NO135592B - - Google Patents
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- Publication number
- NO135592B NO135592B NO2694/72A NO269472A NO135592B NO 135592 B NO135592 B NO 135592B NO 2694/72 A NO2694/72 A NO 2694/72A NO 269472 A NO269472 A NO 269472A NO 135592 B NO135592 B NO 135592B
- Authority
- NO
- Norway
- Prior art keywords
- alkali metal
- alkyl
- nitro
- compounds
- nitroimidazoles
- Prior art date
Links
- 229910052783 alkali metal Inorganic materials 0.000 claims description 4
- -1 alkali metal alkoxides Chemical class 0.000 claims description 4
- 150000004959 2-nitroimidazoles Chemical class 0.000 claims description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims description 2
- 239000002585 base Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 150000003512 tertiary amines Chemical class 0.000 claims description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 2
- 229920002554 vinyl polymer Polymers 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- ULMDEURZWMWRAF-UHFFFAOYSA-N 5-(2-chloroethyl)-1-ethyl-2-nitroimidazole Chemical compound CCN1C(CCCl)=CN=C1[N+]([O-])=O ULMDEURZWMWRAF-UHFFFAOYSA-N 0.000 description 1
- WYZIGOITRAONMZ-UHFFFAOYSA-N 5-(2-chloroethyl)-1-methyl-2-nitroimidazole Chemical compound CN1C(CCCl)=CN=C1[N+]([O-])=O WYZIGOITRAONMZ-UHFFFAOYSA-N 0.000 description 1
- ZKHWQLRAMLAJAS-UHFFFAOYSA-N 5-ethenyl-1-ethyl-2-nitroimidazole Chemical compound CCN1C(C=C)=CN=C1[N+]([O-])=O ZKHWQLRAMLAJAS-UHFFFAOYSA-N 0.000 description 1
- NZPWAZZKZMQLTL-UHFFFAOYSA-N 5-ethenyl-1-methyl-2-nitroimidazole Chemical compound CN1C(C=C)=CN=C1[N+]([O-])=O NZPWAZZKZMQLTL-UHFFFAOYSA-N 0.000 description 1
- 241000193468 Clostridium perfringens Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 241000224527 Trichomonas vaginalis Species 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000004957 nitroimidazoles Chemical class 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO762176A NO762176L (xx) | 1971-07-30 | 1976-06-23 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT4297871 | 1971-07-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO135592B true NO135592B (xx) | 1977-01-17 |
| NO135592C NO135592C (xx) | 1977-04-27 |
Family
ID=11254772
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2694/72A NO135592C (xx) | 1971-07-30 | 1972-07-27 | |
| NO2693/72A NO135591C (xx) | 1971-07-30 | 1972-07-27 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2693/72A NO135591C (xx) | 1971-07-30 | 1972-07-27 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US3954789A (xx) |
| JP (2) | JPS528832B1 (xx) |
| AR (4) | AR199084A1 (xx) |
| AT (3) | AT316545B (xx) |
| AU (1) | AU462723B2 (xx) |
| BE (1) | BE785024A (xx) |
| CA (1) | CA997340A (xx) |
| CH (4) | CH574933A5 (xx) |
| CS (1) | CS180585B2 (xx) |
| DD (2) | DD99996A5 (xx) |
| DE (2) | DE2229248C3 (xx) |
| DK (1) | DK154295C (xx) |
| ES (3) | ES405343A1 (xx) |
| FI (1) | FI57255C (xx) |
| FR (1) | FR2148073B1 (xx) |
| GB (1) | GB1362444A (xx) |
| HU (2) | HU164926B (xx) |
| IE (1) | IE36530B1 (xx) |
| IL (1) | IL39880A (xx) |
| LU (1) | LU65816A1 (xx) |
| NL (2) | NL148602B (xx) |
| NO (2) | NO135592C (xx) |
| PL (4) | PL85190B1 (xx) |
| RO (6) | RO61517A (xx) |
| SE (3) | SE417711B (xx) |
| SU (4) | SU466684A3 (xx) |
| ZA (1) | ZA724723B (xx) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1480192A (en) * | 1975-01-15 | 1977-07-20 | Lepetit Spa | 1-methyl-2-nitro-imidazole-5-methanol derivatives |
| GB1526451A (en) * | 1976-01-27 | 1978-09-27 | Lepetit Spa | Alpha,alpha,1-trimethyl-2-nitroimidazole-5-methanol derivatives |
| US4218460A (en) * | 1976-09-29 | 1980-08-19 | Basf Aktiengesellschaft | Nitroimidazoles |
| US4199592A (en) * | 1978-08-29 | 1980-04-22 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-nitroimidazoles |
| ZW24982A1 (en) * | 1981-11-30 | 1983-06-15 | Hoffmann La Roche | 2-nitroimidazoles |
| JPH10338673A (ja) * | 1997-06-04 | 1998-12-22 | Nippon Bayeragrochem Kk | イソニコチン酸ヒドラジド誘導体および有害生物防除剤 |
| ZA200507752B (en) | 2003-03-28 | 2007-01-31 | Threshold Pharmaceuticals Inc | Compositions and methods for treating cancer |
| PL1896040T3 (pl) | 2005-06-29 | 2012-12-31 | Threshold Pharmaceuticals Inc | Proleki alkilatora fosforoamidowego |
