GB2161158B - Benzylpyrimidine synthesis & intermediates - Google Patents
Benzylpyrimidine synthesis & intermediatesInfo
- Publication number
- GB2161158B GB2161158B GB08515932A GB8515932A GB2161158B GB 2161158 B GB2161158 B GB 2161158B GB 08515932 A GB08515932 A GB 08515932A GB 8515932 A GB8515932 A GB 8515932A GB 2161158 B GB2161158 B GB 2161158B
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzylpyrimidine
- intermediates
- synthesis
- benzylpyrimidine synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31964381A | 1981-11-09 | 1981-11-09 |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8515932D0 GB8515932D0 (en) | 1985-07-24 |
GB2161158A GB2161158A (en) | 1986-01-08 |
GB2161158B true GB2161158B (en) | 1986-07-30 |
Family
ID=23243118
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB08231983A Expired GB2109375B (en) | 1981-11-09 | 1982-11-09 | Benzylpyrimidine synthesis and intermediates |
GB08515931A Expired GB2161805B (en) | 1981-11-09 | 1985-06-24 | Benzylpyrimidine synthesis and intermediates |
GB08515932A Expired GB2161158B (en) | 1981-11-09 | 1985-06-24 | Benzylpyrimidine synthesis & intermediates |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB08231983A Expired GB2109375B (en) | 1981-11-09 | 1982-11-09 | Benzylpyrimidine synthesis and intermediates |
GB08515931A Expired GB2161805B (en) | 1981-11-09 | 1985-06-24 | Benzylpyrimidine synthesis and intermediates |
Country Status (5)
Country | Link |
---|---|
JP (4) | JPS5888368A (en) |
CH (4) | CH664960A5 (en) |
DE (1) | DE3241134C2 (en) |
FR (1) | FR2516081B1 (en) |
GB (3) | GB2109375B (en) |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE323746C (en) | 1919-10-30 | 1920-08-04 | Huebner Johannes | Fire protection apparatus for cinematographic projection apparatus |
AT323745B (en) * | 1971-04-16 | 1975-07-25 | Wellcome Found | METHOD FOR PRODUCING NEW 2,4-DIAMINO-5-BENZYLPYRIMIDINES OR THEIR SALT |
GB1401612A (en) * | 1971-04-16 | 1975-07-16 | Wellcome Found | 2,4-diamino-5-benzylpyrimidines and preparations thereof |
CH592066A5 (en) * | 1973-02-26 | 1977-10-14 | Hoffmann La Roche | |
US3923807A (en) * | 1973-09-10 | 1975-12-02 | Takeda Chemical Industries Ltd | 6-Aminouracil derivatives |
CH591456A5 (en) * | 1973-09-12 | 1977-09-15 | Hoffmann La Roche | |
US4008236A (en) * | 1975-07-31 | 1977-02-15 | Abbott Laboratories | 2,4-Diamino-5-benzylpyrimidines |
JPS5353385A (en) * | 1976-10-26 | 1978-05-15 | Seiko Epson Corp | Clocking device |
GR71725B (en) * | 1977-11-10 | 1983-06-22 | Hoffmann La Roche | |
CH639273A5 (en) * | 1978-09-12 | 1983-11-15 | Hoffmann La Roche | DIURETIC MEANS. |
-
1982
- 1982-11-08 CH CH4395/86A patent/CH664960A5/en not_active IP Right Cessation
- 1982-11-08 DE DE3241134A patent/DE3241134C2/en not_active Expired - Fee Related
- 1982-11-08 CH CH4396/86A patent/CH664961A5/en not_active IP Right Cessation
- 1982-11-08 CH CH6481/82A patent/CH658246A5/en not_active IP Right Cessation
- 1982-11-08 CH CH4394/86A patent/CH664959A5/en not_active IP Right Cessation
- 1982-11-08 JP JP57195848A patent/JPS5888368A/en active Granted
- 1982-11-08 FR FR8218670A patent/FR2516081B1/en not_active Expired
- 1982-11-09 GB GB08231983A patent/GB2109375B/en not_active Expired
-
1985
- 1985-06-24 GB GB08515931A patent/GB2161805B/en not_active Expired
- 1985-06-24 GB GB08515932A patent/GB2161158B/en not_active Expired
-
1993
- 1993-01-28 JP JP5012770A patent/JPH07606B2/en not_active Expired - Lifetime
-
1994
- 1994-06-15 JP JP6133295A patent/JP2657150B2/en not_active Expired - Lifetime
-
1997
- 1997-02-20 JP JP9036735A patent/JPH09227530A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JPH0549665B2 (en) | 1993-07-26 |
GB2161805A (en) | 1986-01-22 |
GB2161158A (en) | 1986-01-08 |
GB2109375B (en) | 1986-08-06 |
CH664959A5 (en) | 1988-04-15 |
JPS5888368A (en) | 1983-05-26 |
JPH07606B2 (en) | 1995-01-11 |
GB8515931D0 (en) | 1985-07-24 |
DE3241134C2 (en) | 1996-04-11 |
FR2516081B1 (en) | 1987-05-29 |
FR2516081A1 (en) | 1983-05-13 |
GB2109375A (en) | 1983-06-02 |
JPH09227530A (en) | 1997-09-02 |
GB8515932D0 (en) | 1985-07-24 |
GB2161805B (en) | 1986-07-30 |
JPH069576A (en) | 1994-01-18 |
CH664960A5 (en) | 1988-04-15 |
JP2657150B2 (en) | 1997-09-24 |
CH664961A5 (en) | 1988-04-15 |
JPH08188574A (en) | 1996-07-23 |
DE3241134A1 (en) | 1983-05-19 |
CH658246A5 (en) | 1986-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19971109 |