * | 1978-09-12 | 1983-11-15 | Hoffmann La Roche | Diuretische mittel. |
-
1982
- 1982-11-08 FR FR8218670A patent/FR2516081B1/fr not_active Expired
- 1982-11-08 CH CH4394/86A patent/CH664959A5/de not_active IP Right Cessation
- 1982-11-08 CH CH6481/82A patent/CH658246A5/de not_active IP Right Cessation
- 1982-11-08 CH CH4395/86A patent/CH664960A5/de not_active IP Right Cessation
- 1982-11-08 JP JP57195848A patent/JPS5888368A/ja active Granted
- 1982-11-08 DE DE3241134A patent/DE3241134C2/de not_active Expired - Fee Related
- 1982-11-08 CH CH4396/86A patent/CH664961A5/de not_active IP Right Cessation
- 1982-11-09 GB GB08231983A patent/GB2109375B/en not_active Expired
-
1985
- 1985-06-24 GB GB08515931A patent/GB2161805B/en not_active Expired
- 1985-06-24 GB GB08515932A patent/GB2161158B/en not_active Expired
-
1993
- 1993-01-28 JP JP5012770A patent/JPH07606B2/ja not_active Expired - Lifetime
-
1994
- 1994-06-15 JP JP6133295A patent/JP2657150B2/ja not_active Expired - Lifetime
-
1997
- 1997-02-20 JP JP9036735A patent/JPH09227530A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
GB2161158A (en) | 1986-01-08 |
DE3241134A1 (de) | 1983-05-19 |
GB2161805A (en) | 1986-01-22 |
CH664960A5 (de) | 1988-04-15 |
JPH069576A (ja) | 1994-01-18 |
JPH07606B2 (ja) | 1995-01-11 |
CH658246A5 (de) | 1986-10-31 |
GB2109375A (en) | 1983-06-02 |
FR2516081A1 (fr) | 1983-05-13 |
GB8515931D0 (en) | 1985-07-24 |
GB8515932D0 (en) | 1985-07-24 |
JP2657150B2 (ja) | 1997-09-24 |
JPH0549665B2 (fr) | 1993-07-26 |
JPS5888368A (ja) | 1983-05-26 |
JPH08188574A (ja) | 1996-07-23 |
CH664961A5 (de) | 1988-04-15 |
GB2161805B (en) | 1986-07-30 |
GB2109375B (en) | 1986-08-06 |
GB2161158B (en) | 1986-07-30 |
DE3241134C2 (de) | 1996-04-11 |
JPH09227530A (ja) | 1997-09-02 |
CH664959A5 (de) | 1988-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
ST | Notification of lapse |