| US8552048B2 (en) | 2006-12-26 | 2013-10-08 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs for the treatment of cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL124627C (xx) * | 1964-08-12 | |||
| NL143227B (nl) * | 1968-11-15 | 1974-09-16 | Lepetit Spa | Werkwijze ter bereiding van imidazoolderivaten met bactericide werking. |
| US3583985A (en) * | 1969-04-09 | 1971-06-08 | Richardson Merrell Inc | Nitroimidazolyl nitrones |
| US3711495A (en) * | 1970-01-07 | 1973-01-16 | Merck & Co Inc | Isoxazalin-3-yl-substituted-5-nitroimidazoles |
-
1972
- 1972-06-15 DE DE2229248A patent/DE2229248C3/de not_active Expired
- 1972-06-15 DE DE2229223A patent/DE2229223C3/de not_active Expired
- 1972-06-16 BE BE785024A patent/BE785024A/xx not_active IP Right Cessation
- 1972-06-30 FI FI1864/72A patent/FI57255C/fi active
- 1972-07-05 IE IE944/72A patent/IE36530B1/xx unknown
- 1972-07-05 AU AU44228/72A patent/AU462723B2/en not_active Expired
- 1972-07-11 ZA ZA724723A patent/ZA724723B/xx unknown
- 1972-07-11 IL IL39880A patent/IL39880A/en unknown
- 1972-07-13 GB GB3288672A patent/GB1362444A/en not_active Expired
- 1972-07-20 AR AR243172A patent/AR199084A1/es active
- 1972-07-20 AR AR243170A patent/AR193999A1/es active
- 1972-07-20 AR AR243171A patent/AR193885A1/es active
- 1972-07-25 SU SU1812193A patent/SU466684A3/ru active
- 1972-07-25 SU SU1812191A patent/SU463263A3/ru active
- 1972-07-26 US US05/275,415 patent/US3954789A/en not_active Expired - Lifetime
- 1972-07-26 DK DK369072A patent/DK154295C/da not_active IP Right Cessation
- 1972-07-27 JP JP47075508A patent/JPS528832B1/ja active Pending
- 1972-07-27 NO NO2694/72A patent/NO135592C/no unknown
- 1972-07-27 NO NO2693/72A patent/NO135591C/no unknown
- 1972-07-27 NL NL727210339A patent/NL148602B/xx not_active IP Right Cessation
- 1972-07-27 NL NL727210340A patent/NL149491B/xx not_active IP Right Cessation
- 1972-07-27 JP JP47075507A patent/JPS5038111B1/ja active Pending
- 1972-07-27 CS CS7200005305A patent/CS180585B2/cs unknown
- 1972-07-28 SE SE7209897A patent/SE417711B/xx unknown
- 1972-07-28 HU HULE664A patent/HU164926B/hu unknown
- 1972-07-28 AT AT652772A patent/AT316545B/de not_active IP Right Cessation
- 1972-07-28 DD DD164752A patent/DD99996A5/xx unknown
- 1972-07-28 PL PL1972156989A patent/PL85190B1/pl unknown
- 1972-07-28 CH CH1521075A patent/CH574933A5/xx not_active IP Right Cessation
- 1972-07-28 RO RO71770A patent/RO61517A/ro unknown
- 1972-07-28 RO RO71769A patent/RO62787A/ro unknown
- 1972-07-28 FR FR7227293A patent/FR2148073B1/fr not_active Expired
- 1972-07-28 AT AT652872A patent/AT315164B/de not_active IP Right Cessation
- 1972-07-28 RO RO7200079770A patent/RO63048A/ro unknown
- 1972-07-28 RO RO7200075751A patent/RO63453A/ro unknown
- 1972-07-28 CH CH1127772A patent/CH572040A5/xx not_active IP Right Cessation
- 1972-07-28 DD DD164754A patent/DD99995A5/xx unknown
- 1972-07-28 LU LU65816D patent/LU65816A1/xx unknown
- 1972-07-28 AT AT686873A patent/AT323736B/de not_active IP Right Cessation
- 1972-07-28 RO RO7200079771A patent/RO63049A/ro unknown
- 1972-07-28 SE SE7209898A patent/SE392615B/xx unknown
- 1972-07-28 RO RO7200079769A patent/RO63047A/ro unknown
- 1972-07-28 HU HULE663A patent/HU167622B/hu unknown
- 1972-07-28 PL PL1972156990A patent/PL82980B1/pl unknown
- 1972-07-28 CH CH1127672A patent/CH580596A5/xx not_active IP Right Cessation
- 1972-07-28 CH CH1521175A patent/CH574934A5/xx not_active IP Right Cessation
- 1972-07-28 PL PL1972163819A patent/PL87673B1/pl unknown
- 1972-07-28 PL PL1972175045A patent/PL84350B1/pl unknown
- 1972-07-29 ES ES405343A patent/ES405343A1/es not_active Expired
- 1972-07-29 ES ES405341A patent/ES405341A1/es not_active Expired
- 1972-07-31 CA CA148,336A patent/CA997340A/en not_active Expired
-
1973
- 1973-06-27 SU SU7301932092A patent/SU581863A3/ru active
- 1973-08-02 AR AR249413A patent/AR199680A1/es active
- 1973-09-20 ES ES418921A patent/ES418921A1/es not_active Expired
- 1973-12-24 SU SU7301978810A patent/SU567404A3/ru active
-
1975
- 1975-03-18 SE SE7503080A patent/SE417200B/xx not_active IP Right Cessation
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